Last Updated:
2023.11.16

生化学分野 -Department of Biochemistry-

Select language: 
日本語 /
English

研究業績

細胞 細胞

過去の研究業績です。見たい年をクリックして下さい。

2023年の研究業績

原著

  1. Koki Amano*, Yuuki Kurebayashi*, Tadanobu Takahashi* (*They contributed equally as first authors), Yutaka Narimichi, Tadamune Otsubo, Kiyoshi Ikeda, Akira Minami, Hideyuki Takeuchi
    Visualizing intracellular sialidase activity of influenza A virus neuraminidase using a fluorescence imaging probe
    J. Virol. Methods 323, 114838 (2023)
  2. Rina Hanai, Hiroshi Matsushita, Akira Minami, Yuki Abe, Rika Tachibana, Kazushi Watanabe, Hideyuki Takeuchi, Akihiko Wakatsuki
    Effects of 10-Hydroxy-2-decenoic Acid and 10-Hydroxydecanoic Acid in Royal Jelly on Bone Metabolism in Ovariectomized Rats: A Pilot Study
    J Clin Med. 12(16), 5309 (2023)

Reviews

  1. 南 彰,松下 宏,金澤 寛明,紅林 佑希,高橋 忠伸,鈴木 隆,若槻 明彦,竹内 英之
    閉経モデルラットが示す中枢神経の機能低下に対する機能性食品の効果
    In press (2023)
  2. Yuuki Kurebayashi, Hideyuki Takeuchi
    Special Issue: New Insights into Protein Glycosylation
    Molecules 28 (7), 3263 (2023)
  3. Katsuki Sato, Tadanobu Takahashi, and Hideyuki Takeuchi.
    Assay of protein O-glucosyltransferase 1 (POGLUT1) glycosyltransferase activity.
    Glycoscience Protocols (GlycoPODv2) (2023)
  4. Amika Yoshioka, Yuuki Kurebayashi, and Hideyuki Takeuchi.
    Assay of glucoside α1,3-xylosyltransferase 1/2 (GXYLT1/2) and xyloside α1,3-xylosyltransferase 1 (XXYLT1) xylosyltransferase activity.
    Glycoscience Protocols (GlycoPODv2) (2023)

2022年の研究業績

原著

  1. Azliza Mad Anuar, Akira Minami, Hiroshi Matsushita, Kanako Ogino, Kosei Fujita, Hatsune Nakao, Shota Kimura, Vikineswary Sabaratnam, Kaoru Umehara, Yuuki Kurebayashi, Tadanobu Takahashi, Hiroaki Kanazawa, Akihiko Wakatsuki, Takashi Suzuki, Hideyuki Takeuchi
    Ameliorating Effect of the Edible Mushroom Hericium erinaceus on Depressive-Like Behavior in Ovariectomized Rats
    Biol Pharm Bull. 45(10), 1438-1443 (2022)
  2. Ailing Zhang, Yohei Tsukamoto, Hideyuki Takeuchi, Kimitoshi Nishiwaki, Yuko Tashima, Tetsuya Okajima
    Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation
    Anal Biochem. 656, 114881 (2022)
  3. Chenyu Ma*, Yohei Tsukamoto* (*They contributed equally as first authors), Hideyuki Takeuchi
    Generation of Properly Folded Epidermal Growth Factor-Like (EGF) Repeats and Glycosyltransferases Enables In Vitro O-Glycosylation
    Methods Mol Biol. 2472, 27-38 (2022)
  4. Kaori Kobayashi, Chika Shono, Takuya Mori, Hidefumi Kitazawa, Noriyasu Ota, Yuki Kurebayashi, Takashi Suzuki
    Protein-bound sialic acid in saliva contributes directly to salivary anti-influenza virus activity
    Sci Rep. 12(1), 6636 (2022)
  5. Yohei Tsukamoto, Mitsutaka Ogawa, Kentarou Yogi, Yuko Tashima, Hideyuki Takeuchi, Tetsuya Okajima
    Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH1
    Glycobiology 32(7), 616-628 (2022)

Reviews

  1. Weiwei Wang, Tetsuya Okajima, Hideyuki Takeuchi
    Significant Roles of Notch O-Glycosylation in Cancer
    Molecules 27 (6), 1783 (2022)

2021年の研究業績

原著

  1. Tadanobu Takahashi*, Yuuki Kurebayashi* (*They contributed equally as first authors), Kazumasa Tani, Mika Yamazaki, Akira Minami, Hideyuki Takeuchi
    The antiviral effect of catechins on mumps virus infection
    J Funct Foods. 87, 104817 (2021)
  2. Yuki Kurebayashi, Shringkhala Bajimaya, Masahiro Watanabe, Nicholas Lim, Michael Lutz, Megan Dunagan, Toru Takimoto
    Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells
    PLoS Pathog. 17(9), e1009908 (2021)
  3. Beatriz Piniello, Erandi Lira-Navarrete, Hideyuki Takeuchi, Megumi Takeuchi, Robert S. Haltiwanger, Ramon Hurtado-Guerrero, Carme Rovira
    Asparagine Tautomerization in Glycosyltransferase Catalysis. The Molecular Mechanism of Protein O-Fucosyltransferase 1
    ACS Catal 11, 9926-9932 (2021)
  4. Tadanobu Takahashi, Yuuki Kurebayashi, Tadamune Otsubo, Kiyoshi Ikeda, Akira Minami, Takashi Suzuki
    Live Imaging of Virus-Infected Cells by Using a Sialidase Fluorogenic Probe
    Methods Mol. Biol. 2274, 141-154 (2021)
  5. Rashu Barua, Kazuyuki Mizuno, Yuko Tashima, Mitsutaka Ogawa, Hideyuki Takeuchi, Ayumu Taguchi, Tetsuya Okajima
    Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers
    Molecules 26 (4), 882 (2021)
  6. Akira Minami, Yuka Fujita, Jun Goto, Ayano Iuchi, Kosei Fujita, Yasuyo Mikami, Mako Shiratori, Ami Ishii, Samir Mitragotri, Yasunori Iwao, Hiroaki Kanazawa, Yuuki Kurebayashi, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki
    Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2
    Sci. Rep. 11, 3302 (2021)

Reviews

  1. Yohei Tsukamoto, Hideyuki Takeuchi
    Other Types of Glycosylation
    Adv Exp Med Biol. 1325, 117-135 (2021)
  2. Wataru Saiki, Chenyu Ma, Tetsuya Okajima, Hideyuki Takeuchi
    Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions.
    Biomolecules 11 (2), 309 (2021)
  3. Akira Minami, Yuuki Kurebayashi, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki
    The Function of Sialidase Revealed by Sialidase Activity Imaging Probe.
    Int. J. Mol. Sci. 22 (6), 3187 (2021)

2020年の研究業績

原著

  1. Shintaro Onishi, Takuya Mori, Hidetoshi Kanbara, Taichi Habe, Noriyasu Ota, Yuki Kurebayashi, Takashi Suzuki.
    Green tea catechins adsorbed on the murine pharyngeal mucosa reduce influenza A virus infection
    J. Funct. Foods. 68, 103894 (2020)
  2. Akira Minami, Yuka Fujita, Sumika Shimba, Mako Shiratori, Yukiko K. Kaneko, Toshiaki Sawatani, Tadamune Otsubo, Kiyoshi Ikeda, Hiroaki Kanazawa, Yasuyo Mikami, Risa Sekita, Yuuki Kurebayashi, Tadanobu Takahashi, Taeko Miyagi, Tomohisa Ishikawa, Takashi Suzuki.
    The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion
    Sci. Rep. 10, 5918 (2020)
  3. Akira Minami, Yasuyo Mikami, Takahiro Kano, Hiroshi Matsushita, Yuka Fujita, Marina Yoshimura, Yuki Abe, Hiromi Watanabe, Masaomi Hara, Yuki Kurebayashi, Tadanobu Takahashi, Hiroaki Kanazawa, Akihiko Wakatsuki, Takashi Suzuki.
    Mitigation of Memory Impairment in Ovariectomized Rats Using Garlic Powder Treated with Subcritical Water
    Biol. Pharm. Bull. 43(3), 546-549 (2020)

Reviews

  1. Yuuki Kurebayashi, Tadanobu Takahashi, Tadamune Otsubo, Akira Minami, Kiyoshi Ikeda, Takashi Suzuki
    Detection and Isolation of a Drug-Resistant Influenza Virus Using a Sialidase Fluorescence Imaging Technique
    Trends Glycosci. Glycotechnol. 32 (186), E37-E43 (2020)
  2. 高橋忠伸、鈴木 隆
    V-9 感染と糖鎖
    糖鎖生物学 生命現象と糖鎖情報(北島 健・佐藤ちひろ・門松健治・加藤晃一 編)(名古屋大学出版会)(2020)

2019年の研究業績

原著

  1. Yuuki Kurebayashi*, Tadanobu Takahashi* (* These authors contributed equally to this work), Tomomi Miura, Tadamune Otsubo, Akira Minami, Yuka Fujita, Keiko Sakakibara, Momoko Tanabe, Ayano Iuchi, Ryohei Ota, Kiyoshi Ikeda, Takashi Suzuki
    Fluorogenic probes for accurate in situ imaging of viral and mammalian sialidases
    ACS Chem. Biol. 14 (6), 1195-1204 (2019)
  2. Keijo Fukushima1, Tadanobu Takahashi1 (1They contributed equally as first authors), Masahiro Takaguchi, Seigo Ito, Chihiro Suzuki, Takashi Agarikuchi, Yuuki Kurebayashi, Minami Akira, Takashi Suzuki
    A I131V substitution in the fusion glycoprotein of human parainfluenza virus type 1 enhances syncytium formation and virus growth
    Biol. Pharm. Bull. 42 (5), 827-832 (2019)
  3. Tomonari Tanaka, Keita Nakashima, Sotaro Tsuji, Xiaoyu Han, Jianxin Zhao, Yoshitomo Honda, Keiko Sakakibara, Yuuki Kurebayashi, Tadanobu Takahashi, Takashi Suzuki
    Controlled Synthesis of Glycopolymers with Pendant Complex-Type Sialylglycopeptides and Their Binding Affinity with a Lectin and an Influenza Virus
    Polym. Chem. 10, 5124-5130 (2019)

