{"id":2064,"date":"2023-02-01T12:01:27","date_gmt":"2023-02-01T03:01:27","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/dev\/?p=2064"},"modified":"2024-07-30T18:58:58","modified_gmt":"2024-07-30T09:58:58","slug":"%e5%a4%a9%e7%84%b6%e7%89%a9%e3%82%a2%e3%82%ba%e3%83%a9%e3%82%af%e3%83%88%e3%83%b3%e3%81%8c%e7%99%ba%e8%a6%8b%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f","status":"publish","type":"post","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=2064","title":{"rendered":"\u5929\u7136\u7269\u30a2\u30ba\u30e9\u30af\u30c8\u30f3\u304c\u767a\u898b\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"<p style=\"font-weight: 400;\">\u672c\u5b66\u85ac\u5b66\u90e8 \u6e21\u8fba \u8ce2\u4e8c \u6559\u6388\u3001\u5cb8\u672c \u771f\u6cbb \u8b1b\u5e2b\u3001\u85ac\u5b66\u90e8\u4fee\u58eb2\u5e74\u751f\u5357\u6b69\u5b9f\u3055\u3093\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u751f\u7269\u304c\u30a2\u30ba\u30e9\u30af\u30c8\u30f3\u3092\u4f5c\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p style=\"font-weight: 400;\">\u3000\u30a2\u30ba\u30e9\u30af\u30c8\u30f3\u3068\u306f\u30a2\u30df\u30c9\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u9178\u7d20\u304c\u540c\u4e00\u5206\u5b50\u5185\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u57fa\u3068\u30a8\u30b9\u30c6\u30eb\u7d50\u5408\u3057\u305f\u542b\u7a92\u7d205\u54e1\u74b0\u30e9\u30af\u30c8\u30f3\u306e\u3053\u3068\u3067\u3042\u308a\u3001\u5171\u9cf4\u5b89\u5b9a\u5316\u306b\u3088\u308a4\u4f4d\u6c34\u7d20\u304c\u5bb9\u6613\u306b\u8131\u96e2\u3059\u308b\u3068\u3044\u3046\u6027\u8cea\u3092\u6709\u3059\u308b\u3002\u5f93\u3063\u3066\u30da\u30d7\u30c1\u30c9\u5408\u6210\u306b\u304a\u3044\u3066\u30a2\u30ba\u30e9\u30af\u30c8\u30f3\u304c\u751f\u3058\u305f\u5834\u5408\u3001\u30a2\u30df\u30ce\u9178\u306e\u03b1\u4f4d\u306e\u30a8\u30d4\u5316\u306e\u8981\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u30a2\u30ba\u30e9\u30af\u30c8\u30f3\u306f4\u4f4d\u6c34\u7d20\u306e\u8131\u96e2\u3067\u751f\u3058\u308b\u8ca0\u96fb\u8377\u306b\u3088\u308a\u6c42\u6838\u6027\u3092\u6709\u3057\u3066\u3044\u308b\u3060\u3051\u3067\u306a\u304f\u30015\u4f4d\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u70ad\u7d20\u304c\u6c42\u96fb\u5b50\u6027\u3092\u6709\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u9ad8\u3044\u53cd\u5fdc\u6027\u3092\u6709\u3057\u3066\u3044\u308b\u3002\u305d\u306e\u305f\u3081\u4e00\u90e8\u306e\u5b89\u5b9a\u306a\u30a2\u30ba\u30e9\u30af\u30c8\u30f3\u3092\u9664\u304d\u3001\u6709\u6a5f\u5408\u6210\u306e\u9014\u4e2d\u3067\u751f\u3058\u3066\u3082\u5358\u96e2\u3055\u308c\u308b\u3053\u3068\u306f\u306a\u3044\u3002\u3053\u306e\u3088\u3046\u306a\u53cd\u5fdc\u6027\u306b\u5bcc\u3093\u3060\u30a2\u30ba\u30e9\u30af\u30c8\u30f3\u306f\u5929\u7136\u3067\u306f\u3053\u308c\u307e\u3067\u306b\u898b\u51fa\u3055\u308c\u3066\u3053\u306a\u304b\u3063\u305f\u304c\u3001\u6211\u3005\u306f\u7cf8\u72b6\u83ccAspergillus lentulus\u306e\u751f\u7523\u3059\u308b\u65b0\u898f\u5316\u5408\u7269lentofuranine\u3068fumimycin\u306e\u751f\u5408\u6210\u7814\u7a76\u306e\u904e\u7a0b\u3067\u30a2\u30ba\u30e9\u30af\u30c8\u30f3\u3067\u3042\u308bfumarylazlactone\u304c\u751f\u5408\u6210\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u76f4\u63a5\u89b3\u6e2c\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u305f\u3002\u3053\u306e\u4e16\u754c\u3067\u521d\u3081\u3066\u306e\u767a\u898b\u306b\u3088\u3063\u3066\u5929\u7136\u3067\u306f\u3054\u304f\u3042\u308a\u3075\u308c\u305f\u9175\u7d20\u3092\u4f7f\u3063\u3066\u5929\u7136\u7269\u306e\u8907\u96d1\u306a\u5316\u5b66\u69cb\u9020\u306b\u3055\u3089\u306b\u591a\u69d8\u6027\u3092\u4e0e\u3048\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n<p