{"id":4389,"date":"2020-12-30T10:57:00","date_gmt":"2020-12-30T01:57:00","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=4389"},"modified":"2024-10-18T10:59:25","modified_gmt":"2024-10-18T01:59:25","slug":"%e5%85%8d%e7%96%ab%e6%8a%91%e5%88%b6%e6%b4%bb%e6%80%a7%e7%89%a9%e8%b3%aafr901483%e3%81%ae%e5%85%a8%e7%94%9f%e5%90%88%e6%88%90%e3%81%ab%e6%88%90%e5%8a%9f","status":"publish","type":"post","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=4389","title":{"rendered":"\u514d\u75ab\u6291\u5236\u6d3b\u6027\u7269\u8ceaFR901483\u306e\u5168\u751f\u5408\u6210\u306b\u6210\u529f"},"content":{"rendered":"\n

\u3000\u672c\u5b66\u85ac\u5b66\u90e8 \u751f\u85ac\u5b66\u5206\u91ce \u6e21\u8fba \u8ce2\u4e8c \u6559\u6388\u3068UCLA\u306b\u6240\u5c5e\u3059\u308bYi Tang \u6559\u6388\u3089\u306f\u3001\u7cf8\u72b6\u83ccCladobotryum sp. <\/em>No 11231\u306e\u751f\u7523\u3059\u308b\u514d\u75ab\u6291\u5236\u6d3b\u6027\u3092\u6301\u3064\u7269\u8cea\u300cFR901483\u300d\u306e\u751f\u5408\u6210\u306b\u95a2\u308f\u308b\u5168\u3066\u306e\u9175\u7d20\u3092\u898b\u51fa\u3057\u3001\u305d\u308c\u3089\u3092\u7528\u3044\u3066\u300cFR901483\u300d\u306e\u5168\u751f\u5408\u6210\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u3084\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3A\u306f\u3001\u514d\u75ab\u6291\u5236\u6d3b\u6027\u5264\u3068\u3057\u3066\u81e8\u5e8a\u3067\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u533b\u85ac\u54c1\u3067\u3042\u308a\u3001\u81d3\u5668\u79fb\u690d\u306e\u969b\u306e\u62d2\u7d76\u53cd\u5fdc\u306e\u6291\u5236\u7b49\u306b\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4e8c\u3064\u306e\u5316\u5408\u7269\u306f\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u8907\u5408\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3067IL-2\u7523\u751f\u963b\u5bb3\u3092\u8d77\u3053\u3057\u3001\u514d\u75ab\u5fdc\u7b54\u306e\u963b\u5bb3\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u7cf8\u72b6\u83cc\u306e\u4e00\u7a2e\u3067\u3042\u308bCladobotryum<\/em> sp. No 11231\u304c\u7523\u751f\u3059\u308b\u5316\u5408\u7269FR901483\u306f\u3001\u3053\u308c\u3089IL-2\u7523\u751f\u963b\u5bb3\u306b\u57fa\u3065\u304b\u306a\u3044\u4f5c\u7528\u6a5f\u5e8f\u3092\u6709\u3059\u308b\u514d\u75ab\u6291\u5236\u6d3b\u6027\u7269\u8cea\u3068\u3057\u3066\u30011995\u5e74\u306b\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u4f5c\u7528\u6a5f\u5e8f\u306f\u3044\u307e\u3060\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u306f\u3044\u307e\u305b\u3093\u304c\u3001\u3053\u308c\u307e\u3067\u306b\u767a\u898b\u3055\u308c\u3066\u3044\u308b\u514d\u75ab\u6291\u5236\u5264\u3068\u306f\u7570\u306a\u308b\u3053\u3068\u304b\u3089\u3001\u65b0\u305f\u306a\u514d\u75ab\u6291\u5236\u5264\u958b\u767a\u306e\u8db3\u639b\u3051\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000\u307e\u305fFR901483\u306f\u3001\u542b\u7a92\u7d20\u4e09\u74b0\u6027\u9aa8\u683c\u304a\u3088\u3073\u591a\u5f69\u306a\u5b98\u80fd\u57fa\u3092\u6709\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u6709\u6a5f\u5408\u6210\u5316\u5b66\u7684\u306b\u3082\u6ce8\u76ee\u3055\u308c\u3001\u3053\u308c\u307e\u3067\u306b\u6570\u591a\u304f\u306e\u5168\u5408\u6210\u7814\u7a76\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u305d\u306e\u8907\u96d1\u306a\u69cb\u9020\u306e\u305f\u3081\u3001\u305d\u306e\u5168\u884c\u7a0b\u306e\u53ce\u7387\u306f10%\u672a\u6e80\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001FR901483\u306e\u751f\u5408\u6210\u306b\u95a2\u308f\u308b\u9175\u7d20\u3092\u7279\u5b9a\u3057\u3001\u305d\u308c\u3089\u3059\u3079\u3066\u306e\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u52a0\u3048\u3066\u3001\u3059\u3079\u3066\u306e\u9175\u7d20\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u3001FR901483\u306e\u5168\u751f\u5408\u6210\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308aFR901483\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u751f\u5408\u6210\u904e\u7a0b\u306e\u4e2d\u9593\u4f53\u7b49\u304c\u52b9\u7387\u3088\u304f\u7372\u5f97\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306eFR901483\u3092\u30ea\u30fc\u30c9\u5316\u5408\u7269\u3068\u3057\u305f\u65b0\u305f\u306a\u514d\u75ab\u6291\u5236\u5264\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u7d50\u679c\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000\u672c\u6210\u679c\u306f\u3001\u672c\u5b66\u85ac\u5b66\u90e8 \u751f\u85ac\u5b66\u5206\u91ce \u6e21\u8fba \u8ce2\u4e8c \u6559\u6388\u3001\u5927\u9d6c\u85ac\u54c1\u5de5\u696d\u682a\u5f0f\u4f1a\u793e\u3068UCLA\u306b\u6240\u5c5e\u3059\u308bYi Tang \u6559\u6388\u3089\u306b\u3088\u308b\u5171\u540c\u7814\u7a76\u6210\u679c\u3067\u3059\u3002\u5316\u5b66\u5206\u91ce\u306b\u304a\u3044\u3066\u6a29\u5a01\u306e\u3042\u308b\u56fd\u969b\u5316\u5b66\u96d1\u8a8c\u300cJournal of American Chemical Society\u300d(Impact Factor: 1\uff14.612) \u96fb\u5b50\u7248\u306b2020\u5e7412\u670829\u65e5\u4ed8\u3051\u3067\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u3008\u63b2\u8f09\u3055\u308c\u305f\u8ad6\u6587\u3009<\/p>\n\n\n\n

Biosynthesis of the Immunosuppressant (-)-FR901483<\/strong><\/p>\n\n\n\n

Zhuan Zhang, Yui Tamura, Mancheng Tang, Tianzhang Qiao, Michio Sato, Yoshihiro Otsu, Satoshi Sasamura, Masatoshi Taniguchi, Kenji Watanabe* and Yi Tang*<\/p>\n\n\n\n

\u95a2\u9023\u30ea\u30f3\u30af\uff1a<\/p>\n\n\n\n

American Chemical Society<\/p>\n\n\n\n

\nhttps:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c12352\n<\/div><\/figure>\n\n\n\n

\u9759\u5ca1\u770c\u7acb\u5927\u5b66 \u85ac\u5b66\u90e8 \u751f\u85ac\u5b66\u7814\u7a76\u5ba4<\/p>\n\n\n\n

http:\/\/sweb.u-shizuoka-ken.ac.jp\/~kenji55-lab\/<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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