Reviews

  1. 鈴木 隆
    インフルエンザウイルス感染における糖鎖機能の解明と医療への応用
    ファルマシア 55 (12), 1111-1115 (2019)
  2. 鈴木 隆
    レーニンジャーの新生化学(第7版下巻 分担訳)、Principles of Biochemistry 生化学と分子生物学の基本原理
    広川書店 (2019)
  3. Tadanobu Takahashi
    Function of Molecular Species of Influenza Virus-Binding Sialic Acid and Development of a Sialidase-Based Technique for Detecting Virus
    Trends Glycosci. Glycotechnol., Article for JSCR 40th Anniversary Issue, 31 (181), SE80-SE82 (2019)
  4. 高橋忠伸
    インフルエンザウイルスが結合するシアル酸分子種の機能解明とシアリダーゼを利用したウイルス検出技術の開発
    Trends Glycosci. Glycotechnol., Article for JSCR 40th Anniversary Issue, 31 (181), SJ80-SJ82 (2019)
  5. 南 彰、鈴木 隆
    シアリダーゼの機能解析ツールの開発と脳組織への応用
    化学と生物、57 (6), 346-351 (2019)

2018年の研究業績

原著

  1. Yasunori Iwao, Izumi Tomiguchi, Ayaka Domura, Yusuke Mantaira, Akira Minami, Takashi Suzuki, Takashi Ikawa, Shin-ichiro Kimura, Shigeru Itai
    Inflamed site-specific drug delivery system based on the interaction of human serum albumin nanoparticles with myeloperoxidase in a murine model of experimental colitis
    Eur J Pharm Biopharm. 125, 141-147 (2018)
  2. Akira Minami, Ami Ishii, Sumika Shimba, Takahiro Kano, Eri Fujioka, Saki Sai, Nagisa Oshio, Sayaka Ishibashi, Tadanobu Takahashi, Yuuki Kurebayashi, Hiroaki Kanazawa, Nobuhiro Yuki, Tadamune Otsubo, Kiyoshi Ikeda and Takashi Suzuki
    Down-regulation of glutamate release from hippocampal neurons by sialidase
    J Biochem. 163(4), 273-280 (2018)
  3. Daisuke Kato*, Yuuki Kurebayashi*, Tadanobu Takahashi* (*they contributed equally as first authors), Tadamune Otsubo, Hitomi Otake, Mika Yamazaki, Chihiro Tamoto, Akira Minami, Kiyoshi Ikeda, Takashi Suzuki
    An easy, rapid, and sensitive method for detection of drug-resistant influenza virus by using a sialidase fluorescent imaging probe, BTP3-Neu5Ac
    PLoS ONE 13(7), e0200761 (2018)
  4. Saki Shimizu, Hiroshi Matsushita, Akira Minami, Hiroaki Kanazawa, Takashi Suzuki, Kazushi Watanabe, Wakatsuki Akihiko
    Royal jelly does not prevent bone loss but improves bone strength in ovariectomized rats
    Climacteric, 21 (6), 601-606 (2018)

Reviews

  1. 高橋 忠伸,紅林 佑希,大坪 忠宗,池田 潔,南 彰,鈴木 隆
    薬剤耐性インフルエンザの蛍光検出単離法
    BIO Clinica 33 (3), 38-44 (2018) (2018年3月号、株式会社 北隆館)
  2. 高橋 忠伸,紅林 佑希,加藤 大介,大坪 忠宗,池田 潔,南 彰,鈴木 隆
    薬剤耐性インフルエンザの単離法と簡易高感度検出法
    BIO Clinica 33 (9), 98-103 (2018) (2018年8月号、株式会社 北隆館)
  3. 高橋忠伸、紅林佑希、加藤大介、大坪忠宗、池田 潔、南 彰、鈴木 隆
    薬剤耐性インフルエンザの蛍光イメージング法の開発
    アグリバイオ 2 (13) (2018年12月号), 81-87 (2018)
  4. 南 彰、鈴木 隆
    記憶におけるシアリダーゼの役割
    生化学、90(1), 94-98 (2018)
  5. 大坪忠宗、池田 潔、紅林佑希、南 彰、高橋忠伸、鈴木 隆
    固体発光性色素を用いたシアリダーゼライブイメージングプローブの開発
    有機合成化学協会誌 76 (12), 1272-1280 (2018)

2017年の研究業績

原著

  1. Hiroshi Matsushita, Akira Minami, Hiroaki Kanazawa, Takashi Suzuki, Sanan Subhadhirasakul, Kazushi Watanabe, Akihiko Wakatsuki
    Long-term supplementation with young coconut juice does not prevent bone loss but rather alleviates body weight gain in ovariectomized rats
    Biomedical. Reports. 6, 585-591 (2017)
  2. Tomonari Tanaka, Yiting Zhou, Chihiro Tamoto, Yuuki Kurebayashi, Tadanobu Takahashi, Takashi Suzuki
    An a2,3-linked sialylglycopolymer as a multivalent glycoligand against avian and human influenza viruses
    J Appl Glycosci. 64, 43-48 (2017)
  3. Akira Minami, Yuko Meguro, Sayaka Ishibashi, Ami Ishii, Mako Shiratori, Saki Sai, Yuuki Horii, Hirotaka Shimizu, Hokuto Fukumoto, Sumika Shimba, Risa Taguchi, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda and Takashi Suzuki
    Rapid regulation of sialidase activity in response to neural activity and sialic acid removal during memory processing in rat hippocampus
    J Biol Chem. 292, 5645-5654 (2017)

Reviews

  1. Takashi Suzuki
    Imaging of sialidase activity and its clinical application
    Biol. Pharm. Bull. 40, 2015-2023 (2017)
  2. 鈴木 隆
    ヒトパラインフルエンザウイルスの糖鎖結合性と感染制御
    生化学 第89 巻第5 号,pp. 1-6(2017)
  3. 高橋忠伸、紅林佑希、大坪忠宗、池田 潔、南 彰、鈴木 隆
    シアリダーゼを利用したウイルス感染細胞の蛍光イメージング
    公益社団法人 日本分析化学会「分析化学」総説論文65 (12), 689-701 (2016) 2017年1月12日公開
  4. 高橋忠伸
    インフルエンザウイルスが結合する糖鎖分子の機能解明
    日本ウイルス学会誌「ウイルス」第66巻1号, 101-116 (2016) 2017年5月9日公開
  5. 高橋忠伸
    高精度化・高感度化をめざしたウイルス酵素イメージング剤の開発と応用法の確立
    一般財団法人 東海産業技術振興財団 TFTニュース No. 60, 15-22 (2017)
  6. 高橋忠伸
    ウイルスシアリダーゼの酸性安定性の新機能研究
    赤枝医学研究財団「あゆみ」第2号, 42-43 (2017)

2016年の研究業績

原著

  1. Akira Minami, Masakazu Saito, Shou Mamada, Daisuke Ieno, Tomoya Hikita, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda and Takashi Suzuki
    Role of sialidase in long-term potentiation at mossy fiber-CA3 synapses and hippocampus-dependent spatial memory
    PLoS One 11, e0165257 (2016)
  2. Akira Minami, Hiroshi Matsushita, Daisuke Ieno, Yukino Matsuda, Yuuki Horii, Ami Ishii, Tadanobu Takahashi, Hiroaki Kanazawa, Akihiko Wakatsuki, Takashi Suzuki
    Improvement of neurological disorders in postmenopausal model rats by administration of royal jelly
    Climacteric 19, 568-573 (2016)
  3. Tadanobu Takahashi, Saori Unuma, Sawako Kawagishi, Yuuki Kurebayashi, Maiko Takano, Hiroki Yoshino, Akira Minami, Takashi Yamanaka, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki
    Substrate specificity of equine and human influenza A virus sialidase to molecular species of sialic acid
    Biol. Pharm. Bull. 39, 1728-1733 (2016)
    doi:10.1248/bpb.b16-00345
  4. Masanori Nagao, Yuuki Kurebayashi, Hirokazu Seto, Tadanobu Takahashi, Takashi Suzuki, Yu Hoshino, Yoshiko Miura
    Polyacrylamide backbones for polyvalent bioconjugates using “post-click” chemistry
    Polym. Chem. 7, 5920-5924 (2016)
    doi:10.1039/C6PY00904B
  5. Yuuki Kurebayashi*, Tadanobu Takahashi* (*they contributed equally as first authors), Chihiro Tamoto, Keiji Sahara, Tadamune Otsubo, Tatsuya Yokozawa, Nona Shibahara, Hirohisa Wada, Akira Minami, Kiyoshi Ikeda, Takashi Suzuki
    High-efficiency capture of drug resistant-influenza virus by live imaging of sialidase activity
    PLoS One 11(5): e0156400 (2016)
    doi:10.1371/journal.pone.0156400
  6. Masanori Nagano, Yuuki Kurebayashi, Hirokazu Seto, Tomonari Tanaka, Tadanobu Takahashi, Takashi Suzuki, Yu Hoshino, Yoshiko Miura
    Synthesis of well-controlled glycopolymers bearing oligosaccharides and their interactions with influenza viruses
    Polym. J. 48, 745-749 (2016)
    doi:10.1038/pj.2016.14
  7. Tomohiro Asakawa, Atsushi Yoshida, Yasuo Hirooka, Takashi Suzuki, Kunihiko Itoh, Kosuke Shimizu, Naoto Oku, Takumi Furuta,Toshiyuki Wakimoto, Makoto Inai, Toshiyuki Kan
    Synthesis of chemical-biology tools enabling in vivo imaging and analysis of epigallocatechin gallate
    Heterocycles in press doi: 10.3987/COM-15-S(T)25

Reviews

  1. 紅林佑希
    抗インフルエンザ薬耐性ウイルスの高感度検出分離法の開発
    The Japanese Journal of Antibiotics, 69 (6), 357-366 (2016)
  2. 高橋忠伸
    化学・生物素材研究開発奨励賞受賞者のご紹介
    一般財団法人 バイオインダストリー協会誌 B&I 74 (5)、p.463 (2016)
  3. 高橋忠伸
    レクチンを用いたシアロ糖鎖末端構造の検出
    Cosmo Bio News No.122「Application Note」, 26-27 (2016)(コスモ・バイオ学術論文賞2015受賞論文選出)
  4. 大坪 忠宗、池田 潔、南 彰、高橋 忠伸、鈴木 隆
    蛍光組織染色が可能なシアリダーゼ蛍光プローブ
    和光純薬時報 Vol.84 No.2 (2016年4月発行), 5-7 (2016)
  5. 高橋忠伸
    ウイルスシアリダーゼの酸性安定性の新機能研究
    公益財団法人 赤枝医学研究財団「あゆみ」創刊号, p. 38 (2016)
  6. 高橋忠伸
    インフルエンザウイルスのスルファチド結合機構をターゲットとした創薬研究
    公益財団法人 薬学研究奨励財団「薬学研究の進歩」32, 41-48 (2016)
  7. Tomonari Tanaka, Tadanobu Takahashi, Takashi Suzuki
    Protecting-Group-Free Synthesis of Glycopolymers and Their Binding Assay with Lectin and Influenza Virus.
    Methods Mol. Biol. (Springer Publishing) 1367, 39-48 (2016)
    doi: 10.1007/978-1-4939-3130-9_4