style=\"font-weight: 400;\">\u3000\u672c\u6210\u679c\u306f\u3001\u5316\u5b66\u5206\u91ce\u306b\u304a\u3044\u3066\u6700\u3082\u6a29\u5a01\u306e\u3042\u308b\u56fd\u969b\u5316\u5b66\u96d1\u8a8c\u300cJournal of the American Chemical Society\u300d(Impact Factor: 16.383) \u96fb\u5b50\u7248\u306b2023\u5e741\u670827\u65e5\u4ed8\u3051\u3067\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p style=\"font-weight: 400;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft  wp-image-2654\" src=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2023\/02\/download.png\" alt=\"\" width=\"922\" height=\"514\" srcset=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2023\/02\/download.png 798w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2023\/02\/download-300x167.png 300w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2023\/02\/download-768x428.png 768w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2023\/02\/download-465x259.png 465w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2023\/02\/download-695x388.png 695w\" sizes=\"auto, (max-width: 922px) 100vw, 922px\" \/><\/p>\n<p style=\"font-weight: 400;\">\u3008\u63b2\u8f09\u3055\u308c\u305f\u8ad6\u6587\u3009<\/p>\n<p style=\"font-weight: 400;\"><strong>Reactive azlactone intermediate drives fungal secondary metabolite cross-pathway generation<\/strong><strong><br \/>\n<\/strong><\/p>\n<p style=\"font-weight: 400;\">Shinji Kishimoto, Ayumi Minami, Yoshimitsu Aoki, Yuya Matsubara, Shogo Watanabe and Kenji Watanabe<\/p>\n<p style=\"font-weight: 400;\">\u95a2\u9023\u30ea\u30f3\u30af\uff1a<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.1c13621\">American Chemical Society<\/a><\/p>\n<p style=\"font-weight: 400;\">https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.2c13188<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u5b66\u85ac\u5b66\u90e8 \u6e21\u8fba \u8ce2\u4e8c \u6559\u6388\u3001\u5cb8\u672c \u771f\u6cbb \u8b1b\u5e2b\u3001\u85ac\u5b66\u90e8\u4fee\u58eb2\u5e74\u751f\u5357\u6b69\u5b9f\u3055\u3093\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u751f\u7269\u304c\u30a2\u30ba\u30e9<span class=\"more-link\"><a href=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=2064\">Continue Reading<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":2067,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,39],"tags":[],"class_list":["entry","author-w3pharm","post-2064","post","type-post","status-publish","format-standard","has-post-thumbnail","category-uncategorized","category-39"],"_links":{"self":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2064","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2064"}],"version-history":[{"count":4,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2064\/revisions"}],"predecessor-version":[{"id":2656,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2064\/revisions\/2656"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/media\/2067"}],"wp:attachment":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2064"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2064"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}