{"id":4382,"date":"2021-03-02T10:21:00","date_gmt":"2021-03-02T01:21:00","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=4382"},"modified":"2024-10-18T10:23:24","modified_gmt":"2024-10-18T01:23:24","slug":"diels-alder%e5%8f%8d%e5%bf%9c%e3%82%92%e8%a7%a6%e5%aa%92%e3%81%99%e3%82%8b%e9%85%b5%e7%b4%a0%e3%81%ae%e6%a9%9f%e8%83%bd%e8%a7%a3%e6%98%8e%e3%81%8a%e3%82%88%e3%81%b3%e3%81%9d%e3%81%ae%e6%94%b9%e5%a4%89","status":"publish","type":"post","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=4382","title":{"rendered":"Diels-Alder\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\u306e\u6a5f\u80fd\u89e3\u660e\u304a\u3088\u3073\u305d\u306e\u6539\u5909\u306b\u6210\u529f"},"content":{"rendered":"\n

\u3000\u672c\u5b66\u85ac\u5b66\u90e8 \u6e21\u8fba \u8ce2\u4e8c \u6559\u6388\u3001\u6a4b\u672c \u535a \u6559\u6388\u304a\u3088\u3073\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5927\u5b66\u30ed\u30b5\u30f3\u30bc\u30eb\u30b9\u6821 (UCLA) \u306b\u6240\u5c5e\u3059\u308bYi Tang\u6559\u6388\u3001Kendall N.Houk\u6559\u6388\u3089\u306e\u56fd\u969b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001Diels-Alder\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\u306e\u7cbe\u5bc6\u6a5f\u80fd\u89e3\u6790\u3092\u884c\u3044\u3001\u305d\u306e\u9175\u7d20\u306e\u69cb\u9020\u3092\u57fa\u76e4\u3068\u3057\u305f\u6539\u5909\u306b\u3088\u308a\u3001\u7acb\u4f53\u9078\u629e\u6027\u306e\u7570\u306a\u308b\u5316\u5408\u7269\u3092\u751f\u6210\u3059\u308b\u9175\u7d20\u3092\u4f5c\u51fa\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000Diels-Alder\u53cd\u5fdc\u306f\u3001\u4f4d\u7f6e\u304a\u3088\u3073\u7acb\u4f53\u9078\u629e\u7684\u306b\u70ad\u7d20\u2015\u70ad\u7d20\u7d50\u5408\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u6709\u6a5f\u5408\u6210\u5316\u5b66\u5206\u91ce\u306b\u304a\u3044\u3066\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u53cd\u5fdc\u3067\u3059\u3002\u4e00\u65b9\u3067\u5fae\u751f\u7269\u3084\u690d\u7269\u304c\u7523\u751f\u3059\u308b\u5316\u5408\u7269\u306e\u4e2d\u306b\u306f\u3001Diels-Alder\u53cd\u5fdc\u306b\u3088\u3063\u3066\u69cb\u7bc9\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u5316\u5408\u7269\u304c\u6570\u591a\u304f\u898b\u3089\u308c\u308b\u3053\u3068\u304b\u3089\u3001\u5929\u7136\u306b\u3082Diels-Alder\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u9175\u7d20\u3001\u3059\u306a\u308f\u3061Diels-Alderase (DAase) \u304c\u5b58\u5728\u3059\u308b\u3068\u793a\u5506\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u4e16\u754c\u4e2d\u3067\u305d\u306eDAase\u306e\u63a2\u7d22\u304c\u884c\u308f\u308c\u3001\u73fe\u5728\u307e\u3067\u306b\u69d8\u3005\u306aDAase\u304c\u767a\u898b\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001DAase\u306b\u95a2\u3059\u308b\u8a73\u7d30\u306a\u5206\u5b50\u6a5f\u69cb\u3001\u3059\u306a\u308f\u3061\u53cd\u5fdc\u306e\u99c6\u52d5\u529b\u3084\u4f4d\u7f6e\u304a\u3088\u3073\u7acb\u4f53\u9078\u629e\u6027\u306e\u767a\u73fe\u8981\u56e0\u306b\u3064\u3044\u3066\u8a73\u7d30\u306b\u89e3\u660e\u3055\u308c\u305f\u5831\u544a\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