{"id":4875,"date":"2018-07-20T14:23:00","date_gmt":"2018-07-20T05:23:00","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=4875"},"modified":"2024-11-26T14:27:59","modified_gmt":"2024-11-26T05:27:59","slug":"%e5%a4%a9%e7%84%b6%e7%89%a9%e3%81%ae%e3%82%ad%e3%83%8e%e3%83%ad%e3%83%b3%e9%aa%a8%e6%a0%bc%e3%82%92%e4%b8%80%e6%ae%b5%e9%9a%8e%e3%81%ae%e5%8f%8d%e5%bf%9c%e3%81%a7%e4%bd%9c%e3%82%8a%e5%87%ba%e3%81%99","status":"publish","type":"post","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=4875","title":{"rendered":"\u5929\u7136\u7269\u306e\u30ad\u30ce\u30ed\u30f3\u9aa8\u683c\u3092\u4e00\u6bb5\u968e\u306e\u53cd\u5fdc\u3067\u4f5c\u308a\u51fa\u3059\u65b0\u898f\u9175\u7d20\u3092\u30ab\u30d3\u304b\u3089\u767a\u898b\u3059\u308b\u3053\u3068\u306b\u6210\u529f"},"content":{"rendered":"\n<p>\u672c\u5b66\u85ac\u5b66\u90e8&nbsp;\u751f\u85ac\u5b66\u5206\u91ce&nbsp;\u6e21\u8fba&nbsp;\u8ce2\u4e8c&nbsp;\u6559\u6388\u3068\u540c&nbsp;\u751f\u547d\u7269\u7406\u5316\u5b66\u5206\u91ce&nbsp;\u6a4b\u672c&nbsp;\u535a&nbsp;\u6559\u6388\u3089\u306f\u3001\u30d8\u30e2\u30b7\u30a2\u30cb\u30f3\u306b\u4f3c\u305f\u9175\u7d20\u304c\u4e8c\u6b21\u4ee3\u8b1d\u7269\u306e\u751f\u5408\u6210\u306b\u95a2\u308f\u308a\u3001\u3053\u308c\u307e\u3067\u4e0d\u660e\u3067\u3042\u3063\u305f\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u300c\u30d3\u30ea\u30b8\u30ab\u30c1\u30f3\u300d\u985e\u306e\u751f\u5408\u6210\u7d4c\u8def\u306b\u304a\u3044\u3066\u3001\u305d\u306e\u5316\u5b66\u69cb\u9020\u306b\u542b\u307e\u308c\u308b\u300c\u30ad\u30ce\u30ed\u30f3\u9aa8\u683c\u300d\u304c\u3001\u4e00\u3064\u306e\u9175\u7d20\u306b\u3088\u308b\u9023\u7d9a\u7684\u306a\u4f5c\u7528\u306b\u3088\u308a\u5f62\u4f5c\u3089\u308c\u308b\u3053\u3068\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u767a\u898b\u3057\u305f\u9175\u7d20\u3092\u4eba\u5de5\u7684\u306b\u6539\u5909\u3059\u308b\u3053\u3068\u3067\u3001\u5c06\u6765\u7684\u306b\u306f\u6709\u6a5f\u5316\u5408\u7269\u306e\u69cb\u9020\u3092\u81ea\u5728\u306b\u5909\u63db\u3067\u304d\u308b\u89e6\u5a92\u3092\u5275\u88fd\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u300c\u30ad\u30ce\u30ed\u30f3\u30a2\u30eb\u30ab\u30ed\u30a4\u30c9\u300d\u985e\u306f\u6297\u83cc\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u3001\u6297\u30de\u30e9\u30ea\u30a2\u304a\u3088\u3073\u6297\u816b\u760d\u3068\u3044\u3063\u305f\u591a\u304f\u306e\u6709\u7528\u306a\u751f\u7269\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3001\u307e\u305f\u3001\u3053\u308c\u3089\u306e\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u306f\u69d8\u3005\u306a\u751f\u7269\u7a2e\u304b\u3089\u5358\u96e2\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u4e2d\u3067\u3082\u300c\u30d3\u30ea\u30b8\u30ab\u30c1\u30f3\u300d\u985e\u306f\u3001\u305d\u306e\u5316\u5b66\u69cb\u9020\u4e2d\u306b\u7279\u7570\u306a6,6-\u30ad\u30ce\u30ed\u30f3\u9aa8\u683c\u3092\u6709\u3059\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u304c\u4e00\u4f53\u3069\u306e\u3088\u3046\u306b\u4f5c\u3089\u308c\u308b\u306e\u304b\u8208\u5473\u304c\u6301\u305f\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u305d\u306e\u30d3\u30ea\u30b8\u30ab\u30c1\u30f3\u306e\u69cb\u9020\u4e2d\u306b\u542b\u307e\u308c\u308b6,6-\u30ad\u30ce\u30ed\u30f3\u9aa8\u683c\u306b\u3064\u3044\u3066\u3001\u30d8\u30e2\u30b7\u30a2\u30cb\u30f3\u306b\u4f3c\u305f\u30b7\u30af\u30ed\u30da\u30ca\u30fc\u30bc\u3068\u3044\u3046\u9175\u7d20\u304c\u6301\u3064\u4e9c\u925b\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\u4e2d\u306b\u304a\u3044\u3066\u57fa\u8cea\u30b7\u30af\u30ed\u30da\u30cb\u30f3\u306e\u30ab\u30eb\u30dc\u30cb\u30eb\u9178\u7d20\u3068\u30a8\u30dd\u30ad\u30b7\u30c9\u306b\u4e9c\u925b\u30a4\u30aa\u30f3\u304c\u914d\u4f4d\u3057\u3066\u6d3b\u6027\u5316\u3057\u3001\u8131\u82b3\u9999\u5316\u3057\u3066\u65b0\u305f\u306a6\u54e1\u74b0\u304c\u307e\u305a\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u7d9a\u3044\u3066\u30e1\u30c1\u30eb\u30a4\u30bd\u30b7\u30a2\u30cd\u30fc\u30c8\u304c\u8131\u96e2\u3057\u3066\u518d\u82b3\u9999\u5316\u304c\u8d77