著書

  1. 鈴木 隆、高橋忠伸
    ウイルス学総論、ウイルス学各論、ウイロイド、プリオンの項目
    微生物学 病原微生物と治療薬(編集 今井康之、増澤俊幸)改定第7版(南江堂)、p. 241-299 (2016)

2015年の研究業績

原著

  1. Tadanobu Takahashi, Takashi Agarikuchi, Yuuki Kurebayashi, Nona Shibahara, Chihiro Suzuki, Akiko Kishikawa, Keijo Fukushima, Maiko Takano, Fumie Suzuki, Hirohisa Wada, Tadamune Otsubo, Kiyoshi Ikeda, Akira Minami, Takashi Suzuki
    Easy and Rapid Detection of Mumps Virus by Live Fluorescent Visualization of Virus-Infected Cells
    PLoS One 10, e0144038 (2015)
    doi:10.1371/journal.pone.0144038
  2. Yuko Morii, Hiroshi Matsushita, Akira Minami, Hiroaki Kanazawa, Takashi Suzuki, Sanan Subhadhirasakul, Kazushi Watanabe, Akihiko Wakatsuki
    Young Coconut Juice Supplementation Results in Greater Bone Mass and Bone Formation Indices in Ovariectomized Rats: A Preliminary Study.
    Phytother. Res. (2015)
    doi: 10.1002/ptr.5489
  3. Risa Taguchi*, Akira Minami* (*they contributed equally as first authors), Yukino Matsuda, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki
    Preferential accumulation of 14C-N-glycolylneuraminic acid over 14C-N-acetylneuraminic acid in the rat brain after tail vein injection.
    PLoS One 10, e0131061 (2015)
    doi:10.1371/journal.pone.0131061
  4. Ippei Watanabe, Tomoya Hikita, Haruka Mizuno, Risa Sekita, Akira Minami, Ami, Ishii, Yuka Minamisawa, Kiyoshi Suzuki, Hiroshi Maeda, Kazuya I P J Hidari, Takashi Suzuki
    Isolation and characterization of monoclonal antibodies specific for chondroitin sulfate E.
    Glycobiology 25, 953-962 (2015)
    doi: 10.1093/glycob/cwv039
  5. Tadanobu Takahashi, Sawako Kawagishi, Hiroki Funahashi, Nonoka Hayashi, Takashi Suzuki
    Production and purification of secretory simian cytidine monophosphate-N-acetyl neuraminic acid hydroxylase by using baculovirus-protein expression system.
    Biol. Pharm. Bull. 38, 1220-1226 (2015)
    doi:10.1248/bpb.b15-00299
  6. Tadanobu Takahashi*, Maiko Takano* (*they contributed equally as first authors), Yuuki Kurebayashi, Takashi Agarikuchi, Chihiro Suzuki, Keijo Fukushima, Shunsaku Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Akira Minami, Takashi Suzuki
    Rapid fluorescent detection assay for human parainfluenza viruses.
    Biol. Pharm. Bull. 38, 1214-1219 (2015)
    doi:10.1248/bpb.b15-00298
  7. Keijo Fukushima*, Tadanobu Takahashi* (*they contributed equally as first authors), Hiroo Ueyama, Masahiro Takaguchi, Seigo Ito, Kenta Oishi, Akira Minami, Erika Ishitsubo, Hiroaki Tokiwa, Toru Takimoto, Takashi Suzuki
    Amino acid substitutions contributing to α2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase.
    FEBS Lett. 589, 1278-1282 (2015)
    doi:10.1016/j.febslet.2015.03.036.
  8. Kentaro Shoji, Tadanobu Takahashi, Kohta Kurohane, Koki Iwata, Takeshi Matsuoka, Shogo Tsuruta, Takatomo Sugino, Masaki Miyake, Takashi Suzuki, Yasuyuki Imai
    Recombinant IgA specific for influenza A virus hemagglutinin: production, functional analysis and formation of secretory IgA.
    Viral Immunol. 28, 170-178 (2015)
    doi:10.1089/vim.2014.0098.
  9. Tomohiro Kawahara, Tadanobu Takahashi, Kenta Oishi, Hiromu Tanaka, Midori Masuda, Shunsaku Takahashi, Maiko Takano, Tatsuya Kawakami, Keijo Fukushima, Hiroaki Kanazawa, Takashi Suzuki
    Consecutive oral administration of Bifidobacterium longum MM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model.
    Microbiol. Immunol. 59, 1-12 (2015)
    doi: 10.1111/1348-0421.12210.
  10. Mikiko Tsukimoto, Rikiya Ohashi, Nao Torimoto, Yoko Togo, Takashi Suzuki, Toshio Maeda, Yoshiyuki Kagawa
    Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys.
    Biopharm. Drug Dispos. 36, 15-33 (2015)
    DOI: 10.1002/bdd.1920

Reviews

  1. Tadanobu Takahashi and Takashi Suzuki
    Low-pH Stability of Influenza A Virus Sialidase Contributing to Virus Replication and Pandemic.
    Biol. Pharm. Bull. 38, 817-826 (2015)
    http://doi.org/10.1248/bpb.b15-00120
  2. Tadanobu Takahashi and Takashi Suzuki
    Role of Sulfatide in Influenza A virus Replication.
    Biol. Pharm. Bull. 38, 809-816 (2015)
    http://doi.org/10.1248/bpb.b15-00119
  3. 高橋忠伸
    ウイルス酵素を利用したウイルスや感染細胞の簡便、迅速な検出試薬の開発とその応用
    羊土社 実験医学(2015年8月号)Vol. 33. No. 13, p. 2114 (2015)
  4. Tadanobu Takahashi
    Properties of and a new technique for fluorescent detection of influenza virus sialidase.
    Trends Glycosci. Glycotechnol. 27 (158), E49-E60 (2015)
  5. 高橋忠伸
    インフルエンザウイルスのシアリダーゼの性状と新しい蛍光検出法
    Trends Glycosci. Glycotechnol. 27 (158), J49-J60 (2015)
  6. Tadanobu Takahashi and Takashi Suzuki
    Role of glycans in viral infection.
    Sugar Chains, Springer Publishing, p. 71-93 (2015)
    DOI: 10.1007/978-4-431-55381-6_5
  7. 高橋忠伸
    インフルエンザウイルスの新たな創薬や防疫戦略の開発をめざした研究
    -長寿フロントライン- Aging & Health 73号(2015年4月発行、株式会社厚生科学研究所), 38-41 (2015)
  8. 南 彰
    海馬における興奮性神経伝達調節機構の多角的解析と糖鎖機能分析ツールの開発
    Yakugaku-Zasshi 135 (12), 1341-1348 (2015)

2014年の研究業績

原著

  1. Yohei Watanabea, Tetsuo Ito, Madiha S. Ibrahim, Yasuha Arai, Kozue Hotta, Hoang Vu Mai Phuong, Nguyen Le Khanh Hang, Le Quynh Mai, Kosuke Soda, Masaoki Yamaoka, Emmanuel Djoko Poetranto, Laksmi Wulandari, Hiroaki Hiramatsu, Tomo Daidoji, Ritsuko Kubota-Koketsu, Nongluk Sriwilaijaroen, Takaaki Nakaya, Yoshinobu Okuno, Tadanobu Takahashi, Takashi Suzuki, Toshihiro Ito, Hak Hotta, Tetsu Yamashiro, Tsukasa Hayashi, Kouichi Morita, Kazuyoshi Ikuta, Yasuo Suzuki
    A novel immunochromatographic system for easy-to-use detection of group 1 avian influenza viruses with acquired human-type receptor binding specificity.
    Biosens. Bioelectron. 65, 211-219 (2014)
  2. Tomonari Tanaka, Hideki Ishitani, Yoshiko Miura, Kenta Oishi, Tadanobu Takahashi, Takashi Suzuki, Shin-ichiro Shoda, Yoshiharu Kimura
    Protecting-group-free Synthesis of Glycopolymers Bearing Sialyloligosaccharide and their High Binding with Influenza Virus.
    ACS Macro Lett. 3, 1074-1078 (2014)
  3. Tadanobu Takahashi, Maiko Takano, Takashi Agarikuchi, Yuuki Kurebayashi, Akira Minami, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki
    A novel method for detection of Newcastle disease virus with a fluorescent sialidase substrate.
    J. Virol. Methods 209, 136-142 (2014)
  4. Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Akira Minami, Takashi Suzuki
    Histochemical imaging of alkaline phosphatase using a novel fluorescent substrate.
    Biol. Pharm. Bull. 37, 1668-1673 (2014)

