{"id":1811,"date":"2021-12-24T15:23:16","date_gmt":"2021-12-24T06:23:16","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/?page_id=1811"},"modified":"2026-04-06T09:21:39","modified_gmt":"2026-04-06T00:21:39","slug":"%e5%ad%a6%e4%bc%9a%e7%99%ba%e8%a1%a8-2","status":"publish","type":"page","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/?page_id=1811","title":{"rendered":"\u5b66\u4f1a\u767a\u8868"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1811\" class=\"elementor elementor-1811\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d9fbb02 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d9fbb02\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-54e1dbc\" data-id=\"54e1dbc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-152cb0b elementor-widget__width-inherit elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"152cb0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2221\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2221\" aria-expanded=\"false\">2026<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2222\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2222\" aria-expanded=\"false\">2025<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2223\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2223\" aria-expanded=\"false\">2024<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2224\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2224\" aria-expanded=\"false\">2023<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2225\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2225\" aria-expanded=\"false\">2022<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2226\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"6\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2226\" aria-expanded=\"false\">2021<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2227\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"7\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2227\" aria-expanded=\"false\">2020<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2228\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"8\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2228\" aria-expanded=\"false\">2019<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2229\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"9\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2229\" aria-expanded=\"false\">2018<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-22210\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"10\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-22210\" aria-expanded=\"false\">2017<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-22211\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"11\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-22211\" aria-expanded=\"false\">2016<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-22212\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"12\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-22212\" aria-expanded=\"false\">2015<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2221\" aria-expanded=\"false\">2026<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2221\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2221\" tabindex=\"0\" hidden=\"false\"><ul><li><span style=\"color: #000000; font-family: arial, helvetica, sans-serif;\"><span style=\"font-size: 16px;\">\u68ee\u5cf6 \u5343\u6674\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u5c71\u53e3 \u6843\u751f\u3001\u6cb3\u5408 \u4f51\u7f8e\u3001\u91d1\u6ca2 \u8cb4\u61b2\u3001\u77f3\u5ddd \u667a\u4e45 : \u81b5\u03b2\u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u5bfe\u3059\u308b\u690d\u7269\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u69d8\u30ca\u30ce\u7c92\u5b50\u306e\u52b9\u679c\u3068\u6a5f\u5e8f\u306e\u89e3\u660e <\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-family: arial, helvetica, sans-serif;\"><span style=\"font-size: 16px;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c146\u5e74\u4f1a\uff08\u5927\u962a\uff09\u300129-62-am-23S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a262\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.199\u30012026\u5e743\u670829\u65e5<\/span><\/span><\/p><p>\u00a0<\/p><ul><li><span style=\"color: #000000; font-family: arial, helvetica, sans-serif;\"><span style=\"font-size: 12pt;\">\u4f50\u91ce\u529f\u5178\u3001<\/span><\/span><span dir=\"ltr\" style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\" role=\"presentation\">\u7530\u908a\u7965\u592a<\/span><span dir=\"ltr\" style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\" role=\"presentation\">\u3001\u5c71\u53e3\u6843\u751f<\/span><span dir=\"ltr\" style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\" role=\"presentation\">\u3001\u91d1\u5b50\u96ea\u5b50<\/span><span dir=\"ltr\" style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\" role=\"presentation\">\u3001\u6e21\u9089\u76f4\u4e5f<\/span><span dir=\"ltr\" style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\" role=\"presentation\">\u3001\u67f4\u7530\u6dbc\u543e<\/span><span dir=\"ltr\" style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\" role=\"presentation\">\u3001\u5927\u5ca1\u592e<\/span><span dir=\"ltr\" style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\" role=\"presentation\">\u3001\u77f3\u5ddd\u667a<\/span><span dir=\"ltr\" style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\" role=\"presentation\">\u4e45\uff1a\u81b5 \u03b2\u7d30\u80de\u7531\u6765\u56e0\u5b50\u306b\u7740\u76ee\u3057\u305f\u9ad8\u8840\u7cd6\u306b\u3088\u308bMASH\u9032\u5c55\u30c8\u30ea\u30ac\u30fc\u30b7\u30b0\u30ca\u30eb\u306e\u89e3\u660e<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c146\u5e74\u4f1a\uff08\u5927\u962a\uff09\u300127-26-am10S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a262\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.123\u30012026\u5e743\u670827\u65e5<\/span><\/p><p>\u00a0<\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u6728\u6751\u4fca\u79c0\u3001\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5f8c\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c146\u5e74\u4f1a\uff08\u5927\u962a\uff09\u300127-11-pm02\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a262\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p120.\u30012026\u5e743\u670827\u65e5<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u00a0<\/span><\/p><ul><li style=\"text-align: left;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\"><span style=\"text-align: start;\">\u9234\u6728\u5065\u8cc7\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5c0f\u8c37\u512a\u5983\u3001\u5927\u5ca1\u592e\u3001\u5c71\u4e0b\u65e5\u5948\u5b50\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u7dda\u7dad\u5316\u306b\u304a\u3051\u308b\u809d\u661f\u7d30\u80dePRMT5\u306e\u5f79\u5272\u3068\u305d\u306e\u5206\u5b50\u6a5f\u69cb<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\"><span dir=\"ltr\" role=\"presentation\">\u7b2c<\/span><span dir=\"ltr\" role=\"presentation\">99<\/span><span dir=\"ltr\" role=\"presentation\">\u56de<\/span><span dir=\"ltr\" role=\"presentation\">\u65e5<\/span><span dir=\"ltr\" role=\"presentation\">\u672c<\/span><span dir=\"ltr\" role=\"presentation\">\u85ac<\/span><span dir=\"ltr\" role=\"presentation\">\u7406<\/span><span dir=\"ltr\" role=\"presentation\">\u5b66<\/span><span dir=\"ltr\" role=\"presentation\">\u4f1a\u5408<\/span><span dir=\"ltr\" role=\"presentation\">\u540c<\/span><span dir=\"ltr\" role=\"presentation\">\u5927\u4f1a\uff08\u4ed9\u53f0\uff09\u30011-YIA-DC-12\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.230 \u30012026\u5e743\u670816\u65e5<\/span><br \/><\/span><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2222\" aria-expanded=\"false\">2025<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2222\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2222\" tabindex=\"0\" hidden=\"hidden\"><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u6885\u7530\u5b97\u4e00\u90ce\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u7530\u57ce\u771f\u5e06\u3001\u5fd7\u6d25\u601c\u592a\u3001\u5409\u6210\u6d69\u4e00\u3001\u5c71\u53e3\u6843\u751f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a \u81b5\u03b2\u7d30\u80de\u4fdd\u8b77\u3092\u76ee\u7684\u3068\u3057\u305fDDAH2\u767a\u73fe\u3092\u5897\u5927\u3055\u305b\u308b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u5275\u51fa\u7814\u7a76<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\uff08\u4e09\u91cd\uff09\u3001M-9\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u8981\u65e8\u96c6 p.174\u30012025\u5e7410\u670826\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u6749\u68ee\u4ec1\u594f\u3001\u91d1\u5b50\u96ea\u5b50\u3001Stella Amarachi Ihim\u3001\u5c71\u672c\u840c\u7d75\u3001\u77f3\u5ddd\u667a\u4e45\uff1aApigenin\u306e\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u6297\u7cd6\u5c3f\u75c5\u52b9\u679c\u3068\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\uff08\u4e09\u91cd\uff09\u3001M-8\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u8b1b\u6f14\u8981\u65e8\u96c6 p.174\u30012025\u5e7410\u670826\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7a32\u6751\u9999\u7e54\u3001\u5927\u5ca1\u592e\u3001\u5c71\u53e3\u6843\u751f\u3001\u7a32\u4e95\u8aa0\u3001\u5800\u7530\u304f\u308b\u307f\u3001\u9577\u6fa4\u67da\u5e0c\u3001\u5c71\u4e0b\u8ce2\u4e8c\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u5409\u6210\u6d69\u4e00\u3001\u77f3\u5ddd\u667a\u4e45\u3001\u6ff1\u5cf6\u7fa9\u9686\uff1aDIF-1\u3092\u30ea\u30fc\u30c9\u5316\u5408\u7269\u3068\u3059\u308b\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u85ac\u5275\u51fa\u3092\u6307\u5411\u3057\u305f\u69cb\u9020\u6d3b\u6027\u76f8\u95a2\u7814\u7a76\u3068\u63a1\u7528\u6a5f\u5e8f\u306e\u63a2\u7d22<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\uff08\u4e09\u91cd\uff09\u3001F-3\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u8981\u65e8\u96c6 p.124\u30012025\u5e7410\u670826\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u4f50\u91ce\u529f\u5178\u3000\u5c71\u53e3\u6843\u751f\u3000\u91d1\u5b50\u96ea\u5b50\u3000\u7530\u908a\u7965\u592a\u3000\u6e21\u9089\u76f4\u4e5f\u3000\u67f4\u7530\u6dbc\u543e\u3000\u5927\u5ca1\u592e\u3000\u77f3\u5ddd\u667a\u4e45\uff1a\u9ad8\u8840\u7cd6\u306b\u3088\u308bMASH\u9032\u5c55\u306e\u30c8\u30ea\u30ac\u30fc\u3068\u306a\u308b\u81b5 \u03b2\u7d30\u80de\u7531\u6765\u56e0\u5b50\u306e\u4f5c\u7528\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7b2c153\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u5c71\u68a8\uff09\u3001MS-6-3\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.8\u30012025\u5e7410\u670825\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u5c71\u53e3\u6843\u751f\u3001\u571f\u80a5\u76f4\u8cb4\u3001\u5927\u5ca1\u592e\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1aMASH\u9032\u5c55\u306e\u30b9\u30a4\u30c3\u30c1\u3068\u306a\u308b\u809d\u81d3\u5185\u30a2\u30c7\u30ce\u30b7\u30f3\u52d5\u614b\u306e\u5909\u5316<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7b2c72\u56de\u4e2d\u90e8\u65e5\u672c\u751f\u7406\u5b66\u4f1a\uff08\u9759\u5ca1\uff09\u3001P-21\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.52\u30012025\u5e7410\u670817\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u91d1\u5b50\u96ea\u5b50\u3001\u6e21\u9089\u76f4\u4e5f\u3001\u77f3\u539f\u5bff\u5149\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7d30\u80de\u5185\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30b7\u30b0\u30ca\u30eb\u5236\u5fa1\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306e\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7b2c72\u56de\u4e2d\u90e8\u65e5\u672c\u751f\u7406\u5b66\u4f1a\uff08\u9759\u5ca1\uff09\u3001P-9\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.46\u30012025\u5e7410\u670817\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u5c0f\u8c37\u512a\u5983\u3001\u9234\u6728\u5065\u8cc7\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5927\u5ca1\u592e\u3001\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u661f\u7d30\u80dePRMT5\u304c\u809d\u7dda\u7dad\u5316\u3092\u4fc3\u9032\u3059\u308b\u6a5f\u69cb\u306e\u89e3\u660e<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u9759\u5ca1\u5b9f\u9a13\u52d5\u7269\u7814\u7a76\u4f1a\u7b2c52\u56de\u7814\u7a76\u767a\u8868\u4f1a \uff08\u4e09\u5cf6\uff09\u3001No. 2\u3001\u8981\u65e8\u96c6p.6\u30012024\u5e7410\u67083\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u5c0f\u8c37\u512a\u5983\u3001\u9234\u6728\u5065\u8cc7\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5927\u5ca1\u592e\u3001\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u6728\u6751\u4fca\u79c0\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u661f\u7d30\u80de\u306e\u5f62\u8cea\u8ee2\u63db\u3092\u5236\u5fa1\u3059\u308bPRMT5\u306e\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u6a19\u7684\u5206\u5b50\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2025 \uff08\u4ed9\u53f0\uff09\u3001O6-1\u3001\u8981\u65e8\u96c6p.42\u30012025\u5e748\u670830\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7a32\u6751\u9999\u7e54\u3001\u5927\u5ca1\u592e\u3001\u5c71\u53e3\u6843\u751f\u3001\u7a32\u4e95\u8aa0\u3001\u5800\u7530\u304f\u308b\u307f\u3001\u9577\u6fa4\u67da\u5e0c\u3001\u5c71\u4e0b\u8ce2\u4e8c\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u5409\u6210\u6d69\u4e00\u3001\u77f3\u5ddd\u667a\u4e45\u3001\u6ff1\u5cf6\u7fa9\u9686\uff1aDIF-1\u3092\u30ea\u30fc\u30c9\u5316\u5408\u7269\u3068\u3059\u308b\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u85ac\u5275\u51fa\u3092\u6307\u5411\u3057\u305f\u69cb\u9020\u6d3b\u6027\u76f8\u95a2\u7814\u7a76\u3068\u63a1\u7528\u6a5f\u5e8f\u306e\u63a2\u7d22<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2025\uff08\u4ed9\u53f0\uff09\u3001P-C11\u3001\u8981\u65e8\u96c6p.71\u30012025\u5e748\u670828\u201329\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u5c0f\u8c37\u512a\u5983\u3001\u9234\u6728\u5065\u8cc7\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5927\u5ca1\u592e\u3001\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u6728\u6751\u4fca\u79c0\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u661f\u7d30\u80de\u306e\u5f62\u8cea\u8ee2\u63db\u3092\u5236\u5fa1\u3059\u308bPRMT5\u306e\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u6a19\u7684\u5206\u5b50\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2025\uff08\u4ed9\u53f0\uff09\u3001P-C04\u3001\u8981\u65e8\u96c6p.67\u30012025\u5e748\u670828\u201329\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u5c71\u53e3\u6843\u751f\u3001\u571f\u80a5\u76f4\u8cb4\u3001\u5927\u5ca1\u592e\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u81d3\u5185\u30a2\u30c7\u30ce\u30b7\u30f3\u52d5\u614b\u306e\u5909\u5316\u304cMASH\u9032\u884c\u3078\u306e\u30b9\u30a4\u30c3\u30c1\u3068\u306a\u308b\u3001Altered intrahepatic adenosine dynamics switch MASH progression<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7b2c52\u56de\u65e5\u672c\u6bd2\u6027\u5b66\u4f1a\u5b66\u8853\u5e74\u4f1a\uff08\u6c96\u7e04\uff09\u3001P-246\u3001<em>The Journal of Toxicological Sciences<\/em> 50 <em>Supplement <\/em>I, p.198\u30012025\u5e747\u67083\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7af9\u5185 \u4f51\u592a\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u82b1\u5c71 \u96bc\u4ec1\u3001\u91d1\u6ca2 \u8cb4\u61b2\uff1a PEG\u8102\u8cea\u304a\u3088\u3073\u6295\u4e0e\u7d4c\u8def\u304c\u53ca\u307c\u3059\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u81b5\u81d3\u30fb\u81b5\u5cf6\u3078\u306e\u79fb\u884c\u6027\u3068mRNA\u5c0e\u5165\u9818\u57df\u3078\u306e\u5f71\u97ff<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u65e5\u672c\u6838\u9178\u533b\u85ac\u5b66\u4f1a \u7b2c10\u56de\u5e74\u4f1a\uff08\u795e\u6238\uff09\u3001P-032\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p23\u30012025\u5e747\u67081\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u6885\u7530\u5b97\u4e00\u90ce\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u7530\u57ce\u771f\u5e06\u3001\u5fd7\u6d25\u601c\u592a\u3001\u5409\u6210\u6d69\u4e00\u3001\u5c71\u53e3\u6843\u751f\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1a DDAH\u767a\u73fe\u4e0a\u6607\u306b\u3088\u308b\u81b5\u03b2\u7d30\u80de\u4fdd\u8b77\u3092\u76ee\u7684\u3068\u3057\u305f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u63a2\u7d22<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7b2c152\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001C-1-5\u3001\u8981\u65e8\u96c6p.39\u30012025\u5e746\u670828\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u571f\u4e95\u9999\u5b9f\u3001\u6728\u6751\u4fca\u79c0\u3001\u671b\u6708\u53cb\u83dc\u3001\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u77f3\u5ddd\u667a\u4e45\uff1a \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5f8c\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7b2c152\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001C-1-1\u3001\u8981\u65e8\u96c6p.36\u30012025\u5e746\u670828\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">Yuta Takeuchi, Yukiko K. Kaneko, Takanori Kanazawa: Effects of PEG lipids and route of administration on the migration of lipid nanoparticles into the pancreas and islets and mRNA Delivery regions.<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u00a0The 4th Workshop for Korea-Japan Young Scientists on Pharmaceutics (Seoul, Korea). Jun 25-27, 2025<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7af9\u5185 \u4f51\u592a\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u91d1\u6ca2 \u8cb4\u61b2\uff1a\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u81b5\u81d3\u30fb\u81b5\u5cf6\u3078\u306e\u79fb\u884c\u6027\u3068mRNA\u5c0e\u5165\u9818\u57df\u306b\u53ca\u307c\u3059PEG\u8102\u8cea\u304a\u3088\u3073\u6295\u4e0e\u7d4c\u8def\u306e\u5f71\u97ff<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7b2c41\u56de\u65e5\u672cDDS\u5b66\u8853\u96c6\u4f1a\uff08\u5343\u8449\uff09\u3001Jp20-F-01\u30012025\u5e746\u670818\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7af9\u5185 \u4f51\u592a\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u91d1\u6ca2 \u8cb4\u61b2\uff1a\u9001\u9054\u56f0\u96e3\u306a\u81b5\u81d3\u30fb\u81b5\u03b2\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308bmRNA-LNP\u306e\u8a2d\u8a08\u3068\u8a55\u4fa1<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u7b2c68\u56de\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a\uff08\u5ca1\u5c71\uff09\u3001I-43-2\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.127\u30012025\u5e745\u670829\u65e5<\/span><\/p><ul><li style=\"text-align: left;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u6728\u6751\u4fca\u79c0\u3001\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u77f3\u5ddd\u667a\u4e45\uff1aGDP\u578bRab27a\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5f8c\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c68\u56de\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a\uff08\u5ca1\u5c71\uff09\u3001I-41-5\u3001\u8981\u65e8\u96c6p.140\u30012025\u5e745\u670829\u65e5<\/span><\/p><ul><li><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u4f50\u91ce\u529f\u5178\u3001<span dir=\"ltr\" role=\"presentation\">\u7530\u908a\u7965\u592a<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u5c71\u53e3\u6843\u751f<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u91d1\u5b50\u96ea\u5b50<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u6e21\u9089\u76f4\u4e5f<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u67f4\u7530\u6dbc\u543e<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u5927\u5ca1\u592e<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u77f3\u5ddd\u667a<\/span><span dir=\"ltr\" role=\"presentation\">\u4e45\uff1a\u81b5 \u03b2\u7d30\u80de\u7531\u6765\u56e0\u5b50\u306b\u7740\u76ee\u3057\u305f\u9ad8\u8840\u7cd6\u306b\u3088\u308bMASH\u9032\u5c55\u30c8\u30ea\u30ac\u30fc\u30b7\u30b0\u30ca\u30eb\u306e\u89e3\u660e<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c145\u56de\u5e74\u4f1a\uff08\u798f\u5ca1\uff09\u300129-11-am14S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a2\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.\u30012025\u5e743\u670829\u65e5<\/span><\/p><ul><li><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u5ca1\u90e8\u78e8\u5e78\u3001\u5c71\u53e3\u6843\u751f\u3001\u5927\u5ca1\u592e\u3001\u5c0f\u6fa4\u5143\u5e0c\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u9234\u6728\u6e13\u3001\u4e45\u7530\u8cb4\u7fa9\u3001\u671b\u6708\u6df3\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u975e\u4fb5\u8972\u7684\u306aMASLD\u8a3a\u65ad\u65b9\u6cd5\u306e\u958b\u767a<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c145\u56de\u5e74\u4f1a\uff08\u798f\u5ca1\uff09\u300129-11-am07S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a2\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.\u30012025\u5e743\u670829\u65e5<\/span><\/p><ul><li><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\"> <span dir=\"ltr\" role=\"presentation\">\u7a32\u6751\u9999\u7e54<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u5927\u5ca1\u592e<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u9577\u6fa4\u67da\u5e0c<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u5c71\u53e3\u6843\u751f<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u5c71\u4e0b\u8ce2\u4e8c<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u9f4a\u85e4\u771f\u4e5f<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u7a32\u4e95\u8aa0<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u77f3\u5ddd\u667a\u4e45<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u6ff1\u5cf6<\/span><span dir=\"ltr\" role=\"presentation\">\u7fa9\u9686<\/span>\uff1a<span dir=\"ltr\" role=\"presentation\">\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3092\u6307\u5411\u3057\u305f<\/span><span dir=\"ltr\" role=\"presentation\">DIF-1<\/span><span dir=\"ltr\" role=\"presentation\">\u306e\u69cb\u9020\u6d3b\u6027\u76f8\u95a2\u7814\u7a76\u3068\u4f5c\u7528\u6a5f\u5e8f\u306e\u89e3\u660e<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c145\u56de\u5e74\u4f1a\uff08\u798f\u5ca1\uff09\u300127P-pm169S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a2\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.