{"id":5890,"date":"2025-11-25T05:40:02","date_gmt":"2025-11-24T20:40:02","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=5890"},"modified":"2025-11-25T05:41:12","modified_gmt":"2025-11-24T20:41:12","slug":"%e5%bf%83%e4%b8%8d%e5%85%a8%e7%99%ba%e7%97%87%e3%83%bb%e9%80%b2%e5%b1%95%e3%81%ab%e5%af%be%e3%81%99%e3%82%8bnobiletin%e3%81%ae%e5%bf%83%e4%bf%9d%e8%ad%b7%e5%8a%b9%e6%9e%9c%e3%81%a8%e3%83%a1%e3%82%ab","status":"publish","type":"post","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=5890","title":{"rendered":"\u5fc3\u4e0d\u5168\u767a\u75c7\u30fb\u9032\u5c55\u306b\u5bfe\u3059\u308bNobiletin\u306e\u5fc3\u4fdd\u8b77\u52b9\u679c\u3068\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e"},"content":{"rendered":"\n<p class=\"has-black-color has-text-color has-link-color wp-elements-0b06285870d27943d623a3d4457ee23d\">\u672c\u5b66\u85ac\u5b66\u90e8&nbsp;\u7802\u5ddd&nbsp;\u967d\u4e00&nbsp;\u8b1b\u5e2b\u3001\u5200\u5742&nbsp;\u6cf0\u53f2&nbsp;\u51c6\u6559\u6388\u3001\u6e05\u6c34&nbsp;\u8061\u53f2&nbsp;\u52a9\u6559\u3001\u68ee&nbsp;\u6f54&nbsp;\u7279\u4efb\u6559\u6388\u3001\u68ee\u672c&nbsp;\u9054\u4e5f&nbsp;\u5ba2\u54e1\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5fc3\u4e0d\u5168\u767a\u75c7\u30fb\u9032\u5c55\u306b\u5bfe\u3059\u308bNobiletin\u306e\u5fc3\u4fdd\u8b77\u52b9\u679c\u3068\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002\u672c\u6210\u679c\u306f\u5faa\u74b0\u5668\u5206\u91ce\u306b\u304a\u3044\u3066\u6a29\u5a01\u306e\u3042\u308b\u56fd\u969b\u7d19\u300eHypertension\u300f(Impact factor:8.6)&nbsp;\u96fb\u5b50\u7248\u306b2025\u5e7411\u670821\u65e5\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-4c49c9a1a49a0c040021dc092aca0355\"><strong>\u3010\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\u3011<\/strong><br><strong>\u300eNobiletin Prevents Cardiac Hypertrophy via SIRT5-Mediated Downregulation of p300\u300f<\/strong>https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.125.25083<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-343ee5ec5dd8f75b009ff94279878906\"><strong>\u3010\u6982\u8981\u56f3\u3011<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"398\" height=\"338\" src=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2025\/11\/image.jpeg\" alt=\"\" class=\"wp-image-5891\" style=\"width:655px;height:auto\" srcset=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2025\/11\/image.jpeg 398w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/wp-content\/uploads\/2025\/11\/image-300x255.jpeg 300w\" sizes=\"auto, (max-width: 398px) 100vw, 398px\" \/><\/figure>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-2c8596bdca69c1eae72596890a887a0f\"><strong>\u3010\u672c\u7814\u7a76\u6210\u679c\u306e\u30dd\u30a4\u30f3\u30c8\u3011<\/strong><strong><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list has-black-color has-text-color has-link-color wp-elements-63fd4c4842dc2cfc8fc0027d6e83b749\">\n<li><strong>Nobiletin<\/strong><strong>\u306f\u5727\u8ca0\u8377\u306b\u3088\u308b\u5fc3\u7b4b\u80a5\u5927\u3001\u5fc3\u6a5f\u80fd\u4f4e\u4e0b\u3092\u6291\u5236<\/strong><\/li>\n\n\n\n<li><strong>\u30d7\u30ed\u30fc\u30d6\u5316<\/strong><strong>Nobiletin<\/strong><strong>\u3092\u7528\u3044\u305f\u624b\u6cd5\u306b\u3088\u308a\u3001<\/strong><strong>Nobiletin<\/strong><strong>\u6a19\u7684\u56e0\u5b50\u3068\u3057\u3066<\/strong><strong>SIRT5<\/strong><strong>\u3092\u540c\u5b9a<\/strong><\/li>\n\n\n\n<li class=\"has-black-color has-text-color has-link-color wp-elements-5368f91a93df10b35d20f2c45bc37dc8\"><strong>Nobiletin<\/strong><strong>\u306f<\/strong><strong>SIRT5<\/strong><strong>\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001<\/strong><strong>p300<\/strong><strong>\u306e\u8131\u30b9\u30af\u30b7\u30cb\u30eb\u5316\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067<\/strong><strong>p300<\/strong><strong>\u306e\u30d2\u30b9\u30c8\u30f3\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u6d3b\u6027\u4e26\u3073\u306b<\/strong><strong>GATA4<\/strong><strong>\u4f9d\u5b58\u7684\u306a\u5fc3\u7b4b\u80a5\u5927\u53cd\u5fdc\u3092\u6291\u5236<\/strong><\/li>\n\n\n\n<li><strong>\u5fc3\u4e0d\u5168\u306e\u767a\u75c7\u30fb\u9032\u5c55\u3092\u4e88\u9632\u3059\u308b\u5929\u7136\u7531\u6765\u6a5f\u80fd\u6027\u6210\u5206\u3068\u3057\u3066\u3001<\/strong><strong>Nobiletin<\/strong><strong>\u306e\u81e8\u5e8a\u5fdc\u7528\u3078\u767a\u5c55\u3059\u308b