{"id":2733,"date":"2024-03-27T09:30:19","date_gmt":"2024-03-27T00:30:19","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=2733"},"modified":"2024-08-01T09:40:51","modified_gmt":"2024-08-01T00:40:51","slug":"%e5%bf%83%e4%b8%8d%e5%85%a8%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%b7%9a%e7%b6%ad%e5%8c%96%e3%81%ae%e9%81%ba%e4%bc%9d%e5%ad%90%e7%99%ba%e7%8f%be%e5%88%b6%e5%be%a1%e3%83%a1%e3%82%ab%e3%83%8b%e3%82%ba","status":"publish","type":"post","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=2733","title":{"rendered":"\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u7dda\u7dad\u5316\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e"},"content":{"rendered":"\n<p><strong>\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u7dda\u7dad\u5316\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e<\/strong><\/p>\n\n\n\n<p>\u672c\u5b66\u85ac\u5b66\u90e8\u5206\u5b50\u75c5\u614b\u5b66\u5206\u91ce\u306e\u5200\u5742\u6cf0\u53f2 \u8b1b\u5e2b\u3001\u68ee\u672c\u9054\u4e5f \u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u7dda\u7dad\u5316\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002\u672c\u6210\u679c\u306f\u3001Nature&nbsp;\u95a2\u9023\u8a8c\u306e\u7dcf\u5408\u79d1\u5b66\u30b8\u30e3\u30fc\u30ca\u30eb\u300cNature Communications\u300d\uff08Impact Factor: 16.6\uff09\u306b2024\u5e743\u670819\u65e5\u4ed8\u3051\u3067\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3000\u6162\u6027\u5fc3\u4e0d\u5168\u306f\u9ad8\u8840\u5727\u3084\u5fc3\u7b4b\u6897\u585e\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u4e88\u5f8c\u4e0d\u826f\u306e\u6162\u6027\u75be\u60a3\u3067\u3059\u3002\u5fc3\u4e0d\u5168\u306e\u9032\u884c\u306b\u304a\u3044\u3066\u3001\u5fc3\u81d3\u306e\u7dda\u7dad\u5316\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u7dda\u7dad\u5316\u306e\u969b\u306b\u306f\u5fc3\u81d3\u306e\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u9032\u5c55\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4ea2\u9032\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4e0d\u660e\u3067\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u30a2\u30eb\u30ae\u30cb\u30f3\u30e1\u30c1\u30eb\u5316\u9175\u7d20\uff08PRMT5\uff09\u304c\u3001\u30d2\u30b9\u30c8\u30f3\u306e\u30e1\u30c1\u30eb\u5316\u3092\u901a\u3057\u3066\u7dda\u7dad\u5316\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306bPRMT5\u963b\u5bb3\u5264\u304c\u7dda\u7dad\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u5fc3\u4e0d\u5168\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u85ac\u7269\u6cbb\u7642\u6cd5\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p>\u3008\u63b2\u8f09\u3055\u308c\u305f\u8ad6\u6587\u3009<\/p>\n\n\n\n<p>Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice<\/p>\n\n\n\n<p>Yasufumi Katanasaka, Harumi Yabe, Noriyuki Murata, Minori Sobukawa, Yuga Sugiyama, Hikaru Sato, Hiroki Honda, Yoichi Sunagawa, Masafumi Funamoto, Satoshi Shimizu, Kana Shimizu, Toshihide Hamabe-Horiike, Philip Hawke, Maki Komiyama, Kiyoshi Mori, Koji Hasegawa, Tatsuya Morimoto<\/p>\n\n\n\n<p>\u95a2\u9023\u30ea\u30f3\u30af\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41467-024-46711-z\">Nature Communications<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/byoutai\/\">\u9759\u5ca1\u770c\u7acb\u5927\u5b66&nbsp;\u5206\u5b50\u75c5\u614b\u5b66\u30db\u30fc\u30e0\u30da\u30fc\u30b8<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u7dda\u7dad\u5316\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e \u672c\u5b66\u85ac\u5b66\u90e8\u5206\u5b50\u75c5\u614b\u5b66\u5206\u91ce\u306e\u5200\u5742\u6cf0\u53f2 \u8b1b\u5e2b\u3001\u68ee\u672c<span class=\"more-link\"><a href=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=2733\">Continue Reading<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[39],"tags":[],"class_list":["entry","author-w3pharm","post-2733","post","type-post","status-publish","format-standard","category-39"],"_links":{"self":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2733","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2733"}],"version-history":[{"count":1,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2733\/revisions"}],"predecessor-version":[{"id":2734,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2733\/revisions\/2734"}],"wp:attachment":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2733"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2733"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}