{"id":13,"date":"2020-11-26T12:25:05","date_gmt":"2020-11-26T03:25:05","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/immunol\/?page_id=13"},"modified":"2023-09-20T11:23:26","modified_gmt":"2023-09-20T02:23:26","slug":"research","status":"publish","type":"page","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/immunol\/research\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"<p class=\"mt_20\">\u3000\u52d5\u7269\u306e\u8eab\u4f53\u306e\u69cb\u9020\u3092\u30b7\u30f3\u30d7\u30eb\u306b\u3059\u308b\u3068\u3001\u3061\u3087\u3046\u3069\u7d30\u9577\u3044\u7b52\u306e\u4e21\u7aef\u304b\u3089\u7a74\u3092\u3042\u3051\u3066\u7ba1\u3092\u901a\u3057\u305f\u3088\u3046\u306a\u5f62\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u7ba1\u304c\u53e3\u304b\u3089\u809b\u9580\u307e\u3067\u7d9a\u304f\u6d88\u5316\u7ba1\u306b\u76f8\u5f53\u3057\u307e\u3059\u3002\u6d88\u5316\u7ba1\u306f\u9032\u5316\u306e\u6975\u3081\u3066\u521d\u671f\u6bb5\u968e\u3067\u5f62\u6210\u3055\u308c\u3001\u305d\u308c\u306b\u4f34\u3063\u3066\u5fae\u751f\u7269\u3082\u6d88\u5316\u7ba1\u306b\u68f2\u307f\u3064\u3044\u305f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6d88\u5316\u7ba1\u3067\u306f\u3001\u9577\u3044\u5e74\u6708\u3092\u304b\u3051\u3066\u75c5\u539f\u4f53\u3092\u6392\u9664\u3057\u3064\u3064\u3001\u5e38\u5728\u6027\u5fae\u751f\u7269\u3068\u3046\u307e\u304f\u5171\u751f\u3059\u308b\u3068\u3044\u3046\u3001\u6975\u3081\u3066\u30e6\u30cb\u30fc\u30af\u306a\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u3092\u69cb\u7bc9\u3057\u3066\u304d\u307e\u3057\u305f\u3002<br \/>\n\u8fd1\u5e74\u306e\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b9\u6280\u8853\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u30d2\u30c8\u306e\u8178\u7ba1\u306b\u306f\u7d041000\u7a2e\u985e\u3001100\u5146\u500b\u306b\u3082\u306e\u307c\u308b\u8178\u5185\u7d30\u83cc\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u8178\u5185\u7d30\u83cc\u306f\u5bbf\u4e3b\u306e\u5065\u5eb7\u306b\u5927\u304d\u304f\u5f71\u97ff\u3057\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3084\u80a5\u6e80\u306a\u3069\u306e\u4ee3\u8b1d\u75be\u60a3\u306e\u75c5\u614b\u306b\u3082\u6df1\u304f\u95a2\u4fc2\u3059\u308b\u3053\u3068\u304c\u6b21\u3005\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u30d2\u30c8\u3068\u8178\u5185\u7d30\u83cc\u53e2\u306e\u9593\u306b\u306f\u5171\u751f\u30b7\u30b9\u30c6\u30e0\u304c\u5b58\u5728\u3057\u3001\u8178\u5185\u7d30\u83cc\u53e2\u3092\u5065\u3084\u304b\u306b\u4fdd\u3064\u3053\u3068\u306f\u30d2\u30c8\u306e\u5065\u5eb7\u7dad\u6301\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u3001\u2460\u7c98\u819c\u7d44\u7e54\u306e\u514d\u75ab\u76e3\u8996\u6a5f\u69cb\u3001\u2461\u8178\u5185\u7d30\u83cc\u3084\u98df\u4e8b\u306a\u3069\u306e\u74b0\u5883\u56e0\u5b50\u306b\u3088\u308a\u751f\u6210\u3055\u308c\u308b\u4ee3\u8b1d\u5206