{"id":4361,"date":"2021-05-08T10:06:00","date_gmt":"2021-05-08T01:06:00","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=4361"},"modified":"2024-10-18T10:08:21","modified_gmt":"2024-10-18T01:08:21","slug":"%e4%b8%8d%e6%b4%bb%e6%80%a7%e5%9e%8b%e9%a3%bd%e5%92%8c%e7%82%ad%e5%8c%96%e6%b0%b4%e7%b4%a0%e3%81%b8%e3%81%ae%e5%a4%9a%e9%87%8d%e5%a1%a9%e7%b4%a0%e5%8c%96%e3%82%92%e8%a7%a6%e5%aa%92%e3%81%99%e3%82%8b","status":"publish","type":"post","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=4361","title":{"rendered":"\u4e0d\u6d3b\u6027\u578b\u98fd\u548c\u70ad\u5316\u6c34\u7d20\u3078\u306e\u591a\u91cd\u5869\u7d20\u5316\u3092\u89e6\u5a92\u3059\u308b\u30d5\u30e9\u30d3\u30f3\u4f9d\u5b58\u578b\u30cf\u30ed\u30b2\u30ca\u30fc\u30bc\u306e\u6a5f\u80fd\u89e3\u660e\u306b\u6210\u529f"},"content":{"rendered":"\n<p>\u3000\u8102\u80aa\u65cf\u70ad\u7d20\u306e\u30cf\u30ed\u30b2\u30f3\u5316\u3092\u89e6\u5a92\u3067\u304d\u308b\u9175\u7d20\u306f\u3001\u5408\u6210\u304a\u3088\u3073\u751f\u4f53\u89e6\u5a92\u306e\u5206\u91ce\u306b\u3068\u3063\u3066\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u3082\u306e\u3067\u3059\u3002&nbsp;\u4eca\u56de\u3001\u30b8\u30af\u30ed\u30ed\u30c0\u30a4\u30a2\u30dd\u30fc\u30c1\u30f3\u306e\u751f\u5408\u6210\u306b\u304a\u3044\u30661,3-\u30b8\u30b1\u30c8\u30f3\u57fa\u8cea\u306b\u5bfe\u3057\u3066\u30bf\u30f3\u30c7\u30e0<em>gem\u2013<\/em>dichlorination\u5316\u3092\u89e6\u5a92\u3059\u308b\u30d5\u30e9\u30d3\u30f3\u4f9d\u5b58\u578b\u30cf\u30ed\u30b2\u30ca\u30fc\u30bc\uff08FDH\uff09\u3067\u3042\u308bAoiQ\u306e\u53cd\u5fdc\u6a5f\u69cb\u89e3\u660e\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002&nbsp;AoiQ\u306f\u8102\u80aa\u65cf\u57fa\u8cea\u3092\u30cf\u30ed\u30b2\u30f3\u5316\u3067\u304d\u308b\u751f\u5408\u6210\u9175\u7d20\u3068\u3057\u3066\u521d\u3081\u3066\u6a5f\u80fd\u89e3\u660e\u3055\u308c\u305fFDH\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000\u6297\u751f\u7269\u8cea\u300c\u30c0\u30a4\u30a2\u30dd\u30fc\u30c1\u30f3\u300d\u306e\u751f\u5408\u6210\u7d4c\u8def\u306b\u304a\u3044\u3066\u3001\u305d\u306e\u5316\u5b66\u69cb\u9020\u306b\u542b\u307e\u308c\u308b\u30b8\u30af\u30ed\u30ed\u30e1\u30c1\u30eb\u69cb\u9020\u304c\u30d5\u30e9\u30d3\u30f3\u4f9d\u5b58\u578b\u30cf\u30ed\u30b2\u30f3\u5316\u9175\u7d20\u306e\u4e00\u7a2e\u3067\u3042\u308bAoiQ\u3068\u3044\u3046\u9175\u7d20\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u4e00\u822c\u306b\u3001\u30e1\u30c1\u30eb\u57fa\u306a\u3069\u306e\u8102\u80aa\u65cf\u70ad\u5316\u6c34\u7d20\u306e\u70ad\u7d20\u2014\u6c34\u7d20\u7d50\u5408\u306f\u5316\u5b66\u7684\u306b\u4e0d\u6d3b\u6027\u3067\u3042\u308a\u3001\u91d1\u5c5e\u89e6\u5a92\u306a\u3069\u3092\u7528\u3044\u3066\u3053\u306e\u7d50\u5408\u3092\u958b\u88c2\u3055\u305b\u308b\u3068\u3044\u3046\u6311\u6226\u7684\u306a\u7814\u7a76\u304c\u4e16\u754c\u4e2d\u3067\u76db\u3093\u306b\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u751f\u4f53\u89e6\u5a92\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306e\u53cd\u5fdc\u3092\u53f8\u308b\u9175\u7d20\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u6d3b\u6027\u4e2d\u5fc3\u306b\u306f\u9244\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3068\u3053\u308d\u304c\u3001\u4eca\u56de\u767a\u898b\u3057\u305f\u30cf\u30ed\u30b2\u30f3\u5316\u9175\u7d20AoiQ\u306f\u305d\u306e\u6d3b\u6027\u4e2d\u5fc3\u306b\u9244\u306a\u3069\u306e\u91d1\u5c5e\u3092\u6301\u305f\u305a\u3001\u4ee3\u308f\u308a\u306b\u88dc\u9175\u7d20\u3068\u3057\u3066\u30d5\u30e9\u30d3\u30f3\u3092\u6709\u3059\u308b\u4f8b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u9a5a\u304f\u3079\u304d\u3053\u3068\u306bAoiQ\u306e\u9175\u7d20\u6a5f\u80fd\u306f\u3053\u308c\u3060\u3051\u306b\u7559\u307e\u3089\u305a\u3001\u305d\u306e\u30bf\u30f3\u30d1\u30af\u8ceaC\u672b\u7aef\u9818\u57df\u306b\u5b58\u5728\u3059\u308b\u30e1\u30c1\u30eb\u57fa\u8ee2\u79fb\u9175\u7d20\u30c9\u30e1\u30a4\u30f3\u306b\u3088