\u3053\u3068\u3092\u671f\u5f85<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-b01d8292461fb378d0c9aacf8510bd75\"><strong>\u3010\u6982\u8981\u3011<\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-0a93eaa282e1078f6014b13bef07937a\">Nobiletin\u306f\u67d1\u6a58\u7cfb\u679c\u76ae\u306b\u542b\u307e\u308c\u308b\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3067\u3042\u308a\u3001\u6297\u9178\u5316\u4f5c\u7528\u3084\u8a8d\u77e5\u6a5f\u80fd\u6539\u5584\u4f5c\u7528\u3092\u6709\u3059\u308b\u306a\u3069\u3001\u5065\u5eb7\u306b\u5bc4\u4e0e\u3059\u308b\u6a5f\u80fd\u6027\u6210\u5206\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u5fc3\u4e0d\u5168\u767a\u75c7\u306e\u8981\u56e0\u306e1\u3064\u3067\u3042\u308b\u5fc3\u7b4b\u7d30\u80de\u80a5\u5927\u3092\u6307\u6a19\u306b\u5929\u7136\u7269\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u304b\u3089\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u3001Nobiletin\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001Nobiletin\u304c\u5727\u8ca0\u8377\u306b\u3088\u308b\u5fc3\u7b4b\u80a5\u5927\u3001\u5fc3\u6a5f\u80fd\u4f4e\u4e0b\u3092\u6709\u610f\u306b\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u3001\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u7814\u7a76\u306b\u3088\u308a\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u6297\u8001\u5316\u907a\u4f1d\u5b50\u30d5\u30a1\u30df\u30ea\u30fc\u306e1\u3064\u3067\u3042\u308bSIRT5\u304cNobiletin\u306e\u6a19\u7684\u5206\u5b50\u3067\u3042\u308b\u3053\u3068\u3001Nobiletin\u304cSIRT5\u306e\u6d3b\u6027\u5316\/p300\u306e\u30a2\u30bb\u30c1\u30eb\u5316\u6d3b\u6027\u306e\u5236\u5fa1\u3092\u4ecb\u3057\u3066\u5fc3\u7b4b\u7d30\u80de\u80a5\u5927\u3084\u5fc3\u4e0d\u5168\u306e\u767a\u75c7\u30fb\u9032\u5c55\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u3001SIRT5\u306e\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u6210\u679c\u306b\u3088\u308a\u3001Nobiletin\u3092\u7528\u3044\u305f\u5fc3\u4e0d\u5168\u767a\u75c7\u30fb\u9032\u5c55\u306b\u5bfe\u3059\u308b\u4e88\u9632\u6226\u7565\u306b\u767a\u5c55\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-99729c28805b6c9656f7e228708b2c2d\"><strong>\u3010\u7279\u8a18\u4e8b\u9805\u3011<\/strong><strong><\/strong><\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color wp-elements-c20656ec7241489d45cdd52722c36ceb\">\u3000\u672c\u7814\u7a76\u306f\u3001\u9759\u5ca1\u770c\u7acb\u5927\u5b66\u3001\u6771\u6d77\u5927\u5b66\u3001\u5175\u5eab\u770c\u7acb\u5927\u5b66\u3001\u4eac\u90fd\u5927\u5b66\u3001\u56fd\u7acb\u75c5\u9662\u6a5f\u69cb\u4eac\u90fd\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3066\u5b9f\u65bd\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002\u307e\u305f\u3001\u672c\u7814\u7a76\u306f\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u79d1\u5b66\u7814\u7a76\u8cbb\u52a9\u6210\u4e8b\u696d(\u7802\u5ddd\u967d\u4e00; 23K06098, 19K16396,&nbsp;\u68ee\u672c\u9054\u4e5f; 20K07070,&nbsp;\u9577\u8c37\u5ddd\u6d69\u4e8c; 18K08121)\u3001\u6b66\u7530\u79d1\u5b66\u632f\u8208\u8ca1\u56e3\u7814\u7a76\u52a9\u6210(\u7802\u5ddd\u967d\u4e00)\u3001\u516c\u76ca\u4fe1\u8a17&nbsp;\u5faa\u74b0\u5668\u5b66\u7814\u7a76\u632f\u8208\u57fa\u91d1(\u7802\u5ddd\u967d\u4e00)\u3001\u65e5\u672c\u5fc3\u81d3\u8ca1\u56e3\u7814\u7a76\u52a9\u6210(\u7802\u5ddd\u967d\u4e00)\u304b\u3089\u306e\u652f\u63f4\u3092\u5f97\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u5b66\u85ac\u5b66\u90e8&nbsp;\u7802\u5ddd&nbsp;\u967d\u4e00&nbsp;\u8b1b\u5e2b\u3001\u5200\u5742&nbsp;\u6cf0\u53f2&nbsp;\u51c6\u6559\u6388\u3001<span class=\"more-link\"><a href=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/?p=5890\">Continue Reading<\/a><\/span><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[39],"tags":[],"class_list":["entry","author-hpmember","post-5890","post","type-post","status-publish","format-standard","category-39"],"_links":{"self":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/5890","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5890"}],"version-history":[{"count":2,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/5890\/revisions"}],"predecessor-version":[{"id":5893,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/5890\/revisions\/5893"}],"wp:attachment":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5890"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5890"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}