Clinical Pharmacology & Genetics, University of Shizuoka
It is known that the efficiency of drugs is often varied from person to
person. We consider one of the possible reasons to be the genetic defects
of drug-metabolizing enzymes, receptors, and transporters. Analysis of
the presence of genetic defects, that is to say the genetic polymorphisms,
affecting the drug response in patients in advance will help the physicians
select the suitable drugs with optimal dose and route of administration
for patients to be going on medication. This may serve the avoidance of
administration of drugs to non-responsive patients followed by the saving
of drug expenses.
We aim at the clinical application of personal genetic information for
optimization of medication, for prevention and therapy of the diseases,
and for development of antibody-based medicines.