u4eca\u56de\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u3053\u306e\u9175\u7d20\u7684Diels-Alder\u53cd\u5fdc\u306e\u89e6\u5a92\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u3001\u9175\u7d20\u2015\u5316\u5408\u7269\u306e\u5171\u7d50\u6676\u69cb\u9020\u3092\u3082\u3068\u306b\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u9175\u7d20\u306e\u57fa\u8cea\u7d50\u5408\u90e8\u4f4d\u306b\u5909\u7570\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u975e\u5929\u7136\u578b\u306e\u7acb\u4f53\u5316\u5b66\u3092\u6709\u3059\u308b\u751f\u6210\u7269\u3092\u4e0e\u3048\u308b\u6539\u5909\u578b\u9175\u7d20\u306e\u4f5c\u51fa\u3082\u9054\u6210\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001Diels-Alder\u53cd\u5fdc\u306e\u7279\u6027\u4e0a\u554f\u984c\u3068\u306a\u308a\u5f97\u308b\u751f\u6210\u7269\u306b\u3088\u308b\u9175\u7d20\u53cd\u5fdc\u963b\u5bb3\u3092DAase\u304c\u3069\u306e\u3088\u3046\u306b\u56de\u907f\u3057\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u3001\u9175\u7d20\u4e2d\u306b\u304a\u3051\u308b\u57fa\u8cea\u306e\u5316\u5b66\u69cb\u9020\u3068\u8a08\u7b97\u5316\u5b66\u306b\u3088\u308b\u9077\u79fb\u72b6\u614b\u306e\u81ea\u7531\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u89e3\u6790\u306b\u3088\u308a, \u5408\u7406\u7684\u306a\u8aac\u660e\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001DAase\u306e\u69cb\u9020\u57fa\u76e4\u306b\u9769\u65b0\u7684\u306a\u77e5\u898b\u3092\u4e0e\u3048\u305f\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u3088\u308a\u9ad8\u6027\u80fd\u9ad8\u52b9\u7387\u306a\u89e6\u5a92\u6d3b\u6027\u3092\u6709\u3059\u308bDAase\u306e\u5275\u51fa\u3001\u3059\u306a\u308f\u3061DAase\u306e\u30a8\u30f3\u30b8\u30cb\u30a2\u30ea\u30f3\u30b0\u306b\u95a2\u3059\u308b\u4eca\u5f8c\u306e\u91cd\u8981\u306a\u6307\u91dd\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000\u672c\u6210\u679c\u306f\u3001\u672c\u5b66\u85ac\u5b66\u90e8\u3068UCLA\u3068\u306e\u5171\u540c\u7814\u7a76\u6210\u679c\u3067\u3059\u3002\u89e6\u5a92\u5316\u5b66\u5206\u91ce\u306b\u304a\u3044\u3066\u6a29\u5a01\u306e\u3042\u308b\u56fd\u969b\u5316\u5b66\u96d1\u8a8c\u300cNature Catalysis\u300d(Impact Factor: 30.471) \u96fb\u5b50\u7248\u306b2021\u5e743\u67081\u65e5\u4ed8\u3051\u3067\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u3008\u63b2\u8f09\u3055\u308c\u305f\u8ad6\u6587\u3009<\/p>\n\n\n\n

Catalytic mechanism and endo<\/em>-to-exo<\/em> selectivity reversion of an octalin-forming natural Diels-Alderase<\/strong><\/p>\n\n\n\n

Sato M., Kishimoto S., Yokoyama M., Jamieson C.S., Narita K., Maeda N., Hara K., Hashimoto H., Tsunematsu Y., Houk K.N., Tang Y., Watanabe K.<\/p>\n\n\n\n

\u95a2\u9023\u30ea\u30f3\u30af\uff1a<\/p>\n\n\n\n

Nature Publishing Group<\/p>\n\n\n\n

\nhttps:\/\/www.nature.com\/articles\/s41929-021-00577-2\n<\/div><\/figure>\n\n\n\n

\u9759\u5ca1\u770c\u7acb\u5927\u5b66 \u85ac\u5b66\u90e8 \u751f\u85ac\u5b66\u7814\u7a76\u5ba4<\/p>\n\n\n\n

http:\/\/sweb.u-shizuoka-ken.ac.jp\/~kenji55-lab\/<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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