{"id":91,"date":"2024-07-26T14:06:36","date_gmt":"2024-07-26T05:06:36","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/CPFR\/?page_id=91"},"modified":"2026-01-23T12:03:04","modified_gmt":"2026-01-23T03:03:04","slug":"%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be","status":"publish","type":"page","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/CPFR\/?page_id=91","title":{"rendered":"\u7814\u7a76\u696d\u7e3e"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">2025\u5e74<\/h4>\n\n\n\n<p><a>[\u539f\u8457\u8ad6\u6587]<\/a><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Shizuo\u00a0Yamada, Michiyo Shirai, Koji Nagashima, Jun Mochizuki, Ken Ono\u00a0and Shinji Kageyama:\u3000Beneficial effects of Enoki mushroom extract on male menopausal symptoms in Japanese subjects: A randomized, double-blind, placebo-controlled study<br><em>Nutrients<\/em>\u00a017:\u00a01208 (2025); https:\/\/doi.org\/10.3390\/nu17071208\u00a0<br><\/li>\n\n\n\n<li>Shizuo Yamada, Masae Mochizuki, Kana Maruyama-Fumoto, Satomi Kagota, Kazumasa Shinozuka:\u00a0Additive effects of mirabegron on muscarinic receptor binding and on relaxation of cholinergic detrusor muscle contraction by antimuscarinics.<br><em>J Pharmacol Sci.<\/em>158:\u00a0363-367 (2025)<br><\/li>\n\n\n\n<li>Ho-Ching Chong, Shu-Ting Tang, Yu-Chieh Tseng, Suh-Ching Yang, Yasuo Watanabe, Shizuo Yamada, Yu-Chen SH Yang, Ya-Ling Chen:\u00a0Matcha green tea improves cafeteria-diet-induced NAFLD by modulating the gut microbiota in rat<br><em>Nutrients<\/em>\u00a017:\u00a03051 (2025);\u00a0<a href=\"https:\/\/doi.org\/10.3390\/nu17193051\">https:\/\/doi.org\/10.3390\/nu17193051<\/a><br><\/li>\n\n\n\n<li>Norihito Shimizu, Ryoma Shimizu, Masahiro Yagihashi, Kazunori Goto, Hiroshi Shimoda, Marina Hirano, Hiroyuki Shimizu, Shizuo Yamada:\u00a0Seaberry\u00a0ursolic\u00a0acid\u00a0improves\u00a0daytime\u00a0frequency and\u00a0urgency of\u00a0urination in\u00a0healthy Japanese\u00a0subjects: A\u00a0randomized,\u00a0placebo-controlled,\u00a0double-blind\u00a0trial\u00a0<br><em>Functional Foods in Health and Disease<\/em>\u00a015:\u00a0316-332 (2025)\u00a0<br><\/li>\n\n\n\n<li>Fumihiro Mizokami, Tomohiro Mizuno, Rena Taguchi, Izumi Nasu, Sayaka Arai, Kiichiro Higashi, Ayaka Matsumoto, Miwako Kamei, Taro Kojima, Takayoshi Sakai, Yuka Shibata, Yasushi Takeya, Masaki Mogi, Shizuo Yamada, Masahiro Akishita.Development of the Japanese anticholinergic risk scale: English translation of the Japanese article.<br><em>Geriatr Gerontol Int.<\/em>\u00a025\uff1a5-13.\u00a0(2025)\u00a0<br><\/li>\n\n\n\n<li>\u5c71\u7530\u9759\u96c4\u3001\u767d\u4e95\u307f\u3061\u4ee3\u3001\u9577\u5cf6\u6d69\u4e8c\u3001\u671b\u6708\u3000\u6df3\uff1a\u00a0\u66f4\u5e74\u671f\u306e\u75c7\u72b6\u306b\u304a\u3051\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u306e\u5f79\u5272\uff08\u7279\u96c6\uff09.\u00a0\u30a8\u30ce\u30ad\u30bf\u30b1\u62bd\u51fa\u7269\u306b\u3088\u308b\u7537\u6027\u66f4\u5e74\u671f\u95a2\u9023\u75c7\u72b6\u306e\u6539\u5584\u4f5c\u7528\u3000<br><em>\u6a5f\u80fd\u6027\u98df\u54c1\u3068\u85ac\u7406\u30fb\u6804\u990a<\/em>\u300018: 286-292 (2025)<\/li>\n<\/ol>\n\n\n\n<p>[\u7dcf\u8aac]<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Yutaka Nakagawa, Shizuo Yamada:\u00a0Novel hypothesis and therapeutic interventions for irritable bowel syndrome: interplay between metal dyshomeostasis, gastrointestinal dysfunction, and neuropsychiatric sympto<strong>ms<\/strong>\u00a0(Review)<br><em>Mol Cell Biochem.<\/em>\u00a0480:\u00a02661-2676 (2025)\u00a0doi: 10.1007\/s11010-024-05153-3<br><\/li>\n\n\n\n<li>Yutaka Nakagawa, Shizuo Yamada:\u00a0Crosstalk between inflammation, voiding dysfunction, and psychiatric symptoms: novel hypothesis and therapeutics for urinary incontinence (Review)<br><em>J Pharmacol Exp Ther.<\/em>\u00a0392:\u00a0103640\u00a0(2025).\u00a0doi: 10.1016\/j.jpet.2025.103640.<br><\/li>\n\n\n\n<li>Shizuo Yamada, Michiyo Shirai, Kimio Sugaya, Je Tae Woo:\u00a0Beneficial effects of a representative flavonoid, nobiletin on cognitive and urinary dysfunctions (Review)\u00a0<br><em>BIO Web of Conferences\u00a0<\/em>187:\u00a005004 (2025),\u00a0<a href=\"https:\/\/doi.org\/10.1051\/bioconf\/202518705004\">doi.org\/10.1051\/bioconf\/202518705004<\/a><br><\/li>\n\n\n\n<li>Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada:\u00a0Further insights into anticholinergic action informed by Japanese anticholinergic risk scale (Review)<br><em>Geriatr Gerontol Int.<\/em>\u00a02025 Dec 3,\u00a0doi: 10.1111\/ggi.70278.\u00a0<br><\/li>\n\n\n\n<li>\u5c71\u7530\u975c\u96c4\u3001\u4f0a\u85e4\u7531\u5f66\u3001\u79b9\u3000\u6e08\u6cf0,\u3000\u83c5\u8c37\u516c\u7537\uff1a\u3000\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u6392\u5c3f\u969c\u5bb3\u6539\u5584\u4f5c\u7528<br><em>FOOD Style21<\/em>,\u00a029:\u00a041-45 (2025)<br><\/li>\n\n\n\n<li>\u5c71\u7530\u975c\u96c4\uff1a\u3000\u66f4\u5e74\u671f\u306e\u75c7\u72b6\u3068\u6a5f\u80fd\u6027\u98df\u54c1\u306e\u5f79\u5272<br><em>\u6a5f\u80fd\u6027\u98df\u54c1\u3068\u85ac\u7406\u6804\u990a\uff08\u7279\u96c6\uff09<\/em>\u00a018:\u00a0267\uff082025\uff09<br><\/li>\n\n\n\n<li>\u8302\u6728\u6b63\u6a39\u3001\u5289\u3000\u723d\u3001\u9234\u6728\u5eb7\u4e4b\u3001\u5c71\u7530\u975c\u96c4\uff0e\u201c\u6297\u30b3\u30ea\u30f3\u69d8\u4f5c\u7528\u201d\u3092\u6df1\u5800\u3059\u308b\u3000\u300c\u65e5\u672c\u7248\u6297\u30b3\u30ea\u30f3\u85ac\u30ea\u30b9\u30af\u30b9\u30b1\u30fc\u30eb\u300d\u306e\u767a\u8868\u3092\u53d7\u3051\u3066\u6539\u3081\u3066\u8003\u3048\u308b<br><em>\u65e5\u672c\u8001\u5e74\u85ac\u5b66\u4f1a\u8a8c\u3000<\/em>7\uff1a69-76\u00a0\uff082025\uff09<br><\/li>\n\n\n\n<li>\u8302\u6728\u6b63\u6a39\u3001\u5289\u3000\u723d\u3001\u9234\u6728\u5eb7\u4e4b\u3001\u67f4\u7530\u3086\u3046\u304b\u3001\u5c71\u7530\u975c\u96c4\uff0e\u201c\u6297\u30b3\u30ea\u30f3\u69d8\u4f5c\u7528\u201d\u3092\u6df1\u5800\u3059\u308b\u2461\u3000\u300c\u30b9\u30b3\u30a2\uff11\u300d\u306e\u85ac\u5264\u306e\u6297\u30b3\u30ea\u30f3\u69d8\u4f5c\u7528<br><em>\u65e5\u672c\u8001\u5e74\u85ac\u5b66\u4f1a\u8a8c<\/em>\u30008\uff1a45-57\u00a0\uff082025\uff09\u3000<\/li>\n<\/ol>\n\n\n\n<p>[\u8457\u66f8]<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u5c71\u7530\u975c\u96c4\uff1a\u3000\u4e0a\u7d1a\u98df\u80b2\u6307\u5c0e\u58eb\u8b1b\u7fd2\u30c6\u30ad\u30b9\u30c8\u3000\u3000\u7b2c\uff12\u7ae0\u3000\u7d71\u5408\u533b\u7642\u3068\u98df\u80b2<br>\u4e0a\u7d1a\u6307\u5c0e\u58eb\u8b1b\u7fd2\u30c6\u30ad\u30b9\u30c8\uff08\u65e5\u672c\u98df\u80b2\u5354\u4f1a\u7de8\uff09\u3000P15-20\u3000\uff082025\uff09<\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2024\u5e74<\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Shizuo Yamada, Michiyo Shirai, Masahiro Katsumata, Masahiro Kurono, Yoshiharu Matahira, Ken Ono, Shinji Kageyama. Beneficial effects of a formulated supplement of Ascidiacea (Halocynthia-roretzi)-derived plasmalogen and Tuna-derived elastin on memory function in elderly Japanese subjects; A randomized, double-blind, placebo-controlled study<br>J. Oleo Sci. 73: 1319-1328 (2024)<br><\/li>\n\n\n\n<li>Shizuo Yamada, Tsutomu Warashina, Osamu Shirota, Yoshihisa Kato, Toshiyuki Fukuda. Identification of Petit vert leaf-derived sinapic acid derivatives and their enhancement of glucose uptake in C2C12 murine myoblasts<br>Biomolecules 14:1246.doi: 10.3390\/biom14101246 (2024)<br><\/li>\n\n\n\n<li>Mizuki Shiho, Gaku Akashita, Eriko Nakatani, Shimako Tanaka, Shizuo Yamada, Takashi Okura. Predicting muscarinic receptor occupancy in human bladder mucosa from urinary concentrations of antimuscarinic agents for overactive bladder.