\u5b50\u304c\u514d\u75ab\u7cfb\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3001\u2462\u8178\u5185\u7d30\u83cc\u53e2\u306b\u3088\u308b\u5bbf\u4e3b\u6a5f\u80fd\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790\u3001\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u514d\u75ab\u7d30\u80de\u306f\u5468\u56f2\u306e\u74b0\u5883\u304b\u3089\u69d8\u3005\u306a\u30b7\u30b0\u30ca\u30eb\u3092\u53d7\u3051\u53d6\u308a\u3001\u6a5f\u80fd\u3092\u767a\u63ee\u3057\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u2463\u77e5\u899a\u795e\u7d4c\u53d7\u5bb9\u4f53\u523a\u6fc0\u306b\u3088\u308b\u5316\u5b66\u7269\u8cea\u30a2\u30ec\u30eb\u30ae\u30fc\u4fc3\u9032\u6a5f\u69cb\u306b\u3064\u3044\u3066\u3082\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\n<span class=\"c_red\"><strong>\u3053\u306e\u3088\u3046\u306b\u79c1\u305f\u3061\u306f\u7c98\u819c\u514d\u75ab\u7cfb\u306e\u6a5f\u80fd\u89e3\u6790\u3092\u8ef8\u306b\u3001\u751f\u4f53\u74b0\u5883\u3092\u91cd\u8996\u3057\u305f\u514d\u75ab\u5b66\u7814\u7a76\u3092\u5c55\u958b\u3057\u3066\u3044\u307e\u3059\u3002<\/strong><\/span><\/p>\n<h3>1) \u7c98\u819c\u7d44\u7e54\u306b\u304a\u3051\u308b\u514d\u75ab\u7cfb\u306e\u6a5f\u80fd\u89e3\u6790<\/h3>\n<p>\u8178\u7ba1\u306e\u514d\u75ab\u7d30\u80de\u306f\u514d\u75ab\u5fdc\u7b54\u306e\u5834\u3067\u3042\u308b\u30ea\u30f3\u30d1\u7d44\u7e54\uff08\u30d1\u30a4\u30a8\u30eb\u677f\u306a\u3069\uff09\u306b\u5b58\u5728\u3059\u308b\u4ed6\u3001\u514d\u75ab\u7d30\u80de\u304c\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u80fd\u3092\u767a\u63ee\u3059\u308b\u7d68\u6bdb\u306e\u7c98\u819c\u56fa\u6709\u5c64\u306b\u3082\u6563\u5728\u3057\u3066\u3044\u307e\u3059\u3002\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u6a39\u72b6\u7d30\u80de\u306a\u3069\u81ea\u7136\u514d\u75ab\u7cfb\u306e\u7d30\u80de\u306f\u7d44\u7e54\u3084\u74b0\u5883\u306b\u5fdc\u3058\u3066\u30e6\u30cb\u30fc\u30af\u306a\u6a5f\u80fd\u3092\u767a\u63ee\u3057\u3001\u514d\u75ab\u5fdc\u7b54\u306e\u8d77\u70b9\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u7c98\u819c\u7d44\u7e54\u306b\u304a\u3051\u308b\u81ea\u7136\u514d\u75ab\u7cfb\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u8ef8\u3068\u3057\u305f\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\n\u4e00\u65b9\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4e71\u308c\u306f\u30c7\u30a3\u30b9\u30d0\u30a4\u30aa\u30fc\u30b7\u30b9\u3068\u3088\u3070\u308c\u3001\u69d8\u3005\u306a\u75be\u60a3\u306e\u7d20\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u9ad8\u8102\u80aa\u98df\u306a\u3069\u306e\u504f\u3063\u305f\u98df\u4e8b\u306f\u76f4\u63a5\u751f\u4f53\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3060\u3051\u3067\u306a\u304f\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306b\u3082\u5909\u5316\u3092\u53ca\u307c\u3057\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u8178\u5185\u7d30\u83cc\u3084\u98df\u4e8b\u304c\u751f\u7406\u6a5f\u80fd\u3084\u514d\u75ab\u7cfb\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"img_c