    本論文は「Biol. Pharm. Bull. 37 (10), 2014」の表紙に選ばれました。
    本論文は同学術誌の「Highlighted papers 2014 selected by Editor-in-Chief」11報の中の一つに選ばれました。
  5. Keijo Fukushima 1, Tadanobu Takahashi 1 (1, they contributed equally as first authors), Seigo Ito, Masahiro Takaguchi, Maiko Takano, Yuuki Kurebayashi, Kenta Oishi, Akira Minami, Tatsuya Kato, Enoch Y Park, Hidekazu Nishimura, Toru Takimoto, Takashi Suzuki
    Terminal Sialic Acid Linkages Determine Different Cell Infectivities of Human Parainfluenza Virus Type 1 and Type 3.
    Virology 464-465, 424-431 (2014)
  6. Tomoko Abe, Ayumi Sando, Fumiteru Teraoka, Tadamune Otsubo, Kouichi Morita, Hiroaki Tokiwa, Kiyoshi Ikeda, Takashi Suzuki, Kazuya I.P.J. Hidari
    Computational design of a sulfoglucuronide derivative fitting into a hydrophobic pocket of dengue virus E protein.
    Biochem. Biophys. Res. Commun. 449, 32-37 (2014)
  7. Tadanobu Takahashi, Maiko Takano, Yuuki Kurebayashi, Midori Masuda, Sawako Kawagishi, Masahiro Takaguchi, Takashi Yamanaka, Akira Minami, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki
    N-glycolylneuraminic Acid on Human Epithelial Cells Prevents Entry of Influenza A Virus with N-glycolylneuraminic Acid Binding Ability.
    J. Virol. 88, 8445-8456 (2014)
  8. Tohru Yoneyama, Chikara Ohyama, Shingo Hatakeyama, Shintaro Narita, Tomonori Habuchi, Takuya Koie, Kazuyuki Mori, Kazuya I Hidari, Maho Yamaguchi, Takashi Suzuki, Yuki Tobisawa
    Measurement of aberrant glycosylation of prostate specific antigen can improve specificity in early detection of prostate cancer.
    Biochem. Biophys. Res. Commun. 448, 390-396 (2014)
  9. Yuuki Kurebayashi 1, Tadanobu Takahashi 1 (1, they contributed equally as first authors), Tadamune Otsubo, Kiyoshi Ikeda, Shunsaku Takahashi, Maiko Takano, Takashi Agarikuchi, Tsubasa Sato, Yukino Matsuda, Akira Minami, Hiroaki Kanazawa, Yuko Uchida, Takehiko Saito, Yoshihiro Kawaoka, Toshihiro Yamada, Fumihiko Kawamori, Robin Thomson, Mark von Itzstein, Takashi Suzuki
    Imaging of influenza virus sialidase activity in living cells.
    Sci. Rep., 4, 4877 (2014)
  10. Maiko Takano 1, Tadanobu Takahashi 1 (1, they contributed equally as first authors), Takashi Agarikuchi, Yuuki Kurebayashi, Akira Minami, Tadamune Otsubo, Kiyoshi Ikeda, Hiroaki Kanazawa, Takashi Suzuki
    Histochemical fluorescent staining of Sendai virus-infected cells with a novel sialidase substrate.
    Virology 464-465, 206-212 (2014)
  11. Akira Minami, Tadamune Otsubo, Daisuke Ieno, Kiyoshi Ikeda, Hiroaki Kanazawa, Kosuke Shimizu, Ko Ohata, Tsunehiro Yokochi, Yuuki Horii, Hokuto Fukumoto, Risa Taguchi, Tadanobu Takahashi, Naoto Oku and Takashi Suzuki
    Visualization of sialidase activity in mammalian tissues and cancer detection with a novel fluorescent sialidase substrate.
    PLoS ONE 9, e81941 (2014)
  12. Yuriko Ohyama, Hiroshi Matsushita, Akira Minami, Hiroaki Kanazawa, Takashi Suzuki, Kazushi Watanabe, Akihiko Wakatsuki
    Lack of effect of the ethanol extract of Pleurotus eryngii on bone metabolism in ovariectomized rats.
    Climacteric 17, 492-499 (2014)
  13. Makoto Ogata, Hirotaka Uzawa, Kazuya I. P. J. Hidari, Takashi Suzuki, Enoch Y.Park, and Taichi Usui
    Facile Synthesis of Sulfated Sialoglycopolypeptides with a γ-Polyglutamic Acid Backbone as Hemagglutinin Inhibitors against Influenza Virus.
    J. Appl. Glycosci. 61, 1-7 (2014)
  14. Mai Oba, Yayoi Ueno, Satoru Kitani, Takuya Hayakawa, Tadanobu Takahashi, Takashi Suzuki, Masayuki Sato, Kiyoshi Ikeda
    Ferrier glycosylation reaction catalyzed by Bi(OTf)3-montmorillonite K-10: efficient synthesis of 3,4-unsaturated sialic acid derivatives: synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1.
    Heterocycles 89, 69-81 (2014)

Reviews

  1. 高橋忠伸
    ウイルス感染における糖鎖の機能解明
    Yakugaku-Zasshi 134 (8), 889-899 (2014)
  2. Tadanobu Takahashi and Takashi Suzuki
    Binding of influenza viruses to glycans.
    Glycoscience: Biology and Medicine (Part IIIV, Microbial Glycobiology and Infection, Glycobiology: Role of Glycans in Infections), Springer Publishing, pp 769-774 (2014)

2013年の研究業績

原著

  1. Akira Minami, Hiroshi Matsushita, Yuuki Horii, Daisuke Ieno, Yukino Matsuda, Masakazu Saito, Hiroaki Kanazawa, Yuriko Ohyama, Akihiko Wakatsuki, Atsushi Takeda, Kazuya I.P.J. Hidari, Vikineswary Sabaratnam, and Takashi Suzuki
    Improvement of depression-like behavior and memory impairment with the ethanol extract of Pleurotus eryngii in ovariectomized rats.
    Biol. Pharm. Bull. 36, 1990-1995 (2013)
  2. Tadanobu Takahashi, Tatsuya Kawakami, Takashi Mizuno, Akira Minami, Yuko Uchida, Takehiko Saito, Shigeyuki Matsui, Makoto Ogata, Taichi Usui, Nongluk Sriwilaijaroen, Hiroaki Hiramatsu, Yasuo Suzuki, and Takashi Suzuki
    Sensitive and direct detection of receptor binding specificity of highly pathogenic avian influenza A virus in clinical samples.
    PLoS ONE 8, e78125 (2013)
  3. Kazuya I.P.J. Hidari, Maho Yamaguchi, Fumihiko Ueno, Tomoko Abe, Kazuhiro Yoshida and Takashi Suzuki
    Influenza virus utilizes N-linked sialoglycans as receptors in A549 cells.
    Biochem. Biophys. Res. Commun. 436, 394-399 (2013)
  4. Akira Minami, Sayaka Ishibashi, Kiyoshi Ikeda, Erika Ishitsubo, Takanori Hori, Hiroaki Tokiwa, Risa Taguchi, Daisuke Ieno, Tadamune Otsubo, Yukino Matsuda, Saki Sai, Mari Inada and Takashi Suzuki
    Catalytic preference of Salmonella typhimurium LT2 sialidase for N-acetylneuraminic acid residue over N-glycolylneuraminic acid residue.
    FEBS Open Bio 3, 231-236 (2013)
  5. Tadanobu Takahashi, Jiasheng Song, Takashi Suzuki, Yoshihiro Kawaoka
    Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic.
    PLoS ONE 8, e64439 (2013)
  6. Tadanobu Takahashi, Sawako Kawagishi, Midori Masuda, Takashi Suzuki
    Binding kinetics of sulfatide with influenza A virus hemagglutinin.
    Glycoconj. J. 30, 709-716 (2013)
  7. Tadanobu Takahashi, Masahiro Takaguchi, Tatsuya Kawakami, Takashi Suzuki
    Sulfatide regulates caspase-3-independent apoptosis of influenza A virus through viral PB1-F2 protein.
    PLoS ONE 8, e61092 (2013)
  8. Kazuya I.P.J. Hidari, Tomoko Abe, Takashi Suzuki
    Crabohydrate-related inhibitors of dengue virus entry.
    Viruses 5, 605-618 (2013)
  9. Tadamune Otsubo, Akira Minami, Haruna Fujii, Risa Taguchi, Tadanobu Takahashi, Takashi Suzuki, Fumiteru Teraoka, Kiyoshi Ikeda
    2-(Benzothiazol-2-yl)-phenyl-β-D-galactopyranoside derivatives as fluorescent pigment dyeing substrates and their application for the assay of β-D-galactosidase activities.
    Bioorg. Med. Chem. Lett. 23, 2245-2249 (2013)
  10. Reiko Nishino, Takuya Hayakawa, Tadanobu Takahashi, Takashi Suzuki, Masayuki Sato, and Kiyoshi Ikeda
    Syntheses of 2-Deoxy-2,3-didehydro-N-acetylneuraminic Acid Analogues Modified by a-Acylaminoamido Groups at the C-4 Position Using Isocyanide-Based Four-Component Coupling and Biological Evaluation as Inhibitors of Human Parainfluenza Virus Type 1.
    Chem. Pharm. Bull. 61(1), 69-74 (2013)

Reviews

  1. 鈴木 隆: 緑茶によるインフルエンザウイルスの予防効果
    ファルマシア, 49,1080-1084 (2013)
  2. 鈴木 隆: インフルエンザ・かぜ予防. 新板茶の機能
    新版 茶の機能(企画:日本茶業中央会)pp.151-159 (2013)
  3. 高橋 忠伸: 糖鎖生物学を背景にしたウイルス研究
    研究戦略YAKU学-研究現場から臨床へ-、薬事日報、薬事日報社、pp.8、2013年10月2日

2012年の研究業績

原著

  1. Tadanobu Takahashi, Chairul A. Nidom, Mai thi Quynh Le,Takashi Suzuki, Yoshihiro Kawaoka
    Amino acid determinants conferring stable sialidase activity at low pH for H5N1 influenza A virus neuraminidase.
    FEBS Open Bio 2, 261-266 (2012)
  2. Tomohiro Nohara, Akihiro Imamura, Maho Yamaguchi, Kazuya I. P. J. Hidari, Takashi Suzuki, Tatsuya Komori, Hiromune Ando, Hideharu Ishida, Makoto Kiso.
    Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses.
    Molecules. 17, 9590-9620 (2012)
  3. Kazuya I.P.J. Hidari, Kiyoshi Ikeda, Ippei Watanabe, Tomoko Abe, Ayumi Sando, Yuji Itoh, Hiroaki Tokiwa, Kouichi Morita, Takashi Suzuki.
    3-O-sulfated glucuronide derivative as a potential anti-dengue virus agent.
    Biochem. Biophys. Res. Commun. 424, 573-578 (2012)
  4. Tadanobu Takahashi, Kazuhiko Ito, Keijo Fukushima, Masahiro Takaguchi, Takuya Hayakawa, Yasuo Suzuki, and Takashi Suzuki.
    Sulfatide Negatively Regulates the Fusion Process of Human Parainfluenza Virus Type 3.
    J. Biochem. 152, 373-380 (2012)
  5. Takashi Yamanaka, Manabu Nemoto, Hiroshi Bannai, Koji Tsujimura, Takashi Kondo, Tomio Matsumura, Masanori Muranaka, Takanori Ueno, Yuta Kinoshita, Hidekazu Niwa, Kazuya I. P. J. Hidari and Takashi Suzuki.
    No evidence of horizontal infection in horses kept in close contact with dogs experimentally infected with canine influenza A virus (H3N8).
    Acta Vet. Scand. 54, 25 (2012)
  6. Yuji Itoh, Ayumi Sando, Kiyoshi Ikeda, Takashi Suzuki, Hiroaki Tokiwa.
    Origins of the inhibitory activity of 4-O-substituented sialic derivatives of human parainfluenza virus.
    Glycoconj. J. 29, 231-237 (2012)
  7. Shinya Yamada, Kyoko Shinya, Ayato Takada, Toshihiro Ito, Takashi Suzuki, Yasuo Suzuki, Quynh Le, Masahito Ebina, Noriyuki Kasai, Hiroshi Kida, Taisuke Horimoto, Pierre Rivailler, Limei Chen, Ruben Donis, Yoshihiro Kawaoka.
    Adaptation of a duck influenza A virus in quail.
    J. Virol. 86, 1411-1420 (2012)
  8. Hirokazu Yagi, Shinya Watanabe, Takashi Suzuki, Tadanobu Takahashi, Yasuo Suzuki, Koichi Kato.
    Comparative Analyses of N-Glycosylation Profiles of Influenza A Viruses Grown in Different Host Cells.
    Open Glycoscience 5, 2-12 (2012)
  9. Kei-ichi Watanabe, Kazuya I.P.J. Hidari, Takashi Suzuki.
    Cold-shock protein expression system facilitates the solubility of human ST6Gal I in Escherichia coli.
    Open Glycoscience 5, 13-18 (2012)