\u30012025\u5e743\u670827\u65e5<\/span><\/p><ul><li><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\"><span dir=\"ltr\" role=\"presentation\">\u6cb3\u5408\u4f51\u7f8e<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u5c71\u53e3\u6843\u751f<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u5927\u5ca1 \u592e<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u68ee\u7d14\u9234<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u67f4\u7530\u6dbc\u543e<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u5ca1\u90e8\u78e8\u5e78<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u91d1\u6ca2\u8cb4\u61b2<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u98ef\u5ca1\u771f\u543e<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u91d1\u5b50\u96ea\u5b50<\/span><span dir=\"ltr\" role=\"presentation\">\u3001\u77f3\u5ddd\u667a\u4e45<\/span>\uff1a<span dir=\"ltr\" role=\"presentation\">\u809d\u661f\u7d30\u80de\u6d3b\u6027\u5316\u306b\u5bfe\u3059\u308b\u690d\u7269\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u69d8\u30ca\u30ce\u7c92\u5b50\u306e\u4f5c\u7528\u89e3\u6790\u304a\u3088\u3073\u7d30\u80de\u3078\u306e\u53d6\u308a<\/span><span dir=\"ltr\" role=\"presentation\">\u8fbc\u307f\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c145\u56de\u5e74\u4f1a\uff08\u798f\u5ca1\uff09\u300127P-am237S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a2\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.\u30012025\u5e743\u670827\u65e5<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u00a0<\/span><\/p><ul><li style=\"text-align: left;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\"><span dir=\"ltr\" style=\"text-align: start;\" role=\"presentation\">\u6e21\u8fba\u96c4\u592a\u3001\u5c71\u53e3\u6843\u751f<\/span><span dir=\"ltr\" style=\"text-align: start;\" role=\"presentation\">\u3001\u571f\u80a5\u76f4\u8cb4<\/span><span dir=\"ltr\" style=\"text-align: start;\" role=\"presentation\">\u3001\u5927\u5ca1\u592e<\/span><span dir=\"ltr\" style=\"text-align: start;\" role=\"presentation\">\u3001\u9f4a\u85e4\u771f\u4e5f\u3001<\/span><span dir=\"ltr\" style=\"text-align: start;\" role=\"presentation\">\u77f3\u5ddd\u667a\u4e45<\/span><span style=\"text-align: start;\">\uff1aCaffeine\u306e\u809d\u661f\u7d30\u80de\u6d3b\u6027\u5316\u6291\u5236\u4f5c\u7528\u306b\u5bfe\u3059\u308bprostaglandinE2\u306e\u5897\u5f37\u52b9\u679c\u306b\u306fNRF2-\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u4ee3\u8b1d\u8ef8\u304c\u95a2\u4e0e\u3059\u308b\u3001Involvement of NRF2-glutathione metabolic axis in prostaglandin E2-induced facilitation of the inhibitory effect of caffeine on hepatic stellate cell activation<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\"><span dir=\"ltr\" role=\"presentation\">APPW2025\uff08The 130th Annual Meeting of the Japanese Association of Anatomists (JAA) &#8211; The 102nd Annual Meeting of the Physiological Society of Japan (PSJ) \u2022 The 98th Annual Meeting of the Japanese Pharmacological Society (JPS)\uff09\u7b2c<\/span><span dir=\"ltr\" role=\"presentation\">130<\/span><span dir=\"ltr\" role=\"presentation\">\u56de<\/span><span dir=\"ltr\" role=\"presentation\">\u65e5<\/span><span dir=\"ltr\" role=\"presentation\">\u672c<\/span><span dir=\"ltr\" role=\"presentation\">\u89e3<\/span><span dir=\"ltr\" role=\"presentation\">\u5256<\/span><span dir=\"ltr\" role=\"presentation\">\u5b66<\/span><span dir=\"ltr\" role=\"presentation\">\u4f1a<\/span><span dir=\"ltr\" role=\"presentation\">\/<\/span><span dir=\"ltr\" role=\"presentation\">\u7b2c<\/span><span dir=\"ltr\" role=\"presentation\">102<\/span><span dir=\"ltr\" role=\"presentation\">\u56de<\/span><span dir=\"ltr\" role=\"presentation\">\u65e5<\/span><span dir=\"ltr\" role=\"presentation\">\u672c\u751f<\/span><span dir=\"ltr\" role=\"presentation\">\u7406<\/span><span dir=\"ltr\" role=\"presentation\">\u5b66<\/span><span dir=\"ltr\" role=\"presentation\">\u4f1a<\/span><span dir=\"ltr\" role=\"presentation\">\/<\/span><span dir=\"ltr\" role=\"presentation\">\u7b2c<\/span><span dir=\"ltr\" role=\"presentation\">98<\/span><span dir=\"ltr\" role=\"presentation\">\u56de<\/span><span dir=\"ltr\" role=\"presentation\">\u65e5<\/span><span dir=\"ltr\" role=\"presentation\">\u672c<\/span><span dir=\"ltr\" role=\"presentation\">\u85ac<\/span><span dir=\"ltr\" role=\"presentation\">\u7406<\/span><span dir=\"ltr\" role=\"presentation\">\u5b66<\/span><span dir=\"ltr\" role=\"presentation\">\u4f1a\u5408<\/span><span dir=\"ltr\" role=\"presentation\">\u540c<\/span><span dir=\"ltr\" role=\"presentation\">\u5927\u4f1a\uff08\u5e55\u5f35\uff09\u3001ST-11-13 (2P-248)\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p. \u30012025\u5e743\u670818\u65e5<\/span><br \/><\/span><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2223\" aria-expanded=\"false\">2024<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2223\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2223\" tabindex=\"0\" hidden=\"hidden\"><ul><li><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u5c0f\u8c37\u512a\u5983\u3001\u9234\u6728\u5065\u8cc7\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5927\u5ca1\u592e\u3001\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u91d1\u5b50\u5b50\u3001\u6728\u6751\u79c0\u4fca\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u661f\u7d30\u80de\u306e\u5f62\u8cea\u8ee2\u63db\u3092\u5236\u5fa1\u3059\u308b\u809d\u7dda\u7dad\u5316\u4fc3\u9032\u5206\u5b50 PRMT5<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u7b2c34\u56de\u65e5\u672c\u5faa\u74b0\u85ac\u7406\u5b66\u4f1a\uff08\u9759\u5ca1\uff09\u3001PUG-06\u3001\u8981\u65e8\u96c6p.41\u30012024\u5e7412\u670820\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u5800\u7530\u304f\u308b\u307f\u3001\u5927\u5ca1\u592e\u3001\u5c71\u53e3\u6843\u751f\u3001\u7a32\u6751\u9999\u7e54\u3001\u7a32\u4e95\u8aa0\u3001\u9577\u6fa4\u67da\u5e0c\u3001\u5c71\u4e0b\u8ce2\u4e8c\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u6728\u6751\u79c0\u4fca\u3001\u6ff1\u5cf6\u7fa9\u9686\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u6d3b\u6027\u578b\u809d\u661f\u7d30\u80de\u306e\u8131\u6d3b\u6027\u5316\u306b\u7740\u76ee\u3057\u305f\u809d\u5b9f\u8cea\u6cbb\u7642\u6a19\u7684\u5206\u5b50\u306e\u63a2\u7d22<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt;\">\u7b2c34\u56de\u65e5\u672c\u5faa\u74b0\u85ac\u7406\u5b66\u4f1a\uff08\u9759\u5ca1\uff09\u3001PUG-05\u3001\u8981\u65e8\u96c6p.40\u30012024\u5e7412\u670820\u65e5<\/span><\/p><ul><li style=\"text-align: left;\"><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u6885\u7530\u5b97\u4e00\u90ce\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u7530\u57ce\u771f\u5e06\u3001\u5fd7\u6d25\u601c\u592a\u3001\u5409\u6210\u6d69\u4e00\u3001\u5c71\u53e3\u6843\u751f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u4fdd\u8b77\u3092\u76ee\u7684\u3068\u3057\u305fDDAH2\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u5275\u51fa\u7814\u7a76 Development of novel diabetes therapeutics targeting \u03b2-cell protection through the regulation of DDAH2 expression<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u7b2c34\u56de\u3000\u65e5\u672c\u5faa\u74b0\u85ac\u7406\u5b66\u4f1a\uff08\u9759\u5ca1\uff09\u3000\u3001PUG-04\u3001\u8981\u65e8\u96c6p.39\u30012024\u5e7412\u670820\u65e5<\/span><\/p><ul><li><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u77f3\u5ddd\u667a\u4e45\u3001\u5c71\u53e3\u6843\u751f\uff1a\u809d\u661f\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u809d\u708e\uff08MASH\uff09\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3000\u2212 \u5929\u7136\u7269\u7531\u6765\u6210\u5206\u3092\u7528\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1 \u2212\u3010\u7279\u5225\u8b1b\u6f14\u3011<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u7b2c15\u56de\u5c90\u961c\u85ac\u79d1\u5927\u5b66\u6a5f\u80fd\u6027\u5065\u5eb7\u98df\u54c1\u7814\u7a76\u8b1b\u6f14\u4f1a\uff08\u5c90\u961c\uff09\u30012024\u5e7411\u670830\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308bGDP\u578bRab27a\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5236\u5fa1<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c47\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a\uff08\u798f\u5ca1\uff09\u30011P-364\u3001<span style=\"text-align: right;\">2024\u5e7411\u670827\u65e5<\/span><\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7af9\u5185\u4f51\u592a\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u91d1\u6ca2\u8cb4\u61b2\uff1a\u81b5\u03b2\u7d30\u80de\u3078\u306e mRNA \u5c0e\u5165\u306b\u5411\u3051\u305f mRNA-LNP \u306e\u8a2d\u8a08\u3068\u8a55\u4fa1<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c63\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u30fb\u65e5\u672c\u85ac\u5264\u5e2b\u4f1a\u30fb\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u3000\u4e2d\u56db\u56fd\u652f\u90e8\u5b66\u8853\u5927\u4f1a\uff08\u5ca1\u5c71\uff09\u3001P17-11\u30012024\u5e7411\u670816\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u3067GDP\u578bRab27a\u304c\u5236\u5fa1\u3059\u308b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c98\u56de\u65e5\u672c\u751f\u5316\u5b66\u4f1a\u5927\u4f1a\uff08\u6a2a\u6d5c\uff09\u30013P-169\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.200\u30012024\u5e7411\u67088\u65e5<\/span><\/p><ul><li style=\"text-align: left;\"><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u9577\u8c37\u5ddd\u967d\u5e73\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u91d1\u6ca2\u8cb4\u61b2\u3001\u4f50\u85e4\u84ee\u3001\u5c3e\u718a\u8cb4\u4e4b\u3001\u8fd1\u85e4\u5553\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u5cf6\u3078\u306e\u85ac\u7269\u9001\u9054\u6280\u8853\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u305f\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u7d44\u6210\u304a\u3088\u3073\u7c92\u5b50\u5f84\u306e\u691c\u8a0e<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\uff08\u5c90\u961c\uff09\u3000F-17\u30002024\u5e7410\u670827\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u9234\u6728\u5065\u8cc7\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u5c0f\u8c37\u512a\u5983\u3001\u5ca1\u90e8\u78e8\u5e78\u3001\u5927\u5ca1\u592e\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u661f\u7d30\u80dePRMT5\u304c\u809d\u7dda\u7dad\u5316\u3092\u4fc3\u9032\u3059\u308b\u6a5f\u69cb\u306e\u89e3\u660e<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u9759\u5ca1\u5b9f\u9a13\u52d5\u7269\u7814\u7a76\u4f1a\u7b2c51\u56de\u7814\u7a76\u767a\u8868\u4f1a \uff08\u6d5c\u677e\uff09\u3001No. 2\u3001\u8981\u65e8\u96c6p.6\u30012024\u5e7410\u670825\u65e5<\/span><\/p><ul><li style=\"text-align: left;\"><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u7af9\u5185\u4f51\u592a\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u91d1\u6ca2\u8cb4\u61b2: DDS\u7814\u7a76\u30bb\u30f3\u30bf\u81b5\u03b2\u7d30\u80de\u3078\u306emRNA\u5c0e\u5165\u306b\u5411\u3051\u305fmRNA-LNP\u306e\u8a2d\u8a08\u3068\u8a55\u4fa1<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">\u7b2c45\u56de\u751f\u4f53\u819c\uff7c\uff9d\uff8e\uff9f\uff7c\uff9e\uff73\uff91\uff08\u5fb3\u5cf6\uff09\u3001P2-34\u30012024\u5e7410\u670811\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u9234\u6728\u5065\u8cc7\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u5927\u5ca1\u592e\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u7dda\u7dad\u5316\u3092\u4fc3\u9032\u3055\u305b\u308b\u809d\u661f\u7d30\u80dePRMT5 \u306e\u5f79\u5272<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2024 \uff08\u4eac\u90fd\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001P-46\u3001\u8981\u65e8\u96c6p.116 \u30012024\u5e748\u670831\u65e5<\/span><\/p><ul><li><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u5ca1\u90e8 \u78e8\u5e78\u3001\u5c71\u53e3\u6843\u751f\u3001\u9ad9\u6a4b\u4eae\u6c70\u3001\u5927\u5ca1\u592e\u3001\u77f3\u5ddd\u667a\u4e45<\/span><br \/><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; color: #000000;\">\u809d\u7dda\u7dad\u5316 ex vivo \u30e2\u30c7\u30eb\u306e\u78ba\u7acb\u3068\u809d\u7dda\u7dad\u5316\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u85ac\u7269\u3092\u7528\u3044\u305f\u691c\u8a3c<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2024 \uff08\u4eac\u90fd\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001P-10\u3001\u8981\u65e8\u96c6p.20\u30012024\u5e748\u670831\u65e5<\/span><\/p><ul><li><p><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif;\"><span style=\"color: #000000;\">\u4f50\u85e4\u84ee\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u91d1\u6ca2\u8cb4\u61b2\u3001\u82b9\u6ca2\u672a\u6765<\/span><span style=\"color: #000000;\">\u3001\u5927\u5ca1\u592e\u3001\u5c71\u53e3\u6843\u751f\u3001\u5c3e\u718a\u8cb4\u4e4b\u3001\u8fd1\u85e4\u5553\u3001<\/span><span style=\"color: #000000;\">\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u3078\u306e\u85ac\u7269\u9001\u9054\u3092\u76ee\u6307\u3057\u305f\u81b5\u5cf6\u96c6\u7a4d\u578b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u958b\u767a\u7814\u7a76<\/span><\/span><\/p><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2024 \uff08\u4eac\u90fd\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001P-22\u3001\u8981\u65e8\u96c6p.94 \u30012024\u5e748\u670831\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5c71\u53e3\u6843\u751f\u3001\u77f3\u5ddd\u667a\u4e45\uff1aMASH\u30c8\u30ea\u30ac\u30fc\u30b7\u30b0\u30ca\u30eb\u3068\u3057\u3066\u306e\u809d\u81d3\u30a2\u30c7\u30ce\u30b7\u30f3\u52d5\u614b\u3092\u6a19\u7684\u3068\u3057\u305f\u809d\u661f\u7d30\u80de\u6d3b\u6027\u5316\u5236\u5fa1\u3010\u62db\u5f85\u8b1b\u6f14\u3011<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2024\uff08\u4eac\u90fd\uff09\u3001S3-2\u30012024\u5e748\u670829\u201330\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u9234\u6728\u5065\u8cc7\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u5927\u5ca1\u592e\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u7dda\u7dad\u5316\u3092\u4fc3\u9032\u3055\u305b\u308b\u809d\u661f\u7d30\u80dePRMT5 \u306e\u5f79\u5272<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt; text-align: right;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2024\uff08\u4eac\u90fd\uff09\u3001P7-7\u30012024\u5e748\u670829\u201330\u65e5<\/span><\/p><ul><li><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif;\"><span style=\"color: #000000;\">\u4f50\u85e4\u84ee\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u91d1\u6ca2\u8cb4\u61b2\u3001\u82b9\u6ca2\u672a\u6765<\/span><span style=\"color: #000000;\">\u3001\u5927\u5ca1\u592e\u3001\u5c71\u53e3\u6843\u751f\u3001\u5c3e\u718a\u8cb4\u4e4b\u3001\u8fd1\u85e4\u5553\u3001<\/span><span style=\"color: #000000;\">\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u3078\u306e\u85ac\u7269\u9001\u9054\u3092\u76ee\u6307\u3057\u305f\u81b5\u5cf6\u96c6\u7a4d\u578b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u958b\u767a\u7814\u7a76<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2024\uff08\u4eac\u90fd\uff09\u3001P6-3\u30012024\u5e748\u670829\u201330\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">Mikana Sugimori, Yukiko K. Kaneko, Megumi Kaji, Ran Kano, Yoshiki Maeda, Tomohisa Ishikawa: Evaluation of anti-diabetic effects of flavonoids from citrus peels in INS-1 \u03b2-cells. OP1 . <\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">5th Bandung-Shizuoka Food and Pharma Conference (Shizuoka, \u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u30012024\u5e748\u670827\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5c71\u53e3\u6843\u751f\uff1a\u809d\u661f\u7d30\u80de\u6d3b\u6027\u5316\u6291\u5236\u3092\u6a19\u7684\u3068\u3057\u305f\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3010\u53d7\u8cde\u8b1b\u6f14\u3011<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c70\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5927\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u30012024\u5e747\u67086\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\"><span style=\"color: #000000;\">\u9234\u6728\u5065\u8cc7\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u5927\u5ca1\u592e\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a<\/span>\u809d\u7dda\u7dad\u5316\u3092\u4fc3\u9032\u3055\u305b\u308b\u30a2\u30eb\u30ae\u30cb\u30f3\u30e1\u30c1\u30eb\u57fa\u8ee2\u79fb\u9175\u7d20<span class=\"s1\">PRMT5<\/span>\u306e\u5f79\u5272<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c70\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5927\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u30012024\u5e747\u67086\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u9234\u6728\u5065\u8cc7\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u5927\u5ca1\u592e\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u7dda\u7dad\u5316\u767a\u75c7\u306b\u304a\u3051\u308b PRMT5 \u306e\u5f79\u5272<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c150\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001C-3-6\u30012024\u5e746\u670829\u65e5<\/span><\/p><ul><li><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">Takanori Kanazawa, Takayuki Oguma, Yukiko K. Kaneko, Ren Sato, Akira Ooka, Momoka Yamaguchi, Tomohisa Ishikawa, Hiromu Kondo: Effects of phospholipid components and particle size on distribution of lipid nanoparticles in vivo and in pancreatic islet.<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">18th LIPOSOME RESEARCH DAYS 2024, Glasgow Scotland, June 26 to29, 2024<\/span><\/p><ul><li><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif;\"><span style=\"color: #000000;\"><span style=\"color: #000000;\">\u5927\u5ca1 \u592e\u3001\u5c71\u53e3 \u6843\u751f\u3001\u9577\u6fa4 \u67da\u5e0c\u3001\u672c\u6a4b \u5357\u5948\u5b9f\u3001\u5c71\u4e0b \u8ce2\u4e8c\u3001\u6ff1\u5cf6 \u7fa9\u9686\u3001\u9f4a\u85e4 \u771f\u4e5f\u3001\u77f3\u5ddd \u667a\u4e45\uff1a<\/span>\u809d\u661f\u7d30\u80de\u306e\u5206\u5316\u8ee2\u63db\u8abf\u7bc0\u85ac\u306e\u69cb\u9020\u306b\u57fa\u3065\u3044\u305f\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u6a19\u7684\u306e\u63a2\u7d22<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u56de\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u300129-416-am05S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a260\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.105\u30012024\u5e743\u670830\u65e5<\/span><\/p><ul><li><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u6749\u68ee \u4ec1\u594f\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u68b6 \u840c\u3001\u72e9\u91ce \u862d\u3001\u524d\u7530 \u826f\u898f\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u5bfe\u3059\u308b\u67d1\u6a58\u679c\u76ae\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u304a\u3088\u3073\u95a2\u9023\u8a98\u5c0e\u4f53\u306e\u6297\u7cd6\u5c3f\u75c5\u6d3b\u6027\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u56de\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u300131-211-am09S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a260\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.111\u30012024\u5e743\u670831\u65e5<\/span><\/p><ul><li><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u00a0<span style=\"color: #000000;\">\u6e21\u9089 \u76f4\u4e5f\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u77f3\u539f \u5bff\u5149\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b6\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"font-size: 12pt; font-family: arial, helvetica, sans-serif;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c144\u56de\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u300130-412-pm02S\u3001<\/span><span style=\"color: #000000;\">\u30d5\u30a1\u30eb\u30de\u30b7\u30a260\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.109\u30012024\u5e743\u670830\u65e5<\/span><\/span><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2224\" aria-expanded=\"false\">2023<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2224\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2224\" tabindex=\"0\" hidden=\"hidden\"><ul><li><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">Stella Amarachi Ihim, Yukiko K. Kaneko, Moe Yamamoto, Tomohisa Ishikawa\uff1aInsulin secretory and anti-apoptotic effect of apigenin on INS-ID pancreatic \u03b2-cell<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c97\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\u30fb\u7b2c44\u56de\u65e5\u672c\u81e8\u5e8a\u85ac\u7406\u5b66\u4f1a\u5b66\u8853\u7dcf\u4f1a\uff08\u795e\u6238\uff09\u3001<span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt; text-align: right;\">1-B-YIA1-5\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.\u30012023\u5e7412\u670814\u201316\u65e5<\/span><\/span><\/p><ul><li style=\"text-align: left;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">Watanabe Yuta\uff0cMomoka Yamaguchi\uff0cNaoki Dohi\uff0cAkira Ooka\uff0cShin-ya Saito\uff0cTomohisa Ishikawa\uff1aInvolvement of NRF2 transcription activity in prostaglandin E<sub>2<\/sub>-induced facilitation of the inhibitory effect of caffeine on hepatic stellate cell activation.