<br>Drug Metab. Pharmacokinet. 56 100998.doi: 10.1016\/j.dmpk.2024.100998 (2024).<br><\/li>\n\n\n\n<li>Satomi Kagota, Risa Futokoro, Kana Maruyama-Fumoto, Junko Chimoto, Shizuo Yamada, Kazumasa Shinozuka. Functional anticholinergic activity of drugs classified as strong and moderate on the anticholinergic burden scale on bladder and ileum.<br>Basic Clinical Pharmacol. Toxicol. 135: 451-463 (2024)<br><\/li>\n\n\n\n<li>Keizo Umegaki, Mika Ito, Kaori Yokotani, Shizuo Yamada. Improved indophenol titration method for ascorbic acid using a dropper and electronic balance: enhanced convenience and efficiency\u3000<br>Food Hyg. Saf. Sci. 65: 1-6 (2024)\u3000<br><\/li>\n\n\n\n<li>Fumihiro Mizokami, Tomohiro Mizuno, Rena Taguchi, Izumi Nasu, Sayaka Arai, Kiichiro Higashi, Ayaka Matsumoto, Miwako Kamei, Taro Kojima, Takayoshi Sakai, Yuka Shibata, Yasushi Takeya, Masaki Mogi, Shizuo Yamada, Masahiro Akishita. Development of the Japanese anticholinergic risk scale: English translation of the Japanese article.<br>Geriatrics and Gerontology International. doi: 10.1111\/ggi.15001. (2024)<br><\/li>\n\n\n\n<li>Shizuo Yamada, Yoshihiko Ito, Risa Futokoro, Satomi Kagota, Kazumasa Shinozuka. Effects of new saw palmetto extract on urological parameters, bladder contractility and muscarinic receptors in rats<br>Pharmacometrics,107: 29-34 (2024)<br><\/li>\n\n\n\n<li>\u6e9d\u795e\u6587\u535a\u3001\u6c34\u91ce\u667a\u535a\u3001\u7530\u53e3\u601c\u5948\u3001\u90a3\u9808\u3044\u305a\u307f\u3001\u65b0\u4e95\u3055\u3084\u304b\u3001\u6771\u3000\u656c\u4e00\u6717\u3001\u677e\u672c\u5f69\u52a0\u3001\u4e80\u4e95\u7f8e\u548c\u5b50\u3001\u5c0f\u5cf6\u592a\u90ce\u3001\u962a\u4e95\u4e18\u82b3\u3001\u67f4\u7530\u3086\u3046\u304b\u3001\u7af9\u5c4b\u3000\u6cf0\u3001\u8302\u6728\u6b63\u6a39\u3001\u5c71\u7530\u975c\u96c4\u3001\u79cb\u4e0b\u96c5\u5f18\uff0e\u65e5\u672c\u7248\u6297\u30b3\u30ea\u30f3\u85ac\u30ea\u30b9\u30af\u30b9\u30b1\u30fc\u30eb<br>\u65e5\u672c\u8001\u5e74\u85ac\u5b66\u4f1a\u96d1\u8a8c 7, S1 \uff08\u7279\u5225\u53f7\uff09, 1-26 (2024)\u3000<\/li>\n<\/ol>\n\n\n\n<p>[\u7dcf\u8aac]<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Shizuo Yamada, Masae Mochizuki, Kazutaka Atobe, Yoshihisa Kato: Pharmacokinetic and pharmacodynamic considerations for the anticholinergic burden scale of drugs. (review)<br>Geriatr Gerontol Int. 24\uff1a81-87 (2024)<br><\/li>\n\n\n\n<li>Yutaka Nakagawa, Shizuo Yamada: Novel hypothesis and therapeutic interventions for irritable bowel syndrome: interplay between metal dyshomeostasis, gastrointestinal dysfunction, and neuropsychiatric symptoms (Review)<br>Mol Cell Biochem, doi: 10.1007\/s11010-024-05153-3 (2024)<br><\/li>\n\n\n\n<li>\u5c71\u7530\u975c\u96c4\uff0c\u671b\u6708\u6b63\u6804\uff1a\u3000\u591a\u5264\u4f75\u7528\u306b\u3088\u308b\u6297\u30b3\u30ea\u30f3\u6027\u6709\u5bb3\u4e8b\u8c61\u3068\u6297\u30b3\u30ea\u30f3\u8ca0\u8377\u30b9\u30b3\u30a2\uff08\u7dcf\u8aac\uff09<br>\u65e5\u672c\u8001\u5e74\u533b\u5b66\u4f1a\u96d1\u8a8c 61:256-270\uff082024\uff09<br><\/li>\n\n\n\n<li>\u5c71\u7530\u975c\u96c4\uff1a\u3000\u4eba\u751f100\u5e74\u6642\u4ee3\u306e\u5065\u5eb7\u9577\u5bff\u3092\u8003\u3048\u308b\uff5e\u3053\u3053\u308d\u30fb\u304b\u3089\u3060\u30fb\u305f\u3079\u3082\u306e\u30fb\u304f\u3059\u308a<br>\u65e5\u672c\u7d71\u5408\u533b\u7642\u5b66\u4f1a\u8a8c, 17: 1-7\uff082024\uff09<br><\/li>\n\n\n\n<li>\u79b9\u3000\u6e08\u6cf0,\u3000\u7167\u5c4b\u4fca\u660e, \u5c71\u7530\u9759\u96c4\uff1a\u3000\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u8a8d\u77e5\u6a5f\u80fd\u6539\u5584\u52b9\u679c<br>FOOD Style 28: 36-41 (2024)\u3000<\/li>\n<\/ol>\n\n\n\n<p>[\u8457\u66f8]<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u4f0a\u85e4\u7531\u5f66\u3001\u4f0a\u85e4\u90a6\u5f66.\u00a0\u7b2c1\u7ae0 \u85ac\u7406\u5b66\u7dcf\u8ad6<br><em>\u30b3\u30e1\u30c7\u30a3\u30ab\u30eb\u306e\u305f\u3081\u306e\u85ac\u7406\u5b66\u7b2c4\u7248<\/em>\u3001\u671d\u5009\u66f8\u5e97\u3001pp.1-23 (2024)<\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2023\u5e74<\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">[\u539f\u8457\u8ad6\u6587]<\/h5>\n\n\n\n<p>1. Shizuo Yamada, Masae Mochizuki, Junko Chimoto, Risa Futokoro, Satomi Kagota, Kazumasa Shinozuka. Development of a pharmacological evidence-based anticholinergic burden scale for medications used in older adults.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37313633\/\">Geriatrics and Gerontology International, 23: 558\u2013564 (2023)<\/a><\/p>\n\n\n\n<p>2. Kazutaka Atobe, Yoshihisa Kato, Shizuo Yamada. Activation by Acanthopanax senticosus of vascular endothelium-specific receptor tyrosine kinase Tie2 in human umbilical vein endothelial cells (HUVECs)<br><a href=\"https:\/\/mol.medicalonline.jp\/archive\/search?jo=ef4oyoya&amp;ye=2023&amp;vo=105&amp;issue=1%2F2\">Pharmacometrics,105: 43-48 (2023)<\/a><\/p>\n\n\n\n<p>3. \u5c71\u7530\u975c\u96c4\u3001\u767d\u4e95\u307f\u3061\u4ee3\u3001\u5c0f\u91ce\u3000\u61b2\u3001\u5c71\u91ce\u4e9c\u7d00\u3001\u7167\u5c4b\u4fca\u660e\u3001\u3000\u79b9 \u6e08\u6cf0\uff1a\u3000\u30ce\u30d3\u30ec\u30c1\u30f3\u9ad8\u7d14\u5ea6\u7c89\u672b\u542b\u6709\u6442\u53d6\u306b\u3088\u308b\u8a8d\u77e5\u6a5f\u80fd\u3078\u306e\u5f71\u97ff<br>\u65e5\u672c\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u5b66\u4f1a\u96d1\u8a8c\u300012\uff1a41-48\uff082023\uff09<\/p>\n\n\n\n<p>4. \u767d\u4e95\u307f\u3061\u4ee3\u3001\u671b\u6708\u7f8e\u6625\u3001\u5c0f\u91ce\u3000\u61b2\u3001\u5c71\u7530\u975c\u96c4\uff1a\u3000\u6e29\u6cc9\u30fb\u904b\u52d5\u30fb\u98df\u306b\u3088\u308b\u30b4\u30eb\u30d5\u30a2\u30b9\u30ea\u30fc\u30c8\u306e\u6253\u7403\u98db\u8ddd\u96e2\u53ca\u3073\u4e3b\u89b3\u7684\u5065\u5eb7\u89b3\u306b\u95a2\u3059\u308b\u7814\u7a76<br><a href=\"https:\/\/mol.medicalonline.jp\/archive\/search?jo=ef4oyoya&amp;ye=2023&amp;vo=104&amp;issue=3%2F4\">\u5fdc\u7528\u85ac\u7406\u3000104\uff1a33-39\u3000\uff082023\uff09<\/a><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u7dcf\u8aac]<\/h5>\n\n\n\n<p>1. Shizuo Yamada, Masae Mochizuki, Kazutaka Atobe, Yoshihisa Kato. Pharmacokinetic and pharmacodynamic considerations for the anticholinergic burden scale of drugs. (review)<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37872832\/\">Geriatrics and Gerontology International, 2023 Oct 23. doi: 10.1111\/ggi.14706.<\/a><\/p>\n\n\n\n<p>2. Yutaka Nakagawa, Shizuo Yamada: The relationships among metal homeostasis, mitochondria, and locus coeruleus in psychiatric and neurodegenerative disorders: Potential pathogenetic mechanism and therapeutic implications<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35635600\/\">Cellular and Molecular Neurobiology, 43: 963-989\uff082023)<\/a><\/p>\n\n\n\n<p>3. Yutaka Nakagawa and Shizuo Yamada: Alterations in brain neural network and stress system in atopic dermatitis: novel therapeutic interventions (Review)<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36828629\/\">J Pharmacol Exp Ther, 385: 78-87\uff082023)<\/a><\/p>\n\n\n\n<p>4. \u5c71\u7530\u975c\u96c4\uff1a\u3000\u7279\u96c6\u300c\u6a5f\u80fd\u6027\u98df\u54c1\u3068\u3057\u3066\u306e\u30ad\u30ce\u30b3\u300d\u3000\u5dfb\u982d\u8a00<br>\u6a5f\u80fd\u6027\u98df\u54c1\u3068\u85ac\u7406\u30fb\u6804\u990a, 15: 347\uff082023\uff09<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">2022\u5e74<\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">[\u539f\u8457\u8ad6\u6587]<\/h5>\n\n\n\n<p>1.Shizuo Yamada, Ryo Niiya, Yoshihiko Ito, Yoshihisa Kato, Satomi Onoue. Comparative characterization on \u03b2-adrenoceptors in the bladder, heart and lung of rats: Alterations in spontaneously hypertensive rats.