Reviews

  1. Akira Minami and Takashi Suzuki.
    Activity and the Role of Sialidase in the Brain. -脳におけるシアリダーゼの活性分布と役割-
    Trends in Glycoscience and Glycotechnology Vol. 24 (No. 137), 112-121 (2012)
  2. Tadanobu Takahashi and Takashi Suzuki.
    Role of sulfatide in normal and pathological cells and tissues.
    J. Lipid Res. 53, 1437-1450 (2012)

2011年の研究業績

原著

  1. Jiancheng Chen, Shuhei Yamada, Yoshiki Hama, Ajaya Kumar Shetty, Takanari Kobayashi, Hiroshi Oda, Kosuke Seiki, Eunmi Kim, Takashi Kimura, Naonori Takahashi, Kazuya I. P. J. Hidari, Takashi Suzuki, Yasuo Suzuki, Kazuyuki Sugahara.
    Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus.
    Biochem. Biophys. Res. Commun. 412, 136-142 (2011)
  2. Akira Minami, Hirotaka Shimizu, Yuko Meguro, Naoki Shibata, Hiroaki Kanazawa, Kiyoshi Ikeda and Takashi Suzuki.
    Imaging of sialidase activity in rat brain sections by a highly sensitive fluorescent histochemical method.
    NeuroImage 58, 34-40 (2011)
  3. Keijo Fukushima, Tadanobu Takahashi, Masahiro Takaguchi, Hiroo Ueyama, Seigo Ito, Yuuki Kurebayashi, Tomohiro Kawanishi, Jennifer L. Mckimm-Breschkin, Toru Takimoto, Akira Minami, Takashi Suzuki.
    Plaque formation assay for human parainfluenza virus type 1.
    Biol. Pharm. Bull. 34, 996-1000 (2011)
  4. Reiko Nishino, Kiyoshi Ikeda, Takuya Hayakawa, Tadanobu Takahashi, Takashi Suzuki, Masayuki Sato.
    Syntheses of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of human parainfluenza virus type 1.
    Bioorg. Med. Chem., 19, 2418-2427 (2011)
  5. Sineewanlaya Wichit, Akanitt Jittmittraphap, Kazuya I.P.J. Hidari, Butsaya Thaisomboonsuk, Songsak Petmitr, Sukathida Ubol, Chie Aoki, Saki Itonori, Koichi Morita, Takashi Suzuki, Yasuo Suzuki, Wipawee Jampangern.
    Dengue virus type 2 recognizes carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells.
    Microbiol. Immunol. 55, 135-140 (2011)
  6. Atsushi Yoshida, Yasuo Hirooka, Yusuke Sugata, Mariko Nitta, Tamiko Manabe, Shunsuke Ido, Kouki Murakami, Repon Kumer Saha, Takashi Suzuki, Motohiro Ohshima, Akira Yoshida, Kunihiko Itoh, Kosuke Shimizu, Naoto Oku, Takumi Furuta, Tomohiro Asakawa, Toshiyuki Wakimoto, Toshiyuki Kan.
    Concise synthesis of catechin probes that would enable analysis and imaging of EGCg dynamics.
    Chem. Comm. 47, 1794-1796 (2011)
  7. Masahiro Takaguchi, Tadanobu Takahashi, Chika Hosokawa, Hiroo Ueyama, Keijo Fukushima, Takuya Hayakawa, Kazuhiko Itoh, Kiyoshi Ikeda, Takashi Suzuki.
    A single amino acid mutation at position 170 of human parainfluenza virus type 1 fusion glycoprotein induces obvious syncytium formation and caspase-3-dependent cell death.
    J. Biochem. 149, 191-202 (2011)
  8. Masanori Muranaka, Takashi Yamanaka, Yoshinari katayama, Kazuya I.P.J. Hidari, Hiroaki Kanazawa, Takashi Suzuki, Kazuomi Oku, Toshifumi Oyamadai.
    Distribution of influenza virus sialoreceptors on upper and lower respiratory tract in horses and dogs.
    J. Vet. Med. Sci. 73, 125-127 (2011)

Reviews

  1. Kazuya I.P.J. Hidari and Takashi Suzuki.
    Dengue virus receptor.
    Tropical Medicine and Health.

  2. Kazuya I.P.J. Hidari and Takashi Suzuki.
    Antiviral agents targeting glycans on dengue virus E-glycoprotein.
    Expert Rev. Anti Infect. Ther. 9 (11), 983-985, 2011.

  3. Tadanobu Takahashi and Takashi Suzuki.
    Function of membrane rafts in viral lifecycles and host cellular response.
    Biochemistry Research International vol. 2011, Article ID 245090, 23 pages, 2011.

2010年の研究業績

原著

  1. Tadanobu Takahashi, Yuuki Kurebayashi, Kumiko Ikeya, Takashi Mizuno, Keijo Fukushima, Hiroko Kawamoto, Yoshihiro Kawaoka, Yasuo Suzuki, Takashi Suzuki
    The Low-pH Stability Discovered in Neuraminidase of 1918 Pandemic Influenza A Virus Enhances Virus Replication
    PLoS One. 5 (12), e15556 (2010)
  2. Daisuke Kato,, Shota Era, Ippei Watanabe, Masataka Arihara, Nobuo Sugiura, Koji Kimata, Yasuo Suzuki, Kouichi Morita, Kazuya I.P.J. Hidari, Takashi Suzuki
    Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein
    Antiviral. Res. 88, 236-243 (2010)
  3. Kazuya IP J. Hidari, Takashi Suzuki
    Glycan receptor for influenza virus
    Open Antimicobial Agents J. 2, 26-33 (2010)
  4. Chairul A. Nidom, Ryo Takano, Shinya Yamada, Yuko Sakai-Tagawa, Syafril Daulay, Didi Aswadi, Takashi Suzuki, Yasuo Suzuki, Kyoko Shinya, Kyoko Iwatsuki-Horimoto, Yukiko Muramoto, Yoshihiro Kawaoka
    Influenza A (H5N1) viruses from pigs, Indonesia
    Emerg. Infect. Dis. 16, 1515-1523 (2010)
  5. Takashi Yamanaka, Koji Tsujimura, Takashi Kondo, Tomio Matsumura, Hideharu Ishida, Makoto Kiso, Kazuya IP J. Hidari, Takashi Suzuki
    Infectivity and pathogenicity of canine H3N8 influenza a virus in horses
    Influenza Other Respi. Viruses 4, 345-351 (2010)
  6. Repon Kumer Saha, Tadanobu Takahashi, Yuuki Kurebayashi, Keijo Fukushima, Akira Minami, Noriaki Kinbara, Masaki Ichitani, Yuko M. Sagesaka, Takashi Suzuki
    Antiviral effect of strictinin on influenza virus replication
    Antiviral. Res., 88, 10-18 (2010)
  7. Tadanobu Takahashi, Hiroaki Satoh, Masahiro Takaguchi, Suguru Takafuji, Hideshi Yokoyama, Satoshi Fujii, Takashi Suzuki
    Binding of sulfatide to recombinant hemagglutinin of influenza A virus produced by a baculovirus protein expression system.
    J. Biochem., 147, 459-462 (2010)

Reviews

  1. 鈴木 隆、鈴木康夫
    宿主細胞からのウイルスの放出
    現代化学, 476, 45-50 (2010)
  2. 鈴木 隆
    抗インフルエンザ薬について
    実験 治療, 699, 48-54 (2010)
  3. 左 一八、鈴木 隆
    デングウイルス感染に関わる糖鎖分子の構造と機能
    生化学, 82, 751-755 (2010)
  4. 高橋忠伸、鈴木 隆
    スルファチドによるインフルエンザA型ウイルス増殖の促進
    Glycoforum, http://www.glycoforum.gr.jp/science/glycomicrobiology/GM05/GM05J.html, SEIKAGAKU CORPORATION (2010)
  5. Tadanobu Takahashi and Takashi Suzuki
    Role of sulfatide in virus infection and replication.
    TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY (TIGG), Official Journal of the Japanese Society of Carbohydrate Research, Gakushin Publishing 学進出版, Vol. 21 No. 121, 255-265 (2009)

2009年の研究業績

原著

  1. Tadanobu Takahashi, Asako Hashimoto, Mami Maruyama, Hideharu Ishida, Makoto Kiso, Yoshihiro Kawaoka, Yasuo Suzuki, Takashi Suzuki
    Identification of amino acid residues of influenza A virus H3 HA contributing to the recognition of molecular species of sialic acid.
    FEBS Lett. 583, 3171-3174 (2009)
  2. Nongluk Sriwilaijaroen, Prapon Wilairat, Hiroaki Hiramatsu, Tadanobu Takahashi, Takashi Suzuki, Morihiro Ito, Yasuhiko Ito, Masato Tashiro, Yasuo Suzuki
    Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities.
    Virol. J. 6, 124 (2009)
  3. Jun-Ichi Sakamoto, Tetsuo Koyama, Daisei Miyamoto, Sangchai Yingsakmongkon, Kazuya I.P.J. Hidari, Wipawee Jampangern, Takashi Suzuki, Yasuo Suzuki, Yasuaki Esumi, Takemichi Nakamura, Ken Hatano, Daiyo Terunuma, Koji Matsuoka
    Systematic syntheses of influenza neuraminidase inhibitors: A series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties.
    Bioorg. Med. Chem. 17, 5451-5464 (2009)
  4. Makoto Ogata, Kazuya I. P. J. Hidari, Wataru Kozaki, Takeomi Murata, Jun Hiratake, Enoch Y. Park, Takashi Suzuki, Taichi Usui
    Molecular Design of Spacer-N-Linked Sialoglycopolypeptide as Polymeric Inhibitors Against Influenza Virus Infection.
    Biomacromolecules 10, 1894-1903 (2009)
  5. Repon Kumer Saha, Tadanobu Takahashi, Takashi Suzuki
    Glucosyl Hesperidin Prevents Influenza A Virus Replication In Vitro by Inhibition of Viral Sialidase.
    Biol. Pharm. Bull. 32, 1188-1192 (2009)
  6. Kazuya I.P.J. Hidari, Kin-ichi Oyama, Go Ito, Miho Nakayama, Makoto Inai, Shiho Goto, Yugo Kanai, Kei-ichi Watanabe, Kumi Yoshida, Takumi Furuta, Toshiyuki Kan, Takashi Suzuki
    Identification and characterization of flavonoids as sialyltransferase inhibitors.
    Biochem. Biophys. Res. Commun. 382, 609-613 (2009)
  7. Makoto Ogata, Kazuya I. P. J. Hidari, Takeomi Murata, Shizumi Shimada, Wataru Kozaki, Enoch Y. Park, Takashi Suzuki and Taichi Usui
    Chemoenzymatic Synthesis of Sialoglycopolypeptides As Glycomimetics to Block Infection by Avian and Human Influenza Viruses.
    Bioconjug. Chem. 20, 538-549 (2009)

