{"id":2414,"date":"2019-09-24T15:26:06","date_gmt":"2019-09-24T06:26:06","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=2414"},"modified":"2024-07-30T18:13:45","modified_gmt":"2024-07-30T09:13:45","slug":"2019-09-24%e3%80%80%e5%a4%a7%e5%ad%a6%e9%99%a2%e7%89%b9%e5%88%a5%e8%ac%9b%e7%be%a9%e3%80%80ken-cham-fai-leung-%e5%85%88%e7%94%9f","status":"publish","type":"post","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=2414","title":{"rendered":"2019\/09\/24\u3000\u5927\u5b66\u9662\u7279\u5225\u8b1b\u7fa9\u3000Ken Cham-Fai Leung \u5148\u751f"},"content":{"rendered":"\n

\u5927\u5b66\u9662\u7279\u5225\u8b1b\u7fa9 <\/strong> \u3000<\/strong><\/p>\n\n\n\n

\u65e5\u6642\uff1a<\/strong>\u4ee4\u548c\u5143\u5e749\u670824\u65e5\uff08\u706b\uff09 15:30\u301c17:00<\/p>\n\n\n\n

\u5834\u6240\uff1a<\/strong>\u9759\u5ca1\u770c\u7acb\u5927\u5b66 \u8349\u8599\u30ad\u30e3\u30f3\u30d1\u30b9 6329\u6559\u5ba4<\/p>\n\n\n\n

\u4e16\u8a71\u6559\u5ba4\uff1a<\/strong> \u533b\u85ac\u54c1\u5275\u88fd\u5316\u5b66\u8b1b\u5ea7<\/p>\n\n\n\n

\u5bfe\u8c61\uff1a<\/strong>\u5927\u5b66\u9662\u751f\uff0c\u5b66\u90e8\u751f\uff0c\u6559\u8077\u54e1\uff08\u5b66\u5916\u8005\u306e\u53c2\u52a0\u3082\u6b53\u8fce\u3057\u307e\u3059\uff09<\/p>\n\n\n\n

\u6f14\u984c\uff1a”Functional Dendritic and Polymeric Hybrid Materials for Controlled Drug Delivery”<\/strong><\/p>\n\n\n\n

\u8b1b\u5e2b\uff1aProf. Ken Cham-Fai Leung <\/strong><\/p>\n\n\n\n

      \uff08Department of Chemistry, The Hong Kong Baptist University)<\/strong><\/p>\n\n\n\n

\u8b1b\u6f14\u6982\u8981\uff1a\u30ca\u30ce\u7c92\u5b50\u306e\u8868\u9762\u4fee\u98fe\u3092\u5229\u7528\u3059\u308b\u85ac\u7269\u5305\u6442\u3068\u85ac\u7269\u9001\u9054\u306e\u7814\u7a76<\/strong><\/p>\n\n\n\n

  Our research group is focusing on nanoparticle surface functionalization, acting as gates for controlled drug encapsulation and delivery. These functionalizations can be stimuli-responsive polymers or supramolecular motifs. By using poly(vinylalcohol)s (PVA) with different hydrolyzed percentages and degree of polymerization, PVA can act as the gate component for anticancer drug doxorubicin (DOX) encapsulation and release from porous nanoparticles. This system was applied for in vivo magnetic resonance imaging (MRI) and successfully treated liver cancer in four days [Angew. Chem. Int. Ed.<\/em> 2014<\/strong>, 53, 4812-4815].<\/p>\n\n\n\n

 On the other hand, type III-B rotaxane dendrimers (T3B-RDs) are hyperbranched macromolecules with mechanical bonds on every branching unit. Here we demonstrate the design, synthesis, and characterization of first to third (G1\u2013G3), and up to the fourth (G4) generation (MW > 22,000Da) of pure organic T3B-RDs and dendrons through the copper-catalyzed alkyne\u2013azide cycloaddition (CuAAC) reaction. By utilizing multiple molecular shuttling of the mechanical bonds within the sphere-like macromolecule, a collective three dimensional contract-extend molecular motion is demonstrated by diffusion ordered spectroscopy (DOSY) and atomic force microscopy (AFM). The discrete T3B-RDs are further observed and characterized by AFM, dynamic light scattering (DLS), and mass spectrometry (MS). The binding of chlorambucil, a drug for leukemia treatment, and pH-triggered switching of the T3B-RDs are also characterized by NMR spectroscopy [Nat. Commun.<\/em> 2018<\/strong>, 9, 497.]. <\/strong><\/p>\n\n\n\n

\u672c\u8b1b\u7fa9\u306f\u300c\u85ac\u79d1\u5b66\u7279\u8ad6\u300d\u306e\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u3002\u51fa\u5e2d\u30ab\u30fc\u30c9\u3092\u6301\u53c2\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/strong><\/p>\n\n\n\n

\u3000\u3000\u554f\u3044\u5408\u308f\u305b\u5148\uff1a                                          <\/p>\n\n\n\n

\u9759\u5ca1\u770c\u7acb\u5927\u5b66 \u85ac\u5b66\u90e8 \u533b\u85ac\u54c1\u5275\u88fd\u5316\u5b66\u8b1b\u5ea7       <\/p>\n\n\n\n

\u3000\u3000\u6ff1\u5cf6 \u7fa9\u9686 (hamashima[at]u-shizuoka-ken.ac.jp)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5927\u5b66\u9662\u7279\u5225\u8b1b\u7fa9  \u3000 \u65e5\u6642\uff1a\u4ee4\u548c\u5143\u5e749\u670824\u65e5\uff08\u706b\uff09 15:30\u301c17:00 \u5834Continue Reading<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[40,46],"tags":[],"class_list":["entry","author-w3pharm","post-2414","post","type-post","status-publish","format-standard","category-40","category-46"],"_links":{"self":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2414"}],"version-history":[{"count":1,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2414\/revisions"}],"predecessor-version":[{"id":2415,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2414\/revisions\/2415"}],"wp:attachment":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}