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34924129\/\">J Pharmacol Sci, 148: 51\u201355 (2022)<\/a><\/p>\n\n\n\n<p>2.Shizuo Yamada, Yoshihisa Kato. Effects of saw palmetto extract on the vanilloid receptor TRPV1.&nbsp;<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34672430\/\">Lower Urinary Tract Symptoms,14: 117-121 (2022)<\/a><\/p>\n\n\n\n<p>3.Shizuo Yamada, Michiyo Shirai, Ken Ono, Shinji Kageyama. Beneficial effects of saw palmetto fruit extract on urinary symptoms in Japanese female subjects by a multicenter, randomized, double-blind, placebo-controlled study.&nbsp;<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35334848\/\">Nutrients, 14: 1190, doi:10.3390\/nu14061190 (2022)<\/a><\/p>\n\n\n\n<p>4.Shizuo Yamada, Michiyo Shirai, Yuko Inaba, Tsuyoshi Takara. Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: A randomized, placebo-controlled, double-blind parallel-group study.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35776034\/\">Eur Rev Med Pharmacol Sci., 26: 4331-4345 (2022)<\/a><\/p>\n\n\n\n<p>5.Shinji Kageyama, Seiji Ohmura, Shinsuke Hayami, Michiko Suzawa, Shizuo Yamada. A case report of active surveillance therapy: Citrus-peel extracts\u2019 efficacy against prostate cancer\u3000\u3000&nbsp;<br>Case Report &amp; Reviews. https:\/\/dx.doi.org\/10.26717\/BJSTR.2022.42.006827 (2022)&nbsp;<\/p>\n\n\n\n<p>6.Masaharu Akita, Osamu Kimura, Kazutaka Atobe, Tetsuya Endo, Shizuo Yamada, Koichi Haraguchi, Yoshihisa Kato: Teratogenic effects of organohalogen contaminants extracted from whale bacon in a whole-rat-embryo culture system.&nbsp;<br>Int. J. Environ. Res. Public Health. 19, 12065. https:\/\/doi.org\/10.3390\/ijerph191912065. (2022)<\/p>\n\n\n\n<p>7.\u5c71\u7530\u975c\u96c4\u3001\u4f0a\u85e4\u7531\u5f66\uff1a\u3000\u30ce\u30b3\u30ae\u30ea\u30e4\u30b7\u679c\u5b9f\u30a8\u30ad\u30b9\u306e\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u6539\u5584\u4f5c\u7528<br>\u65e5\u672c\u6392\u5c3f\u6a5f\u80fd\u5b66\u4f1a\u8a8c\u3000\u7279\u96c6\u300c\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u3092\u6539\u5584\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u300d\u300032: 397\u2013399\uff082022\uff09<\/p>\n\n\n\n<p>8.\u5f71\u5c71\u614e\u4e8c\u3001\u4f50\u3005\u6728\u7f8e\u6674\u3001\u4f0a\u85e4\u7531\u5f66\u3001\u5c71\u7530\u975c\u96c4\uff1a\u3000\u5973\u6027\u904e\u6d3b\u52d5\u8180\u80f1\u60a3\u8005\u306b\u5bfe\u3059\u308b\u30dc\u30bf\u30f3\u30dc\u30a6\u30d5\u30a8\u30ad\u30b9\u306e\u81e8\u5e8a\u52b9\u679c<br>\u65e5\u672c\u6392\u5c3f\u6a5f\u80fd\u5b66\u4f1a\u8a8c\u3000\u7279\u96c6\u300c\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u3092\u6539\u5584\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u300d\u300032: 402\u2013405\uff082022\uff09<\/p>\n\n\n\n<p>9.\u9152\u672c\u8c9e\u662d\u3001\u5f71\u5c71\u614e\u4e8c\u3001\u524d\u5cf6\u9756\u52f2\u3001\u5c71\u7530\u975c\u96c4\uff1a\u3000\u9593\u8cea\u6027\u8180\u80f1\u708e\u306b\u5bfe\u3059\u308b\u767a\u82bd\u305d\u3070\u767a\u9175\u30a8\u30ad\u30b9\u306e\u81e8\u5e8a\u6210\u7e3e<br>\u65e5\u672c\u6392\u5c3f\u6a5f\u80fd\u5b66\u4f1a\u8a8c\u3000\u7279\u96c6\u300c\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u3092\u6539\u5584\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u300d\u300032: 411-414\uff082022\uff09<\/p>\n\n\n\n<p>10.\u767d\u4e95\u307f\u3061\u4ee3\u3001\u5f71\u5c71\u614e\u4e8c\u3001\u9234\u6728\u7406\u6075\u5b50\u3001\u5c71\u7530\u9759\u96c4\uff1a\u3000DHA\/EPA\u5f37\u5316\u306f\u3093\u307a\u3093\u304a\u3088\u3073\u30ce\u30d3\u30ec\u30c1\u30f3\u6dfb\u52a0\u85ac\u81b3\u91ce\u83dc\u30b9\u30fc\u30d7\u306b\u3088\u308b\u5065\u5eb7QOL\u306e\u6539\u5584\u52b9\u679c<br>\u5fdc\u7528\u85ac\u7406\u3000103\uff1a45-51\uff082022\uff09<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u7dcf\u8aac]&nbsp;<\/h5>\n\n\n\n<p>1.Yutaka Nakagawa, Shizuo Yamada: The relationships among metal homeostasis, mitochondria, and locus coeruleus in psychiatric and neurodegenerative disorders: Potential pathogenetic mechanism and therapeutic implications<br>Cellular and Molecular Neurobiology,&nbsp;<a href=\"https:\/\/doi.org\/10.1007\/s10571-022-01234-3\">https:\/\/doi.org\/10.1007\/s10571-022-01234-3<\/a>&nbsp;892: 173737\uff082022)<\/p>\n\n\n\n<p>2.\u5c71\u7530\u975c\u96c4\u3001\u52a0\u85e4\u5584\u4e45\u3001\u901f\u6c34\u614e\u4ecb\uff1a \u30df\u30e9\u30d9\u30b0\u30ed\u30f3\u306b\u3088\u308b\u8180\u80f1\u03b23\u53d7\u5bb9\u4f53\u4ee5\u5916\u306eOff-target\u52b9\u679c-\u30e0\u30b9\u30ab\u30ea\u30f3\u6027\u53d7\u5bb9\u4f53\u3092\u4e2d\u5fc3\u306b<br>\u65e5\u672c\u6392\u5c3f\u6a5f\u80fd\u5b66\u4f1a\u8a8c\u300032: 465\u2013470\uff082022\uff09<\/p>\n\n\n\n<p>3.\u5c71\u7530\u975c\u96c4\uff1a\u3000\u6a5f\u80fd\u6027\u98df\u54c1\u3068\u533b\u98df\u540c\u6e90\uff08\u7dcf\u8ad6\uff09<br>\u65e5\u672c\u6392\u5c3f\u6a5f\u80fd\u5b66\u4f1a\u8a8c\u3000\u7279\u96c6\u300c\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u3092\u6539\u5584\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u300d\u300032: 393\u2013394\uff082022\uff09<\/p>\n\n\n\n<p>4.\u5c71\u7530\u975c\u96c4\uff1a\u3000\u533b\u98df\u540c\u6e90\u3068\u5065\u5eb7\u98df\u54c1\u2015\u6392\u5c3f\u969c\u5bb3\u9069\u7528\u3067\u306e\u79d1\u5b66\u7684\u5b9f\u8a3c<br>\u5fdc\u7528\u85ac\u7406, 102: 47\u201354\uff082022\uff09<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u8457\u66f8]<\/h5>\n\n\n\n<p>1.\u5c71\u7530\u9759\u96c4\uff1a\u3000\u88dc\u5b8c\u4ee3\u66ff\u533b\u7642\u3068\u5065\u5eb7\u98df\u54c1<br>\u5fdc\u7528\u7d30\u80de\u88dc\u5b8c\u4ee3\u66ff\u533b\u7642\u5b66\u3000\u7b2c\uff12\u5dfb-\u5065\u5eb7\u3092\u88dc\u5b8c\u4ee3\u66ff\u533b\u7642\u306b\u6c42\u3081\u3066-.\u3000\u732a\u5ca1\u5c1a\u5fd7\u3001\u5149\u672c\u6cf0\u79c0\u3000\u76e3\u4fee<br>\uff08\u592a\u967d\u66f8\u623f\u51fa\u7248\uff09\u3001pp. 145-158 (2022)<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">2021\u5e74<\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">[\u539f\u8457\u8ad6\u6587]<\/h5>\n\n\n\n<p>1.&nbsp;Shizuo Yamada, Junko Chimoto, Mizuki Shiho, Takashi Okura, Kana Morikawa, Satomi Kagota, Hirokazu Wakuda, Kazumasa Shinozuka. Possible involvement of muscarinic receptor blockade in mirabegron therapy for patients with overactive bladder<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33658313\/\">J Pharmacol Exp Ther, 377: 201\u2013206 (2021)<\/a><\/p>\n\n\n\n<p>2.&nbsp;Satomi Kagota, Kana Morikawa, Hirotake Ishida, Junko Chimoto, Kana Maruyama-Fumoto, Shizuo Yamada, Kazumasa Shinozuka. Vasorelaxant effects of benzodiazepine, non-benzodiazepine sedative-hypnotics, and tandospirone on isolated rat arteries.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33220270\/\">Eur J Pharmacol, 892: 173744 (2021)&nbsp;<\/a><\/p>\n\n\n\n<p>3.&nbsp;Shizuo Yamada, Junko Chimoto, Mizuki Shiho, Takashi Okura, Kana Morikawa, Satomi Kagota, Kazumasa Shinozuka. Demonstration of muscarinic receptor binding activity of vibegron and its receptor occupancy in the bladder.