<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c97\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\u30fb\u7b2c44\u56de\u65e5\u672c\u81e8\u5e8a\u85ac\u7406\u5b66\u4f1a\u5b66\u8853\u7dcf\u4f1a\uff08\u795e\u6238\uff09\u3001<span style=\"text-align: right;\">1-B-SS01-3\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.144\u30012023\u5e7412\u670814\u65e5<\/span><\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">Akira Ooka, Momoka Yamaguchi, Yuzuki Nagasawa, Kenji Yamashita, Kaori Inamura, Makoto Inai, Shin-ya Saito, Yoshitaka Hamashima, Tomohisa Ishikawa\uff1aExploration of signaling molecules involved in the reversion of activated hepatic stellate cells utilizing structural modification of small molecule compounds<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c97\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\u30fb\u7b2c44\u56de\u65e5\u672c\u81e8\u5e8a\u85ac\u7406\u5b66\u4f1a\u5b66\u8853\u7dcf\u4f1a\uff08\u795e\u6238\uff09\u3001<span style=\"text-align: right;\">1-B-SS02-3\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.145\u30012023\u5e7412\u670814\u65e5<\/span><\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1aGDP\u578bRab27a\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5f8c\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c46\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a\uff08\u795e\u6238\uff09\u30012P-378\u3001<span style=\"text-align: right;\">2023\u5e7412\u67086\u65e5\u20138\u65e5<\/span><\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u67f4\u7530\u6dbc\u543e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u5c71\u53e3\u6843\u751f\u3001\u68ee\u91ce\u7d14\u9234\u3001\u91d1\u6ca2\u8cb4\u61b2\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u690d\u7269\u7531\u6765\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u69d8\u30ca\u30ce\u7c92\u5b50\u304c\u81b5\u03b2\u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306e\u691c\u8a0e<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a2023\u3001N-5\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u8b1b\u6f14\u8981\u65e8\u96c6\u00a0 p.199\uff08\u540d\u53e4\u5c4b\uff092023\u5e7411\u670812\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6e21\u8fba\u96c4\u592a\u3001\u5c71\u53e3\u6843\u751f\u3001\u571f\u80a5\u76f4\u8cb4\u3001\u5927\u5ca1\u592e\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1aProstaglandin E<sub>2<\/sub>\u3068Caffeine\u5171\u51e6\u7f6e\u306b\u3088\u308bp62\u306e\u30ea\u30f3\u9178\u5316\u304a\u3088\u3073\u51dd\u96c6\u4f53\u5f62\u6210\u306e\u4fc3\u9032\u306fNRF2\u306e\u8ee2\u5199\u4ea2\u9032\u3092\u8a98\u5c0e\u3057\u3066\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a2023\u3001N-4\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u8b1b\u6f14\u8981\u65e8\u96c6\u00a0 p.198\uff08\u540d\u53e4\u5c4b\uff092023\u5e7411\u670812\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u82b9\u6fa4\u672a\u6765\u3001\u91d1\u6ca2\u8cb4\u61b2\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u4f50\u85e4\u84ee\u3001\u5927\u5ca1\u592e\u3001\u5c71\u53e3\u6843\u751f\u3001\u98ef\u5ca1\u771f\u543e\u3001\u5c3e\u718a\u8cb4\u4e4b\u3001\u77f3\u5ddd\u667a\u4e45\u3001\u8fd1\u85e4\u5553\uff1a\u9759\u8108\u6295\u4e0e\u306b\u3088\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u81b5\u5cf6\u5206\u5e03\u7279\u6027\u306b\u53ca\u307c\u3059\u30ea\u30f3\u8102\u8cea\u304a\u3088\u3073\u7c92\u5b50\u5f84\u306e\u5f71\u97ff<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a2023\u3001K-23\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u8b1b\u6f14\u8981\u65e8\u96c6\u00a0 p.185\uff08\u540d\u53e4\u5c4b\uff092023\u5e7411\u670812\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6e21\u9089\u76f4\u4e5f\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u539f\u5bff\u5149\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u03b2\u7d30\u80de\u306b\u767a\u73fe\u3059\u308bDGK\u03b6\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u4fc3\u9032\u56e0\u5b50\u3067\u3042\u308b<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c96\u56de\u65e5\u672c\u751f\u5316\u5b66\u4f1a\u5927\u4f1a\uff08\u798f\u5ca1\uff09\u30011P-072\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.126\u30012023\u5e7410\u670831\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1aGDP\u578bRab27a\u304c\u5236\u5fa1\u3059\u308b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c96\u56de\u65e5\u672c\u751f\u5316\u5b66\u4f1a\u5927\u4f1a\uff08\u798f\u5ca1\uff09\u30011P-272\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.141\u30012023\u5e7410\u670831\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6e21\u8fba\u3042\u3086\u307f\u3001\u6728\u6751\u4fca\u79c0\u3001\u5c0f\u5bfa\u8061\u56db\u6717\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5f8c\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c96\u56de\u65e5\u672c\u751f\u5316\u5b66\u4f1a\u5927\u4f1a(\u798f\u5ca1)\u30011P-529\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.160\u30012023\u5e7410\u670831\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u671b\u6708\u53cb\u83dc\u3001\u6728\u6751\u4fca\u79c0\u3001\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u77f3\u5ddd\u667a\u4e45\uff1aGDP\u578bG\u30bf\u30f3\u30d1\u30af\u8cea\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u306e\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c96\u56de\u65e5\u672c\u751f\u5316\u5b66\u4f1a\u5927\u4f1a\uff08\u798f\u5ca1\uff09\u30012P-365\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.199\u30012023\u5e7410\u670831\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u4f50\u85e4\u84ee\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u91d1\u6ca2\u8cb4\u61b2\u3001\u82b9\u6fa4\u672a\u6765\u3001\u5927\u5ca1\u592e\u3001\u5c71\u53e3\u6843\u751f\u3001\u771f\u91ce\u7d50\u5948\u3001\u98ef\u5ca1\u771f\u543e\u3001\u5c3e\u718a\u8cb4\u4e4b\u3001\u8fd1\u85e4\u5553\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u5cf6\u306b\u96c6\u7a4d\u3059\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u305f\u30ea\u30f3\u8102\u8cea\u306e\u7d44\u6210\u304a\u3088\u3073\u7c92\u5b50\u5f84\u306e\u691c\u8a0e<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c44\u56de\u751f\u4f53\u819c\u3068\u85ac\u7269\u306e\u76f8\u4e92\u4f5c\u7528\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff08\u798f\u5ca1\uff09\u3001P12\u3001\u8b1b\u6f14\u8981\u65e8\u96c6 p.111\u30012023\u5e7410\u670819\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u68ee\u91ce\u7d14\u9234\u3001\u5c71\u53e3\u6843\u751f\u3001\u5ca1\u90e8\u78e8\u5e78\u3001\u6cb3\u5408\u4f51\u7f8e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u67f4\u7530\u6dbc\u543e\u3001\u5927\u5ca1\u592e\u3001\u91d1\u6ca2\u8cb4\u61b2\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u690d\u7269\u7531\u6765\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u69d8\u30ca\u30ce\u7c92\u5b50\u304c\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u5236\u5fa1\u304a\u3088\u3073\u7d30\u80de\u3078\u306e\u53d6\u308a\u8fbc\u307f\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c44\u56de\u751f\u4f53\u819c\u3068\u85ac\u7269\u306e\u76f8\u4e92\u4f5c\u7528\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff08\u798f\u5ca1\uff09\u3001P11\u3001\u8b1b\u6f14\u8981\u65e8\u96c6 p.110\u30012023\u5e7410\u670819\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">Takayuki Oguma\uff0cTakanori Kanazawa, Yukiko K. Kaneko\uff0cRen Sato\uff0cMiku Serizawa\uff0cAkira Ooka\uff0cMomoka Yamaguchi\uff0cYuuna Mano\uff0cShingo Iioka\uff0cTomohisa Ishikawa\uff0cHiromu Kondo\uff1aEffects of in vivo distribution kinetics and intrapancreatic islet distribution of Lipid nanoparticles by their phospholipid components and particle size<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u85ac\u7269\u52d5\u614b\u5b66\u4f1a\u7b2c<span lang=\"EN-US\" style=\"text-align: right;\">38<\/span><span style=\"text-align: right;\">\u56de\u5e74\u4f1a \u7b2c<\/span><span lang=\"EN-US\" style=\"text-align: right;\">23<\/span><span style=\"text-align: right;\">\u56de\u30b7\u30c8\u30af\u30ed\u30e0<\/span><span lang=\"EN-US\" style=\"text-align: right;\">P450<\/span><span style=\"text-align: right;\">\u56fd\u969b\u4f1a\u8b70 \u56fd\u969b\u5408\u540c\u5927\u4f1a\uff08\u9759\u5ca1\uff09\u30012023\u5e749\u670825-29\u65e5<\/span><\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">Yuta Watanabe\u3001Momoka Yamaguchi, Takanori Kanazawa, Sumire Morino, Shingo Iioka, Naoki Dohi, Kenjirou Higashi, Hiromo Kondo, Tomohisa Ishikawa:Treatment of hepatocytes with palmitic acid induces the release of extracellular vesicles with tropism to activated hepatic stellate cells<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u85ac\u7269\u52d5\u614b\u5b66\u4f1a\u7b2c<span lang=\"EN-US\">38<\/span>\u56de\u5e74\u4f1a \u7b2c<span lang=\"EN-US\">23<\/span>\u56de\u30b7\u30c8\u30af\u30ed\u30e0<span lang=\"EN-US\">P450<\/span>\u56fd\u969b\u4f1a\u8b70 \u56fd\u969b\u5408\u540c\u5927\u4f1a\uff08\u9759\u5ca1\uff09<span style=\"text-align: right;\">\u30012023\u5e749\u670825-29\u65e5<\/span><\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\"><span dir=\"ltr\" role=\"presentation\">\u5c71\u53e3 \u6843\u751f\u3001\u5927\u5ca1\u592e\u3001\u77f3\u5ddd\u667a\u4e45<\/span><span dir=\"ltr\" role=\"presentation\">\uff1a<\/span>\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3092\u30ea\u30fc\u30c9\u5316\u5408\u7269\u3068\u3057\u305f\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u6a19\u7684\u306e\u63a2\u7d22<span dir=\"ltr\" role=\"presentation\">\u3010\u4f9d\u983c\u8b1b\u6f14\u3011<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u9759\u5ca1\u770c\u5927\u5b66\u7814\u7a76\u9023\u643a\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff08UniCReSS\uff092023\uff08\u9759\u5ca1\uff09\u30012023\u5e748\u670829\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5927\u5ca1 \u592e\u3001\u5c71\u53e3 \u6843\u751f\u3001\u5c71\u4e0b \u8ce2\u4e8c\u3001\u9f4a\u85e4 \u771f\u4e5f\u3001\u6ff1\u5cf6 \u7fa9\u9686\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u4f4e\u5206\u5b50\u5316\u5408\u7269<span dir=\"ltr\" role=\"presentation\">DIF-1<\/span> <span dir=\"ltr\" role=\"presentation\">\u306b<\/span><span dir=\"ltr\" role=\"presentation\">\u3088\u308b\u6297\u809d\u7dda\u7dad\u5316\u4f5c\u7528\u306e\u89e3\u6790<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 <span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">2023<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\uff08\u5fb3\u5cf6\uff09<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\u3001<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">P35<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 <\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">p25<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\u3001<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">2023<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\u5e74<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">8<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\u6708<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">26<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\u65e5<\/span><\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6e21\u8fba \u96c4\u592a\uff0c\u571f\u80a5 \u76f4\u8cb4\uff0c\u5c71\u53e3 \u6843\u751f\uff0c\u5927\u5ca1 \u592e,\u9f4a\u85e4 \u771f\u4e5f\uff0c\u77f3\u5ddd \u667a\u4e45\uff1aProstaglandin E<sub>2<\/sub>\u3068Caffeine\u306e\u4f75\u7528\u306fNRF2\u306e\u8ee2\u5199\u4ea2\u9032\u3092\u4ecb\u3057\u3066\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02023\uff08\u5fb3\u5cf6\uff09\u3001P-18\u3001\u8981\u65e8\u96c6p74\u30012023\u5e748\u670826\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u67f4\u7530\u6dbc\u543e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u5c71\u53e3\u6843\u751f\u3001\u68ee\u91ce\u7d14\u9234\u3001\u91d1\u6ca2\u8cb4\u61b2\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5 \u03b2 \u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u5bfe\u3059\u308b\u690d\u7269\u7531\u6765\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u69d8\u30ca\u30ce\u7c92\u5b50\u306e\u52b9\u679c\u306e\u691c\u8a3c<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02023\uff08\u5fb3\u5cf6\uff09\u3001P-8\u3001\u8981\u65e8\u96c6p64\u30012023\u5e748\u670826\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7530\u9089\u7965\u592a\u3001\u5c71\u53e3\u6843\u751f\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u6e21\u9089\u76f4\u4e5f\u3001\u67f4\u7530\u6dbc\u543e\u3001\u5927\u5ca1\u592e\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5 \u03b2 \u7d30\u80de\u7531\u6765\u56e0\u5b50\u306e\u5909\u5316\u304c NASH \u9032\u5c55\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2023 \uff08\u5fb3\u5cf6\uff09\u3001P-7\u3001\u8981\u65e8\u96c6p63\u30012023\u5e748\u670826\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5927\u5ca1 \u592e\u3001\u5c71\u53e3 \u6843\u751f\u3001\u5c71\u4e0b \u8ce2\u4e8c\u3001\u9f4a\u85e4 \u771f\u4e5f\u3001\u6ff1\u5cf6 \u7fa9\u9686\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u4f4e\u5206\u5b50\u5316\u5408\u7269<span dir=\"ltr\" role=\"presentation\">DIF-1<\/span> <span dir=\"ltr\" role=\"presentation\">\u306b<\/span><span dir=\"ltr\" role=\"presentation\">\u3088\u308b\u6297\u809d\u7dda\u7dad\u5316\u4f5c\u7528\u306e\u89e3\u6790<\/span><\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 <span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">2023<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\uff08\u5fb3\u5cf6\uff09\u3001<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">P38-H<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u8981\u65e8\u96c6<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">p83<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\u3001<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">2023<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\u5e74<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">8<\/span><span dir=\"ltr\" style=\"text-align: right;\" role=\"presentation\">\u670824\u201325\u65e5<\/span><\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6e21\u8fba \u96c4\u592a\uff0c\u571f\u80a5 \u76f4\u8cb4\uff0c\u5c71\u53e3 \u6843\u751f\uff0c\u5927\u5ca1 \u592e,\u9f4a\u85e4 \u771f\u4e5f\uff0c\u77f3\u5ddd \u667a\u4e45\uff1aProstaglandin E<sub>2<\/sub>\u3068Caffeine\u306e\u4f75\u7528\u306fNRF2\u306e\u8ee2\u5199\u4ea2\u9032\u3092\u4ecb\u3057\u3066\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02023\uff08\u5fb3\u5cf6\uff09\u3001P31-E\u3001\u8981\u65e8\u96c6p40\u30012023\u5e748\u670824\u201325\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7530\u9089\u7965\u592a\u3001\u5c71\u53e3\u6843\u751f\u3001\u6e21\u9089\u76f4\u4e5f\u3001\u67f4\u7530\u6dbc\u543e\u3001\u5927\u5ca1\u592e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5 \u03b2 \u7d30\u80de\u7531\u6765\u56e0\u5b50\u306e\u5909\u5316\u304c NASH \u9032\u5c55\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 2023\uff08\u5fb3\u5cf6\uff09\u3001P30-F\u30012023\u5e748\u670824\u201325\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">Akira Ooka, Momoka Yamaguchi, Nanami Motohashi, Shin-ya Saito, Tomohisa Ishikawa\uff1aAnalysis of the mechanism underlying the DIF-1 effect on HSCs transdifferentiation<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">the 19th World Congress of Basic and Clinical Pharmacology (WCP2023)\uff08Glasgow\uff09\u3001P1029\u30012023\u5e747\u67086\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">Momoka Yamaguchi, Naoki Dohi, Yuta Watanabe, Akira Ooka, Shin-ya Saito, Tomohisa Ishikawa\uff1aInhibition of adenosine receptors induces the inversion of prostaglandin E<sub>2<\/sub> effects on hepatic stellate cell activation<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">the 19th World Congress of Basic and Clinical Pharmacology (WCP2023)\uff08Glasgow\uff09\u3001OC153\u30012023\u5e747\u67085\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">Stella Amarachi Ihim, Yukiko K. Kaneko, Moe Yamamoto, Tomohisa Ishikawa\uff1aInsulin-secretory and anti-apoptotic effects of apigenin in INS-ID pancreatic \u03b2-cells<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">International Diabetes Federation Western Pacific Region Congress 2023\uff08Kyoto\uff09\u3001WPCS-14-8\u30012023\u5e747\u670823\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u68b6\u840c\u3001\u91d1\u5b50\u96ea\u5b50\u3001Ihim Stella\u3001\u72e9\u91ce\u862d\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30b7\u30fc\u30af\u30ef\u30fc\u30b5\u30fc\u679c\u76ae\u62bd\u51fa\u7269\u306e\u7d4c\u53e3\u6442\u53d6\u306f\u30de\u30a6\u30b9\u81b5\u03b2\u7d30\u80de\u91cf\u4fdd\u6301\u306b\u3088\u308b\u6297\u7cd6\u5c3f\u75c5\u52b9\u679c\u3092\u793a\u3059<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c148\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u5343\u8449\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001C-2-4\u30012023\u5e746\u670817\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u6e21\u9089\u76f4\u4e5f\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u539f\u5bff\u5149\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306e\u6838\u5185\u306b\u304a\u3051\u308b\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b6\u306e\u6a5f\u80fd\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c66\u56de\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a\uff08\u9e7f\u5150\u5cf6\uff09\u3001\u53e3\u6f1455\u30012023\u5e745\u670811\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5c71\u53e3\u6843\u751f\u3001\u5927\u5ca1\u592e\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u69cb\u9020\u6d3b\u6027\u76f8\u95a2\u3092\u30d9\u30fc\u30b9\u3068\u3057\u305f\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u6a19\u7684\u5206\u5b50\u306e\u63a2\u7d22\u3010\u62db\u5f85\u8b1b\u6f14\u3011<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c143\u56de\u5e74\u4f1a\uff08\u672d\u5e4c\uff09\u3001S52-05\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a259\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.77\u30012023\u5e743\u670828\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u91d1\u5b50 \u96ea\u5b50\u3001\u68ee\u9ebb\u7f8e\uff1a\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u65b0\u305f\u306a\u4e88\u9632\u30fb\u6cbb\u7642\u6cd5\u306e\u5275\u51fa\u3092\u76ee\u6307\u3057\u305f\u6b21\u4e16\u4ee3\u82e5\u624b\u7814\u7a76\u8005\u306b\u3088\u308b\u7814\u7a76\u5c55\u958b\u3010\u62db\u5f85\u8b1b\u6f14\u3011<\/span><\/li><\/ul><p><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c143\u56de\u5e74\u4f1a\uff08\u672d\u5e4c\uff09\u3001\u4e00\u822c\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 S52\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a259\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.77\u30012023\u5e743\u670828\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7530\u57ce \u771f\u5e06\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u6e21\u9089 \u76f4\u4e5f\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u9ad8\u7cd6\u6761\u4ef6\u4e0b\u3067\u306eDDAH2\u767a\u73fe\u4f4e\u4e0b\u306b\u3088\u308bADMA\u84c4\u7a4d\u306f\u81b5\u03b2\u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u4fc3\u9032\u3055\u305b\u308b<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c143\u56de\u5e74\u4f1a\uff08\u672d\u5e4c\uff09\u300127P1-pm2-132S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a259\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.194\u30012023\u5e743\u670827\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5ca1\u90e8 \u78e8\u5e78\u3001\u5c71\u53e3 \u6843\u751f\u3001\u5927\u5ca1 \u592e\u3001\u68ee\u91ce \u7d14\u9234\u3001\u67f4\u7530 \u6dbc\u543e\u3001\u91d1\u6ca2 \u8cb4\u61b2\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306b\u5bfe\u3059\u308b\u690d\u7269\u7531\u6765\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\u69d8\u30ca\u30ce\u7c92\u5b50\u306e\u4f5c\u7528\u89e3\u6790<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c143\u56de\u5e74\u4f1a\uff08\u672d\u5e4c\uff09\u300126P2-pm1-039S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a259\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.185\u30012023\u5e743\u670826\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5927\u5ca1 \u592e\u3001\u5c71\u53e3 \u6843\u751f\u3001\u9577\u6fa4 \u67da\u5e0c\u3001\u672c\u6a4b \u5357\u5948\u5b9f\u3001\u5c71\u4e0b \u8ce2\u4e8c\u3001\u6ff1\u5cf6 \u7fa9\u9686\u3001\u9f4a\u85e4 \u771f\u4e5f\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u809d\u661f\u7d30\u80de\u306e\u5206\u5316\u8ee2\u63db\u8abf\u7bc0\u85ac\u306e\u69cb\u9020\u306b\u57fa\u3065\u3044\u305f\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u6a19\u7684\u306e\u63a2\u7d22<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c143\u56de\u5e74\u4f1a\uff08\u672d\u5e4c\uff09\u300126P2-pm1-005S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a259\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.184\u30012023\u5e743\u670826\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">Ihim Stella\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u5c71\u672c \u840c\u7d75\u3001\u65e9\u5ddd \u7531\u771f\u3001\u4fdd\u5742 \u5353\u81e3\u3001\u77f3\u5ddd \u667a\u4e45\uff1a Investigation of the anti-diabetic effect of apigenin on the function of INS-ID pancreatic \u03b2-cell<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c147\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\u3001\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u958b\u50ac\uff09\u3001D-02\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.57\u30012023\u5e743\u670821\u65e5<\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u5927\u5ca1 \u592e\u3001\u5c71\u53e3 \u6843\u751f\u3001\u9577\u6fa4 \u67da\u5e0c\u3001\u5c71\u4e0b \u8ce2\u4e8c\u3001\u672c\u6a4b \u5357\u5948\u5b9f\u3001\u9f4a\u85e4 \u771f\u4e5f\u3001\u6ff1\u5cf6 \u7fa9\u9686\u3001\u77f3\u5ddd \u667a\u4e45\uff1aExploration of therapeutic targets for liver fibrosis based on the structure of transdifferentiation regulators of hepatic stellate cells: \u6297\u809d\u7dda\u7dad\u5316\u4f5c\u7528\u3092\u6709\u3059\u308b\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306e\u6a19\u7684\u5206\u5b50\u306e\u63a2\u7d22<\/span><\/li><\/ul><p style=\"text-align: right;\"><span style=\"color: #000000; font-size: 12pt; font-family: arial, helvetica, sans-serif;\">\u7b2c147\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\u3001\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u958b\u50ac\uff09\u3001C-09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u8981\u65e8\u96c6 p.54\u30012023\u5e743\u670821\u65e5<\/span><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2225\" aria-expanded=\"false\">2022<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2225\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2225\" tabindex=\"0\" hidden=\"hidden\"><div class=\"c-message_kit__blocks c-message_kit__blocks--rich_text\"><div class=\"c-message__message_blocks c-message__message_blocks--rich_text\" data-qa=\"message-text\"><div class=\"p-block_kit_renderer\" data-qa=\"block-kit-renderer\"><div class=\"p-block_kit_renderer__block_wrapper p-block_kit_renderer__block_wrapper--first\"><div class=\"p-rich_text_block\" dir=\"auto\"><p><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u6e21\u9089\u76f4\u4e5f\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b6\u306e\u81b5\u03b2\u7d30\u80de\u5185\u5c40\u5728\u3068\u6a5f\u80fd\u306e\u95a2\u9023\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u7b2c96\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u30014-B-P-318\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.340\u30012022\u5e7412\u67083\u65e5<\/span><\/p><p><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1aGDP\u578bRab27a\u304c\u5236\u5fa1\u3059\u308b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u7b2c45\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a\uff08\u5e55\u5f35\uff09\u30013P-068\u30012022\u5e7412\u67082\u65e5<\/span><\/p><div><div><p style=\"text-align: left;\"><span id=\"page53R_mcid212\" class=\"markedContent\" style=\"color: #000000;\"><span dir=\"ltr\" role=\"presentation\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif;\">\u4f50\u7af9\u826f\u592a\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45:\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308bG\u03b1\u306e\u6a5f\u80fd\u89e3\u6790<\/span><\/span><\/span><\/p><p style=\"text-align: right;\"><span id=\"page53R_mcid212\" class=\"markedContent\" style=\"color: #000000;\"><span dir=\"ltr\" role=\"presentation\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif;\">\u7b2c45\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a(\u5e55\u5f35)\u30012P-259\u30012022\u5e7412\u67081\u65e5<\/span><\/span><\/span><\/p><p><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u68b6\u840c\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u81b5\u03b2\u7d30\u80de\u306b\u5bfe\u3059\u308b\u6297\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u4f5c\u7528\u6a5f\u5e8f\u306e\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u7b2c96\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u30012-B-SS12-1\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.193\u30012022\u5e7412\u67081\u65e5<\/span><\/p><p><span style=\"color: #000000; font-size: 14pt;\">\u9ad9\u6a4b\u4eae\u6c70\u3001\u5c71\u53e3\u6843\u751f\u3001\u68ee\u91ce\u7d14\u9234\u3001\u5ca1\u90e8\u78e8\u5e78\u3001\u5927\u5ca1\u592e\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u7dda\u7dad\u5316ex vivo\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u6297\u7dda\u7dad\u5316\u6d3b\u6027\u8a55\u4fa1\u7cfb\u306e\u78ba\u7acb<\/span><\/p><p style=\"text-align: right;\"><span id=\"page53R_mcid212\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\"><span style=\"font-size: 14pt; 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font-family: arial, helvetica, sans-serif; color: #000000;\">\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1aGDP\u578bRab27a\u304c\u5236\u5fa1\u3059\u308b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u7b2c95\u56de\u65e5\u672c\u751f\u5316\u5b66\u4f1a\u5927\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u30012P-216\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.174\u30012022\u5e7411\u670810\u65e5<\/span><\/p><p><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u5c71\u53e3\u6843\u751f\u3001\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5927\u5ca1\u592e\u3001\u571f\u80a5\u76f4\u8cb4\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30a2\u30eb\u30ae\u30cb\u30f3\u30e1\u30c1\u30eb\u57fa\u8ee2\u79fb\u9175\u7d20PRMT5\u306f\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u809d\u7dda\u7dad\u5316\u3092\u4fc3\u9032\u6027\u306b\u5236\u5fa1\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8 \u5408\u540c\u5b66\u8853\u5927\u4f1a2022\uff08\u9759\u5ca1\uff09\u3001J-18\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.45\u30012022\u5e7411\u67086\u65e5<\/span><\/p><p><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5927\u5ca1\u592e\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1aPRMT5\u6b20\u640d\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u809d\u7dda\u7dad\u5316\u767a\u75c7\u6291\u5236\u6a5f\u69cb\u306e\u89e3\u660e<span class=\"Apple-converted-space\">\u00a0<\/span><\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u9759\u5ca1\u5b9f\u9a13\u52d5\u7269\u7814\u7a76\u4f1a\u4ee4\u548c4\u5e74\u5ea6\u5927\u4f1a\uff08\u9759\u5ca1\uff09\u3001\u6f14\u984c\uff11\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.5\u30012022\u5e7410\u670828\u65e5<\/span><\/p><p><span style=\"font-size: 14pt; color: #000000; font-family: arial, helvetica, sans-serif;\">\u68ee\u91ce\u7d14\u9234\u3001\u5c71\u53e3\u6843\u751f\u3001\u91d1\u6ca2\u8cb4\u61b2\u3001\u98ef\u5ca1\u771f\u543e\u3001\u6771\u9855\u4e8c\u90ce\u3001\u6e21\u8fba\u96c4\u592a\u3001\u571f\u80a5\u76f4\u8cb4\u3001\u8fd1\u85e4\u5553\u3001\u77f3\u5ddd\u667a\u4e45<span class=\"Apple-converted-space\">\uff1a<\/span>\u8102\u80aa\u9178\u66dd\u9732\u304c\u809d\u5b9f\u8cea\u7d30\u80de\u7531\u6765\u7d30\u80de\u5916\u5c0f\u80de\u306e\u6d3b\u6027\u578b\u809d\u661f\u7d30\u80de\u3078\u306e\u53d6\u308a\u8fbc\u307f\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 14pt; color: #000000; font-family: arial, helvetica, sans-serif;\">\u7b2c43\u56de\u751f\u4f53\u819c\u3068\u85ac\u7269\u306e\u76f8\u4e92\u4f5c\u7528\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff08\u672d\u5e4c\uff09\u3001P-01\u3001\u8981\u65e8\u96c6p.93\u30012022\u5e7410\u67086\u65e5<\/span><\/p><p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">\u6e21\u8fba\u96c4\u592a\u3001\u5c71\u53e3\u6843\u751f\u3001\u91d1\u6ca2\u8cb4\u61b2\u3001\u68ee\u91ce\u7d14\u9234\u3001\u98ef\u5ca1\u771f\u543e\u3001\u571f\u80a5\u76f4\u8cb4\u3001\u6771\u9855\u4e8c\u90ce\u3001\u8fd1\u85e4\u5553\u3001\u77f3\u5ddd\u667a\u4e45\uff1a<span id=\"page53R_mcid210\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">\u8102\u80aa\u9178\u66b4\u9732\u306b\u3088\u308a<\/span><\/span><span id=\"page53R_mcid211\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">AML<\/span><span dir=\"ltr\" role=\"presentation\">\u2013<\/span><span dir=\"ltr\" role=\"presentation\">12<\/span><\/span><span id=\"page53R_mcid212\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">\u7d30\u80de\u306f\u6d3b\u6027\u578b\u809d\u661f\u7d30<\/span><span dir=\"ltr\" role=\"presentation\">\u80de\u306b\u6307\u5411\u6027\u3092\u6709\u3059\u308b<\/span><\/span><span id=\"page53R_mcid213\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">EV<\/span><\/span><span id=\"page53R_mcid214\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">\u3092\u653e\u51fa\u3059\u308b<\/span><\/span><\/span><\/p><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; 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color: #000000; font-family: arial, helvetica, sans-serif;\">\u9ad9\u6a4b\u4eae\u6c70\u3001\u5c71\u53e3\u6843\u751f\u3001\u68ee\u91ce\u7d14\u9234\u3001\u5ca1\u90e8\u9ebf\u5e78\u3001\u5927\u5ca1\u592e\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u969c\u5bb3ex vivo\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u5275\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u7cfb\u306e\u69cb\u7bc9<\/span><\/div><div style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02022\u9759\u5ca1\uff08\u9759\u5ca1\u3001\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u958b\u50ac\uff09\u3001F-2\u3001\u8981\u65e8\u96c6 p.100\u30012022\u5e748\u670827\u65e5<\/span><\/div><div>\u00a0<\/div><div>\u00a0<\/div><div>\u00a0<\/div><div><span style=\"font-size: 14pt; color: #000000; font-family: arial, helvetica, sans-serif;\">\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5927\u5ca1\u592e\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30a2\u30eb\u30ae\u30cb\u30f3\u30e1\u30c1\u30eb\u57fa\u8ee2\u79fb\u9175\u7d20PRMT5\u306f\u809d\u7dda\u7dad\u5316\u3092\u4fc3\u9032\u6027\u306b\u5236\u5fa1\u3059\u308b<\/span><\/div><div style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02022\u9759\u5ca1\uff08\u9759\u5ca1\u3001\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u958b\u50ac\uff09\u3001C-4\u3001\u8981\u65e8\u96c6 p.80\u30012022\u5e748\u670827\u65e5<\/span><\/div><\/div><div>\u00a0<\/div><div>\u00a0<\/div><div><span id=\"page72R_mcid0\" class=\"markedContent\" style=\"color: #000000; font-size: 14pt; font-family: arial, helvetica, sans-serif;\"><span dir=\"ltr\" role=\"presentation\">Stella Amarachi Ihim\u3001Yukiko K. Kaneko\u3001Moe Yamamoto\u3001Yuma Hayakawa\u3001Takuomi Hosaka\u3001Koichi Yoshinari\u3001Tomohisa Ishikawa\uff1aInvestigation of the anti-diabetic effect of apigenin on the function of INS-1D pancreatic \u03b2-cell<\/span><\/span><\/div><div><span style=\"font-family: arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02022\u9759\u5ca1\uff08\u9759\u5ca1\u3001\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u958b\u50ac\uff09\u3001B-3-3\u3001\u8981\u65e8\u96c6 p.64\u30012022\u5e748\u670827\u65e5<\/span><\/div><div>\u00a0<\/div><div class=\"p-rich_text_block\" dir=\"auto\"><div>\u00a0<\/div><div>\u00a0<\/div><div style=\"text-align: left;\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u72e9\u91ce\u862d\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u591a\u826f\u52c7\u8f1d\u3001\u5c71\u672c\u840c\u7d75\u3001\u68b6 \u840c\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u67d1\u6a58\u679c\u76ae\u6210\u5206\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u6d3b\u6027\u306e\u6bd4\u8f03\u7814\u7a76<\/span><\/div><div style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02022\u9759\u5ca1\uff08\u9759\u5ca1\u3001\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u958b\u50ac\uff09\u3001P43-G\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.25\u30012022\u5e748\u670825-6\u65e5<\/span><\/div><\/div><div>\u00a0<\/div><div class=\"p-rich_text_block\" dir=\"auto\"><div>\u00a0<\/div><div style=\"text-align: left;\"><span style=\"font-size: 14pt; color: #000000; font-family: arial, 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sans-serif;\">\u5c71\u4e0b\u65e5\u83dc\u5b50\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5927\u5ca1\u592e\u3001\u68ee\u672c\u9054\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30a2\u30eb\u30ae\u30cb\u30f3\u30e1\u30c1\u30eb\u57fa\u8ee2\u79fb\u9175\u7d20PRMT5\u306f\u809d\u7dda\u7dad\u5316\u3092\u4fc3\u9032\u6027\u306b\u5236\u5fa1\u3059\u308b<\/span><\/div><div style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02022\u9759\u5ca1\uff08\u9759\u5ca1\u3001\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u958b\u50ac\uff09\u3001P1-A\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.20\u30012022\u5e748\u670825-6\u65e5<\/span><\/div><div>\u00a0<\/div><div>\u00a0<\/div><div class=\"p-rich_text_section\"><span style=\"color: #000000; font-size: 14pt; font-family: arial, helvetica, sans-serif;\">\u6e21\u9089\u76f4\u4e5f\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304a\u3088\u3073\u81b5\u03b2\u7d30\u80de\u5897\u6b96\u306b\u5bfe\u3059\u308b\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b6\u306e\u6a5f\u80fd\u89e3\u6790<\/span><\/div><div class=\"p-rich_text_section\" style=\"text-align: right;\"><span style=\"color: #000000; font-size: 14pt; font-family: arial, helvetica, sans-serif;\">\u7b2c68\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u7dcf\u4f1a\u30fb\u5927\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u3001E-14S\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.76\u30012022\u5e747\u67089\u65e5<\/span><\/div><div>\u00a0<\/div><\/div><div>\u00a0<\/div><div style=\"text-align: left;\"><span id=\"page72R_mcid0\" class=\"markedContent\" style=\"color: #000000; font-size: 14pt; font-family: arial, helvetica, sans-serif;\"><span dir=\"ltr\" role=\"presentation\">Ihim Stella\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u5c71\u672c\u840c\u7d75\u3001\u77f3\u5ddd\u667a\u4e45\uff1aEvaluation of the anti-diabetic effect of apigenin on INS-1D pancreatic \u03b2 -cell<\/span><\/span><\/div><div style=\"text-align: right;\"><span id=\"page72R_mcid0\" class=\"markedContent\" style=\"color: #000000; font-size: 14pt; font-family: arial, helvetica, sans-serif;\">\u7b2c146\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001O-B-2-5\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.59\u30012022\u5e746\u670818\u65e5<br \/><\/span><\/div><\/div><\/div><div>\u00a0<\/div><div class=\"p-block_kit_renderer\" data-qa=\"block-kit-renderer\"><div class=\"p-block_kit_renderer__block_wrapper p-block_kit_renderer__block_wrapper--first\"><div>\u00a0<\/div><div><span id=\"page236R_mcid0\" class=\"markedContent\" style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\"><span dir=\"ltr\" role=\"presentation\">\u6e21\u9089\u76f4\u4e5f\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b6\u306e\u5c40\u5728\u3068\u6a5f\u80fd\u89e3\u6790<\/span><\/span><\/div><div style=\"text-align: right;\"><span id=\"page72R_mcid0\" class=\"markedContent\" style=\"color: #000000; font-size: 14pt; font-family: arial, helvetica, sans-serif;\">\u7b2c146\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001O-B-2-4\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.58\u30012022\u5e746\u670818\u65e5<\/span><\/div><\/div><\/div><\/div><\/div><p><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u5927\u5ca1 \u592e\u3001\u672c\u6a4b \u5357\u5948\u5b9f\u3001\u5c71\u53e3 \u6843\u751f\u3001\u9f4a\u85e4 \u771f\u4e5f\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u809d\u661f\u7d30\u80de\u306e\u5f62\u8cea\u8ee2\u63db\u3092\u5236\u5fa1\u3059\u308b\u4f4e\u5206\u5b50\u5316\u5408\u7269DIF-1\u306e\u809d\u7dda\u7dad\u5316\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c142\u56de\u5e74\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u3001GS02-5\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a258\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.57\u30012022\u5e743\u670828\u65e5<\/span><\/p><p><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u571f\u80a5\u76f4\u8cb4\u3001\u5c71\u672c\u5f69\u8449\uff1a\u591a\u69d8\u306a\u81d3\u5668\u304b\u3089\u8003\u3048\u308b\u7dda\u7dad\u75c7\u6cbb\u7642\u3078\u306e\u6700\u5148\u7aef\u30a2\u30d7\u30ed\u30fc\u30c1<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c142\u56de\u5e74\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u3001GS02-5\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a258\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.57\u30012022\u5e743\u670828\u65e5<\/span><\/p><p><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u91d1\u5b50\u96ea\u5b50\uff1a<strong><span style=\"color: #339966;\">\u53d7\u8cde\u8b1b\u6f14<\/span><\/strong>\u3000\u81b5\u03b2\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u305f\u306a\u4f5c\u7528\u6a5f\u5e8f\u3092\u6709\u3059\u308b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u958b\u767a\u306b\u5411\u3051\u305f\u85ac\u7406\u7814\u7a76<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c142\u56de\u5e74\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u3001AL-15\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a258\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.25\u30012022\u5e743\u670828\u65e5<\/span><\/p><p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">\u68ee\u91ce \u7d14\u9234\u3001\u5c71\u53e3 \u6843\u751f\u3001\u91d1\u6ca2 \u8cb4\u61b2\u3001\u98ef\u5ca1 \u771f\u543e\u3001\u571f\u80a5 \u76f4\u8cb4\u3001\u8fd1\u85e4 \u5553\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u809d\u5b9f\u8cea\u7d30\u80de\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u7269\u6027\u306a\u3089\u3073\u306b\u809d\u661f\u7d30\u80de\u3078\u306e\u53d6\u308a\u8fbc\u307f\u306e\u8a55\u4fa1<\/span><\/p><p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 14pt; color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c142\u56de\u5e74\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u300127I-am06S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a258\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.103\u30012022\u5e743\u670827\u65e5<\/span><\/p><p><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 14pt;\">\u6e21\u9089\u76f4\u4e5f\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b6\u306e\u81b5\u03b2\u7d30\u80de\u3067\u306e\u5c40\u5728\u304a\u3088\u3073\u6a5f\u80fd\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000; font-family: arial, helvetica, sans-serif; font-size: 14pt;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c142\u56de\u5e74\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u300126PO4-am2-02S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a258\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.144\u30012022\u5e743\u670826\u65e5<\/span><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"6\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2226\" aria-expanded=\"false\">2021<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2226\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2226\" tabindex=\"0\" hidden=\"hidden\"><section class=\"elementor-section elementor-top-section elementor-element elementor-element-650c40d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"650c40d\" data-element_type=\"section\"><div class=\"elementor-container elementor-column-gap-default\"><div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-73001bd\" data-id=\"73001bd\" data-element_type=\"column\"><div class=\"elementor-widget-wrap elementor-element-populated\"><div class=\"elementor-element elementor-element-be96b34 elementor-widget elementor-widget-text-editor\" data-id=\"be96b34\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><p><span dir=\"ltr\" style=\"color: #000000;\" role=\"presentation\">\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u3001\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span dir=\"ltr\" style=\"color: #000000;\" role=\"presentation\">\u7b2c44\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u30011P-0249\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.16\u30012021\u5e7412\u67081\u65e5<\/span><\/p><p><span style=\"color: #000000;\"><span dir=\"ltr\" role=\"presentation\">Akira Ooka, Nanami Motohashi, Momoka Yamaguchi, Sin-ya Saito,<\/span> <span dir=\"ltr\" role=\"presentation\">Tomohisa Ishikawa: <\/span><span dir=\"ltr\" role=\"presentation\">DIF-1, a differentiation-inducing factor from cellular slime mold,<\/span> <span dir=\"ltr\" role=\"presentation\">regulates transdifferentiation of hepatic stellate cells and ameliorates liver<\/span> <span dir=\"ltr\" role=\"presentation\">fibrosis<\/span><\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\"><span dir=\"ltr\" role=\"presentation\">The 26<\/span><sup><span dir=\"ltr\" role=\"presentation\">th<\/span><\/sup><span dir=\"ltr\" role=\"presentation\"> Shizuoka Forum on Health and Longevity<\/span>, 19, <span dir=\"ltr\" role=\"presentation\">p.21<\/span>, <span dir=\"ltr\" role=\"presentation\">2021<\/span> <span dir=\"ltr\" role=\"presentation\">\u5e74<\/span><span dir=\"ltr\" role=\"presentation\">11<\/span> <span dir=\"ltr\" role=\"presentation\">\u6708<\/span><span dir=\"ltr\" role=\"presentation\">26<\/span> <span dir=\"ltr\" role=\"presentation\">\u65e5<\/span><\/span><\/p><p><span style=\"color: #000000;\">Megumi Kaji, Yukiko Kaneko, Yuki Tara, Toshiyuki Kan, Tomohisa Ishikawa: Comparative analysis of anti-diabetic effects of nobiletin and other citrus flavonoids on pancreatic \u03b2-cell function<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">The 26<sup>th<\/sup> Shizuoka Forum on Health and Longevity, 18, p.20, 2021\u5e7411\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u9ad9\u6a4b\u4eae\u6c70\u3001\u5c71\u53e3\u6843\u751f\u3001\u68ee\u91ce\u7d14\u9234\u3001\u672c\u6a4b\u5357\u83dc\u5b9f\u3001\u5927\u5ca1\u592e\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u969c\u5bb3ex vivo\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u809d\u75be\u60a3\u6cbb\u7642\u85ac\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u9759\u5ca1\u5b9f\u9a13\u52d5\u7269\u7814\u7a76\u4f1a \u4ee4\u548c2-3\u5e74\u5ea6\u5927\u4f1a\uff08\u7b2c48\u56de\u7814\u7a76\u767a\u8868\u4f1a\uff09\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff092021\u5e7410\u670829\u65e5<\/span><\/p><p style=\"text-align: left;\"><span style=\"color: #000000;\">\u4f0a\u85e4 \u614e\u609f\u3001\u6728\u6751 \u4fca\u79c0\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308bInsulin receptor related receptor (IRR) \u306e\u6a5f\u80fd\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c145\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u9759\u5ca1\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001P-03\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.51\u30012021\u5e7410\u670809\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6e21\u9089\u76f4\u4e5f\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b6\u306e\u767a\u73fe\u3068\u6a5f\u80fd\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c145\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u9759\u5ca1\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001P-06\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.15\u30012021\u5e7410\u670809\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u4e00\u702c\u5065\u592a\u6717\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u9ad8\u6a4b\u590f\u5b9f\u3001\u516b\u6728\u96c4\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5 \u03b2 \u7d30\u80de\u306b\u304a\u3051\u308b\u598a\u5a20\u671f\u30e1\u30e9\u30c8\u30cb\u30f3\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u95a2\u9023\u5206\u5b50\u306e\u767a\u73fe\u304a\u3088\u3073\u6a5f\u80fd\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c145\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u9759\u5ca1\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001O-13\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p11\u30012021\u5e7410\u67089\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790\u3000<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30db\u309a\u30b7\u3099\u30a6\u30e02021\uff08\u5317\u6d77\u9053\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001P9\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6\u3000p.23\u30012021\u5e748\u670828\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u672c\u6a4b\u5357\u83dc\u5b9f\u3001\u5927\u5ca1\u592e\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u6ff1\u5cf6\u7fa9\u9686\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u4f4e\u5206\u5b50\u5316\u5408\u7269 DIF-1 \u306f\u809d\u7dda\u7dad\u5316\u8cac\u4efb\u7d30\u80de HSC \u306e\u6d3b\u6027\u5316\u3092\u5236\u5fa1\u3057\u6297\u7dda\u7dad\u5316\u4f5c\u7528\u3092\u793a\u3059<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u82e5\u624b\u306e\u305f\u3081\u306e\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02021\uff08\u5317\u6d77\u9053\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001A-3-4*\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.39\u30012021\u5e748\u670828\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\uff1a\u53d7\u8cde\u8b1b\u6f14\u3000\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u958b\u767a\u3092\u6307\u5411\u3057\u305f\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u30fb\u7d30\u80de\u91cf\u5236\u5fa1\u306b\u95a2\u3059\u308b\u7814\u7a76<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02021\uff08\u672d\u5e4c\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff092021\u5e748\u670827\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790\u3000<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30db\u309a\u30b7\u3099\u30a6\u30e02021\uff08\u5317\u6d77\u9053\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001E15\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6\u3000p.25\u30012021\u5e748\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c0f\u5bfa\u8061\u53f2\u6717\u3001\u6728\u6751\u4fca\u79c0\u3001\u77f3\u5ddd\u667a\u4e45\uff1a<span dir=\"ltr\" role=\"presentation\">\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c67\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u7dcf\u4f1a\u30fb\u5927\u4f1a\uff08\u540d\u53e4\u5c4b\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001F5-S\u3001\u8981\u65e8\u96c6p.83\u30012021\u5e747\u67083\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u672c\u6a4b\u00a0\u5357\u83dc\u5b9f\u3001\u5927\u5ca1\u00a0\u592e\u3001\u5c71\u53e3 \u6843\u751f\u3001\u9f4a\u85e4 \u771f\u4e5f\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u5316\u5408\u7269DIF-1\u306e\u809d\u7dda\u7dad\u5316\u8cac\u4efb\u7d30\u80deHSC\u306b\u5bfe\u3059\u308b\u8131\u6d3b\u6027\u5316\u4f5c\u7528\u306e\u89e3\u6790\u304a\u3088\u3073\u809d\u7dda\u7dad\u5316\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b\u5bfe\u3059\u308b\u6297\u7dda\u7dad\u5316\u4f5c\u7528\u306e\u691c\u8a3c<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c144\u56de\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001P-16\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.13\u30012021\u5e746\u67085\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5927\u5ca1 \u592e\u3001\u5c71\u53e3 \u6843\u751f\u3001\u5927\u6797 \u5f69\u3001\u5c71\u4e0b \u65e5\u83dc\u5b50\u3001\u672c\u6a4b \u5357\u83dc\u5b9f\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u6728\u6751 \u4fca\u79c0\u3001\u9f4a\u85e4 \u771f\u4e5f\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u809d\u7dda\u7dad\u5316\u8cac\u4efb\u7d30\u80deHSC\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u7523\u751f\u306b\u5bfe\u3059\u308bharmine\u306e\u4f5c\u7528\u304a\u3088\u3073\u305d\u306e\u6a5f\u5e8f\u306e\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c144\u56de\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u3001P-15\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.12\u30012021\u5e746\u67085\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6e21\u9089\u76f4\u4e5f\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u9752\u5cf6\u80b2\u7f8e\u3001\u5927\u5ddd\u91cc\u685c\u3001\u77f3\u5ddd\u63da\u5b50\u3001\u77f3\u6e21\u5343\u88d5\u3001\u4f50\u85e4\u592a\u6cbb\u3001\u77f3\u5ddd\u667a\u4e45\uff1aDGK\u03b4\u767a\u73fe\u6291\u5236\u306b\u3088\u308b\u81b5\u03b2\u7d30\u80de\u5897\u6b96\u6a5f\u5e8f\u306e\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c141\u56de\u5e74\u4f1a\uff08\u5e83\u5cf6\uff09\u300129V06-am06S\u3001\u30d5\u30a1\u30eb\u30de\u30b7\u30a257\u5dfb2\u53f7 \u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.88\u30012021\u5e743\u670829\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0S05\u751f\u6d3b\u7fd2\u6163\u75c5\u7814\u7a76\u306e\u9032\u5c55\u3068\u5275\u85ac\u3078\u306e\u5c55\u958b\uff1a\u81b5\u03b2\u7d30\u80de\u8102\u8cea\u4ee3\u8b1d\u5206\u5b50\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5236\u5fa1\u304a\u3088\u30732\u578b\u7cd6\u5c3f\u75c5\u75c5\u614b\u5f62\u6210\u3078\u306e\u95a2\u4e0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c141\u5e74\u4f1a\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff092021\u5e743\u670827\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Naoki Dohi, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa: The alternation of adenosine-related genes likely progress HSC activation in inflammatory condition. \u30a2\u30c7\u30ce\u30b7\u30f3\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u5909\u5316\u304c\u708e\u75c7\u6642\u306b\u304a\u3044\u3066\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c94\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac\uff09\u30013-P2-36\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6241\u30012021\u5e743\u670810\u65e5<\/span><\/p><\/div><\/div><\/div><\/div><\/div><\/section><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"7\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2227\" aria-expanded=\"false\">2020<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2227\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2227\" tabindex=\"0\" hidden=\"hidden\"><section class=\"elementor-section elementor-top-section elementor-element elementor-element-678fa10 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"678fa10\" data-element_type=\"section\"><div class=\"elementor-container elementor-column-gap-default\"><div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f5941ec\" data-id=\"f5941ec\" data-element_type=\"column\"><div class=\"elementor-widget-wrap elementor-element-populated\"><div class=\"elementor-element elementor-element-f8c8fc6 elementor-widget elementor-widget-text-editor\" data-id=\"f8c8fc6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><p><span style=\"color: #000000;\">Naoki Dohi, Kyosuke Iwami, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa\uff1aLiver blood flow is regulated by hepatic stellate cells and sympathetic nerve in the sinusoid<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c93\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u8a8c\u4e0a\u958b\u50ac\uff09\u30011-SS-10\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.164\u30012020\u5e743\u670816\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Megumi Kaji, Yukiko Kaneko, Yuki Tara, Moe Yamamoto, Yuki Aoyagi, Kiriko Akiyama, Toshiyuki Kan, Tomohisa Ishikawa\uff1aComparative analysis of anti-diabetic effects of citrus flavonoids on pancreatic \u03b2-cell function<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c93\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u8a8c\u4e0a\u958b\u50ac\uff09\u30011-SS-13\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.165\u30012020\u5e743\u670816\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Oooka Akira, Momoka Yamaguchi, Shohei Furukawa, Shin-ya Saito, Tomohisa Ishikawa\uff1aThe activation of mouse hepatic stellate cells is suppressed by DIF-1, a morphogen produced by cellular slime molds<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c93\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u8a8c\u4e0a\u958b\u50ac\uff09\u30011-SS-41\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.171\u30012020\u5e743\u670816\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Momoka Yamaguchi, Tomoya Morishita, Syn-Ya Saito, Tomohisa Ishikawa\uff1aCaffeine induces the reversion of activated hepatic stellate cells via antagonizing adenosine receptors<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c93\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u8a8c\u4e0a\u958b\u50ac\uff09\u30012-O-017\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.178\u30012020\u5e743\u670817\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u9752\u5cf6 \u80b2\u7f8e\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u77f3\u5ddd \u63da\u5b50\u3001\u6728\u6751 \u60a0\u5e0c\u3001\u677e\u7530 \u6709\u52a0\u91cc\u3001\u77f3\u5ddd \u667a\u4e45\uff1aDGK\u03b4\u6a5f\u80fd\u6291\u5236\u306b\u3088\u308b\u81b5\u03b2\u7d30\u80de\u5897\u6b96\u6a5f\u5e8f\u306e\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c140\u5e74\u4f1a\uff08\u8a8c\u4e0a\u958b\u50ac\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.76\u30012020\u5e743\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u9ad8\u6a4b \u590f\u5b9f\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u4e00\u702c \u5065\u592a\u6717\u3001\u516b\u6728 \u96c4\u4e5f\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u30e9\u30c3\u30c8\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u30e1\u30e9\u30c8\u30cb\u30f3\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u306e\u767a\u73fe\u304a\u3088\u3073\u6a5f\u80fd\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c140\u5e74\u4f1a\uff08\u8a8c\u4e0a\u958b\u50ac\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6 p.138\u30012020\u5e743\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u571f\u80a5\u76f4\u8cb4\u3001\u5c71\u53e3\u6843\u751f\u3001\u9577\u8c37\u601c\u5948\u3001\u9234\u6728\u826f\u8f14\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81ea\u5f8b\u795e\u7d4c\u306b\u3088\u308b\u809d\u81d3\u306e\u8840\u6d41\u8abf\u7bc0\u306b\u304a\u3044\u3066\u809d\u661f\u7d30\u80de\u304c\u8cac\u4efb\u7d30\u80de\u3068\u306a\u308b\u53ef\u80fd\u6027<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c143\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08Web\u958b\u50ac\uff09\u3001E-5\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.59\u30012020\u5e7410\u670824\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u68b6\u3000\u840c\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u591a\u826f\u52c7\u8f1d\u3001\u5c71\u672c\u840c\u7d75\u3001\u9752\u67f3\u6709\u7d00\u3001\u79cb\u5c71\u5b63\u7406\u5b50\u3001\u83c5\u654f\u5e78\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30ce\u30d3\u30ec\u30c1\u30f3\u3068\u305d\u306e\u985e\u7e01\u4f53\u306e\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u6d3b\u6027\u306e\u6bd4\u8f03\u7814\u7a76<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c143\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08Web\u958b\u50ac\uff09\u3001D-9\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.54\u30012020\u5e7410\u670824\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u571f\u80a5\u76f4\u8cb4\u3001\u5c71\u53e3\u6843\u751f\u3001\u9577\u8c37\u601c\u5948\u3001\u9234\u6728\u826f\u8f14\u3001\u82e5\u6797\u5922\u4eba\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1aET-1\u306b\u3088\u308b\u9759\u6b62\u578b\u809d\u661f\u7d30\u80de\u306e\u53ce\u7e2e\u306b\u95a2\u308f\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8 \u5408\u540c\u5b66\u8853\u5927\u4f1a2020\uff08Web\u958b\u50ac\uff09\u3001B-87\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.170\u30012020\u5e7411\u670821\u201322\u65e5<\/span><\/p><\/div><\/div><\/div><\/div><\/div><\/section><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"8\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2228\" aria-expanded=\"false\">2019<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2228\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2228\" tabindex=\"0\" hidden=\"hidden\"><section class=\"elementor-section elementor-top-section elementor-element elementor-element-ae01028 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ae01028\" data-element_type=\"section\"><div class=\"elementor-container elementor-column-gap-default\"><div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b95fd44\" data-id=\"b95fd44\" data-element_type=\"column\"><div class=\"elementor-widget-wrap elementor-element-populated\"><div class=\"elementor-element elementor-element-576ddc3 elementor-widget elementor-widget-text-editor\" data-id=\"576ddc3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><p><span style=\"color: #000000;\">\u68b6\u840c\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u5c71\u672c\u840c\u7d75\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u6297\u7cd6\u5c3f\u75c5\u6d3b\u6027\u52b9\u679c\u306e\u691c\u8a0e\u3001<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c3\u56de\u30ce\u30d3\u30ec\u30c1\u30f3\u7814\u7a76\u4f1a\u3001\u6284\u9332\u96c6 p.41\u30012019\u5e7412\u670814\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u6297\u7cd6\u5c3f\u75c5\u6d3b\u6027\u52b9\u679c\u306e\u691c\u8a0e\u3001<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c3\u56de\u30ce\u30d3\u30ec\u30c1\u30f3\u7814\u7a76\u4f1a\u3001\u6284\u9332\u96c6 p.30\u30012019\u5e7412\u670814\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Naoki Dohi, Kyosuke Iwami, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa\uff1aHepatic stellate cells contract and regulate sinusoidal blood flow in response to the sympathetic neurotransmitter, noradrenaline.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">50th NIPS international symposium\uff08Okazaki\uff09\u3001Program and Abstracts p.62\u30012019\u5e7412\u67084\u20136\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Momoka Yamaguchi, Akira Ooka, Shohei Furukawa, Shin-ya Saito, Tomohisa Ishikawa\uff1aThe possibility of DIF-1 as a therapeutic agent for liver fibrosis by controling the transdifferentiation of hepatic stellate cells.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">50th NIPS international symposium\uff08Okazaki\uff09\u3001Program and Abstracts p.61\u30012019\u5e7412\u67084\u20136\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Naoki Dohi, Kyosuke Iwami, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa\uff1aLiver blood flow is regulated by hepatic stellate cells in response to the sympathetic neurotransmitter noradrenaline.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">1st KKU and University of Shizuoka (US) joint symposium on medical and pharmaceutical sciences (Khon Kaen)\u3001Program p.2\u30012019\u5e7411\u67084\u20137\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Ooka Akira, Shohei Furukawa, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa\uff1aEffect of the morphogen DIF-1 on the transdifferentiation of hepatic stellate cells: Towards a novel therapeutic agent for liver fibrosis.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">1st KKU and University of Shizuoka (US) joint symposium on medical and pharmaceutical sciences (Khon Kaen)\u3001Program p.1\u30012019\u5e7411\u67084\u20137\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Tomohisa Ishikawa, Yukiko Kaneko\uff1aDiacylglycerol kinase: an intracellular regulator of insulin secretion from pancreatic \u03b2-cells<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">1st KKU and University of Shizuoka (US) joint symposium on medical and pharmaceutical sciences (Khon Kaen)\u3001Program p.1\u30012019\u5e7411\u67084\u20137\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5927\u5ca1\u592e\u3001\u53e4\u5ddd\u7fd4\u5e73\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u5316\u5408\u7269DIF-1\u306e\u809d\u661f\u7d30\u80de\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c8\u56de\u98df\u54c1\u85ac\u5b66\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.86-88\u30012019\u5e7410\u670819\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5927\u5ca1\u592e\u3001\u53e4\u5ddd\u7fd4\u5e73\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u4f4e\u5206\u5b50\u5316\u5408\u7269 DIF-1 \u306f\u809d\u7dda\u7dad\u5316\u8cac\u4efb\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u9759\u5ca1\u5b9f\u9a13\u52d5\u7269\u7814\u7a76\u4f1a \u4ee4\u548c\u5143\u5e74\u5ea6\u5927\u4f1a \u7b2c47\u56de\u7814\u7a76\u767a\u8868\u4f1a\uff08\u6d5c\u677e\uff09\u3001\u8981\u65e8\u96c6p.7\u30012019\u5e7410\u670818\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u68b6\u3000\u840c\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u591a\u826f\u52c7\u8f1d\u3001\u5c71\u672c\u840c\u7d75\u3001\u9752\u67f3\u6709\u7d00\u3001\u77f3\u5ddd\u667a\u4e45\uff1aNobiletin \u306f\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u969c\u5bb3\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u7cd6\u5c3f\u75c5\u6539\u5584\u52b9\u679c\u3092\u793a\u3059<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u9759\u5ca1\u5b9f\u9a13\u52d5\u7269\u7814\u7a76\u4f1a \u4ee4\u548c\u5143\u5e74\u5ea6\u5927\u4f1a \u7b2c47\u56de\u7814\u7a76\u767a\u8868\u4f1a\uff08\u6d5c\u677e\uff09\u3001\u8981\u65e8\u96c6p.6\u30012019\u5e7410\u670818\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u68b6\u3000\u840c\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u591a\u826f\u52c7\u8f1d\u3001\u5c71\u672c\u840c\u7d75\u3001\u9752\u67f3\u6709\u7d00\u3001\u79cb\u5c71\u5b63\u7406\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u67d1\u6a58\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u81b5\u03b2\u7d30\u80de\u306b\u5bfe\u3059\u308b\u6297\u7cd6\u5c3f\u75c5\u52b9\u679c\u306e\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c141\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.8\u30012019\u5e7410\u670812\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Naoki Dohi, Kyosuke Iwami, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa\uff1aHepatic stellate cells contract and regulate sinusoidal blood flow in response to the sympathetic neurotransmitter, noradrenaline<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">JSH International Liver Conference 2019\uff08Osaka\uff09\u3001Program and Abstracts p.105\u30012019\u5e7410\u67081\u20132\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Ooka Akira, Shohei Furukawa, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa\uff1aDiffrentiation-inducing factor-1, derived Dictyostelium discoideum, suppresses the activation of hepatic stellate cells from mice via inhibition of GSK3\u03b2 phosphorylation<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">JSH International Liver Conference 2019\uff08Osaka\uff09\u3001Program and Abstracts p.99\u30012019\u5e7410\u67081\u20132\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5927\u5ca1\u592e\u3001\u53e4\u5ddd\u7fd4\u5e73\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u7dda\u7dad\u5316\u8cac\u4efb\u7d30\u80deHSC\u306e\u5f62\u8cea\u8ee2\u63db\u306b\u5bfe\u3059\u308b\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u5316\u5408\u7269DIF-1\u306e\u4f5c\u7528\u6a5f\u5e8f\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c21\u56de\u5fdc\u7528\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.72\u30012019\u5e749\u670820\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u677e\u6d66\u3000\u670b\u54c9\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u82b9\u6fa4\u3000\u74b0\u3001\u6fa4\u8c37\u3000\u4fca\u660e\u3001\u767d\u4e95\u3000\u5eb7\u4ec1\u3001\u77f3\u5ddd\u3000\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80deI\u578bDGK\u306e\u7cd6\u5c3f\u75c5\u4e0b\u3067\u306e\u767a\u73fe\u3068\u8840\u7cd6\u8abf\u7bc0\u3078\u306e\u5f71\u97ff\u306e\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c21\u56de\u5fdc\u7528\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.66\u30012019\u5e749\u670820\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c71\u7530\u9759\u96c4\u3001\u77f3\u7530\u88d5\u4e08\u3001\u5730\u672c\u7d14\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\u3001\u671b\u6708\u6b63\u6804\u3001\u6d77\u91ce\u7531\u91cc\u5b50\u3001\u9234\u6728\u771f\u7531\u7f8e\u3001\u9ec4\u5009\u5d07\u3001\u901f\u6c34\u614e\u4ecb\uff1a\u30e0\u30b9\u30ab\u30ea\u30f3\u6027\u53d7\u5bb9\u4f53\u7d50\u5408\u6d3b\u6027\u3092\u6307\u6a19\u3068\u3057\u305f\u85ac\u5264\u306e\u6297\u30b3\u30ea\u30f3\u8ca0\u8377\u306e\u30b9\u30b3\u30a2\u5316<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u3000\u7b2c26\u56de\u65e5\u672c\u6392\u5c3f\u6a5f\u80fd\u5b66\u4f1a\uff08\u6771\u4eac\uff09\u3001\u6284\u9332\u96c6p.296\u30012019\u5e749\u670812\u201314\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff13\u3000\u65b0\u305f\u306a\u8996\u70b9\u304b\u3089\u306e\u6cbb\u7642\u3092\u6307\u5411\u3057\u305f\u7cd6\u5c3f\u75c5\u7814\u7a76\u306e\u65b0\u6f6e\u6d41\u3000\u7d30\u80de\u5185\u8102\u8cea\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u306b\u3088\u308b\u81b5\u03b2\u7d30\u80de\u91cf\u306e\u5236\u5fa1\u3001<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u3000\u3000\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02019\uff08\u6771\u4eac\uff09\u3001\u8981\u65e8\u96c6p.54\u30012019\u5e748\u670830\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5927\u5ca1\u592e\u3001\u53e4\u5ddd\u7fd4\u5e73\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u83ca\u5730\u6674\u4e45\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u661f\u7d30\u80de\u306b\u5bfe\u3059\u308b\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u5316\u5408\u7269DIF-1\u306e\u4f5c\u7528\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02019\uff08\u6771\u4eac\uff09\u3001\u8981\u65e8\u96c6p.105\u30012019\u5e748\u670830\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u68b6\u3000\u840c\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u591a\u826f\u52c7\u8f1d\u3001\u5c71\u672c\u840c\u7d75\u3001\u77f3\u5ddd\u667a\u4e45\uff1aNobiletin \u306f\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u969c\u5bb3\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u7cd6\u5c3f\u75c5\u6539\u5584\u52b9\u679c\u3092\u793a\u3059<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02019\uff08\u6771\u4eac\uff09\u3001\u8981\u65e8\u96c6p.101\u30012019\u5e748\u670830\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u571f\u80a5\u76f4\u8cb4\u3001\u5ca9\u898b\u606d\u4ecb\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u809d\u661f\u7d30\u80de\u306f\u4ea4\u611f\u795e\u7d4c\u523a\u6fc0\u306b\u3088\u308a\u53ce\u7e2e\u3057\u809d\u985e\u6d1e\u8840\u6d41\u3092\u8abf\u7bc0\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02019\uff08\u6771\u4eac\uff09\u3001\u8981\u65e8\u96c6p.86\u30012019\u5e748\u670830\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\uff1aDiacylglycerol kinase \u306b\u3088\u308b\u03b2\u7d30\u80de\u5206\u6ccc\u8abf\u7bc0\u3068\u5897\u6b96\u5236\u5fa1\u7814\u7a76<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">Islet Biology\u201919\u30012019\u5e747\u670820\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u82b9\u6fa4 \u74b0\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u6238\u5009 \u5e83\u8cb4\u3001\u677e\u6d66 \u670b\u54c9\u3001\u6fa4\u8c37 \u4fca\u660e\u3001\u77f3\u5ddd \u667a\u4e45\uff1aDGK\u03b3\u6b20\u640d\u306b\u3088\u308b\u81b5\u03b1\u7d30\u80de\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\u306e\u691c\u8a0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c140\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.10\u30012019\u5e747\u67086\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6728\u6751\u4fca\u79c0\u3001\u5c71\u5ca1\u771f\u7f8e\u3001\u77f3\u5d0e\u654f\u7406\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5f8c\u306e\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c140\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.12\u30012019\u5e747\u67086\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5927\u5ca1\u592e\u3001\u53e4\u5ddd\u7fd4\u5e73\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u83ca\u5730\u6674\u4e45\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u5316\u5408\u7269DIF-1\u306e\u809d\u7dda\u7dad\u5316\u8cac\u4efb\u7d30\u80deHSC\u306b\u5bfe\u3059\u308b\u4f5c\u7528\u306e\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c140\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.10\u30012019\u5e747\u67086\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\u3001\u6fa4\u8c37\u4fca\u660e\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30b7\u30f3\u30dd\u30b8\u30a6\u30e08 \u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u306e\u65b0\u305f\u306a\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fc\uff1a\u305d\u306e\u751f\u7406\u3068\u75c5\u614b\uff1aRole of diacylglycerol kinase on the regulation of insulin<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c62\u56de\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a\u3001Journal of the Japan Diabetes Society, 62 suppl. 1, p.S-32,\u00a02019\u5e745\u670824\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u5730\u672c\u7d14\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\u3001\u9ec4\u5009\u5d07\u3001\u5c71\u7530\u9759\u96c4\uff1a\u53d7\u5bb9\u4f53\u7d50\u5408\u6d3b\u6027\u3092\u6307\u6a19\u3068\u3057\u305f\u85ac\u5264\u306e\u6297\u30b3\u30ea\u30f3\u6027\u6709\u5bb3\u4e8b\u8c61\u306e\u4e88\u6e2c<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c3\u56de\u65e5\u672c\u8001\u5e74\u85ac\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u3001\u6284\u9332\u96c6p.151\u30012019\u5e745\u670811\u201312\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Momoka Yamaguchi, Tomoya Morishita, Shin-ya Saito, Tomohisa Ishikawa.\uff1aInhibition of HSC activation via antagonism of adenosine receptors stimulating Akt1 pathway with caffeine<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">The 9h Federation of Asian and Oceanian Physiological Societies Congress (FAOPS2019) (Kobe)\u3001Program and Abstracts p.157\u30012019\u5e743\u670829\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u68ee\u672c\u9054\u4e5f\u3001\u5bae\u5d0e\u96c4\u8f14\u3001\u7802\u5ddd\u967d\u4e00\u3001\u5c71\u53e3\u8ce2\u5f66\u3001\u5c71\u53e3\u6843\u751f\u3001\u5200\u5742\u6cf0\u53f2\u3001\u5c71\ufa11\u6cf0\u5e83\u3001\u5742\u672c\u591a\u7a42\u3001\u8cc0\u5ddd\u7fa9\u4e4b\uff1a\u5730\uff08\u77e5\uff09\u306e\u62e0\u70b9\u6574\u5099\u4e8b\u696d5\u5e74\u9593\u306e\u9759\u5ca1\u770c\u7acb\u5927\u5b66\u306e\u53d6\u308a\u7d44\u307f1 \uff5e\u30e2\u30d0\u30a4\u30eb\u30d5\u30a1\u30fc\u30de\u30b7\u30fc\u3092\u6d3b\u7528\u3057\u305f\u5b9f\u7fd2\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u69cb\u7bc9<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c139\u5e74\u4f1a\uff08\u5343\u8449\uff09\u3001\u8981\u65e8\u96c6(4) p.201\u30012019\u5e743\u670823\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u53e4\u5ddd\u7fd4\u5e73\u3001\u5927\u5ca1\u592e\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u83ca\u5730\u6674\u4e45\u3001\u5927\u5cf6\u5409\u8f1d\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7d30\u80de\u6027\u7c98\u83cc\u7523\u5316\u5408\u7269DIF-1\u306fGSK3\u03b2\u306e\u30ea\u30f3\u9178\u5316\u3092\u963b\u5bb3\u3057\u3001\u30de\u30a6\u30b9\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c139\u5e74\u4f1a\uff08\u5343\u8449\uff09\u3001\u8981\u65e8\u96c6(3) p.81\u30012019\u5e743\u670823\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u85e4\u7530\u512a\u9999\u3001\u5357\u5f70\u3001\u767d\u9ce5\u771e\u5b50\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u6fa4\u8c37\u4fca\u660e\u3001\u5927\u576a\u5fe0\u5b97\u3001\u6c60\u7530\u6f54\u3001\u77f3\u5ddd\u667a\u4e45\u3001\u9234\u6728\u9686\uff1a\u4f4e\u8840\u7cd6\u306e\u526f\u4f5c\u7528\u3092\u56de\u907f\u3059\u308b\u65b0\u3057\u3044\u4f5c\u7528\u6a5f\u5e8f\u3092\u3082\u3063\u305f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u958b\u767a<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c139\u5e74\u4f1a\uff08\u5343\u8449\uff09\u3001\u8981\u65e8\u96c6(3) p.75\u30012019\u5e743\u670823\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u591a\u826f\u52c7\u8f1d\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u5c71\u672c\u840c\u7d75\u3001\u9752\u67f3\u6709\u7d00\u3001\u79cb\u5c71\u5b63\u7406\u5b50\u3001\u83c5\u654f\u5e78\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30ce\u30d3\u30ec\u30c1\u30f3\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u304a\u3088\u3073\u81b5\u03b2\u7d30\u80de\u4fdd\u8b77\u4f5c\u7528\u306b\u3088\u308a\u7cd6\u5c3f\u75c5\u3092\u6539\u5584\u3055\u305b\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c139\u5e74\u4f1a\uff08\u5343\u8449\uff09\u3001\u8981\u65e8\u96c6(3) p.74\u30012019\u5e743\u670822\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u5927\u5b66\u9662\u751f\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u82e5\u624b\u304c\u62d3\u304f\u7cd6\u5c3f\u75c5\u3068\u305d\u306e\u5408\u4f75\u75c7\u306b\u5bfe\u3059\u308b\u591a\u89d2\u7684\u63a2\u7a76\uff5e\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\uff5e\u3001\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308btype-1 DGK\u306b\u3088\u308bDAG\u4ee3\u8b1d\u3092\u4ecb\u3057\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u8abf\u7bc0\u306e\u610f\u7fa9<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c139\u5e74\u4f1a\uff08\u5343\u8449\uff09\u3001\u8981\u65e8\u96c6(1) p.317\u30012019\u5e743\u670821\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Yukiko Kaneko, Tomohisa Ishikawa\uff1a\uff7c\uff9d\uff8e\uff9f\uff7c\uff9e\uff73\uff9126\u3000\u30e6\u30cb\u30fc\u30af\u306a\u5929\u7136\u8cc7\u6e90\u3092\u6d3b\u304b\u3057\u305f\u5730\u57df\u7523\u696d\u3001\u56fd\u969b\u5316\u3001\u533b\u7642\u306b\u8ca2\u732e\u3059\u308b\u85ac\u7406\u5b66\u7814\u7a76\u3001Anti-diabetic effects of citrus flavonoids on pancreatic \u03b2-cell function.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c92\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u5927\u962a\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.117\u30012019\u5e743\u670816\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Tomoya Morishita, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa\uff1aCaffeine caused the reversion of activated hepatic stellate cells in a concentration-dependent manner<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c92\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u5927\u962a\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.337\u30012019\u5e743\u670816\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Reina Hase, Naoki Dohi, Ryosuke Suzuki, Yumeto Wakabayashi, Ryota Nishiyama, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa.\uff1aContraction of hepatic stellate cells by Endothelin-1 is mediated by calcium-MLCK system and Rho-kinase system<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c92\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u5927\u962a\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.299\u30012019\u5e743\u670815\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Akira Ooka, Shohei Furukawa, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Isikawa \uff1aThe possibility of DIF-1 as a therapeutic agent for liver fibrosis<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">International Exchange Seminar 2019 between Univ Shizuoka &amp; UC Davis\uff08Osaka\uff09\u30012019\u5e743\u670815\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Yuki Kimura\u3001Yukiko Kaneko, Takahiro Nakayama, Yoko Ishikawa, Yukari Matsuda, Ikumi Aoshima, Tomohisa Ishikawa\uff1aDGK\u03b4 deficiency in mouse pancreatic \u03b2-cells alleviates STZ-induced diabetes.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c92\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u5927\u962a\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.185\u30012019\u5e743\u670814\u65e5<\/span><\/p><\/div><\/div><\/div><\/div><\/div><\/section><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"9\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2229\" aria-expanded=\"false\">2018<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2229\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2229\" tabindex=\"0\" hidden=\"hidden\"><section class=\"elementor-section elementor-top-section elementor-element elementor-element-f4ab81b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f4ab81b\" data-element_type=\"section\"><div class=\"elementor-container elementor-column-gap-default\"><div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-98194c1\" data-id=\"98194c1\" data-element_type=\"column\"><div class=\"elementor-widget-wrap elementor-element-populated\"><div class=\"elementor-element elementor-element-7902685 elementor-widget elementor-widget-text-editor\" data-id=\"7902685\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><p><span style=\"color: #000000;\">Momoka Yamaguchi, Tomoya Morishita, Shin-ya Saito, Tomohisa Ishikawa\uff1aSuppression of hepatic stellate cell activation through antagonism of adenosine receptors with caffeine<\/span><\/p><p><span style=\"color: #000000;\">The Biophysical Society 62<sup>nd<\/sup> Annual Meeting (BPS18) (San Francisco)\u3001L3474-Pos\u3001\u8981\u65e8\u96c6p.5\u30012018\u5e742\u670818\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u9752\u67f3\u6709\u7d00\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u591a\u826f\u52c7\u8f1d\u3001\u79cb\u5c71\u5b63\u7406\u5b50\u3001\u5c71\u672c\u840c\u7d75\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u67d1\u6a58\u985e\u679c\u76ae\u62bd\u51fa\u6210\u5206\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u6297\u7cd6\u5c3f\u75c5\u52b9\u679c\u306e\u89e3\u6790<\/span><\/p><p><span style=\"color: #000000;\">\u7b2c138\u56de\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\uff09\u3001\u8981\u65e8\u96c6p.90 \u30012018\u5e743\u670810\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u5800\u6c5f\u7dbe\u9999\u3001\u6589\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u8840\u6d41\u969c\u5bb3\u306e\u6539\u5584\u306b\u3088\u308b\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u7de9\u548c\u306e\u53ef\u80fd\u6027<\/span><\/p><p><span style=\"color: #000000;\">\u7b2c138\u56de\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\uff09\u3001\u8981\u65e8\u96c6p. 71\u30012018\u5e743\u670810\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u9d28\u5fd7\u7530\u3042\u308a\u3055\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u516b\u6728\u96c4\u4e5f\u3001\u4e2d\u6751\u54f2\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u6982\u65e5\u30ea\u30ba\u30e0\u5f62\u6210\u306b\u95a2\u308f\u308b\u5206\u5b50\u306e\u767a\u73fe\u304a\u3088\u3073\u6a5f\u80fd\u89e3\u6790<\/span><\/p><p><span style=\"color: #000000;\">\u7b2c138\u56de\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\uff09\u3001\u8981\u65e8\u96c6p. 89\u30012018\u5e743\u670810\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u306b\u968f\u4f34\u3059\u308b\u76ae\u819a\u8840\u6d41\u969c\u5bb3\u306e\u6539\u5584\u306b\u3088\u308b\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u78ba\u7acb\u3001\u5927\u5b66\u9662\u751f\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0GS02 \u30dd\u30b9\u30c8\u30b2\u30ce\u30e0\u6642\u4ee3\u306e\u5275\u85ac\u3092\u76ee\u6307\u3057\u3066<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c138\u5e74\u4f1a\uff08\u91d1\u6ca2\uff09\u3001\u8981\u65e8\u96c61 p.329\u30012018\u5e743\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u91cf\u5897\u52a0\u3092\u76ee\u6307\u3057\u305f\u65b0\u898f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u5275\u85ac\u6a19\u7684\u3068\u3057\u3066\u306e\u81b5\u03b2\u7d30\u80de\u8102\u8cea\u4ee3\u8b1d\u5236\u5fa1\u3001\u4e00\u822c\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0S70\u3000\u82e5\u624b\u304c\u53d6\u308a\u7d44\u3080\u65b0\u898f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u30fb\u4e88\u9632\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u6226\u7565\u3000<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c138\u5e74\u4f1a\uff08\u91d1\u6ca2\uff09\u3001\u8981\u65e8\u96c61 p. 320\u30012018\u5e743\u670828\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u4f50\u91ce\u7f8e\u54b2\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u68ee\u5ca1\u4e9c\u671b\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7cd6\u5c3f\u75c5\u4e0b\u306b\u304a\u3051\u308b\u7d30\u80de\u5185ADMA\u306e\u84c4\u7a4d\u306fNO\u306b\u3088\u308b\u81b5\u03b2\u7d30\u80de\u4fdd\u8b77\u4f5c\u7528\u3092\u6e1b\u5f31\u3055\u305b\u308b<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c138\u5e74\u4f1a\uff08\u91d1\u6ca2\uff09\u3001\u8981\u65e8\u96c63 p. 99\u30012018\u5e743\u670828\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6728\u6751\u60a0\u5e0c\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u63da\u5b50\u3001\u4e2d\u5c71\u8cb4\u5bdb\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u03b2\u7d30\u80de\u306b\u304a\u3051\u308bDGK\u03b4\u6a5f\u80fd\u6291\u5236\u306b\u3088\u308b\u7d30\u80de\u5897\u6b96\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u75c5\u614b\u3078\u306e\u52b9\u679c\u306e\u89e3\u6790<\/span><\/p><p><span style=\"color: #000000;\">\u7b2c60\u56de\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a\uff08\u6771\u4eac\uff09\u3001<em>JDS, <\/em>60 (Supl) p.S-261\u30012018\u5e745\u670825\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308bDGK\u03b1\u304a\u3088\u3073\u03b3\u6a5f\u80fd\u6291\u5236\u306b\u3088\u308bDAG\u84c4\u7a4d\u306f\u7d30\u80de\u5185Ca<sup>2+<\/sup>\u6fc3\u5ea6\u306b\u5bfe\u3057\u3066\u4e8c\u9762\u6027\u3092\u793a\u3059<\/span><\/p><p><span style=\"color: #000000;\">\u7b2c60\u56de\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a\uff08\u6771\u4eac\uff09\u3001<em>JDS, <\/em>60 (Supl) p.S-386\u30012018\u5e745\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Toshiaki Sawatani, Yukiko K. Kaneko, Tomohisa Ishikawa\uff1a DAG accumulation due to type 1 DGK inhibition has a contradictory dual effect on Ca2+ signaling in pancreatic \u03b2-cells.<\/span><\/p><p><span style=\"color: #000000;\">American Diabetes Association Scientific Sessions 2018 (Orlando, USA), <em>Diabetes 67 (supplement 1): 328-OR,<\/em> 2018\u5e746\u670825\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Yukiko K. Kaneko, Misaki Sano, Ami Morioka, Masato Nojiri, Nahoko Kasahara, Tomohisa Ishikawa\uff1aModulation of DDAH\/ADMA\/NOS pthway in pancreatic \u03b2-cells under diabetic condition<\/span><\/p><p><span style=\"color: #000000;\">18<sup>th<\/sup> World Congress of Basic and Clinical Pharmacology (WCP2018) (Kyoto), PO2-7-15, 2018\u5e747\u67083\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Toshiaki Sawatani, Yukiko K. Kaneko, Tomohisa Ishikawa\uff1aTRPV2 channels mediate cell swelling-induced insulin secretion in mouse pancreatic \u03b2-cells.<\/span><\/p><p><span style=\"color: #000000;\">18<sup>th<\/sup> World Congress of Basic and Clinical Pharmacology (WCP2018) (Kyoto), PO2-7-23, 2018\u5e747\u67083\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Momoka Yamaguchi, Tomoya Morishita, Shin-ya Saito, Tomohisa Ishikawa.\uff1aCaffeine suppresses the activation of hepatic stellate cells Akt1 is a key molecule for caffeine-induced inhibition of hepatic stellate cell activation<\/span><\/p><p><span style=\"color: #000000;\">18<sup>th<\/sup> World Congress of Basic and Clinical Pharmacology (WCP2018) (Kyoto), OR17-5, 2018\u5e747\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Syn-ya Saito, Ryosuke Suzuki, Yumeto Wakabayashi, Ryota Nishiyama, Momoka Yamaguchi, Tomohisa Ishikawa\uff1aEndotheline-1 induces contraction in quiescent hepatic stellate cells mediated by myosin light chain kinase and Rho kinase<\/span><\/p><p><span style=\"color: #000000;\">18<sup>th<\/sup> World Congress of Basic and Clinical Pharmacology (WCP2018) (Kyoto), PO4-2-25, 2018\u5e747\u67085\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u571f\u80a5\u76f4\u8cb4\u3001\u5ca9\u898b\u606d\u4ecb\u3001\u9577\u8c37\u601c\u5948\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u9759\u6b62\u578b\u809d\u661f\u7d30\u80de\u306e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306b\u3088\u308b\u53ce\u7e2e\u6a5f\u5e8f\u306e\u89e3\u660e<\/span><\/p><p><span style=\"color: #000000;\">\u7b2c25\u56de\u809d\u7d30\u80de\u7814\u7a76\u4f1a\uff08\u6771\u4eac\uff09\u3001O3-1\u3001\u8981\u65e8\u96c6p.40\u30012018\u5e747\u670812\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u53e4\u5ddd\u7fd4\u5e73\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u5316\u5408\u7269differentiation-inducing factor-1\u306fGSK3\u03b2\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u5236\u5fa1\u3059\u308b<\/span><\/p><p><span style=\"color: #000000;\">\u7b2c25\u56de\u809d\u7d30\u80de\u7814\u7a76\u4f1a\uff08\u6771\u4eac\uff09\u3001P5-2\u3001\u8981\u65e8\u96c6p.66\u30012018\u5e747\u670813\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c71\u53e3\u6843\u751f\u3001\u68ee\u4e0b\u667a\u4e5f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1aCaffeine \u306f\u30a2\u30c7\u30ce\u30b7\u30f3\u53d7\u5bb9\u4f53\u3092\u963b\u5bb3\u3057\u3001cAMP \u3084 ERK1\/2 \u975e\u4f9d\u5b58\u7684\u306b\u30ea\u30f3\u9178\u5316 Akt1 \u306e\u6e1b\u5c11\u3092\u4ecb\u3057\u3066\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b<\/span><\/p><p><span style=\"color: #000000;\">\u7b2c25\u56de\u809d\u7d30\u80de\u7814\u7a76\u4f1a\uff08\u6771\u4eac\uff09\u3001P5-4\u3001\u8981\u65e8\u96c6p.67\u30012018\u5e747\u670813\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3E<sub>2<\/sub>\u306f\u30ab\u30d5\u30a7\u30a4\u30f3\u5b58\u5728\u4e0b\u3067\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b<\/span><\/p><p><span style=\"color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02018\uff08\u798f\u5ca1\uff09\u3001P09\u3001\u8981\u65e8\u96c6p.66\u30012018\u5e748\u670823\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3044\u3066I\u578b\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u6a5f\u80fd\u4f4e\u4e0b\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4e8c\u9762\u6027\u306b\u5236\u5fa1\u3059\u308b<\/span><\/p><p><span style=\"color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02018\uff08\u798f\u5ca1\uff09\u3001BP37\u3001\u8981\u65e8\u96c6p.107\u30012018\u5e748\u670824\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u85e4\u7530\u512a\u9999\u3001\u5357\u3000\u5f70\u3001\u767d\u9ce5\u771e\u5b50\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u6fa4\u8c37\u4fca\u660e\u3001\u699b\u8449\u3059\u307f\u304b\u3001\u95a2\u7530\u7406\u6c99\u3001\u5927\u576a\u5fe0\u5b97\u3001\u6c60\u7530\u6f54\u3001\u91d1\u6fa4\u5bdb\u660e\u3001\u77f3\u5ddd\u667a\u4e45\u3001\u9234\u6728\u9686\uff1a\u30de\u30a6\u30b9\u81b5\u81d3\u306b\u304a\u3051\u308b\u30b7\u30a2\u30ea\u30c0\u30fc\u30bc\u6d3b\u6027\u306e\u5206\u5e03\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306b\u304a\u3051\u308b\u30b7\u30a2\u30ea\u30c0\u30fc\u30bc\u306e\u5f79\u5272<\/span><\/p><p><span style=\"color: #000000;\">\u7b2c15\u56de\u82e5\u624b\u306e\u529b\u30d5\u30a9\u30fc\u30e9\u30e0\uff08\u7cd6\u9396\u79d1\u5b66\u4e2d\u90e8\u62e0\u70b9\uff09(\u9759\u5ca1)\u30012018\u5e749\u67086\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u571f\u80a5\u76f4\u8cb4\u3001\u5ca9\u898b\u606d\u4ecb\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u2f83\u5f8b\u795e\u7d4c\u306b\u3088\u308b\u809d\u661f\u7d30\u80de\u306e\u809d\u985e\u6d1e\u2f8e\u6d41\u8abf\u7bc0\u6a5f\u69cb\u306e\u89e3\u6790<\/span><\/p><p><span style=\"color: #000000;\">\u9759\u5ca1\u5b9f\u9a13\u52d5\u7269\u7814\u7a76\u4f1a \u5e73\u621030\u5e74\u5ea6\u5927\u4f1a \u7b2c46\u56de\u7814\u7a76\u767a\u8868\u4f1a\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.18\u30012018\u5e7410\u670812\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u677e\u5c3e\u8056\u7f85\u3001\u5ca9\u5c3e\u5eb7\u7bc4\u3001\u6771\u9855\u4e8c\u90ce\u3001\u68ee\u90e8\u4e45\u4ec1\u4e00\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u6728\u6751\u664b\u4e00\u90ce\u3001\u8fd1\u85e4\u5553\uff1a\u96e3\u6eb6\u6027\u5316\u5408\u7269Nobiletin\u5c01\u5165\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u88fd\u5264\u306e\u8abf\u88fd\u3068\u7d4c\u53e3\u88fd\u5264\u3068\u3057\u3066\u306e\u6709\u7528\u6027\u8a55\u4fa1<\/span><\/p><p><span style=\"color: #000000;\">\u88fd\u5264\u6a5f\u68b0\u6280\u8853\u5b66\u4f1a\u3000\u7b2c28\u56de\u5927\u4f1a\uff08\u5927\u962a\u5e9c\uff09\u30012018\u5e7410\u670818\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c71\u53e3 \u6843\u751f\u3001\u68ee\u4e0b \u667a\u4e5f\u3001\u9f4a\u85e4 \u771f\u4e5f\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u30ab\u30d5\u30a7\u30a4\u30f3\u306b\u3088\u308b\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u30fb\u8131\u6d3b\u6027\u5316\u5236\u5fa1\u3092\u4ecb\u3057\u305f\u809d\u7dda\u7dad\u5316\u6539\u5584\u306e\u53ef\u80fd\u6027<\/span><\/p><p><span style=\"color: #000000;\">\u751f\u7406\u5b66\u7814\u7a76\u6240\u7814\u7a76\u4f1a2018\uff08\u5ca1\u5d0e\uff09\u3001\u8981\u65e8\u96c6p.12\u30012018\u5e7411\u67081\u20132\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u9577\u8c37\u601c\u5948\u3001\u571f\u80a5\u76f4\u8cb4\u3001\u9234\u6728\u826f\u8f14\u3001\u82e5\u6797\u5922\u4eba\u3001\u897f\u5c71\u826f\u592a\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1aET-1\u306b\u3088\u308b\u9759\u6b62\u578b\u809d\u661f\u7d30\u80de\u306e\u53ce\u7e2e\u306b\u95a2\u308f\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u691c\u8a0e<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a 2018\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.114\u30012018\u5e7411\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u516b\u6728\u96c4\u4e5f\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u9d28\u5fd7\u7530\u3042\u308a\u3055\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u30e1\u30e9\u30c8\u30cb\u30f3\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u95a2\u9023\u5206\u5b50\u306e\u767a\u73fe\u304a\u3088\u3073\u6a5f\u80fd\u89e3\u6790<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a 2018\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.114\u30012018\u5e7411\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u571f\u80a5\u76f4\u8cb4\u3001\u5ca9\u898b\u606d\u4ecb\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u9759\u6b62\u578b\u809d\u661f\u7d30\u80de\u306f\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u306b\u3088\u3063\u3066\u53ce\u7e2e\u3059\u308b<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a 2018\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.137\u30012018\u5e7411\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6728\u6751\u6709\u5e0c\u3001\u5185\u7530\u5149\u54b2\u3001\u5897\u7530\u771f\u4e5f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a5-hydoroxy-4,5-dimethyl-3-(1-oxododecyl)<\/span><\/p><p><span style=\"color: #000000;\">-2(5H)-furanone\u306fRho\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u5e73\u6ed1\u7b4b\u53ce\u7e2e\u3092\u6291\u5236\u3059\u308b<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a 2018\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.143\u30012018\u5e7411\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u68ee\u4e0b\u667a\u4e5f\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30ab\u30d5\u30a7\u30a4\u30f3\u306fAkt1\u306e\u30ea\u30f3\u9178\u5316\u3092\u4ecb\u3057\u3066\u6d3b\u6027\u578b\u809d\u661f\u7d30\u80de\u306e\u5fa9\u5e30\u5909\u7570\u3092\u5f15\u304d\u8d77\u3053\u3059<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a 2018\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.143\u30012018\u5e7411\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c71\u672c\u840c\u7d75\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u591a\u826f\u52c7\u8f1d\u3001\u9752\u67f3\u6709\u7d00\u3001\u79cb\u5c71\u5b63\u7406\u5b50\u3001\u83c5\u654f\u5e78\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u690d\u7269\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u52b9\u679c\u306e\u89e3\u6790<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a 2018\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.144\u30012018\u5e7411\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u677e\u7530\u6709\u52a0\u91cc\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u6728\u6751\u60a0\u5e0c\u3001\u77f3\u5ddd\u63da\u5b50\u3001\u4e2d\u5c71\u8cb4\u5bdb\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308bDGK\u03b4\u6a5f\u80fd\u6291\u5236\u306b\u3088\u308b\u7cd6\u5c3f\u75c5\u75c5\u614b\u6539\u5584\u52b9\u679c\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a 2018\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.144\u30012018\u5e7411\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u767d\u9ce5\u771e\u5b50\u3001\u5357\u5f70\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u6fa4\u8c37\u4fca\u660e\u3001\u85e4\u7530\u512a\u9999\u3001\u5927\u576a\u5fe0\u5b97\u3001\u6c60\u7530\u6f54\u3001\u77f3\u5ddd\u667a\u4e45\u3001\u9234\u6728\u9686\uff1a\u4f4e\u8840\u7cd6\u306e\u526f\u4f5c\u7528\u3092\u56de\u907f\u3059\u308b\u30b7\u30a2\u30ea\u30c0\u30fc\u30bc\u3092\u6a19\u7684\u3068\u3057\u305f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u958b\u767a<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u75c5\u9662\u85ac\u5264\u5e2b\u4f1a\u6771\u6d77\u30d6\u30ed\u30c3\u30af\u30fb\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5408\u540c\u5b66\u8853\u5927\u4f1a2018(\u9759\u5ca1)\u3001\u8981\u65e8\u96c6p.139\u30012018\u5e7411\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Hirotake Ishida, Takuma Furukawa, Ayaka Horie, Shin-ya Saito, Tomohisa Ishikawa\uff1aDoes increased skin blood flow alleviate neuropathic pain?<\/span><\/p><p><span style=\"color: #000000;\">The 14<sup>th<\/sup> Japan-China International Symposium on Health Sciences (Shizuoka), Oral-3, Program and Abstracts p.5, 2018\u5e7411\u670815\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Yuki Tara, Yukiko Kaneko, Yuki Aoyagi, Megumi Kaji, Kiriko Akiyama, Toshiyuki Kan, Tomohisa Ishikawa\uff1aEffects of citrus flavonoids on pancreatic \u03b2-cell function<\/span><\/p><p><span style=\"color: #000000;\">The 4<sup>th<\/sup> International Conference on Pharma and Food (ICPF2018) (Shizuoka), Poster-40, Program and Abstracts p.139, 2018\u5e7411\u670815\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Toshiaki Sawatani, Yukiko Kaneko, Tomohisa Ishikawa\uff1aDiacylglycerol accumulation due to type-1 diacylglycerol kinase dysfunction has a dual response on insulin secretion in pancreatic \u03b2-cells.<\/span><\/p><p><span style=\"color: #000000;\">The 4<sup>th<\/sup> International Conference on Pharma and Food (ICPF2018) (Shizuoka), Poster-41, Program and Abstracts p.140, 2018\u5e7411\u670815\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Yuki Kimura, Yukiko Kaneko, Taiji Sato, Chihiro Ishiwatari, Yoko Ishikawa, Yukari Matsuda, Tomohisa Ishikawa\uff1aDGK\u03b4 deficiency in mouse pancreatic \u03b2-cells improves STZ-induced hyperglycemia.<\/span><\/p><p><span style=\"color: #000000;\">The 4<sup>th<\/sup> International Conference on Pharma and Food (ICPF2018) (Shizuoka), Poster-42, Program and Abstracts p.140, 2018\u5e7411\u670815\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Naoki Dohi, Kyosuke Iwami, Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa\uff1aHepatic stellate cells contract in response to noradrenaline.<\/span><\/p><p><span style=\"color: #000000;\">The 4<sup>th<\/sup> International Conference on Pharma and Food (ICPF2018) (Shizuoka), Poster-46, Program and Abstracts p.142, 2018\u5e7411\u670815\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Yuki Tara, Yukiko Kaneko, Moe Yamamoto, Yuki Aoyagi, Kiriko Akiyama, Toshiyuki Kan, Tomohisa Ishikawa\uff1a Nobiletin exerts anti-diabetic effects involving insulinotropic and anti-apoptotic effects on pancreatic \u03b2-cells.<\/span><\/p><p><span style=\"color: #000000;\">The 13<sup>th<\/sup> Japan-China International symposium on Health Sciences, \u7b2c23\u56de\u9759\u5ca1\u5065\u5eb7\u30fb\u9577\u5bff\u5b66\u8853\u30d5\u30a9\u30fc\u30e9\u30e0 (\u9759\u5ca1), Abstract p.103,\u3000\u8981\u65e8\u96c6p. 70\u30012018\u5e7411\u670816\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Toshiaki Sawatani, Yukiko Kaneko, Isao Dotsu, Ai Ogawa, Tomohisa Ishikawa: Contribution of TRPV2 channels in cell swelling-induced insulin secretion in mouse pancreatic \u03b2-cells.<\/span><\/p><p><span style=\"color: #000000;\">The 13<sup>th<\/sup> Japan-China International symposium on Health Sciences, \u7b2c23\u56de\u9759\u5ca1\u5065\u5eb7\u30fb\u9577\u5bff\u5b66\u8853\u30d5\u30a9\u30fc\u30e9\u30e0 (\u9759\u5ca1), Abstract p.110,\u3000\u8981\u65e8\u96c6p. 74\u30012018\u5e7411\u670816\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Seira Matshuo, Yasunori Iwao, Kenjiro Higashi, Kunikazu Moribe, Yukiko Kaneko, Shin-ichiro Kimura, Hiromu Kondo\uff1aOral formulation development of lipid nanoparticles encapsulated nobiletin, a poorly water-soluble compound.<\/span><\/p><p><span style=\"color: #000000;\">6th International Conference on Pharmaceuticals, Nutraceuticals and Cosmetic Science (Manila, Philippines) 2018\u5e7411\u670822-23\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6728\u6751\u6709\u5e0c\u3001\u5185\u7530\u5149\u54b2\u3001\u5897\u7530\u771f\u4e5f\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a \u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u751f\u7406\u6d3b\u6027\u7269\u8cea\u8a98\u5c0e\u4f53\u306e\u5e73\u6ed1\u7b4b\u306b\u304a\u3051\u308b\u751f\u7406\u6d3b\u6027\u6a5f\u5e8f\u306e\u89e3\u660e<\/span><\/p><p><span style=\"color: #000000;\">\u7b2c28\u56de\u65e5\u672c\u5faa\u74b0\u85ac\u7406\u5b66\u4f1a\uff08\u6771\u4eac\uff09\u3001B-10, \u8981\u65e8\u96c6p.58\u30012018\u5e7412\u67087\u65e5<\/span><\/p><\/div><\/div><\/div><\/div><\/div><\/section><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"10\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-22210\" aria-expanded=\"false\">2017<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-22210\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-22210\" tabindex=\"0\" hidden=\"hidden\"><section class=\"elementor-section elementor-top-section elementor-element elementor-element-f26f6b7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f26f6b7\" data-element_type=\"section\"><div class=\"elementor-container elementor-column-gap-default\"><div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-64621fc\" data-id=\"64621fc\" data-element_type=\"column\"><div class=\"elementor-widget-wrap elementor-element-populated\"><div class=\"elementor-element elementor-element-2f83aba elementor-widget elementor-widget-text-editor\" data-id=\"2f83aba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><p><span style=\"color: #000000;\">Yukiko Kaneko, Tomohisa Ishikawa\uff1aRole of DGKs in the regulation of insulin secretion and \u03b2-cell mass.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">The 7<sup>th<\/sup> mini-international symposium on DGK (Kobe)\u3001Oral-5\u30012017\u5e743\u670813\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Toshiaki Sawatani, Yukiko Kaneko, Tomohisa Ishikawa\uff1aInhibition of type I DGK leads to a dual response on Ca<sup>2+<\/sup> signaling in pancreatic \u03b2-cells<\/span><\/p><p><span style=\"color: #000000;\">The 7<sup>th<\/sup> mini-international symposium on DGK (Kobe)\u3001Poster-3\u30012017\u5e743\u670813\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Yoko Ishikawa, Yukiko Kaneko, Takahiro Nakayama, Yuki Kimura, Chihiro Ishiwatari, Taiji Sato, Tomohisa Ishikawa\uff1aEffect of pancreatic \u03b2-cell specific diacylglycerol kinase \u03b4 deficiency in streptozotocin-induced diabetic mice<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">The 7<sup>th<\/sup> mini-international symposium on DGK (Kobe)\u3001Poster-6\u30012017\u5e743\u670813\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u83f1\u6cbc\u745b\u592a\u3001\u5317\u5ddd\u667a\u7ae0\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1aMechanism for cooling-induced enhancement of \u03b1<sub>1A<\/sub>-adrenoceptor response in the cutaneous artery<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c90\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u9577\u5d0e\uff09\u3001<em>J Pharmacol. Sci<\/em>., 131(Supl) S90\u30012017\u5e743\u670815\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1aContradictory dual effect of type I diacylglycerol kinase dysfunction on intracellular Ca<sup>2+<\/sup> signaling in pancreatic \u03b2 cells<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c90\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u9577\u5d0e\uff09\u3001<em>J Pharmacol. Sci<\/em>., 131(Supl) S100\u30012017\u5e743\u670816\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u8840\u6d41\u6539\u5584\u306f\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u306e\u7de9\u548c\u306b\u6709\u7528\u304b<\/span><\/p><p><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c137\u56de\u5e74\u4f1a\uff08\u4ed9\u53f0\uff09\u3001\u8981\u65e8\u96c61 p.278\u30012017\u5e743\u670825\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u767d\u9ce5\u771e\u5b50\u3001\u5357\u5f70\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u699b\u8449\u3059\u307f\u304b\u3001\u95a2\u7530\u7406\u6c99\u3001\u77f3\u5ddd\u667a\u4e45\u3001\u5927\u576a\u5fe0\u5b97\u3001\u6c60\u7530\u6f54\u3001\u9234\u6728\u9686\uff1a\u30b7\u30a2\u30ea\u30c0\u30fc\u30bc\u306e\u81b5\u81d3\u306b\u304a\u3051\u308b\u6d3b\u6027\u5206\u5e03\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306b\u304a\u3051\u308b\u5f79\u5272<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c137\u5e74\u4f1a\uff08\u4ed9\u53f0\uff09\u3001\u8981\u65e8\u96c62 p. 53\u30012017\u5e743\u670825\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1aTRPV2\u6d3b\u6027\u5316\u306f\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u7d30\u80de\u81a8\u5f35\u8a98\u767a\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u53cd\u5fdc\u306b\u95a2\u4e0e\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c137\u56de\u5e74\u4f1a\uff08\u4ed9\u53f0\uff09\u3001\u8981\u65e8\u96c62 p83\u30012017\u5e743\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u4e2d\u5c71\u8cb4\u5bdb\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u4f50\u85e4\u592a\u6cbb\u3001\u77f3\u6e21\u5343\u88d5\u3001\u77f3\u5ddd\u63da\u5b50\u3001\u6728\u6751\u60a0\u5e0c\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30b9\u30c8\u30ec\u30d7\u30c8\u30be\u30c8\u30b7\u30f3\u8a98\u767a\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u81b5\u03b2\u7d30\u80de\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b4\u6b20\u640d\u306e\u5f71\u97ff<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c137\u5e74\u4f1a\uff08\u4ed9\u53f0\uff09\u3001\u8981\u65e8\u96c62 p.84\u30012017\u5e743\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u7d30\u80de\u81a8\u5f35\u8a98\u767a\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u53cd\u5fdc\u306b\u306fTRPV2\u6d3b\u6027\u5316\u304c\u95a2\u4e0e\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c60\u56de\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u3001<em>JDS, <\/em>60(Supl) p.S-257\u30012017\u5e745\u670819\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u4f50\u91ce\u5b9f\u54b2\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u68ee\u5ca1\u4e9c\u671b\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7cd6\u5c3f\u75c5\u4e0b\u306b\u304a\u3051\u308b\u5185\u56e0\u6027NOS\u963b\u5bb3\u7269\u8cea\u306e\u84c4\u7a4d\u306f\u81b5\u03b2\u7d30\u80de\u969c\u5bb3\u3092\u4ea2\u9032\u3055\u305b\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c136\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\uff09\u3001\u8981\u65e8\u96c6p.16\u30012017\u5e747\u67088\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45: \u81b5\u03b2\u7d30\u80deTRPV2\u6d3b\u6027\u5316\u306f\u7d30\u80de\u81a8\u5f35\u8a98\u767a\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u53cd\u5fdc\u306b\u95a2\u4e0e\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c136\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6771\u4eac\uff09\u3001\u8981\u65e8\u96c6p.18\u30012017\u5e747\u67088\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u8840\u6d41\u969c\u5bb3\u306e\u6539\u5584\u3068\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u306e\u7de9\u548c\u306f\u76f8\u95a2\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c59\u56de\u65e5\u672c\u5e73\u6ed1\u7b4b\u5b66\u4f1a\u7dcf\u4f1a\uff08\u798f\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.54\u30012017\u5e748\u670825\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30a2\u30c7\u30ce\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u4f5c\u7528\u306b\u3088\u308a\u30ab\u30d5\u30a7\u30a4\u30f3\u306f\u30ea\u30f3\u9178\u5316Akt1\u306e\u6e1b\u5c11\u3092\u4ecb\u3057\u3066\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02017\uff08\u4eac\u90fd\uff09\u3001\u8981\u65e8\u96c6p.71\u30012017\u5e748\u670825\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3044\u3066\u7d30\u80de\u81a8\u5f35\u306b\u3088\u308bTRPV2\u6d3b\u6027\u5316\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u53cd\u5fdc\u3092\u60f9\u8d77\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u751f\u4f53\u6a5f\u80fd\u3068\u5275\u85ac\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02017\uff08\u4eac\u90fd\uff09\u3001\u8981\u65e8\u96c6p.85\u30012017\u5e748\u670825\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308bDGK\u03b1\u304a\u3088\u3073\u03b3\u6a5f\u80fd\u6291\u5236\u306f\u7d30\u80de\u5185Ca<sup>2+<\/sup>\u6fc3\u5ea6\u306b\u5bfe\u3057\u3066\u4e8c\u9762\u7684\u4f5c\u7528\u3092\u793a\u3059<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02017\uff08\u4eac\u90fd\uff09\u3001\u8981\u65e8\u96c6p.60\u30012017\u5e748\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u5ddd\u63da\u5b50\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u4e2d\u5c71\u8cb4\u5bdb\u3001\u6728\u6751\u60a0\u5e0c\u3001\u77f3\u5ddd\u667a\u4e45\uff1aDiacylglycerol kinase \u03b4 deficiency in mice pancreatic \u03b2-cells leads to improvement of streptozotocin-induced diabetes<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02017\uff08\u4eac\u90fd\uff09\u3001\u8981\u65e8\u96c6p.70\u30012017\u5e748\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30a2\u30c7\u30ce\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u4f5c\u7528\u306b\u3088\u308a\u30ab\u30d5\u30a7\u30a4\u30f3\u306f\u30ea\u30f3\u9178\u5316Akt1\u306e\u6e1b\u5c11\u3092\u4ecb\u3057\u3066\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02017\uff08\u4eac\u90fd\uff09\u3001\u8981\u65e8\u96c6p.124\u30012017\u5e748\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6728\u6751\u6709\u5e0c\u3001\u5897\u7530\u771f\u4e5f\u3001\u5185\u7530\u5149\u54b2\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u5e73\u6ed1\u7b4b\u3092\u7528\u3044\u305f\u30a2\u30b7\u30eb\u5316\u30d6\u30c6\u30ce\u30ea\u30c9\u8a98\u5c0e\u4f53\u306e\u751f\u7269\u6d3b\u6027\u6a5f\u5e8f\u306e\u89e3\u660e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u9759\u5ca1\u5b9f\u9a13\u52d5\u7269\u7814\u7a76\u4f1a \u5e73\u621029\u5e74\u5ea6\u5927\u4f1a \u7b2c45\u56de\u7814\u7a76\u767a\u8868\u4f1a\uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6p.11\u30012017\u5e749\u670829\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u5ddd\u667a\u4e45\u3001\u68ee\u5ca1\u4e9c\u671b\u3001\u4f50\u91ce\u5b9f\u54b2\u3001\u91d1\u5b50\u96ea\u5b50\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308bNO\u7523\u751f\u8abf\u7bc0\u7cfb\u30682\u578b\u7cd6\u5c3f\u75c5\u75c5\u614b\u3068\u306e\u95a2\u4fc2<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u751f\u7406\u5b66\u7814\u7a76\u6240 \u7814\u7a76\u4f1a2017\uff08\u611b\u77e5\uff09\u3001\u8981\u65e8\u96c6p.19\u30012017\u5e7410\u670812\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Toshiaki Sawatani, Yukiko Kaneko, Tomohisa Ishikawa\uff1aInhibition of Type I DGK leads to a dual response on Ca<sup>2+<\/sup> signaling in pancreatic \u03b2-cells<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">International Symposium on Calcium Binding Proteins and Calcium Function in Health and Disease\uff08CaBP20\uff09\uff08Awaji\uff09\u3001\u8981\u65e8\u96c6p.61\u30012017\u5e7410\u670822-26\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u9234\u6728\u826f\u8f14\u3001\u82e5\u6797\u5922\u4eba\u3001\u897f\u5c71\u826f\u592a\u3001\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u9759\u6b62\u578b\u809d\u661f\u7d30\u80de\u306b\u304a\u3051\u308bET-1\u8a98\u767a\u6027\u53ce\u7e2e\u306e\u767a\u751f\u6a5f\u5e8f<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c27\u56de\u65e5\u672c\u5faa\u74b0\u85ac\u7406\u5b66\u4f1a\uff08\u611b\u77e5\uff09\u3001\u8981\u65e8\u96c6p.45\u30012017\u5e7412\u67081\u65e5<\/span><\/p><\/div><\/div><\/div><\/div><\/div><\/section><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"11\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-22211\" aria-expanded=\"false\">2016<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-22211\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"11\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-22211\" tabindex=\"0\" hidden=\"hidden\"><section class=\"elementor-section elementor-top-section elementor-element elementor-element-4d9137c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4d9137c\" data-element_type=\"section\"><div class=\"elementor-container elementor-column-gap-default\"><div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e3d6a22\" data-id=\"5e3d6a22\" data-element_type=\"column\"><div class=\"elementor-widget-wrap elementor-element-populated\"><div class=\"elementor-element elementor-element-57a02de0 elementor-widget elementor-widget-text-editor\" data-id=\"57a02de0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><p><span style=\"color: #000000;\">\u5ca9\u898b\u606d\u4ecb\u3001\u897f\u5c71\u826f\u592a\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u9759\u6b62\u578b\u809d\u661f\u7d30\u80de\u306f\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306b\u3088\u3063\u3066\u53ce\u7e2e\u3059\u308b\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c26\u56de\u65e5\u672c\u5faa\u74b0\u85ac\u7406\u5b66\u4f1a\uff08\u677e\u672c\uff09\u30012016\u5e7412\u67082\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Yukiko Kaneko, Tomohisa Ishikawa: Nobiletin promotes insulin secretion and prevents \u03b2-cell apoptosis through a cAMP dependent pathway.