sp_w_100 size-full wp-image-162\" src=\"http:\/\/w3pharm.u-shizuoka-ken.ac.jp\/immunol\/wp-content\/uploads\/2021\/04\/research01.png\" alt=\"\" width=\"600\" height=\"420\" srcset=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/immunol\/wp-content\/uploads\/2021\/04\/research01.png 600w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/immunol\/wp-content\/uploads\/2021\/04\/research01-300x210.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/p>\n<h3 class=\"h3_sp\">2) \u514d\u75ab\u7d30\u80de\u306b\u4f5c\u7528\u3059\u308b\u4ee3\u8b1d\u5206\u5b50\u3068\u305d\u306e\u53d7\u5bb9\u4f53\uff08GPCR\uff09\u306e\u6a5f\u80fd\u89e3\u660e<\/h3>\n<div class=\"box w_100\">\n<div class=\"w_50 sp_w_100\"><img decoding=\"async\" src=\"http:\/\/w3pharm.u-shizuoka-ken.ac.jp\/immunol\/wp-content\/uploads\/2021\/04\/research02.gif\" alt=\"\" \/><\/div>\n<div class=\"w_45\">\u8178\u5185\u7d30\u83cc\u306f\u3001\u7ba1\u8154\u5185\u306e\u98df\u4e8b\u6210\u5206\u3068\u76f8\u307e\u3063\u3066\u3001\u304d\u308f\u3081\u3066\u591a\u5f69\u306a\u4ee3\u8b1d\u7523\u7269\u3092\u751f\u307f\u51fa\u3057\u307e\u3059\u304c\u3001\u5bbf\u4e3b\u306e\u7d30\u80de\u306b\u4f5c\u7528\u3059\u308b\u751f\u7406\u6d3b\u6027\u5206\u5b50\u306f\u305d\u306e\u4e00\u90e8\u306b\u904e\u304e\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u751f\u7406\u6d3b\u6027\u5206\u5b50\u306e\u306a\u304b\u306b\u306f\u5bbf\u4e3b\u306eG\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u578b\u53d7\u5bb9\u4f53\uff08GPCR\uff09\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u4f5c\u7528\u3092\u767a\u63ee\u3059\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u4e73\u9178\u83cc\u306a\u3069\u304c\u7523\u751f\u3059\u308b\u30d4\u30eb\u30d3\u30f3\u9178\u3084\u4e73\u9178\u306f\u3001\u5c0f\u8178\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304c\u767a\u73fe\u3059\u308bGPR31\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u305d\u306e\u6a39\u72b6\u7a81\u8d77\u306e\u4f38\u9577\u3092\u4fc3\u9032\u3057\u3001\u7ba1\u8154\u5185\u306e\u7d30\u83cc\u3092\u53d6\u308a\u8fbc\u3080\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u4ee3\u8b1d\u5206\u5b50\u306b\u4f5c\u7528\u3059\u308bGPCR\u304c\u751f\u4f53\u5185\u3067\u514d\u75ab\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u3069\u306e\u3088\u3046\u306b\u5236\u5fa1\u3059\u308b\u304b\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/div>\n<div><\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<h3 class=\"h3_sp\">3) \u8178\u5185\u7d30\u83cc\u53e2\u306b\u3088\u308b\u5bbf\u4e3b\u6a5f\u80fd\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790<\/h3>\n<p>Developmental Origins of Health and Disease (DOHaD)\u3068\u306f\u3001\u80ce\u5150\u671f\u3084\u51fa\u751f\u65e9\u671f\u306e\u74b0\u5883\u56e0\u5b50\u304c\u5c06\u6765\u306e\u5065\u5eb7\u3084\u75be\u60a3\u767a\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u306e\u6982\u5ff5\u3067\u3059\u3002\u6297\u751f\u7269\u8cea\u306e\u670d\u7528\u306a\u3069\u306b\u3088\u308a\u80ce\u5150\u671f\u3084\u51fa\u751f\u65e9\u671f\u306b\u8178\u5185\u7d30\u83cc\u53e2\u304c\u4e71\u308c\u308b\u3068\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306a\u3069\u306e\u514d\u75ab\u6027\u75be\u60a3\u3084\u3001\u6210\u9577\u5f8c\u306e\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u3053\u3068\u304b\u3089\u3001\u6bcd\u4f53\u3084\u5b50\u4f9b\u306e\u8178\u5185\u7d30\u83cc\u53e2\u3082DOHaD\u56e0\u5b50\u3068\u3057\u3066\u8003\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u598a\u5a20\u671f\u3084\u51fa\u751f\u65e9\u671f\u306e\u8178\u5185\u7d30\u83cc\u53e2\u3084\u305d\u306e\u4ee3\u8b1d\u7269\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u5b50\u306e\u4f53\u8cea\u3092\u5f62\u4f5c\u308b\u304b\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3 class=\"h3_sp\">4) \u77e5\u899a\u795e\u7d4c\u53d7\u5bb9\u4f53\u523a\u6fc0\u306b\u3088\u308b\u5316\u5b66\u7269\u8cea\u30a2\u30ec\u30eb\u30ae\u30fc\u4fc3\u9032\u6a5f\u69cb\u306e\u89e3\u660e<\/h3>\n<p>\u76ae\u819a\u306f\u4f53\u3092\u5b88\u308b\u5927\u304d\u306a\u30d0\u30ea\u30a2\u3068\u3057\u3066\u50cd\u3044\u3066\u304a\u308a\u3001\u69d8\u3005\u306a\u5316\u5b66\u7269\u8cea\u304c\u89e6\u308c\u308b\u5834\u6240\u3067\u3059\u3002\u795e\u7d4c\u306b\u767a\u73fe\u3059\u308b\u4fb5\u5bb3\u523a\u6fc0\u53d7\u5bb9\u4f53TRP (transient receptor potential) \u30c1\u30e3\u30cd\u30eb\u306f\u3042\u308b\u7a2e\u306e\u5316\u5b66\u7269\u8cea\u3067\u523a\u6fc0\u3055\u308c\u307e\u3059\u3002\u795e\u7d4c\u523a\u6fc0\u306e\u7d50\u679c\u3001\u76ae\u819a\u306e\u514d\u75ab\u7d30\u80de\u304c\u6d3b\u6027\u5316\u3055\u308c\u30a2\u30ec\u30eb\u30b2\u30f3\u3078\u306e\u611f\u4f5c\u304c\u4fc3\u9032\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u984c\u6750\u306b\u514d\u75ab\u7cfb\u3068\u795e\u7d4c\u7cfb\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u52d5\u7269\u306e\u8eab\u4f53\u306e\u69cb\u9020\u3092\u30b7\u30f3\u30d7\u30eb\u306b\u3059\u308b\u3068\u3001\u3061\u3087\u3046\u3069\u7d30\u9577\u3044\u7b52\u306e\u4e21\u7aef\u304b\u3089\u7a74\u3092\u3042\u3051\u3066\u7ba1\u3092\u901a\u3057\u305f\u3088\u3046\u306a\u5f62\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u7ba1\u304c\u53e3\u304b\u3089\u809b\u9580\u307e\u3067\u7d9a\u304f\u6d88\u5316\u7ba1\u306b\u76f8\u5f53\u3057\u307e\u3059\u3002\u6d88\u5316\u7ba1\u306f\u9032\u5316\u306e\u6975\u3081\u3066\u521d\u671f\u6bb5\u968e\u3067\u5f62\u6210\u3055\u308c\u3001\u305d\u308c\u306b\u4f34\u3063\u3066\u5fae\u751f\u7269\u3082\u6d88\u5316\u7ba1\u306b\u68f2 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