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34545632\/\">Int J Urol, 28: 1298\u20131303 (2021)<\/a><\/p>\n\n\n\n<p>4.&nbsp;Shizuo Yamada, Michiyo Shirai, Ken Ono, Toshiaki Teruya, Aki Yamano, Je Tae Woo. Beneficial effects of a nobiletin-rich formulated supplement of Siikuwha (C. depressa) peel on cognitive function in elderly Japanese subjects; A multicenter, randomized, double-blind, placebo-controlled study.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34925812\/\">Food Sci Nutr, 9: 6844\u20136853 (2021)<\/a><\/p>\n\n\n\n<p>5.&nbsp;Hisae Oku, Fumika Kitagawa, Yoshihisa Kato, Toshitaka Minetoki, Masaomi Hara, Tomoya Miyashita, Shizuo Yamada. Anti-allergic effects of the subcritical water extract powder of Citrus unshiu in mouse and guinea-pig models.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34009024\/\">J Med Food, 24: 533\u2013540 (2021)<\/a><\/p>\n\n\n\n<p>6.&nbsp;Yuki Ito, Rikako Ishibashi, Shiro Tajima, Taro Ueda, Shinji Kageyama, Shizuo Yamada, Jiro Saito. Suppressive effects of a supplement containing pomegranate fruit extract on urinary stress in women-A randomized, single-blind, placebo-controlled, parallel-group, three-arm study: a pilot study.<br>J<a href=\"http:\/\/www.pieronline.jp\/content\/article\/0386-3603\/49010\/155\">ap Pharmacol Ther, 49: 143\u2013153 (2021)<\/a><\/p>\n\n\n\n<p>7.&nbsp;Yuki Ito, Yasumori Matsui, Masakazu Kobayashi, Taro Ueda, Yuji Matsushima, Shinji Kageyama, Shizuo Yamada, Jiro Saito. Suppressive effects of a supplement containing pomegranate fruit-derived punicalagin on urinary stress in healthy adult women-A randomized, double-blind, placebo-controlled, parallel-group study.<br><a href=\"http:\/\/www.pieronline.jp\/content\/article\/0386-3603\/49010\/155\">Jap Pharmacol Ther, 49: 155\u2013166 (2021)<\/a><\/p>\n\n\n\n<p>8.&nbsp;\u5bae\u5cf6\u5d07\u5e83\u3001\u4e2d\u7530\u5b5d\u5e83\u3001\u77f3\u6a4b\u7406\u590f\u5b50\u3001\u677e\u4e95\u4fdd\u516c\u3001\u5f71\u5c71\u614e\u4e8c\u3001\u5c71\u7530\u9759\u96c4\uff0e\u30de\u30f3\u30b4\u30b9\u30c1\u30f3\u679c\u76ae\u7531\u6765\u03b1-\u30de\u30f3\u30b4\u30b9\u30c1\u30f3\u914d\u5408\u98df\u54c1\u6442\u53d6\u306b\u3088\u308b\u7537\u6027\u306e\u591c\u9593\u306e\u6392\u5c3f\u306b\u95a2\u308f\u308b\u751f\u7406\u6a5f\u80fd\u3068\u751f\u6d3b\u306e\u8cea\u306e\u6539\u5584\u52b9\u679c\u2015\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u4e26\u884c\u7fa4\u9593\u6bd4\u8f03\u8a66\u9a13\u2015.<br><a href=\"http:\/\/www.pieronline.jp\/content\/article\/0386-3603\/49120\/2077\">\u85ac\u7406\u3068\u6cbb\u7642, 49: 2077\u20132089 (2021)<\/a><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u7dcf\u8aac]&nbsp;<\/h5>\n\n\n\n<p>1.&nbsp;Yutaka Nakagawa, Shizuo Yamada: A novel hypothesis on metal dyshomeostasis and mitochondrial dysfunction in amyotrophic lateral sclerosis: Potential pathogenetic mechanism and therapeutic implications.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33220280\/\">Eur J Pharmacol, 892: 173737\uff082021)<\/a><\/p>\n\n\n\n<p>2.&nbsp;\u5c71\u7530\u975c\u96c4\u3001\u767d\u4e95\u307f\u3061\u4ee3\u3001\u5409\u6728\u3000\u62d3\u3001\u5ddd\u7530\u3000\u664b: \u30b1\u30eb\u30bb\u30c1\u30f3\u542b\u6709\u98df\u54c1\u306b\u3088\u308b\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u4f5c\u7528\u2015\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u4e26\u884c\u7fa4\u9593\u6bd4\u8f03\u8a66\u9a13\uff0d.<br>\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u81e8\u5e8a, 41: 338\u2013342\uff082021\uff09<\/p>\n\n\n\n<p>3.&nbsp;\u5c71\u7530\u975c\u96c4\u3001\u767d\u4e95\u307f\u3061\u4ee3\u3001\u5409\u6728\u3000\u62d3\u3001\u5ddd\u7530\u3000\u664b: 7\u6708\u53f7\u7279\u96c6\u300c\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u30c1\u30fc\u30e0\u533b\u7642\u3068\u533b\u7642\u884c\u653f\u300d\uff0e\u6a5f\u80fd\u6027\u98df\u54c1\u306b\u3088\u308b\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u4f5c\u7528.&nbsp;<br>\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u81e8\u5e8a, 41:589\u2013593\uff082021\uff09<\/p>\n\n\n\n<p>4.&nbsp;\u5c71\u7530\u975c\u96c4\uff0e\u7279\u96c6\u300c\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u3092\u6539\u5584\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u300d\u3000\u5dfb\u982d\u8a00.&nbsp;<br>\u6a5f\u80fd\u6027\u98df\u54c1\u3068\u85ac\u7406\u30fb\u6804\u990a, 15: 347\uff082021\uff09<\/p>\n\n\n\n<p>5.&nbsp;\u5c71\u7530\u975c\u96c4\u3001\u4f0a\u85e4\u7531\u5f66\uff0e\u7279\u96c6\u300c\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u3092\u6539\u5584\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u300d\uff0e\u30ce\u30b3\u30ae\u30ea\u30e4\u30b7\u679c\u5b9f\u30a8\u30ad\u30b9\u306b\u3088\u308b\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u306e\u6539\u5584\u4f5c\u7528.&nbsp;<br>\u6a5f\u80fd\u6027\u98df\u54c1\u3068\u85ac\u7406\u30fb\u6804\u990a, 15: 354\u2013360\uff082021\uff09<\/p>\n\n\n\n<p>6.&nbsp;\u524d\u5cf6\u9756\u52f2\u3000\u9152\u672c\u8c9e\u662d\u3001\u5f71\u5c71\u614e\u4e8c\u3001\u5c71\u7530\u975c\u96c4\uff0e\u7279\u96c6\u300c\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u3092\u6539\u5584\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u300d\uff0e\u767a\u82bd\u305d\u3070\u767a\u9175\u30a8\u30ad\u30b9\u306e\u6392\u5c3f\u969c\u5bb3\u306b\u95a2\u3059\u308b\u6a5f\u80fd\u6027.&nbsp;<br>\u80fd\u6027\u98df\u54c1\u3068\u85ac\u7406\u30fb\u6804\u990a, 15: 361\u2013364\uff082021\uff09<\/p>\n\n\n\n<p>7.&nbsp;\u5c71\u7530\u975c\u96c4\uff0e\u7279\u96c6\u300c\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u3092\u6539\u5584\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u300d\uff0e\u30ad\u30ca\u9178\u3092\u542b\u6709\u3059\u308b\u30af\u30e9\u30f3\u30d9\u30ea\u30fc\u98f2\u6599\u306b\u3088\u308b\u5065\u5e38\u6210\u4eba\u5973\u6027\u306e\u983b\u5c3f\u6539\u5584\u4f5c\u7528\u2015\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u4e26\u884c\u7fa4\u9593\u6bd4\u8f03\u8a66\u9a13.<br>\u6a5f\u80fd\u6027\u98df\u54c1\u3068\u85ac\u7406\u30fb\u6804\u990a, 15: 371\u2013376\uff082021\uff09<\/p>\n\n\n\n<p>8.&nbsp;\u4f0a\u85e4\u7531\u5f66. \u904e\u6d3b\u52d5\u8180\u80f1\u6cbb\u7642\u85ac\u306f\u306a\u305c\u8180\u80f1\u306b\u4f5c\u7528\u3059\u308b\u306e\u304b<br>\u30d5\u30a1\u30eb\u30de\u30b7\u30a2\uff08\u30bb\u30df\u30ca\u30fc\uff09 57: 927\u2013930\uff082021\uff09<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">2020\u5e74<\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">[\u539f\u8457\u8ad6\u6587]<\/h5>\n\n\n\n<p>1. Shizuo Yamada, Shiori Kuraoka, Yoshihiko Ito, Satomi Kagota, Kazumasa Shinozuka, Satomi Onoue. &nbsp;Direct in vitro and in vivo demonstration of muscarinic receptor binding by the novel radioligand, [3H]5-hydroxymethyltolterodine, in the bladder and other tissues of rats<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31889618\/\">J Pharmacol Sci, 142: 127-130 (2020)<\/a><\/p>\n\n\n\n<p>2. Shino Miyauchi-Wakuda, Satomi Kagota, Kana Maruyama-Fumoto, Yayoi Shiokawa, Shizuo Yamada, Kazumasa Shinozuka. Acanthopanax senticosus root extract exerts dual action on mouse ileal smooth muscle function, leading to modulation of gastrointestinal motility.