{"id":5807,"date":"2025-10-10T17:10:54","date_gmt":"2025-10-10T08:10:54","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=5807"},"modified":"2025-10-10T17:37:27","modified_gmt":"2025-10-10T08:37:27","slug":"%e6%8a%97%e4%bd%93%e8%96%ac%e7%89%a9%e8%a4%87%e5%90%88%e4%bd%93%e3%81%ae%e6%9c%aa%e6%9d%a5%e3%82%92%e6%8b%93%e3%81%8f%ef%bc%9ain-silico%e3%82%92%e6%b4%bb%e7%94%a8%e3%81%97%e3%81%9f%e6%96%b0%e8%a6%8fks","status":"publish","type":"post","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=5807","title":{"rendered":"\u672c\u5b66\u6559\u54e1\u30fb\u5b66\u751f\u306e\u7814\u7a76\u6210\u679c\u304c\u56fd\u969b\u5316\u5b66\u96d1\u8a8c\u300cACS Medicinal Chemistry Letters\u300d\u306e\u8868\u7d19\u306b\u63a1\u629e"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u6297\u4f53\u85ac\u7269\u8907\u5408\u4f53\u306e\u672a\u6765\u3092\u62d3\u304f\uff1ain silico\u3092\u6d3b\u7528\u3057\u305f\u65b0\u898fKSP\u963b\u5bb3\u85ac\u958b\u767a<\/h2>\n\n\n\n<p>\u3000\u672c\u5b66\u5275\u85ac\u63a2\u7d22\u30bb\u30f3\u30bf\u30fc \u5e02\u7530 \u6cf0\u8f1d \u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b3\u5e74\u3001\u5c0f\u90f7 \u5c1a\u4e45 \u8b1b\u5e2b\u3001\u6d45\u4e95 \u7ae0\u826f \u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30e2\u30c7\u30ea\u30f3\u30b0\u8a08\u7b97\u3092\u6d3b\u7528\u3057\u3001\u5f93\u6765\u306e\u6297\u304c\u3093\u85ac\u3068\u306f\u7570\u306a\u308b\u4f5c\u7528\u6a5f\u5e8f\u3092\u6709\u3059\u308b\u30ad\u30cd\u30b7\u30f3\u30e2\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\uff08KSP\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u898f\u963b\u5bb3\u85ac\u306e\u5275\u88fd\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<br>\u3000\u3055\u3089\u306b\u3001\u672c\u963b\u5bb3\u85ac\u304c\u6297\u4f53\u85ac\u7269\u8907\u5408\u4f53\uff08ADC\uff09\u306e\u85ac\u7269\u6210\u5206\uff08\u30da\u30a4\u30ed\u30fc\u30c9\uff09\u3068\u3057\u3066\u5fdc\u7528\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3001\u3053\u308c\u3089\u306e\u6210\u679c\u306f\u56fd\u969b\u5316\u5b66\u96d1\u8a8c\u300cACS Medicinal Chemistry Letters\u300d\u306b2025\u5e7410\u67089\u65e5\u4ed8\u3067\u63b2\u8f09\u3055\u308c\u308b\u3068\u3068\u3082\u306b\u3001\u540c\u8a8c\u306e\u8868\u7d19\u306b\u3082\u63a1\u629e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"770\" height=\"1024\" src=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2025\/10\/amclct.2025.16.issue-10.xlargecover-770x1024.jpg\" alt=\"\" class=\"wp-image-5810\" style=\"width:505px;height:auto\" srcset=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2025\/10\/amclct.2025.16.issue-10.xlargecover-770x1024.jpg 770w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2025\/10\/amclct.2025.16.issue-10.xlargecover-225x300.jpg 225w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2025\/10\/amclct.2025.16.issue-10.xlargecover-768x1022.jpg 768w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2025\/10\/amclct.2025.16.issue-10.xlargecover-413x550.jpg 413w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2025\/10\/amclct.2025.16.issue-10.xlargecover-376x500.jpg 376w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2025\/10\/amclct.2025.16.issue-10.xlargecover.jpg 850w\" sizes=\"auto, (max-width: 770px) 100vw, 770px\" \/><\/figure>\n\n\n\n<p>\u95a2\u9023\u30ea\u30f3\u30af<\/p>\n\n\n\n<p>\u8ad6\u6587\u60c5\u5831\uff1a<br>Pharmacophore-Based Structure Optimization of S-Trityl-l-Cysteine Derivatives for Cytotoxic Payload Applications<br>Taiki Ichida, Naohisa Ogo, Keisuke Murase, Ryota Fukai, Jun-ichi Sawada, Hisashi Murakami, and Akira Asai<\/p>\n\n\n\n<p>ACS Med. Chem. Lett. 2025, 16, 10, 1946\u20131954<br><a href=\"https:\/\/doi.org\/10.1021\/acsmedchemlett.5c00328\">https:\/\/doi.org\/10.1021\/acsmedchemlett.5c00328<\/a><\/p>\n\n\n\n<p>\u8ad6\u6587\u8868\u7d19\uff1a<a href=\"https:\/\/pubs.acs.org\/toc\/amclct\/16\/10\">https:\/\/pubs.acs.org\/toc\/amclct\/16\/10<\/a><\/p>\n\n\n\n<p>\u5275\u85ac\u63a2\u7d22\u30bb\u30f3\u30bf\u30fcHP\uff1a<a href=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/~tansaku\">https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/~tansaku<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6297\u4f53\u85ac\u7269\u8907\u5408\u4f53\u306e\u672a\u6765\u3092\u62d3\u304f\uff1ain silico\u3092\u6d3b\u7528\u3057\u305f\u65b0\u898fKSP\u963b\u5bb3\u85ac\u958b\u767a \u3000\u672c\u5b66\u5275\u85ac\u63a2\u7d22\u30bb\u30f3\u30bf\u30fc<span class=\"more-link\"><a href=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=5807\">Continue Reading<\/a><\/span><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[39],"tags":[],"class_list":["entry","author-hpmember","post-5807","post","type-post","status-publish","format-standard","category-39"],"_links":{"self":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/5807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5807"}],"version-history":[{"count":4,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/5807\/revisions"}],"predecessor-version":[{"id":5813,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/5807\/revisions\/5813"}],"wp:attachment":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}