\u3063\u3066\u30c0\u30a4\u30a2\u30dd\u30fc\u30c1\u30f3\u306e\u82b3\u9999\u65cf\u6c34\u9178\u57fa\u306e\u30e1\u30c1\u30eb\u5316\u304c\u89e6\u5a92\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u307e\u3057\u305f\u3002\u30a8\u30cd\u30eb\u30ae\u30fc\u7684\u306b\u4e0d\u6d3b\u6027\u306a\u70ad\u7d20\u2014\u6c34\u7d20\u7d50\u5408\u3092\u958b\u88c2\u3055\u305b\u3001\u70ad\u7d20\u2014\u5869\u7d20\u7d50\u5408\u3092\u5f62\u6210\u3059\u308b\u306e\u304b\u3068\u3044\u3046\u9577\u5e74\u306e\u7591\u554f\u306b\u4e00\u3064\u306e\u89e3\u304c\u4e0e\u3048\u3089\u308c\u305f\u3068\u5171\u306b\u3001\u9175\u7d20AoiQ\u306e\u6a5f\u80fd\u3092\u7cbe\u5bc6\u306b\u7406\u89e3\u3057\u3001\u6a5f\u80fd\u6539\u5909\u3059\u308b\u3053\u3068\u3067\u671b\u307f\u306e\u4f4d\u7f6e\u306b\u5869\u7d20\u539f\u5b50\u3092\u81ea\u5728\u306b\u5c0e\u5165\u3067\u304d\u308b\u89e6\u5a92\u306e\u5275\u88fd\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000\u672c\u6210\u679c\u306f\u3001\u672c\u5b66\u85ac\u5b66\u90e8 \u751f\u85ac\u5b66\u5206\u91ce \u6e21\u8fba \u8ce2\u4e8c \u6559\u6388\u3001\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5927\u5b66\u30ed\u30b5\u30f3\u30bc\u30eb\u30b9\u6821&nbsp;(UCLA)&nbsp;\u306b\u6240\u5c5e\u3059\u308bYi Tang\u6559\u6388\u3001Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Kn\u00f6ll Institute (HKI)\u306b\u6240\u5c5e\u3059\u308bChristian Hertweck&nbsp;\u6559\u6388\uff08\u30c9\u30a4\u30c4\uff09\u3089\u306b\u3088\u308bJSPS\u982d\u8133\u5faa\u74b0\u5171\u540c\u7814\u7a76\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u6210\u679c\u306f\u5316\u5b66\u5206\u91ce\u306b\u304a\u3044\u3066\u6700\u3082\u6a29\u5a01\u306e\u3042\u308b\u56fd\u969b\u5316\u5b66\u96d1\u8a8c\u300cJournal of the American Chemical Society\u300d(Impact Factor: 14.612)&nbsp;\u96fb\u5b50\u7248\u306b2021\u5e745\u67086\u65e5\u4ed8\u3051\u3067\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"493\" height=\"263\" src=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2024\/10\/21-05-08.png\" alt=\"\" class=\"wp-image-4362\" srcset=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2024\/10\/21-05-08.png 493w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2024\/10\/21-05-08-300x160.png 300w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2024\/10\/21-05-08-465x248.png 465w\" sizes=\"auto, (max-width: 493px) 100vw, 493px\" \/><\/figure>\n\n\n\n<p>\u3008\u63b2\u8f09\u3055\u308c\u305f\u8ad6\u6587\u3009<\/p>\n\n\n\n<p><strong>AoiQ Catalyzes Geminal Dichlorination of 1,3-Diketone Natural Products<\/strong><\/p>\n\n\n\n<p>Mengting Liu, Masao Ohashi, Yiu-Sun Hung, Kirstin Scherlach, Kenji Watanabe,&nbsp;Christian Hertweck, Yi Tang<\/p>\n\n\n\n<p>\u95a2\u9023\u30ea\u30f3\u30af\uff1a<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.1c02868\">American Chemical Society<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u8102\u80aa\u65cf\u70ad\u7d20\u306e\u30cf\u30ed\u30b2\u30f3\u5316\u3092\u89e6\u5a92\u3067\u304d\u308b\u9175\u7d20\u306f\u3001\u5408\u6210\u304a\u3088\u3073\u751f\u4f53\u89e6\u5a92\u306e\u5206\u91ce\u306b\u3068\u3063\u3066\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u3082\u306e\u3067\u3059\u3002<span class=\"more-link\"><a href=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=4361\">Continue Reading<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[39],"tags":[],"class_list":["entry","author-w3pharm","post-4361","post","type-post","status-publish","format-standard","category-39"],"_links":{"self":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/4361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4361"}],"version-history":[{"count":1,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/4361\/revisions"}],"predecessor-version":[{"id":4363,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/4361\/revisions\/4363"}],"wp:attachment":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}