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32378558\/\">Biol Pharm Bull, 43: 817-822 (2020)&nbsp;<\/a>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;<\/p>\n\n\n\n<p>3. Kimio Sugaya, Hidetomi Yamagami, Saori Nishijima, Katsumi Kadekawa, Masanori Hizue, Yoshihiko Ito, Shizuo Yamada: Effects of combined treatment with fesoterodine and mirabegron in a pelvic congestion rat model: Results from in vitro and in vivo functional studies &nbsp; &nbsp; &nbsp;<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31758673\/\">Lower Urinary Tract Symptoms, 12: 173-179 (2020)<\/a><\/p>\n\n\n\n<p>4. Shizuo Yamada, Yoshihiko Ito, Kana Morikawa, Satomi Kagota, Kazumasa Shinozuka. Effect of saw palmetto extract on urodynamic parameters, bladder contractility and pharmacological receptors in female rats<br><a href=\"https:\/\/www.academiapublishing.org\/journals\/ajmp\/abstract\/2020\/Dec\/Yamada%20et%20al.htm\">Academia Journal of Medicinal Plants, 8: 171-178 (2020)<\/a><\/p>\n\n\n\n<p>5. Satomi Kagota, Kana Morikawa, Hirotake Ishida, Junko Chimoto, Kana Maruyama-Fumoto, Shizuo Yamada, Kazumasa Shinozuka. Vasorelaxant effects of benzodiazepine, non-benzodiazepine sedative-hypnotics, and tandospirone on isolated rat arteries.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33220270\/\">Eur J Pharmacol, 2020 Nov 19:173744. doi: 10.1016\/j.ejphar.2020.173744. Online ahead of print.PMID: 33220270<\/a><\/p>\n\n\n\n<p>5. Mizuki Watanabe, Takaaki Kobayashi, Yoshihiko Ito, Shizuo Yamada,Satoshi Shuto. Conformational restriction of histamine with a rigid bicyclo[3.1.0]hexane scaffold provided selective H3 receptor ligands<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32764432\/\">Molecules, 2020 Aug 5;25(16):3562. doi: 10.3390\/molecules25163562.PMID: 32764432<\/a><\/p>\n\n\n\n<p>6.\u671b\u6708\u6b63\u6804\u3001\u5730\u672c\u7d14\u5b50\u3001\u77f3\u7530\u88d5\u4e08\u3001\u77f3\u5ddd\u667a\u4e45\u3001\u8cc0\u5ddd\u7fa9\u4e4b\u3001\u9234\u6728\u5eb7\u4e4b\u3001\u9ce5\u672c\u4e00\u5321\u3001\u9234\u6728\u771f\u7531\u7f8e\u3001\u6d77\u91ce\u7531\u91cc\u5b50\u3001\u901f\u6c34\u614e\u4ecb\u3001\u5c71\u7530 \u9759\u96c4: \u591a\u5264\u670d\u7528\u306e\u9ad8\u9f62\u60a3\u8005\u306b\u304a\u3051\u308b\u6297\u30b3\u30ea\u30f3\u69d8\u6709\u5bb3\u4e8b\u8c61\u3068\u670d\u7528\u85ac\u5264\u306e\u8abf\u67fb\u304a\u3088\u3073\u85ac\u5264\u306e\u30e0\u30b9\u30ab\u30ea\u30f3\u6027\u53d7\u5bb9\u4f53\u7d50\u5408\u6d3b\u6027\u306e\u8a55\u4fa1<br>\u65e5\u672c\u6392\u5c3f\u6a5f\u80fd\u5b66\u4f1a\u96d1\u8a8c, 30: 433-438\uff082020\uff09<\/p>\n\n\n\n<p>7. &nbsp;\u5c71\u7530 \u9759\u96c4\u3001\u767d\u4e95\u307f\u3061\u4ee3\u3001\u7a32\u8449\u7950\u5b50\u3001\u9ad9\u826f\u3000\u6bc5: \u30b1\u30eb\u30bb\u30c1\u30f3\u542b\u6709\u98df\u54c1\u306e\u6442\u53d6\u304c\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u3088\u308b\u9f3b\u76ee\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306b\u53ca\u307c\u3059\u5f71\u97ff\uff0d\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u4e26\u884c\u7fa4\u9593\u6bd4\u8f03\u8a66\u9a13\uff0d<br><a href=\"http:\/\/www.pieronline.jp\/content\/article\/0386-3603\/48110\/1945\">\u85ac\u7406\u3068\u6cbb\u7642, 48: 1945-1959\uff082020\uff09<\/a><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u7dcf\u8aac]&nbsp;<\/h5>\n\n\n\n<p>1.&nbsp;Yutaka Nakagawa, Shizuo Yamada: Metal homeostasis disturbances in neurodegenerative disorders, with special emphasis on Creutzfeldt-Jakob disease &#8211; Potential pathogenetic mechanism and therapeutic implications.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31863817\/\">Pharmacol Ther, 207:107455\uff082020)<\/a><\/p>\n\n\n\n<p>2.&nbsp;\u5c71\u6fa4\u5fb3\u5fd7\u5b50\u3001\u5c71\u7530\u9759\u96c4\uff1a\u3000\u9aa8\u683c\u7b4b\u306e\u6052\u5e38\u6027\u7dad\u6301\u306b\u5bfe\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u7d20\u6750\u306e\u5f79\u5272<br>\u65e5\u672c\u85ac\u7406\u5b66\u96d1\u8a8c\u3000\uff08\u7dcf\u8aac\uff09\u300143, 10-11\uff082020\uff09<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u8457\u66f8]<\/h5>\n\n\n\n<p>1.&nbsp;\u5c71\u7530\u9759\u96c4\u3001\u4f0a\u85e4\u7531\u5f66\u3001\u9234\u6728\u671d\u65e5\u3001\u9ed2\u5ddd\u7f8e\u4fdd\u5b50\u3001\u5f71\u5c71\u614e\u4e8c\uff1a\u3000\u30ce\u30b3\u30ae\u30ea\u30e4\u30b7.&nbsp;<br>\u6a5f\u80fd\u6027\u98df\u54c1\u7d20\u6750\u306e\u305f\u3081\u306e\u30d2\u30c8\u8a55\u4fa1.\u3000\u5c71\u672c\u54f2\u90ce\u76e3\u4fee\u3001\uff08\u30b7\u30fc\u30a8\u30e0\u30b7\u30fc\u51fa\u7248\uff09\u3001pp. 276-283 (2020)<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">2019\u5e74<\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">[\u539f\u8457\u8ad6\u6587]<\/h5>\n\n\n\n<p>1.&nbsp;Shizuo Yamada, Shiori Kuraoka, Yoshihiko Ito, Yoshihisa Kato, and Satomi Onoue: Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration &nbsp;&nbsp;<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31153768\/\">J Pharmacol Sci 140: 73-78 (2019)<\/a><\/p>\n\n\n\n<p>2.&nbsp;Shino Miyauchi-Wakuda, Satomi Kagota, Kana Maruyama-Fumoto, Hirokazu Wakuda, Shizuo Yamada, Kazumasa Shinozuka: &nbsp;Effect of royal jelly on mouse isolated ileum and gastrointestinal motility<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31329014\/\">J Med Food, 22: 789-796 (2019)<\/a><\/p>\n\n\n\n<p>3.&nbsp;Hirokazu Wakuda, Takashi Okura, Kana Maruyama-Fumoto, Satomi Kagota, Yoshihiko Ito, Shino Miyauchi-Wakuda, Naoyuki Otani, Naoto Uemura, Shizuo Yamada, Kazumasa Shinozuka. Effects of anticholinergic drugs used for the therapy of overactive bladder on P-glycoprotein activity<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31787715\/\">Biol Pharm Bull. 42: 1996-2001 (2019)<\/a><\/p>\n\n\n\n<p>4.&nbsp;Yayoi Shiokawa, Shino Miyauchi-Wakuda, Satomi Kagota, Kana Maruyama-Fumoto, Shizuo Yamada, Kazumasa Shinozuka. &nbsp;Acanthopanax senticosus induces vasorelaxation via endothelial nitric oxide-dependent and \u2013independent pathways<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31342475\/\">Planta Medica 85: 1080-1087 (2019)<\/a>&nbsp;<\/p>\n\n\n\n<p>5.&nbsp;Yoshihisa Kato, Sekihiro Tamaki, Koichi Haraguchi, Shin-ichi Ikushiro, Yukiko Fujii, Chiho Ohta, Kazutaka Atobe, Osamu Kimura, Tetsuya Endo, Nobuyuki Koga, Shizuo Yamada, Masakuni Degawa. Kanechlor 500-mediated changes in serum and hepatic thyroxine levels primarily occur in a transthyretin-unrelated manner<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31498458\/\">J Appl Toxicol 39: 1701-1709 (2019)<\/a><\/p>\n\n\n\n<p>6.&nbsp;Hirokazu Wakuda, Shino Miyauchi-Wakuda, Kana Morikawa, Kana Maruyama-Fumoto, Satomi Kagota, Yoshihiko Ito, Naoto Uemura, Shizuo Yamada, Kazumasa Shinozuka. Effect of fermented buckwheat sprouts extract and its ingredients on rat bladder.<br>\u65e5\u672c\u6392\u5c3f\u6a5f\u80fd\u5b66\u4f1a\u8a8c, 29: 451-455 (2019)<\/p>\n\n\n\n<p>7.&nbsp;\u5f71\u5c71\u614e\u4e8c\u3001\u6625\u91ce\u660e\u5f18\u3001\u4f0a\u85e4\u7531\u5f66\u3001\u85e4\u5cf6\u96c5\u57fa\u3001\u7af9\u8170\u82f1\u592b\u3001\u5c71\u7530\u9759\u96c4\uff1a\u3000\u6025\u6027\u8180\u80f1\u708e\u3092\u7e70\u308a\u8fd4\u3059\u6210\u4eba\u5973\u6027\u306b\u5bfe\u3059\u308b\u30af\u30ed\u30ec\u30e9\u306e\u518d\u767a\u4e88\u9632\u52b9\u679c\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u7814\u7a76\u3000<br>\u6392\u5c3f\u969c\u5bb3\u30d7\u30e9\u30af\u30c6\u30a3\u30b9,\u300027\uff1a77-82\uff082019\uff09<\/p>\n\n\n\n<p>8.