Reviews

  1. 高橋忠伸、鈴木 隆
    パンデミックインフルエンザウイルスの出現とノイラミニダーゼの酸性安定性 -Emergence of pandemic influenza viruses and low-pH stability of neuraminidase-
    THE LUNG perspectives Vol. 17 No. 4, p. 83-88、株式会社メディカルレビュー社(2009)
  2. Tadanobu Takahashi, Takashi Suzuki
    Role of membrane rafts in viral infection.
    BENTAM OPEN, The Open Dermatology Jounal 3, 178-194 (2009)

2008年の研究業績

原著

  1. Takumi Furuta, Masayoshi Mochizuki, Mai Ito, Tadanobu Takahashi, Takashi Suzuki, Toshiyuki Kan
    Versatile Synthesis of Head Group Functionalized Phospholipids via Oxime Bond Formation.
    Org. Lett. 10, 4847-4850 (2008)
  2. Kazuya I.P.J. Hidari, Naonori Takahashi, Masataka Arihara, Masato Nagaoka, Koichi Morita, Takashi Suzuki
    Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga.
    Biochem. Biophys. Res. Commun. 376, 91-95 (2008)
  3. Junko Sugatani, Makoto, Osabe, Tadashi Wada, Kasumi Yamakawa, Yasuhiro Yamazaki, Tadanobu Takahashi, Akira Ikari, Masao Miwa
    Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet.
    Eur. J. Nutr. 47, 192-200 (2008)
  4. Kazuya I.P.J. Hidari, Takeomi Murata, Kazuhiro Yoshida, Yoshiharu Takahashi, Yo-hei Minamijima, Yoshinobu Miwa, Satoshi Adachi, Makoto Ogata, Taiichi Usui, Yasuo Suzuki, Takashi Suzuki
    Chemoenzymatic synthesis, characterization, and application of glycopolymers carrying lactosamine repeats as entry inhibitors against influenza virus infection.
    Glycobiology 18, 779-788 (2008)
  5. Kiyoshi Ikeda, Kazuki Sato, Reiko Nishino, Shinya Aoyama, Takashi Suzuki, Masayuki Sato
    2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogs structurally modified by thiocarbamoylalkyl groups at the C-4 position: Synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1.
    Bioorg. Med. Chem. 16, 6783-6788 (2008)
  6. Tadanobu Takahashi, Kouki Murakami, Momoe Nagakura, Hideyuki Kishita, Shinya Watanabe, Koichi Honke, Kiyoshi Ogura, Tadashi Tai, Kazunori Kawasaki, Daisei Miyamoto, Kazuya I.P. J. Hidari, Chao-Tan Guo, Yasuo Suzuki, Takashi Suzuki
    Sulfatide is required for efficient replication of influenza A virus.
    J. Virol. 82, 5940-5950 (2008)
  7. Hirokazu Yagi, Naoko Yasukawa, Shin-Yi Yu, Chao-Tan Guo, Noriko Takahashi, Tadanobu Takahashi, Wakoto Bukawa, Takashi Suzuki, Kay-Hooi Khoo, Yasuo Suzuki, Koichi Kato
    The expression of sialylated high-antennary N-glycans in edible bird’s nest.
    Carbohydr. Res. 343, 1373-1377 (2008)
  8. Tadanobu Takahashi, Yusuke Moriyama, Akira Ikari, Junko Sugatani, Takashi Suzuki, Masao Miwa
    Surface localization of the nuclear receptor CAR in influenza A virus-infected cells.
    Biochem. Biophys. Res. Commun. 368, 550-505 (2008)
  9. Daisei Miyamoto, Sayaka Hasegawa, Nongluk Sriwilaijaroen, Sangchai Yingsakmongkon, Hiroaki Hiramatsu, Tadanobu Takahashi, Kazuya Hidari, Chao-Tan Guo, Yuichi Sakano, Takashi Suzuki, Yasuo Suzuki
    Clarithromycin Inhibits Progeny Virus Production from Human Influenza Virus-Infected Host Cells.
    Biol. Pharm. Bull. 31, 217-222 (2008)
  10. Sangchai Yingsakmongkon, Daisei Miyamoto, Nongluk Sriwilaijaroen, Kimie Fujita, Kosai Matsumoto, Wipawee Jampangern, Hiroaki Hiramatsu, Chao-Tan Guo, Toshihiko Sawada, Tadanobu Takahashi, Kazuya Hidari, Takashi Suzuki, Morihiro Ito, Yasuhiko Ito, Yasuo Suzuki
    In Vitro Inhibition of Human Influenza A Virus Infection by Fruit-Juice Concentrate of Japanese Plum (Prunus mume SIEB. et ZUCC)
    Biol. Pharm. Bull. 31, 511-515 (2008)
  11. Akira Ikari, Midori Ito, Chiaki Okude, Hayato Sawada, Hitoshi Harada, Masakuni Degawa, Hideki Sakai, Tadanobu Takahashi, Junko Sugatani, Masao Miwa
    Claudin-16 is directly phosphorylated by protein kinase a independently of a vasodilator-stimulated phosphoprotein-mediated pathway.
    J. Cell. Physiol. 214, 221-229 (2008)
  12. Akira Ikari, Chiaki Okude, Hayato Sawada, Tadanobu Takahashi, Junko Sugatani, Masao Miwa
    Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A.
    Naunyn. Schmiedebergs. Arch. Pharmacol. 337, 333-343 (2008)

Reviews

  1. 鈴木 隆、高橋忠伸、鈴木康夫.
    インフルエンザウイルス感染におけるスルファチドの機能
    共立出版 蛋白質 核酸 酵素 糖鎖情報の独自性と普遍性 Vol. 53 No. 12, 1676-1682 (2008)

2007の研究業績

原著

  1. Kazuya I.P. J. Hidari, Shizumi Shimada, Yasuo Suzuki, Takashi Suzuki
    Binding kinetics of influenza viruses to sialic acid-containing carbohydrates.
    Glycoconjugate J. 24, 583-590 (2007)
  2. Akira Minami, Yan-fang Xia, Robert S. Zucker. Increased Ca2+ influx through Na+/Ca2+ exchanger during long-term facilitation at crayfish neuromuscular junction.
    J. Physiol. 585, 413-427 (2007)
  3. Patrick M. Collins, Kazuya IP. J. Hidari, Helen Blanchard
    Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols.
    Acta. Cryst. 63, 415-419 (2007)
  4. Kazuki Sato, Kiyoshi Ikeda, Takashi Suzuki, Shinya Aoyama, Naoyoshi Maki, Yasuo Suzuki, Masayuki Sato
    Synthesis of 4-O-[3-(aryl)prop-2-ynyl] -Neu5Ac2en and its 4-epi-analogs modified at C-4 by Sonogashira coupling reaction.
    Tetrahedron. 63, 7571-7581 (2007)
  5. Koji Matsuoka, Chiharu Takita, Tetsuo Koyama, Daisei Miyamoto, Sangchai Yingsakmongkon, Kazuya IP. J. hidari, Wipawee Jampangern, Takashi Suzuki, Yasuo Suzuki, Ken Hatano, Daiyo Terunuma
    Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neraminidase inhibitors.
    Bioorg. Med. Chem. Lett. 17, 3826-3830 (2007)
  6. Chao-Tan Guo, Noriko Takahashi, Hirokazu Yagi, Koichi Kato, Tadanobu Takahashi, Shuang-Qin Yi, Yong Chen, Toshihiro Ito, Koichi Otsuki, Hiroshi Kida, Yoshihiro Kawaoka, Kazuya I.P. J. Hidari, Daisei Miyamoto, Takashi Suzuki, Yasuo Suzuki.
    The qual and chicken intestine have sialyl-Gal sugar chains responsible for the binding of influenza A viruses to human type receptors.
    Glycobiol. 17, 713-724 (2007)
  7. Takumi Furuta, Yasuo Hirooka, Ayako Abe, Yusuke Sugata, Mitsuru Ueda, Kouki Mirakami, Takashi Suzuki, Kiyoshi Tanaka, Toshiyuki Kan
    Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activity.
    Bioorg. Med. Chem. Lett. 17, 3095-3098 (2007)
  8. David J. Tindal, Jeffrey C. Dyason, Robin J. Thomson, Takashi Suzuki, Hiroo Ueyama, Yohta Kuwahara, Naoyoshi Maki, Yasuo Suzuki, Mark von Itzstein
    Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity.
    Bioorg. Med. Chem. Lett. 17, 1655-1658 (2007)
  9. Jun-Ichi Sakamoto, Tetsuo Koyama, Daisei Miyamoto, Sangchai Yingsakmongkon, Kazuya I. P. J. Hidari, Wipawee Jampangern, Takashi Suzuki, Yasuo suzuki, Yasuaki Esumi, Ken Hatano, Daiyo Terunuma, Koji Matsuoka
    Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neraminidase inhibitors
    Bioorg. Med. Chem. Lett. 17, 717-721 (2007)
  10. Akihiro Yamada, Ken Hatano, Tetsuo Koyama, Koji Matsuoka, Naonori Takahashi, Kazuya I. P. J. Hidari, Takashi Suzuki, Yasuo Suzuki, Daiyo Terunuma
    Lactotriaose-containing carbosilane dendrimers: Syntheses and lectin-binding activities.
    Bioorg. Med. Chem. 15, 1606-1614 (2007)
  11. Makoto Ogata, Takeomi Murata, Kouki Murakami, Takashi Suzuki, Kazuya I. P. J. Hidari, Yasuo Suzuki, Taiichi Usui
    Chemoenzymatic synthesis of artificial glycopolypeptides containig multivalent sialyloligosaccharides with a y-polyglutamic acid backbone and their effect on inhibiton of infection by influenza viruses
    Bioorg. Med. Chem. 15, 1383-1393 (2007)

Reviews

  1. 鈴木 隆、高橋忠伸、左 一八.
    インフルエンザウイルス感染におけるスパイク糖タンパク質とシアロ複合糖質の役割
    実験医学増刊 波及・深化する糖鎖研究, 30-36 (2007)