\u304d\u305f\u5f8c\u3001\u30b1\u30c8\u30a8\u30ce\u30fc\u30eb\u4e92\u5909\u7570\u6027\u306b\u3088\u308a\u30d3\u30ea\u30b8\u30ab\u30c1\u30f3\u304c\u751f\u6210\u3059\u308b\u3068\u3044\u3046\u53cd\u5fdc\u6a5f\u69cb\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002\u672c\u6765\u6606\u866b\u306a\u3069\u304c\u9178\u7d20\u904b\u642c\u306b\u5229\u7528\u3059\u308b\u30d8\u30e2\u30b7\u30a2\u30cb\u30f3\u304c\u5fae\u751f\u7269\u306b\u3082\u5b58\u5728\u3057\u3001\u4e00\u822c\u306b\u30d8\u30e2\u30b7\u30a2\u30cb\u30f3\u3067\u306f\u9285\u3067\u3042\u308b\u91d1\u5c5e\u539f\u5b50\u304c\u4e9c\u925b\u306b\u7f6e\u304d\u63db\u308f\u3063\u3066\u3001\u9178\u7d20\u904b\u642c\u3067\u306f\u306a\u304f\u30ad\u30ce\u30ed\u30f3\u9aa8\u683c\u5f62\u6210\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001\u3053\u3046\u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Ken Houk\u6559\u6388\u3001Yi Tang&nbsp;\u6559\u6388\u306b\u3088\u308b\u6587\u90e8\u79d1\u5b66\u7701\u3000\u65b0\u5b66\u8853\u9818\u57df\u7814\u7a76\uff08\u7814\u7a76\u63d0\u6848\u578b\uff09\u5e73\u621028~32\u5e74\u5ea6\u300c\u751f\u5408\u6210\u30ea\u30c7\u30b6\u30a4\u30f3\u300d\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3088\u308b\u56fd\u969b\u5171\u540c\u7814\u7a76\u306e\u6210\u679c\u3067\u3059\u3002\u79d1\u5b66\u5206\u91ce\u306b\u304a\u3044\u3066\u6a29\u5a01\u306e\u3042\u308b\u56fd\u969b\u79d1\u5b66\u96d1\u8a8c\u300cNature Communications\u300d(Impact Factor: 12.124)&nbsp;\u96fb\u5b50\u7248\u306b2018\u5e747\u670820\u65e5\u4ed8\u3051\u3067\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"549\" height=\"377\" src=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2024\/11\/image-1.png\" alt=\"\" class=\"wp-image-4876\" style=\"width:720px;height:auto\" srcset=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2024\/11\/image-1.png 549w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2024\/11\/image-1-300x206.png 300w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2024\/11\/image-1-465x319.png 465w\" sizes=\"auto, (max-width: 549px) 100vw, 549px\" \/><\/figure>\n\n\n\n<p>\u3008\u63b2\u8f09\u3055\u308c\u305f\u8ad6\u6587\u3009<\/p>\n\n\n\n<p><strong>Enzymatic one-step ring contraction for quinolone biosynthesis<\/strong><\/p>\n\n\n\n<p>Shinji Kishimoto, Kodai Hara, Hiroshi Hashimoto, Yuichiro Hirayama, Pier Alexandre Champagne, Kendall N. Houk, Yi Tang, Kenji Watanabe<\/p>\n\n\n\n<p>\u95a2\u9023\u30ea\u30f3\u30af\uff1a<\/p>\n\n\n\n<p>SPRINGER NATURE&nbsp; &nbsp;&nbsp;<\/p>\n\n\n\n<p>\u9759\u5ca1\u770c\u7acb\u5927\u5b66 \u85ac\u5b66\u90e8 \u751f\u85ac\u5b66\u7814\u7a76\u5ba4<\/p>\n\n\n\n<p><a href=\"http:\/\/sweb.u-shizuoka-ken.ac.jp\/~kenji55-lab\/\">http:\/\/sweb.u-shizuoka-ken.ac.jp\/~kenji55-lab\/<\/a><a href=\"http:\/\/sweb.u-shizuoka-ken.ac.jp\/~kenji55-lab\/\"><\/a><\/p>\n\n\n\n<p>\u9759\u5ca1\u770c\u7acb\u5927\u5b66 \u85ac\u5b66\u90e8 \u751f\u547d\u7269\u7406\u5316\u5b66\u7814\u7a76\u5ba4<\/p>\n\n\n\n<p><a href=\"..\/..\/bukka\/index.html\">http:\/\/w3pharm.u-shizuoka-ken.ac.jp\/bukka\/<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u5b66\u85ac\u5b66\u90e8&nbsp;\u751f\u85ac\u5b66\u5206\u91ce&nbsp;\u6e21\u8fba&nbsp;\u8ce2\u4e8c&nbsp;\u6559\u6388\u3068\u540c&nbsp;\u751f\u547d<span class=\"more-link\"><a href=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=4875\">Continue Reading<\/a><\/span><\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[39],"tags":[],"class_list":["entry","author-gp2188","post-4875","post","type-post","status-publish","format-standard","category-39"],"_links":{"self":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/4875","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4875"}],"version-history":[{"count":1,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/4875\/revisions"}],"predecessor-version":[{"id":4878,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/4875\/revisions\/4878"}],"wp:attachment":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4875"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}