\u5bae\u5d0e\u3055\u3084\u304b\u3001\u5c71\u7530\u9759\u96c4\u3001\u6771\u91ce\u5b9a\u5f8b\u3001\u6e21\u9089\u9806\u5b50\u3001\u6c34\u4e0a\u52dd\u7fa9\uff1a\u3000\u5728\u5b85\u533b\u7642\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u51e6\u65b9\u85ac\u5264\u3068\u6392\u5c3f\u969c\u5bb3\u306e\u95a2\u9023<br>\u65e5\u672c\u8001\u5e74\u533b\u5b66\u4f1a\u96d1\u8a8c, 56: 301-311\uff082019\uff09<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">2018\u5e74<\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">[\u539f\u8457\u8ad6\u6587]<\/h5>\n\n\n\n<p>1.&nbsp;Takahisa Suzuki, Atsushi Otsuka, Yoshihiko Ito, Shizuo Yamada, Hideaki Miyake, Seiichiro Ozono. Isosamidin, an extract of Peucedanum japonicum, inhibits phenylephrine-mediated contractions of the human prostate in vitro.&nbsp;<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29388272\/\">Phytotherapy Res., 32: 949-952 (2018)<\/a><\/p>\n\n\n\n<p>2.&nbsp;Yaoyue Liang, Satomi Kagota, Kana Maruyama, Yuri Oonishi, Shino Miyauchi-Wakuda, Yoshihiko Ito, Shizuo Yamada, Kazumasa Shinozuka, Royal jelly increases peripheral circulation by inducing vasorelaxation through nitric oxide production under healthy conditions<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30119189\/\">Biomed Pharmacother, 106, 1210-1219 (2018)<\/a><\/p>\n\n\n\n<p>3.&nbsp;Tsuyoshi Yoshizawa, Yukio Hayashi, Akira Yoshida, Yoshihiko Ito, Kenya Yamaguchi, Shizuo Yamada, Satoru Takahashi: Concomitant alteration in number and affinity of P2X and muscarinic receptors are associated with bladder dysfunction in early stage of diabetic rats&nbsp;<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29368246\/\">Int Urol Nephrol, 50: 451-458 (2018)<\/a><\/p>\n\n\n\n<p>4.&nbsp;Shuhei Kawamura, Yoshihiko Ito, Takatsugu Hirokawa, Eriko Hikiyama, Shizuo Yamada, Satoshi Shuto: Ligand-phospholipid conjugation: a versatile strategy for developing long-acting ligands that bind to membrane proteins by restricting the subcellular localization of the ligand<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29652494\/\">J Med Chem Lett., 61: 4020-4029 (2018)<\/a><\/p>\n\n\n\n<p>5.&nbsp;Mizuki Watanabe, Takaaki Kobayashi, Yoshihiko Ito, Hayato Fukuda, Shizuo Yamada, Mitsuhiro Arisawa, Satoshi Shuto: Design and Synthesis of Histamine H3\/H4 Receptor Ligands with a Cyclopropane Scaffold&nbsp;<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30385161\/\">Bioorg Med Chem Lett., 28: 3630-3633 (2018)<\/a><\/p>\n\n\n\n<p>6.&nbsp;Junko Kimura, Kosuke Shimizu, Koji Kajima, Akihito Yokosuka, Yoshihiro Mimaki, Naoto Oku, Yasushi Ohizumi: Nobiletin reduces intracellular and extracellular \u03b2-amyloid in iPS cell-derived Alzheimer\u2019s disease model neurons<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29607920\/\">Biol Pharm Bull., 41: 451-457 (2018)<\/a><\/p>\n\n\n\n<p>7.&nbsp;Hiroto Sagara, Masaki Kanakogi, Yuki Tara, Hitoshi Ouchi, Junko Kimura, Yukiko Kaneko, Makoto Inai, Tomohiro Asakawa, Tomohisa Ishikawa, Toshiyuki Kan: Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations<br><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403918303915\">Tetrahedron Lett., 59: 1816-1818 (2018)<\/a><\/p>\n\n\n\n<p>8.&nbsp;\u5f71\u5c71\u614e\u4e8c\u3001\u5bcc\u6c38\u5f69\u9999\u3001\u5f15\u5c71\u6075\u68a8\u5b50\u3001\u5317\u6751\u5b9f\u7a42\u3001\u6625\u91ce\u660e\u5f18\u3001\u4f0a\u85e4\u7531\u5f66\u3001\u5c71\u7530\u9759\u96c4\uff1a\u5973\u6027\u904e\u6d3b\u52d5\u8180\u80f1\u60a3\u8005\u306b\u5bfe\u3059\u308b\u30dc\u30bf\u30f3\u30dc\u30a6\u30d5\u30a6\u30a8\u30ad\u30b9\u306e\u81e8\u5e8a\u52b9\u679c<br>\u6ccc\u5c3f\u5668\u5916\u79d1\u300031, 75-80\uff082018\uff09<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u7dcf\u8aac]&nbsp;<\/h5>\n\n\n\n<p>1.&nbsp;Shizuo Yamada, Yoshihiko Ito, Saori Nishijima, Kimio Sugaya: Basic and clinical aspects of antimuscarinic agents used to treat overactive bladder.<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29709423\/\">Pharmacol Ther, 189: 130-148\uff082018)<\/a><\/p>\n\n\n\n<p>2.&nbsp;\u5c71\u7530\u9759\u96c4\u3001\u4f0a\u85e4\u7531\u5f66\u3001\u5bae\u5d0e\u3055\u3084\u304b\u3001\u5f71\u5c71\u614e\u4e8c\uff1a\u3000\u6a5f\u80fd\u6027\u98df\u54c1\u306e\u88dc\u5b8c\u533b\u7642\u7684\u52b9\u7528.\u3000<br>\u65e5\u672c\u814e\u6ccc\u5c3f\u5668\u75be\u60a3\u4e88\u9632\u533b\u5b66\u7814\u7a76\u4f1a\u8a8c\u300026\uff1a17-21\uff082018\uff09<\/p>\n\n\n\n<p>3.\u5bae\u5d0e\u3055\u3084\u304b\u3001\u671b\u6708\u6b63\u6804\u3001\u677e\u4e0b\u7bc4\u5b50\u3001\u4f0a\u85e4\u7531\u5f66\u3001\u95a2\u3000\u6210\u4eba\u3001\u6e21\u9089\u9806\u5b50\u3001\u5c71\u7530\u9759\u96c4\uff1a\u85ac\u5264\u306b\u3088\u308b\u6392\u5c3f\u969c\u5bb3\u2015\u6dfb\u4ed8\u6587\u66f8\u306e\u526f\u4f5c\u7528\u767a\u73fe\u983b\u5ea6\u304b\u3089\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u30fc<br>\u6392\u5c3f\u969c\u5bb3\u30d7\u30e9\u30af\u30c6\u30a3\u30b9, 26 (No 1), 87-99\uff082018\uff09<\/p>\n\n\n\n<p>4.\u5c71\u7530\u9759\u96c4\uff1a\u30bd\u30a6\u30d1\u30eb\u30e1\u30c3\u30c8\uff08\u30ce\u30b3\u30ae\u30ea\u30e4\u30b7\uff09\u306e\u6210\u5206\u3068\u6392\u5c3f\u30c8\u30e9\u30d6\u30eb\u3078\u306e\u5229\u7528<br>Medical Herb\u3000(\u65e5\u672c\u30e1\u30c7\u30a3\u30ab\u30eb\u30cf\u30fc\u30d6\u5354\u4f1a)\u300143, 10-11\uff082018\uff09<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u8457\u66f8]<\/h5>\n\n\n\n<p>1.&nbsp;\u5c71\u7530\u9759\u96c4\uff1a\u3000\u6ccc\u5c3f\u751f\u6b96\u5668\u75be\u60a3\u6cbb\u7642\u85ac<br>\u6cbb\u7642\u85ac\u306e\u81e8\u5e8a\u85ac\u7406\u30c7\u30fc\u30bf\u30d6\u30c3\u30af\uff0e\u6e21\u9089\u88d5\u53f8\u3000\u7de8\u96c6\uff08\u65e5\u672c\u533b\u4e8b\u65b0\u5831\u793e\uff09\u3001pp. 283-311 \uff082018\uff09<\/p>\n\n\n\n<p>2.&nbsp;\u5c3e\u4e0a\u8aa0\u826f\u3001\u5c71\u7530\u9759\u96c4\uff1a\u56fa\u4f53\u5206\u6563\u88fd\u5264\u6280\u8853\u3092\u7528\u3044\u305f\u96e3\u6c34\u6eb6\u6027\u30af\u30eb\u30af\u30df\u30f3\u306e\u6eb6\u89e3\u6027\u306a\u3089\u3073\u306b\u7d4c\u53e3\u5438\u53ce\u6027\u306e\u6539\u5584<br>\u96e3\u5438\u53ce\u6027\u85ac\u7269\u306e\u5438\u53ce\u6027\u6539\u5584\u3068\u65b0\u898f\u6295\u4e0e\u88fd\u5264\u306e\u958b\u767a\uff0e\u5c71\u672c\u3000\u660c\u3000\u76e3\u4fee\uff08\u30b7\u30fc\u30a8\u30e0\u30b7\u30fc\u51fa\u7248\uff09\u3001pp. 34-40 \uff082018\uff09<\/p>\n\n\n\n<p>3.&nbsp;\u5c71\u7530\u9759\u96c4\uff1a\u3000\u7b2c\uff17\u7ae0\u3000\u98df\u54c1\u306e\u85ac\u52b9\u304a\u3088\u3073\u533b\u85ac\u54c1\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u30fb\u4f75\u7528\u52b9\u679c\u306e\u89e3\u6790<br>\u6297\u30b9\u30c8\u30ec\u30b9\u98df\u54c1\u306e\u958b\u767a\u3068\u5c55\u671b\u2161\uff0e\u6a2a\u8d8a\u82f1\u5f66\u3000\u76e3\u4fee\uff08\u30b7\u30fc\u30a8\u30e0\u30b7\u30fc\u51fa\u7248\uff09\u3001pp. 79-90 \uff082018\uff09<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">2017\u5e74<\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">[\u539f\u8457\u8ad6\u6587]<\/h5>\n\n\n\n<p>1.Shinji Kageyama, Masanori Beppu, Hiromu Ohnogi, Sayaka Miyazaki, Akihiro Haruno, Yoshihiko Ito and Shizuo Yamada:&nbsp;Clinical Effects of Formulated Food of Peucedanum japonicum Extract and Saw Palmetto Extract in Male Patients with Lower Urinary Tract Symptoms<br><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12155\/full\">LUTS (Lower Urinary Tract Symptoms), DOI: 10.1111\/luts.12155<\/a><\/p>\n\n\n\n<p>2. Yoshihiko Ito, Shiori Kuraoka, Soma Endo, Ayaka Takahashi, Satomi Onoue, Shizuo Yamada: Urinary imidafenacin contributes to the long-lasting blockade of bladder muscarinic receptors: Effects of bilateral ligation of ureters<br><a href=\"http:\/\/jpet.aspetjournals.org\/content\/360\/1\/69.long\">J Pharmacol Exp Ther., 360: 69-74(2017)<\/a>&nbsp;<\/p>\n\n\n\n<p>3.Akira Mizuno, Tomoshi Kameda, Tomoki Kuwahara, Hideyuki Endoh, Yoshihiko Ito, Shizuo Yamada, Kimiko Hasegawa, Akihito Yamano, Mizuki Watanabe, Mitsuhiro Arisawa, Satoshi Shuto:&nbsp;Cyclopropane-Based Peptidomimetics Mimicking Wide-Ranging Secondary Structures of Peptides: Conformational Analysis and Their Use in Rational Ligand Optimization<br><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chem.201605312\/abstract\">Chemistry, 23: 3159-3168(2017)<\/a><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u7dcf\u8aac]&nbsp;<\/h5>\n\n\n\n<p>1.