2006の研究業績

原著

  1. Pinar Ozcelik, Fatma Betul Bezirci, Yasuo Suzuki, Hitotaka Uzawa, Yoshihiro Nishida, Kazukiyo Kobayashi, Takashi Suzuki, Daisei Miyamoto, Tsuyoshi Nagatake, Kamruddin Ahmed
    Sulfatide and its synthetic analogues recognition by Moraxella catarrhalis
    Microbiol. Immunol. 50, 967-970 (2006)
  2. Shinya Yamada, Yasuo Suzuki, Takashi Suzuki, Mai Q. Le, Chairul A. Nidom, Yuko Tagawa-Sakai, Yukiko Muramoto, Mutsumi Ito, Maki Kiso, Taisuke Horimoto, Kyoko Shinya, Toshihiko Sawada, Makoto Kiso, Taiichi Usui, Takeomi Murata, Yipu Lin, Alan Hay, Lesley F. Haire, David J. Stevens, Rupert J. Russell, Steven J. Gamblin, John J. Skehel, Yoshihiro Kawaoka
    Hemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors.
    Nature 444, 378-382 (2006)
  3. Kiyoshi Ikeda, Kazuki Sato, Satoru Kitani, Takashi Suzuki, Naoyoshi Maki, Yasuo Suzuki, Masayuki Sato
    2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues structurally modified at the C-4 position: Synthesis and biological evaluation as inhibitors of human parainfluenza virus type1.
    Bioorg. Med. Chem. 14, 7893-7897 (2006)
  4. Kazuya I-P Jwa Hidari, Yasuo Suzuki, Takashi Suzuki
    Suppression of the biosynthesis of cellular sphingolipids results in the inhibition of the maturation of influenza virus particles in MDCK cells.
    Biol. Pharm. Bull. 29, 1575-1579 (2006)
  5. Yutaka Makimura, Shinya Watanabe, Takashi Suzuki, Yasuo Suzuki, Hideharu Ishida, Makoto Kiso, Takane Katayama, Hidehiko Kumagai, Kenji Yamamoto
    Chemoenzymatic synthesis and application of a sialoglycopolymer with a chitosan backbone as a potent inhibitor of human influenza virus hemagglutination.
    Carbohydr. Res. 341, 1803-1808 (2006)
  6. Chao-Tan Guo, Tadanobu Takahashi Wakoto Bukawa, Noriko Takahashi, Hirokazu Yagi, Koichi Kato, Kazuya I-P Jwa Hidari, Daisei Miyamoto, Takashi Suzuki, Yasuo Suzuki.
    Edible bird's nest extract inhibits influenza virus infection.
    Antiviral Res. 70, 140-146 (2006)
  7. Krajang Talabnin, Hirokazu Yagi, Noriko Takahashi, Takashi Suzuki, Koichi Kato, Haruki Uemura, Prasert Saicua, Sasithorn Kaewkes, Sopit Wongkham, Yasuo Suzuki, Banchob Sripa
    Glycobiological study of adult Opisthorchis viverrini: Characterization of N-linked oligosaccharides
    Mol. Biochem. Parasit. 147, 230-233 (2006)
  8. Mikhail N. Matrosovich, Takashi Suzuki, Yoshio Hirabayashi, Wolfgang Garten, Robert G Webster, Hans-Dieter Klenk
    Gangliosides are not essential for influenza virus infection.
    Glycoconj. J. 23, 107-113 (2006)
  9. Toshihiro Kogure, Takashi Suzuki, Tadanobu Takahashi, Daisei Miyamoto, Kazuya I. P. J. Hidari, Guo Chao-Tan, Toshihiro Ito, Yoshihiro Kawaoka, Yasuo Suzuki
    Human trachea primary epithelial cells express both sialyl-2,3 Gal receptor for human parainfluenza virus type 1 and avian influenza viruses, and sialyl-2,6 Gal receptor for human influenza viruses
    Glycoconj. J. 23, 101-106 (2006)
  10. Chie Aoki, Kazuya I .P.J. Hidari, Saki Itonori, Akihiro Yamada, Naonori Takahashi, Takeshi Kasama, Futoshi Hasebe, Mohammend Alimul Islam, Ken Hatano, Koji Matsuoka, Takao Taki, Cha-Tan Guo, Tadanobu Takahashi, Yuichi Sakano, Takashi Suzuki, Daisei Miyamoto, Mutsumi Sugita, Daiyo Terunuma, Koichi Morita, Yasuo Suzuki
    Identification and characterization of carbohydrate molecules in mammalian cells recognized by dengue virus type 2.
    J. Biochem. 139, 607-614 (2006)

総説

  1. 鈴木 隆、鈴木康夫
    抗インフルエンザウイルス薬の開発について
    呼吸器科 10(1), 37-41 (2006)
  2. 鈴木康夫、鈴木 隆
    トリ型インフルエンザウイルスの変異と病原性
    日本胸部臨床 65, 873-878 (2006)
  3. Takashi Suzuki, Yasuo Suzuki
    Virus infection and lipid rafts
    Biol. Pharm. Bull. 29, 1538-1541 (2006)
  4. 高橋忠伸、鈴木康夫、鈴木 隆
    インフルエンザウイルスとシアリダーゼ
    生化学 78, 409-413 (2006)

2005の研究業績

原著

  1. Q. Mai Le, Maki Kiso, Kazuhiko Someya, Yuko T. Sakai, T. Hien Nguyen, Khan H. L. Nguyen, N. Dinh Pham, Ha H. Ngyen, Shinya Yamada, Yukiko Muramoto, Taisuke Horimoto, Ayato Takada, Hideo Goto, Takashi Suzuki, Yasuo Suzuki, Yoshihiro Kawaoka
    Isolation of drug-resistant H5N1 virus
    Nature 437, 1108 (2005)
  2. Takashi Suzuki, Tadanobu Takahashi, Chao-Tan Guo, Kazuya I P. J. Hidari, Daisei Miyamoto, Hideo Goto, Yoshihiro Kawaoka, Yasuo Suzuki
    Sialidase activity of influenza A virus in a endocytic pathway enhances viral replication.
    J. Virol. 79, 11705-11715 (2005)
  3. Takumi Furuta, Minatsu Sakai, Hiroyasu Hayashi, Tomohiro Asakawa, Fumi Kataoka, Satoshi Fujii, Takashi Suzuki, Yasuo Suzuki, Kiyoshi Tanaka, Nathan Fishkin, Koji Nakanishi
    Design and synthesis of artifical phospholipid for selective cleavage of integral membrane protein.
    Chem. Comm. 36, 4575-4577 (2005)
  4. Kazuyasu Mori, Chie Sugimoto, Shinji Ohgimoto, Emi E. Nakayama, Tatsuo Shioda, Shigeru Kusagawa, Yutaka Takebe, Munehide Kano, Tetsuro Matano, Takae Yuasa, Daisuke Kitaguchi, Masaaki Miyazawa, Yumiko Takahashi, Michio Yasunami, Akinori Kimura, Naoki Yamamoto, Yasuo Suzuki, Yoshiyuki Nagai
    Influence of glycosylation on the efficacy of an env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS model.
    J. Virol. 79, 10386-10396 (2005)
  5. Atsushi Jinno-Que, Nobuaki Shimizu, Yasushi Soda, Atsushi Tanaka, Takahiro Ohtsuki, Dai Kurosaki, Yasuo Suzuki, Hiroo Hoshino
    The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 human immunodeficiency virus type 1.
    J. Biol. Chem., 280, 30924-30934 (2005)
  6. Shuji Hatakeyama, Yuko Sakai-Tagawa, Maki Kiso, Hideo Goto, Chiharu Kawakami, Keiko Mitamura, Norio Sugaya, Yasuo Suzuki, Yoshihiro Kawaoka
    Enhanced expression of an a2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neraminidase inhibitor
    J. Clin. Microbio. 43, 4139-4146 (2005)
  7. Kiyoko Shinya, Masato Hatta, Shinya Yamada, Ayato Takada, Shinji Watanabe, Peter Halfmann, Taisuke Horimoto, Gabriele Neumann, Wilina Lim, Yi Guan, Malik Peiris, Makoto Kiso, Takashi Suzuki, Yasuo Suzuki, Yoshihiro Kawako
    Characterization of a human H5N1 influenza A virus isolated in 2003
    J. Virol. 79, 9926-9932 (2005)
  8. Kazuya I. P. J. Hidari, Nobuhiro Horie, Takeomi Murata, Disei Miyamoto, Takashi Suzuki, Taiichi Usui, Yasuo Suzuki
    Purification and characterization of a soluble recombinant human ST6Gal I functionally expressed in Escherichia coli
    Glycoconnj. J. 22, 1-11 (2005).
  9. Yasuo Suzuki
    Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses
    Biol. Pharm. Bull. 28, 399-408 (2005)

総説

  1. 鈴木 隆、高橋忠伸、鈴木康夫
    パンデミックインフルエンザA型ウイルスノイラミニダーゼの構造と機能
    遺伝子医学 糖鎖と病気, 261-266 (2005)