\u5c71\u7530\u9759\u96c4\uff1a\u30e1\u30f3\u30ba\u30d8\u30eb\u30b9\u3068\u6a5f\u80fd\u6027\u98df\u54c1.\u3000<em>\u6a5f\u80fd\u6027\u98df\u54c1\u3068\u85ac\u7406\u6804\u990a<\/em>\u300010\uff1a267 (2017)<\/p>\n\n\n\n<p>2.\u4f0a\u85e4\u7531\u5f66\u3001\u5f71\u5c71\u614e\u4e8c\u3001\u5c71\u7530\u9759\u96c4\uff1a\u524d\u7acb\u817a\u80a5\u5927\u306b\u3088\u308b\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u306b\u5bfe\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1.&nbsp;<em>\u6a5f\u80fd\u6027\u98df\u54c1\u3068\u85ac\u7406\u6804\u990a<\/em>\u300010\uff1a268-273 (2017)<\/p>\n\n\n\n<p>3.\u5c71\u7530\u9759\u96c4\u3001\u4f0a\u85e4\u7531\u5f66\u3001\u5f71\u5c71\u614e\u4e8c\uff1a\u30ce\u30b3\u30ae\u30ea\u30e4\u30b7\u679c\u5b9f\u30a8\u30ad\u30b9\u3068\u30dc\u30bf\u30f3\u30dc\u30a6\u30d5\u30a6\u30a8\u30ad\u30b9\u306b\u3088\u308b\u4e0b\u90e8\u5c3f\u8def\u75c7\u72b6\u306e\u6539\u5584.\u3000NewDiet Therapy 33: 55-62 (2017)<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">2016\u5e74<\/h4>\n\n\n\n<h4 class=\"wp-block-heading\">[\u539f\u8457\u8ad6\u6587]<\/h4>\n\n\n\n<p>1.Masaki Ogoda, Yoshihito Ito, Yusuke Fuchihata, Satomi Onoue, Shizuo Yamada: &nbsp;Characterization of muscarinic and P2X receptors in the urothelium and detrusor muscle of the rat bladder&nbsp;<br><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1347861316300378\">J Pharmacol Sci., 124: 1-6(2016)<\/a>\u3000<\/p>\n\n\n\n<p>2.Yoshihiko Ito, Michishi Kashiwabara, Akira Yoshida, Eriko Hikiyama, Satomi Onoue, Shizuo Yamada: Muscarinic receptor binding in rat bladder urothelium and detrusor muscle by intravesical solifenacin<br><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/39\/7\/39_b16-00194\/_article\">Biol Pharm Bull, 39: 1167-1171(2016)<\/a><\/p>\n\n\n\n<p>3.Shiori Kuraoka, Yoshihito Ito, Hirokazu Wakuda, Kazumasa Shinozuka, Satomi Onoue, Shizuo Yamada: &nbsp;Characterization of muscarinic receptor binding by the novel radioligand, [3H]imidafenacin, in the bladder and other tissues of rats<br><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S134786131630072X\">J Pharmacol Sci., 124: 1-6(2016)<\/a><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">2015\u5e74<\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">[\u539f\u8457\u8ad6\u6587]<\/h5>\n\n\n\n<p>1.Hirokazu Wakuda, Shino Miyauchi, Kana Maruyama, Satomi Kagota, Kazuki Nakamura, Keizo Umegaki, Shizuo Yamada, Kazumasa Shinozuka: Differential effects of mitogen-activated protein kinase pathway inhibitors on P-glycoprotein activation.&nbsp;<br><a href=\"http:\/\/pub.iapchem.org\/ojs\/index.php\/admet\/article\/view\/142\">ADMET &amp; DMPK, 3: 77-83 (2015)<\/a><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u7dcf\u8aac]&nbsp;<\/h5>\n\n\n\n<p>1.Pablo P. Werba, Shingen Misaka, Monica G. Giroli, Shizuo Yamada, Vi viana Cavalca, Keisuke Kawabe, Isabella Squellerio, Federica Laguzzi, Satomi Onoue, Fabrizio Veglia, Veronika Myasoedova, Kazuhiko Takeuchi, Eisuke Adachi, Naoki Inui, Elena Tremori, Hiroshi Watanabe: Overview of green tea interaction with cardiovascular drugs.\u3000<br><a href=\"http:\/\/www.eurekaselect.com\/125267\/article\">Current Phamraceutical Design, 21: 1213-1219 (2015)<\/a><\/p>\n\n\n\n<p>2.\u5c71\u7530\u975c\u96c4\uff1a\u3000\u751f\u4f53\u5185\u3067\u306e\u85ac\u7269-\u53d7\u5bb9\u4f53\u7d50\u5408\u3092\u57fa\u76e4\u3068\u3057\u305f\u85ac\u7269\u52d5\u614b\u3068\u85ac\u52b9\u306e\u7d71\u5408\u7684\u89e3\u6790<br>YAKUGAKU ZASSHI 135\uff1a 137-150 (2015)<\/p>\n\n\n\n<p>3.\u5c71\u7530\u9759\u96c4\uff1a \u53d7\u5bb9\u4f53\u30bf\u30f3\u30d1\u30af\u7d50\u5408\u5b9f\u9a13<br>\u547c\u5438\uff08\u8b1b\u5ea7\u3000\u7814\u7a76\u624b\u6cd5\u5165\u9580\uff1a\u85ac\u7406\u751f\u7406\uff09, 34\uff1a286-292\uff082015\uff09<\/p>\n\n\n\n<p>4.\u5c71\u7530\u9759\u96c4\u3001\u4f0a\u85e4\u7531\u5f66\u3001\u5c3e\u4e0a\u8aa0\u826f\uff1a\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u85ac\u7269\u306e\u4f53\u5185\u52d5\u614b\u30fb\u85ac\u52b9\u306e\u5909\u5316\u3068\u98f2\u98df\u7269\u30fb\u6804\u990a\u7d20\u3068\u306e\u76f8\u4e92\u4f5c\u7528<br>New Diet Therapy \u30cb\u30e5\u30fc\u30c0\u30a4\u30a8\u30c3\u30c8\u30bb\u30e9\u30d4\u30fc\u65e5\u672c\u81e8\u5e8a\u6804\u990a\u5354\u4f1a\u8a8c\uff08\u65e5\u672c\u81e8\u5e8a\u6804\u990a\u5354\u4f1a\u7de8\u96c6\uff0931\uff1a35-46\uff082015\uff09<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u8457\u66f8]<\/h5>\n\n\n\n<p>1.\u5c71\u7530\u9759\u96c4\uff1a\u3000\u6a5f\u80fd\u6027\u98df\u54c1\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u85ac\u5b66\u306e\u767a\u5c55<br>\u30d5\u30a1\u30eb\u30de\u30b7\u30a251\uff1a87\uff082015\uff09<\/p>\n\n\n\n<p>2.\u5c71\u7530\u9759\u96c4\uff1a\u3000\u6a5f\u80fd\u6027\u7d20\u6750\u3068\u85ac\u7269\u3068\u306e\u76f8\u4e92\u4f5c\u7528<br>\u30bd\u30d5\u30c8\u30c9\u30ea\u30f3\u30af\u6280\u8853\u8cc7\u6599 177: 395-409\uff082015\uff09<\/p>\n\n\n\n<p>3.\u5c71\u7530\u9759\u96c4\uff1a\u3000\u300c\u98df\u3068\u5065\u5eb7\u306e\u79d1\u5b66\u300d\u306e\u6b63\u3057\u3044\u9032\u5c55\u306b\u5411\u3051\u3066\u30fc\u3053\u308c\u304b\u3089\u306e\u98df\u54c1\u6a5f\u80fd\u7814\u7a76\u306e\u3042\u308a\u65b9\u306b\u3064\u3044\u3066\u306e\u8003\u5bdf<br>\u98df\u3068\u5065\u5eb7\u3092\u79d1\u5b66\u3059\u308b\u3000\u5275\u520a\u53f7\u3000\uff08\u30af\u30ed\u30ec\u30e9\u5065\u5eb7\u6804\u990a\u7814\u7a76\u4f1a\u7de8\u96c6\uff09\u63d0\u8a00\u3000\uff50 69-84\uff082015\uff09<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">2014\u5e74<\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">[\u539f\u8457\u8ad6\u6587]<\/h5>\n\n\n\n<p>1.Sweety Nasrin, Eiji Masuda, Haruna Kugaya, Ayaka Osano, Yoshihito Ito and and Shizuo Yamada: &nbsp;Effect of saw palmetto extract on urodynamic parameters, bladder muscarinic and purinergic receptors and urinary cytokines in rats with cyclophosphamide-induced cystitis<br><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/luts.12015\/full\">LUTS (Lower Urinary Tract Symptoms), 6: 57-63(2014)<\/a><\/p>\n\n\n\n<p>2.Akira Yoshida, Shiori Kuraoka, Yoshihito Ito, Takashi Okura, Yoshiharu Deguchi, Atsushi Otsuka, Seiichiro Ozona, Masayuki Takeda, Keisuke Masuyama, Isao Araki and Shizuo Yamada: &nbsp;Muscarinic receptor binding of the novel radioligand, [3H]imidafenacin in the human bladder and parotid gland<br><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jphs\/124\/1\/124_13193FP\/_article\">J Pharmacol\u3000Sci., 124: 40-46(2014)<\/a><\/p>\n\n\n\n<p>3.Ayaka Osano, Yoshinari Yokoyama, Hideki Hayashi, Kunihiko Ito, Takashi Okura, Yoshiharu Deguchi, Yoshihiko Ito and Shizuo Yamada: Bladder endothelin-1 receptor binding of bosentan and ambrisentan<br><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jphs\/124\/1\/124_13198FP\/_article\">J Pharmacol\u3000Sci., 124: 86-91(2014)<\/a><\/p>\n\n\n\n<p>4.Yoshinari Yokoyama, Ayaka Osano, Hideki Hayashi, Kunihiko Ito, Takashi Okura, Yoshiharu Deguchi, Yoshihiko Ito and Shizuo Yamada: Endothelin-1 receptors in rat tissues: Characterization by bosentan, ambrisentan and CI-1020<br><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/3\/37_b13-00881\/_article\">Biol Pharm Bull., 37: 461-465 (2014)<\/a><\/p>\n\n\n\n<p>5.Shingen Misaka, Junichi Yatabe, Fabian M\u00fcller, Kozue Takano, Keisuke Kawabe, Hartmut Glaeser, Midori Yatabe, Satomi Onoue, Jose P Werba, Hiroshi Watanabe, Shizuo Yamada, Martin F Fromm and Junko Kimura. Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.&nbsp;<br><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/clpt.2013.241\/abstract\">Clin Pharmacol Ther., 95: 432-438 (2014)<\/a>&nbsp;<\/p>\n\n\n\n<p>6.Hirokazu Wakuda, Shinya Uchida, Masahiko Ikeda, Masaki Tabuchi, Yasumitsu Akahoshi, Kazumasa Shinozuka, Shizuo Yamada: Is hyperuricemia a risk factor for arteriosclerosis? &nbsp;Uric acid and arteriosclerosis in apolipoprotein E-deficient mice.&nbsp;<br><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/12\/37_b14-00201\/_article\">Biol Pharm Bull, 37: 1866-1871 (2014)<\/a><\/p>\n\n\n\n<p>7.Yoshihisa Kato, Koichi Haraguchi, Mao Onishi, Shinichi Ikushiro, Tetsuya Endo, Chiho Ohta, Nobuyuki Koga, Shizuo Yamada, and Masakuni Degawa. 3,3&#8242;,4,4&#8242;-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in mice occurs mainly through enhanced accumulation of thyroxine in the liver.<br><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/3\/37_b13-00775\/_article\">Biol Pharm Bull., 37: 504-509 (2014)&nbsp;<\/a><\/p>\n\n\n\n<p>8.Tomoko Hatano, Yuka Sameshima, Mami Kawabata, Shizuo Yamada, Kazumasa Shinozuka, Toshikatsu Nakabayashi, Hideya Mizuno. St. John\u2019s wort promotes adipocyte differentiation and modulates NF-\uf06bB activation in 3T3-L1 cells.<br><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/37\/7\/37_b13-00989\/_article\">Biol Pharm Bull., 37: 1132-1138 (2014)&nbsp;<\/a><\/p>\n\n\n\n<p>9.Kosuke Shimizu, Tomohiro Asakawa, Norihiro Harada, Dai Fukumoto, Hideo Tsukada, Tomohiro Asai, Shizuo Yamada, Toshiyuki Kan and Naoto Oku: Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin<br><a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0085520\">PLOS ONE, 9: e85520. doi:10.1371 (2014)<\/a><\/p>\n\n\n\n<p>10.Nodoka Yasuda, Takayuki Ishii, Dai Oyama, Yurika Agato, Tatsuya Furuka, Akihiko Sato, Kosuke Shimizu, Tomohiro Asai, Tomohiro Asakawa, Toshiyuki Kan, Shizuo Yamada, Yasushi Ohizumi, Naoto Oku: Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebaralartery-occluded rats.&nbsp;<br><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006899314001619\">Brain Res., 1559: 46-54 (2014)<\/a><\/p>\n\n\n\n<p>11.Jinno, Norimasa; Tagashira, Mizuka; Tsurui, Kazuyuki; Yamada, Shizuo: Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: Risk assessment of acylglucuronides using human hepatocytes&#8221;.&nbsp;<br><a href=\"http:\/\/www.tandfonline.com\/doi\/full\/10.3109\/00498254.2014.894219\">Xenobiotica., 44: 644-686 (2014)<\/a>&nbsp;<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u7dcf\u8aac]&nbsp;<\/h5>\n\n\n\n<p>1.\u5c71\u7530\u9759\u96c4\u3001\u4f0a\u85e4\u7531\u5f66\uff1a\u3000\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u6a5f\u80fd\u6027\u98df\u54c1\u306e\u73fe\u6cc1\u3068\u5c55\u671b\u2160. \u6a5f\u80fd\u6027\u98df\u54c1\u306e\u5b89\u5168\u6027\u30fb\u85ac\u7269\u3068\u306e\u76f8\u4e92\u4f5c\u7528<br>Pharma Medica 8\u6708\u53f7\u7279\u96c6\u300018: 24-32 (2014)<\/p>\n\n\n\n<p>2.\u83c5 \u654f\u5e78\u3001\u6d45\u5ddd\u502b\u5b8f\u3001\u5965 \u76f4\u4eba\u3001\u6e05\u6c34\u5e83\u4ecb\u3001\u5c71\u7530\u9759\u96c4\u3001\u539f\u7530\u5178\u5f18\u3001\u585a\u7530\u79c0\u592b: \u30ab\u30c6\u30ad\u30f3\u30d7\u30ed\u30fc\u30d6\u306e\u5408\u6210\u3068\u5206\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u30fc\u7dd1\u8336\u306e\u6709\u52b9\u6210\u5206\u30ab\u30c6\u30ad\u30f3\u3092\u5149\u3089\u305b\u308b<br>\u5316\u5b66 69:38-42 (2014)\u3000&nbsp;<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">[\u8457\u66f8]<\/h5>\n\n\n\n<p>1.Shizuo Yamada, Yuko Taki, Shingen Misaka, Takashi Okura, Yoshiharu Deguchi, Keizo Umegaki, Hiroshi Watanabe, Yasuo Watanabe and Margot Skinner: Pharmacokinetic and pharmacodynamic interaction of functional foods with medicines<br>Bioactives in Fruit: Health Benefits and Functional Foods, First Edition, (authored\/edited By Margot Skinner and Denise Hunter, Wiley-Blackwell, West Sussex, UK) pp. 59-79 (2014)<\/p>\n\n\n\n<p>2.Shizuo Yamada, Shingen Misaka, Yoshihiko Ito, Hiroshi Watanabe and Keizo Umegaki: Effects of natural products on pharmacokinetics and pharmacodynamics of drugs<br>Pharma-Nutrition, AAPS Advances in the Pharmaceutical Sciences Series 12 (edited \uff42y Gert Folkerts and Johan Garssen, American Association of Pharmaceutical Scientists 2014) &nbsp;pp. 189-211 (2014)<\/p>\n\n\n\n<p>3.\u5c71\u7530\u9759\u96c4\u3001\u4f0a\u85e4\u7531\u5f66\uff1a\u3000\u751f\u7269\u85ac\u5264\u5b66\u3000\uff14\uff0e\u85ac\u7269\u5206\u5e03\u5b9f\u9a13\u6cd5 4.1 \u30bf\u30f3\u30d1\u30af\u7d50\u5408\u30004.1.2 \u53d7\u5bb9\u4f53\u30bf\u30f3\u30d1\u30af\u7d50\u5408<br>\u85ac\u5264\u5b66\u5b9f\u9a13\u6cd5\u3000\u5fc5\u643a\u30de\u30cb\u30e5\u30a2\u30eb\u30fcPharmaceutical Scientist\u306e\u305f\u3081\u306b\u3001\u65e5\u672c\u85ac\u5264\u5b66\u4f1a\u51fa\u7248\u59d4\u54e1\u4f1a\u3000\u7de8\u96c6\uff08\u5357\u6c5f\u5802\uff09\u3001pp. 112-123 \uff082014\uff09<\/p>\n\n\n\n<p>4.\u5c71\u7530\u9759\u96c4\uff1a\u3000\u81e8\u5e8a\u30aa\u30ea\u30a8\u30f3\u30c6\u30c9\u30fc\u4e0b\u90e8\u5c3f\u8def\u306e\u53d7\u5bb9\u4f53\u3068\u85ac\u7406<br>\u795e\u7d4c\u56e0\u6027\u8180\u80f1\u30d9\u30c3\u30c9\u30b5\u30a4\u30c9\u30de\u30cb\u30e5\u30a2\u30eb\u3001\u698a\u539f\u9686\u6b21\u3000\u7de8\u96c6\u3001\u3231\u4e2d\u5916\u533b\u5b66\u793e\u51fa\u7248\u3001pp. 21-34\u3000(2014)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2025\u5e74 [\u539f\u8457\u8ad6\u6587] [\u7dcf\u8aac] [\u8457\u66f8] 2024\u5e74 [\u7dcf\u8aac] [\u8457\u66f8] 2023\u5e74 [\u539f\u8457\u8ad6\u6587] 1. Shizuo Yamada, Masae Mochizuki, Junko Chimoto, Risa Fut [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-91","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/CPFR\/index.php?rest_route=\/wp\/v2\/pages\/91","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/CPFR\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/CPFR\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/CPFR\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/CPFR\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=91"}],"version-history":[{"count":4,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/CPFR\/index.php?rest_route=\/wp\/v2\/pages\/91\/revisions"}],"predecessor-version":[{"id":222,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/CPFR\/index.php?rest_route=\/wp\/v2\/pages\/91\/revisions\/222"}],"wp:attachment":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/CPFR\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=91"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}