2004の研究業績

原著

  1. Darwyn kobasa, Ayato Takada, Kyoko Shinya, Masato Hatta, Peter Halfmann, Steven Theriault, Hiroshi Suzuki, Hidekazu Nishimura, Keiko Mitamura, Norio Sugaya, Taichi Usui, Takeomi Murata, Yasuko Maeda, Shinji Watanabe, M. Suresh, Takashi Suzuki, Yasuo Suzuki, Heinz Feldmann, Yoshihiro Kawaoka
    Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus.
    Nature 431, 703-707 (2004)
  2. Takehiko Saito, Yoko Nakaya, Takashi Suzuki, Reiko Ito, Toshinori Saito, Hiroyuki Saito, Shinichi Takao, Keiji Sahara, Takato Odagiri, Takeomi Murata, Taichi Usui, Yasuo Suzuki, and Masato Tashiro
    Antigenic alteration of influenza B virus associated with loss of a glycosylation site due to host-cell adaptation.
    J. Med. Virol. 74, 336-343 (2004)
  3. Kazuya I.-P. Jwa Hidari, Eisaku Tsujii, Jun Hiroi, Eriko Mano, Akihiko Miyatake, Daisei Miyamoto, Takashi Suzuki, and Yasuo Suzuki
    In Vitro and in vivo inhibitory effects of disodium cromoglycate on influenza virus infection.
    Biol. Pharm. Bull. 27(6), 825-830, (2004)
  4. Kiyoshi Ikeda, Satoru Kitani, Kazuki Sato, Takashi Suzuki, Chika Hosokawa, Yasuo Suzuki, kiyoshi Tanaka, and Masayuki Sato
    2,3-Difluorosialic acid derivatives structurally modified at the C-4 position: synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1.
    Carbohyd. Res. 339, 1367-1372, (2004)
  5. Kenji Sasaki, Yoshihiro Nishida, Mikie Kambara, Hirotaka Uzawa, Tadanobu Takahashi, Takashi Suzuki, Yasuo Suzuki, and Kazukiyo Kobayashi
    Design of N-acetyl-6-sulfo-β-D-glucosaminide-based inhibitors of influenza virus sialidase.
    Bioorg. Med. Chem. 12, 1367-1375 (2004)
  6. Takashi Suzuki, Tadanobu Takahashi, Takehiko Saito, Chao-Tan Guo, Kazuya I.-P. Jwa Hidari, Daisei Miyamoto, and Yasuo Suzuki
    Evolutional analysis of human influenza A virus N2 neuraminidase genes based on the transition of the low-pH stability of sialidase activity.
    FEBS Lett. 557, 228-232 (2004)
  7. Daisuke Ogawa, Kenichi Shikata, Koichi Honke, Shinichi Sato, Mitsuhiro Matsuda, Ryo Nagase, Atsuhito Tone, Shinichi Okada, Hitomi Usui, Jun Wada, Masayuki Miyasaka, Hiroto Kawashima, Yasuo Suzuki, Takashi Suzuki, Naoyuki taniguchi, Yukie Hirahata, Keiko Tadano-Aritomi, Ineo Ishizuka, Thomas F. Tedder, and Hirofumi Makino
    Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction.
    J. Biol. Chem. 279(3), 2085-2090 (2004)
  8. Tomohiro Shimizu, Shigeki Furuya, Yoko Shinoda, Junya Mitoma, Tadashi Okamura, Ichiro Miyoshi, Noriyuki Kasai, Yoshio Hirabayashi, Yasuo Suzuki
    Functional analysis of mouse 3-phosphoglycerate dehydrogenase (Phgdh) gene promoter in developing brain.
    J. Neurosci. Res. 76(5), 623-632, (2004)
  9. Junya Mitoma, Shigeki Furuya, Motohiro Shimizu, Yoko Shinoda, Kazuyuki Yoshida, Norihiro Azuma, Hideyuki Tanaka, Yasuo Suzuki, and Yoshio Hirabayashi
    Mouse 3-phosphoglycerate dehydrogenase gene: genomic organization, chromosomal localization, and promoter analysis.
    Gene 334, 15-22, (2004)

2003の研究業績

原著

  1. Takashi Ohta, Nobuaki Miura, Naoki Fujitani, F Nakajima, Kenichi Niikura, Guo Cha-tan, Takashi Suzuki, Yasuo Suzuki, Kenji Monde, and Shin-Ichiro Nishimura
    Glycotentacles: Synthesis of cyclic glycopeptides toward a tailored blocker of influenza virus hemagglutinin.
    Angew. Chem. Int. Ed. 42, 5186-5189, (2003)
  2. Takashi Suzuki, Tadanobu Takahashi, Daisuke Nishinaka, Masanori Murakami, Satoshi Fujii, Kazuya I.-P. Jwa Hidari, Daisei Miyamoto, Yu-Teh Li, and Yasuo Suzuki
    Inhibition of influenza A virus sialidase activity by sulfatide
    FEBS Lett 553, 355-359, (2003)
  3. Tadanobu Takahashi, Takashi Suzuki, Kazuya I.-P. Jwa Hidari, Daisei Miyamoto, and Yasuo Suzuki.
    A molecular mechanism for the low-pH stability of sialidase activity of influenza A virus N2 neuraminidases
    FEBS Lett. 543, 71-75, (2003)
  4. Shinji Kojima, Teruaki Hasegawa, Takahiro Yonemura, Ken Sasaki, Kenji Yamamoto, Yutaka Makimura, Tadanobu Takahashi, Takashi Suzuki, Yasuo Suzuki, and Kazukiyo Kobayashi.
    Ruthenium complexes carrying a disialo complex-type oligosaccharide: enzymatic synthesis and its application to a luminescent probe to detect influenza viruses.
    Chem. Comm. 11, 1250-1251, (2003)
  5. Yuko Matsushima-Hibiya, Masahiko Watanabe, Kazuya I.-P. Jwa Hidari, Daisei Miyamoto, Yasuo Suzuki, Takeshi Kasama, Takashi Kanazawa, Kotaro Koyama, Takashi Sugimura, and Keiji Wakabayashi.
    Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly.
    J. Biol. Chem. 278, 9972-9978, (2003)
  6. Yasuyuki Imai, Takashi Fukui, Kohta Kurohane, Daisei Miyamoto, Yasuo Suzuki, Tomoyuki Ishikawa, Yousuke Ono, and Masaki Miyake.
    Restricted expression of shiga toxin binding sites on mucosal epithelium of mouse distal colon.
    Infect. Immun. 71, 985-990, (2003)
  7. Kazuhide Totani, Takeshi Kubota, Takao Huroda, Takeomi Murata, Kazuya I.-P. Jwa Hidari, Takashi Suzuki, Yasuo Suzuki, Kazukiyo Kobayashi, Hisashi Ashida, Kenji Yamamoto, and Taichi Usui.
    Chemoenzymatic synthesis and application of glycopolymers containing multivalent sialyloligosaccharides with a poly(L-glutamic acid) backbone for inhibition of infection by influenza viruses.
    Glycobiol. 13, 315-326, (2003)

2002の研究業績

原著

  1. Rika Komagome, Hirofumi Sawa, Takashi Suzuki, Yasuo Suzuki, Shinya Tanaka, Walter J. Atwood, Kazuo Nagashima
    Oligosaccharides as receptors for JC virus.
    J. Virol. 76(24), 12992-13000, (2002)
  2. Chao-Tan Guo, Xue-Long Sun, Osamu Kanie, Kennedy Francis Shortridge, Takashi Suzuki, Daisei Miyamoto, Kazuya I.-P. Jwa Hidari, Chi-Huey Wong, and Yasuo Suzuki
    An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses.
    Glycobiol., 12(3), 183-190, (2002)
  3. Junko Sugatani, Naoko Komiyama, Yoru Mochizuki, Minoru Hoshino, Daisei Miyamoto, Takashi Igarashi, Shoji Hoshi, , and Masao Miwa
    Urinary concentrating defect in rats given Shiga toxin: elevation in urinary AQP2 level associated with polyuria.
    life Sciences, 71, 171-189, (2002)
  4. Kamrudlin Ahmed, Yasuo Suzuki, Daisei Miyamoto, Tsuyoshi Nagatake
    Asialo-GM1 and asialo-GM2 are putative adhesion molecules for Moraella catarrhalis.
    Med. Microbiol. Immunol., 191, 5-10, (2002)
  5. Mitsuhiro Matsuda, Kenichi Shikata, Fujio Shimizu, Yasuo Suzuki, Masayuki Miyasaka, Hiroshi Kawachi, Hiroto Kawashima, Jun Wada, Hikaru Sugimoto, Yasushi Shikata, Daisuke Ogawa, Shinichiro J. Tojo, Kazuo Akima, and Hirofumi Makino
    Therapeutic effect of sulphated hyaluronic acid, apotential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis.
    J. Pathol., 198, 407-414, (2002)

総説

  1. 鈴木 隆、鈴木康夫
    パラインフルエンザウイルス感染を阻害する新規シアル酸誘導体の開発
    バイオサイエンスとインダストリー 60 (7), 450-453, (2002)
  2. 鈴木 隆、鈴木康夫
    パラインフルエンザウイルスの選択的感染阻害薬の開発研究
    医学のあゆみ 201(4), 259, (2002)

2001の研究業績

原著

  1. Takashi Suzuki, Kiyoshi Ikeda, Noriko Koyama, Chika Hosokawa, Toshihiro Kogure, Tadanobu Takahashi, Kazuya I.-P. Jwa Hidari, Daisei Miyamoto, Kiyoshi Tanaka, and Yasuo Suzuki.
    Inhibition of human parainfluenza virus type 1 sialidase by analogs of 2-deoxy-2,3-dihehydro-N-acetylnuraminic acid.
    Glycoconjugate J. 18, 331-337, (2001)
  2. Chao-Tan Guo, Shinji Ohta, Akihiro Yoshimoto, Kuniho Nakata, Kennedy F. Shortridge, Tadanobu Takahashi, Takashi Suzuki, Daisei Miyamoto, Kazuya I.-P. Jwa Hidari, and Yasuo Suzuki.
    A unique phosphatidylinositol bearing a novel branched-chain fatty acid from Rhodococcus equi binds to influenza virus hemagglutinin and inhibits the infection of cells.
    J. Biochem. 130(3), 377-384, (2001)
  3. Takehiko Saito, Wilina Lim, Takashi Suzuki, Yasuo Suzuki, Hiroshi Kida, Shin-Ichiro Nishimura, and Masato Tashiro.
    Characterization of a human H9N2 influenza virus isolated in Hong Kong.
    Vaccine 20(1-2), 125-133, (2001)
  4. Tadanobu Takahashi, Yasuo Suzuki, Daisuke Nishinaka, Nana Kawase, Yukiko Kobayashi, Kazuya I.-P. Jwa Hidari, Daisei Miyamoto, Chao-Tan Guo, Kennedy F. Shortridge, and Takashi Suzuki.
    Duck and human pandemic influenza A viruses retain sialidase activity in low pH conditions.
    J. Biochem. 130(2), 279-283, (2001)
  5. Takashi Suzuki, Allen Portner, Ruth A. Scroggs, Makoto Uchikawa, Noriko Koyama, Kazuko Matsuo, Yasuo Suzuki, and Toru Takimoto.
    Receptor specificities of the human respiroviruses.
    J. Virol. 75, 4604-4613, (2001)
  6. Masafumi Kimura, Kazuya, I.-P. Jwa Hidari, Takashi Suzuki, Daisei Miyamoto, and Yasuo Suzuki
    Engagement of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells.
    Glycobiol. 11, 335-343, (2001)
  7. Mark T. Hughes, Martha McGregor, Takashi Suzuki, Yasuo Suzuki, and Yoshihiro Kawaoka.
    Adaptation of Influenza A viruses to cells expressing low levels of sialic acid leads to loss of neuraminidase activity.
    J. Virol., 75, 3766-3770, (2001)
  8. Kiyoshi Ikeda, Kimihiko Sano, Masaki Ito, Megumi Saito, Kazuya Hidari, Takashi Suzuki, Yasuo Suzuki, and Kiyoshi Tanaka.
    Synthesis of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified at the C-4 and C-9 positions and their behaviour towards sialidase from influenza virus and pig liver membrane.
    Carbohydr. Res. 330, 31-41,( 2001)

生体分子薬学分野