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u00a0The 3rd\u3000International Conference on Pharma and Food (\u9759\u5ca1), \u8981\u65e8\u96c6 p.34-35, 2016\u5e7411\u670817\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Toshiaki Sawatani, Yukiko Kaneko, Tomohisa Ishikawa: Involvement of TRPV2 in cell swelling-induced insulin secretion in mouse pancreatic \u03b2-cells.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">The 3rd\u3000International Conference on Pharma and Food (\u9759\u5ca1), p.134, \u8981\u65e8\u96c6 2016\u5e7411\u670817\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u83f1\u6cbc\u745b\u592a\u3001\u5317\u5c71\u667a\u7ae0\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u51b7\u5374\u6761\u4ef6\u4e0b\u306b\u304a\u3051\u308b\u03b1<sub>1<\/sub>\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u76ae\u819a\u8840\u7ba1\u53ce\u7e2e\u5fdc\u7b54\u6027\u5897\u5f37\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c135\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6d5c\u677e\uff09\u3001\u8981\u65e8\u96c6 p.16\u30012016\u5e7410\u67088\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u2160\u578b\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u306e\u6a5f\u80fd\u6291\u5236\u306f\u7d30\u80de\u5185Ca<sup>2+<\/sup>\u6fc3\u5ea6\u306b\u5bfe\u3057\u3066\u4e8c\u9762\u6027\u3092\u793a\u3059.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c135\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6d5c\u677e\uff09\u3001\u8981\u65e8\u96c6 p.39\u30012016\u5e7410\u67088\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u79cb\u5c71\u5b63\u91cc\u5b50\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u7027\u4e95\u7f8e\u6a39\u3001\u9752\u67f3\u6709\u7d00\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u67d1\u6a58\u679c\u76ae\u6210\u5206\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u4f5c\u7528\u89e3\u6790\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c135\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6d5c\u677e\uff09\u3001\u8981\u65e8\u96c6 p.38\u30012016\u5e7410\u67088\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c71\u53e3\u6843\u751f\u3001\u897f\u5c71\u826f\u592a\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30ab\u30d5\u30a7\u30a4\u30f3\u306b\u3088\u308b\u809d\u661f\u7d30\u80de\u6d3b\u6027\u5316\u306b\u5bfe\u3059\u308b\u6291\u5236\u4f5c\u7528\u304a\u3088\u3073\u305d\u306e\u4f5c\u7528\u6a5f\u5e8f\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c135\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u6d5c\u677e\uff09\u3001\u8981\u65e8\u96c6 p.41\u30012016\u5e7410\u67088\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u53e4\u5ddd\u7422\u78e8\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u6642\u306b\u767a\u751f\u3059\u308b\u76ae\u819a\u8840\u6d41\u969c\u5bb3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u9759\u5ca1\u5b9f\u9a13\u52d5\u7269\u7814\u7a76\u4f1a\u3000\u7b2c44\u56de\u7814\u7a76\u767a\u8868\u4f1a(\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6 p.7\u30012016\u5e7410\u67087\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u53e4\u5ddd\u7422\u78e8\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b\u8db3\u5e95\u90e8\u76ae\u819a\u8840\u6d41\u969c\u5bb3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u6790\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02016\uff08\u4ed9\u53f0\uff09\u3001\u8981\u65e8\u96c6 p.28\u30012016\u5e748\u670824\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c71\u53e3\u6843\u751f\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u5358\u96e2\u809d\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306b\u5bfe\u3059\u308b\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3E2\u306e2\u9762\u6027\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02016\uff08\u4ed9\u53f0\uff09\u3001\u8981\u65e8\u96c6 p.62\u30012016\u5e748\u670824\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37 \u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1aI\u578b\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u6a5f\u80fd\u963b\u5bb3\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u6291\u5236\u6a5f\u5e8f\u306e\u89e3\u660e\u30682\u578b\u7cd6\u5c3f\u75c5\u75c5\u614b\u3068\u306e\u95a2\u9023\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c59\u56de\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a\uff08\u4eac\u90fd\uff09\u3001<em>JDS <\/em>(Supl.1) S-461, 2016\u5e745\u670821\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50 \u96ea\u5b50\u3001\u4f50\u85e4 \u592a\u6cbb\u3001\u77f3\u6e21 \u5343\u88d5\u3001\u4e2d\u5c71 \u8cb4\u5bdb\u3001\u77f3\u5ddd \u63da\u5b50\u3001\u77f3\u5ddd \u667a\u4e45\uff1a\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b4\u306f\u81b5\u03b2\u7d30\u80de\u5897\u6b96\u3092\u6291\u5236\u6027\u306b\u5236\u5fa1\u3059\u308b\u5206\u5b50\u3067\u3042\u308b\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c59\u56de\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u5e74\u6b21\u5b66\u8853\u96c6\u4f1a\uff08\u4eac\u90fd\uff09\u3001<em>JDS <\/em>(Supl.1) S-158, 2016\u5e745\u670819\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u5750\u9aa8\u795e\u7d4c\u6162\u6027\u7d5e\u627c\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u306e\u8db3\u5e95\u90e8\u8840\u6d41\u969c\u5bb3\u306b\u304a\u3051\u308b\u8840\u7ba1\u62e1\u5f35\u85ac\u306e\u52b9\u679c\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c136\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u3001\u8981\u65e8\u96c63 p170\u30012016\u5e743\u670829\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\u3001\u79cb\u5c71\u5b63\u7406\u5b50\u3001\u7027\u4e95\u7f8e\u6a39\u3001\u9752\u67f3\u6709\u7d00\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u67d1\u6a58\u679c\u76ae\u6210\u5206\u30ce\u30d3\u30ec\u30c1\u30f3\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u4f5c\u7528\u304a\u3088\u3073\u03b2\u7d30\u80de\u4fdd\u8b77\u52b9\u679c\u3092\u793a\u3059\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c136\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u3001\u8981\u65e8\u96c63 p176\u30012016\u5e743\u670829\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u6e21\u5343\u88d5\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u4f50\u85e4\u592a\u6cbb\u3001\u4e2d\u5c71\u8cb4\u5bdb\u3001\u77f3\u5ddd\u63da\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b4\u306f\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3044\u3066\u7d30\u80de\u5897\u6b96\u6291\u5236\u306b\u50cd\u304f\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c136\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u3001\u8981\u65e8\u96c63 p.57\u30012016\u5e743\u670827\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u68ee\u5ca1\u4e9c\u671b\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u4f50\u91ce\u5b9f\u54b2\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7cd6\u5c3f\u75c5\u6761\u4ef6\u4e0b\u3067\u306e\u7d30\u80de\u5185ADMA\u306e\u84c4\u7a4d\u306f\u03b2\u7d30\u80de\u969c\u5bb3\u3092\u4ea2\u9032\u3059\u308b\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c136\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u3001\u8981\u65e8\u96c63 p.57\u30012016\u5e743\u670827\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7d30\u80de\u5185DAG\u306e\u84c4\u7a4d\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u6291\u5236\u6a5f\u69cb\u306e\u89e3\u6790\u3068\uff12\u578b\u7cd6\u5c3f\u75c5\u75c5\u614b\u3068\u306e\u95a2\u9023\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c136\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u3001\u8981\u65e8\u96c63 p.57\u30012016\u5e743\u670827\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c0f\u539f\u3000\u4e00\u7537\u3001\u5b87\u7530\u3000\u5b97\u6643\u3001\u6edd\u53e3\u3000\u8302\u5e78\u3001\u80fd\u4ee3\u3000\u88d5\u4e5f\u3001\u77f3\u5ddd\u3000\u667a\u4e45\uff1a\u30de\u30a6\u30b9\u9aa8\u683c\u7b4b\u306e\u4f38\u5c55\u8a98\u767a\u6027\u7cd6\u53d6\u308a\u8fbc\u307f\u6a5f\u69cb\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c93\u56de\u65e5\u672c\u751f\u7406\u5b66\u4f1a\u5927\u4f1a\uff08\u672d\u5e4c\uff09\u3001<em>J. Physiol. Sci. <\/em>66(Supl. 1), S112\u30012016\u5e743\u670822\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a2\u578b\u7cd6\u5c3f\u75c5\u75c5\u614b\u306b\u304a\u3051\u308bI\u578b\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u6a5f\u80fd\u4f4e\u4e0b\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u6291\u5236\u6a5f\u5e8f\u306e\u89e3\u6790\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c89\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u3001<em>J Pharmacol. Sci.<\/em>,130(Supl), S144 2016\u5e743\u67089\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u79cb\u5c71\u5b63\u7406\u5b50\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u7027\u4e95\u7f8e\u6a39\u3001\u9752\u67f3\u6709\u7d00\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u67d1\u6a58\u679c\u76ae\u6210\u5206\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u4f5c\u7528\u89e3\u6790\u67d1\u6a58\u985e\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u30fb\u30ce\u30d3\u30ec\u30c1\u30f3\u306fcAMP\u4f9d\u5b58\u6027\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u4f5c\u7528\u3068\u03b2\u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u6291\u5236\u4f5c\u7528\u3092\u793a\u3059\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c89\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u3001<em>J Pharmacol. Sci.<\/em> 130(Supl), S178, 2016\u5e743\u67089\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u53e4\u5ddd\u7422\u78e8\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b\u8db3\u5e95\u52d5\u8108\u53ce\u7e2e\u5fdc\u7b54\u6027\u4ea2\u9032\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790\uff0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c89\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u3001<em>J Pharmacol. Sci.<\/em> 130(Supl), S84, 2016\u5e743\u67089\u65e5<\/span><\/p><\/div><\/div><\/div><\/div><\/div><\/section><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"12\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-22212\" aria-expanded=\"false\">2015<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-22212\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"12\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-22212\" tabindex=\"0\" hidden=\"hidden\"><section class=\"elementor-section elementor-top-section elementor-element elementor-element-5c3a778b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5c3a778b\" data-element_type=\"section\"><div class=\"elementor-container elementor-column-gap-default\"><div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-215da18d\" data-id=\"215da18d\" data-element_type=\"column\"><div class=\"elementor-widget-wrap elementor-element-populated\"><div class=\"elementor-element elementor-element-59fac4b3 elementor-widget elementor-widget-text-editor\" data-id=\"59fac4b3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\"><div class=\"elementor-widget-container\"><p><span style=\"color: #000000;\">\u53e4\u5ddd\u7fd4\u5e73\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u83ca\u5730\u6674\u4e45\u3001\u5927\u5cf6\u5409\u8f1d\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u7d30\u80de\u6027\u7c98\u83cc\u7531\u6765\u5316\u5408\u7269DIF-1\u306e\u809d\u661f\u7d30\u80de\u6d3b\u6027\u5316\u6291\u5236\u4f5c\u7528<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c88\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u3001<em>J. Pharmacol. Sci.<\/em> 128(Supl), S174\u30012015\u5e743\u670818\u65e5<\/span><\/p><\/div><div class=\"elementor-widget-container\"><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d72\uff1a in vitro\u5faa\u74b0\u6a5f\u80fd\u8a55\u4fa1\u6cd5. \u51b7\u5374\u8a98\u767a\u6027\u8840\u7ba1\u53ce\u7e2e\u306b\u95a2\u9023\u3057\u305f\u76ae\u819a\u5fae\u5c0f\u5faa\u74b0\u969c\u5bb3\u30e2\u30c7\u30eb<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c88\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u3001<em>J. Pharmacol. Sci.<\/em> 128(Supl), S80\u30012015\u5e743\u670819\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u5ddd\u667a\u4e45\u3001\u91d1\u5b50\u96ea\u5b50\uff1a\u30b7\u30f3\u30dd\u30b8\u30a6\u30e038\uff1a\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc(DGK)\u306e\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027.\u3000\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u8abf\u7bc0\u306b\u304a\u3051\u308b\u30bf\u30a4\u30d7I\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u306e\u5f79\u5272<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c88\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u5e74\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u3001<em>J. Pharmacol. Sci.<\/em> 128(Supl), S67\u30012015\u5e743\u670820\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u4e00\u822c\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\uff1a\u30ab\u30eb\u30b7\u30a6\u30e0\u30b7\u30b0\u30ca\u30eb\u5236\u5fa1\u7814\u7a76\u304b\u3089\u898b\u3048\u3066\u304d\u305f\u5185\u5206\u6ccc\u30fb\u514d\u75ab\u7cfb\u75be\u60a3\u306e\u65b0\u305f\u306a\u5275\u85ac\u6a19\u7684. \u65b0\u898f2\u578b\u7cd6\u5c3f\u75c5\u5275\u85ac\u6a19\u7684\u3068\u3057\u3066\u306e\u81b5\u03b2\u7d30\u80de\u8102\u8cea\u4ee3\u8b1d\u5236\u5fa1<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c135\u5e74\u4f1a\uff08\u795e\u6238\uff09\u3001\u8981\u65e8\u96c63 p.191\u30012015\u5e743\u670827\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u6fa4\u8c37\u4fca\u660e\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u4f50\u85e4\u592a\u6cbb\u3001\u91ce\u53e3\u4e9c\u5e0c\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1aH<sub>2<\/sub>O<sub>2<\/sub>\u306b\u3088\u308b\u81b5\u03b2\u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u8a98\u5c0e\u6a5f\u69cb\u306e\u89e3\u660e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c135\u5e74\u4f1a\uff08\u795e\u6238\uff09\u3001\u8981\u65e8\u96c63 p.84\u30012015\u5e743\u670827\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1aPhenylephrine\u8a98\u767a\u6027\u53ce\u7e2e\u306b\u304a\u3051\u308b\u03b1<sub>1d<\/sub> \u53d7\u5bb9\u4f53\u306f\u6e29\u5ea6\u611f\u53d7\u6027\u306b\u76f8\u95a2\u6027\u304c\u3042\u308b<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u65e5\u672c\u85ac\u5b66\u4f1a\u7b2c135\u5e74\u4f1a\uff08\u795e\u6238\uff09\u3001\u8981\u65e8\u96c63 p.129\u30012015\u5e743\u670828\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\uff1a\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5b66\u8853\u5968\u52b1\u8cde\u53d7\u8cde\u8b1b\u6f14\uff1a2\u578b\u7cd6\u5c3f\u75c5\u306b\u3088\u308b\u81b5\u03b2\u7d30\u80de\u6a5f\u80fd\u969c\u5bb3\u304b\u3089\u306e\u56de\u5fa9\u3092\u76ee\u6307\u3057\u305f\u65b0\u898f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u6a19\u7684\u306e\u63a2\u7d22\u3068\u6a5f\u80fd\u89e3\u6790\u3000<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c61\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5927\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u8981\u65e8\u96c6 p.31\u30012015\u5e747\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u68ee\u5ca1\u4e9c\u671b\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308bADMA\u3092\u4ecb\u3057\u305fNO\u7523\u751f\u8abf\u7bc0\u6a5f\u69cb\u3068\u7cd6\u5c3f\u75c5\u75c5\u614b\u3078\u306e\u95a2\u4e0e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c61\u56de\u65e5\u672c\u85ac\u5b66\u4f1a\u6771\u6d77\u652f\u90e8\u5927\u4f1a\uff08\u540d\u53e4\u5c4b\uff09\u3001\u8981\u65e8\u96c6 p.79\u30012015\u5e747\u67084\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c0f\u539f\u4e00\u7537\uff1a\u30b7\u30f3\u30dd\u30b8\u30a6\u30e01\uff1a\u30d7\u30ed\u30c6\u30a4\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc2A\u306b\u3088\u308b\u5e73\u6ed1\u7b4b\u53ce\u7e2e\u5236\u5fa1.\u3000\u30df\u30aa\u30b7\u30f3\u8efd\u93963\u30ea\u30f3\u9178\u5316\u8abf\u7bc0\u306b\u304a\u3051\u308bPP2A\u306e\u5f79\u5272<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c57\u56de\u65e5\u672c\u5e73\u6ed1\u7b4b\u5b66\u4f1a\u7dcf\u4f1a\uff08\u5b87\u90e8\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u6284\u9332\u96c6 p.34\u30012015\u5e748\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u7530\u88d5\u4e08\u3001\u53e4\u5ddd\u7422\u9ebb\u3001\u9f4a\u85e4\u771f\u4e5f\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u5750\u9aa8\u795e\u7d4c\u6162\u6027\u7d5e\u627c\u30e2\u30c7\u30eb\u30e9\u30c3\u30c8\u306e\u6458\u51fa\u8db3\u5e95\u52d5\u8108\u306b\u304a\u3051\u308b\u53ce\u7e2e\u5fdc\u7b54\u6027\u4ea2\u9032\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c57\u56de\u65e5\u672c\u5e73\u6ed1\u7b4b\u5b66\u4f1a\u7dcf\u4f1a\uff08\u5b87\u90e8\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u6284\u9332\u96c6 p.57\u30012015\u5e748\u670826\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u6e21\u5343\u88d5\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u4f50\u85e4\u592a\u6cbb\u3001\u4e2d\u5c71\u8cb4\u5bdb\u3001\u77f3\u5ddd\u63da\u5b50\u3001\u5343\u8449\u91cc\u83dc\u3001\u85e4\u8cab\u8cb4\u5927\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b4\u306e\u767a\u73fe\u30fb\u6a5f\u80fd\u89e3\u6790<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u6b21\u4e16\u4ee3\u3092\u62c5\u3046\u5275\u85ac\u30fb\u533b\u7642\u85ac\u7406\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02015\uff08\u6771\u4eac\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u96c6p.41\u30002015\u5e748\u670829\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u77f3\u6e21\u5343\u88d5\u3001\u91d1\u5b50\u96ea\u5b50\u3001\u4f50\u85e4\u592a\u6cbb\u3001\u4e2d\u5c71\u8cb4\u5bdb\u3001\u77f3\u5ddd\u63da\u5b50\u3001\u5343\u8449\u91cc\u83dc\u3001\u85e4\u8cab\u8cb4\u5927\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u81b5\u03b2\u7d30\u80de\u306b\u304a\u3051\u308b\u30b8\u30a2\u30b7\u30eb\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30ad\u30ca\u30fc\u30bc\u03b4\u306e\u5f79\u5272\u306e\u89e3\u660e<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c133\u56de\u65e5\u672c\u85ac\u7406\u5b66\u4f1a\u95a2\u6771\u90e8\u4f1a\uff08\u67cf\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30fb\u8981\u65e8\u96c6p.61\u30012015\u5e7410\u670810\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Hirotake Ishida, Eita Hishinuma, Shin-ya Saito, Tomohisa Ishikawa\uff1aEffect of cooling on contraction mediated by \u03b1<sub>1<\/sub>-adrenoceptor in rat tail artery.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c20\u56de\u9759\u5ca1 \u5065\u5eb7\u30fb\u9577\u5bff\u5b66\u8853\u30d5\u30a9\u30fc\u30e9\u30e0 \uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6 p.91\u30012015\u5e7410\u670830\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Ayaka Horie, Tomohisa Ishikawa\uff1aImpaired blood flow after chronic constriction nerve injury in mice.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c20\u56de\u9759\u5ca1 \u5065\u5eb7\u30fb\u9577\u5bff\u5b66\u8853\u30d5\u30a9\u30fc\u30e9\u30e0 \uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6 p.92\u30012015\u5e7410\u670830\u65e5<\/span><\/p><p><span style=\"color: #000000;\">Momoka Yamaguchi, Shin-ya Saito, Tomohisa Ishikawa\uff1aCaffeine interferes change in expression of EP receptor subtypes during HSC activation.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c20\u56de\u9759\u5ca1 \u5065\u5eb7\u30fb\u9577\u5bff\u5b66\u8853\u30d5\u30a9\u30fc\u30e9\u30e0 \uff08\u9759\u5ca1\uff09\u3001\u8981\u65e8\u96c6 p.93\u30012015\u5e7410\u670830\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u91d1\u5b50\u96ea\u5b50\u3001\u4f50\u85e4\u592a\u6cbb\u3001\u77f3\u6e21\u5343\u88d5\u3001\u4e2d\u5c71\u8cb4\u5bdb\u3001\u77f3\u5ddd\u667a\u4e45\uff1a\u3010\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d7\u3011 DG\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u3068\u7cd6\u5c3f\u75c5\u95a2\u9023\u75be\u60a3\u3000Functional role of diacylglycerol kinase \u03b4 in pancreatic \u03b2-cells.<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b2c38\u56de\u65e5\u672c\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a\u3001\u7b2c88\u56de\u65e5\u672c\u751f\u5316\u5b66\u4f1a\u5927\u4f1a \u5408\u540c\u5927\u4f1a\uff08\u795e\u6238\uff09\u30012015\u5e7412\u67082\u65e5<\/span><\/p><p><span style=\"color: #000000;\">\u5c0f\u539f\u4e00\u7537\uff1a\u30de\u30a6\u30b9\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308b\u4f38\u5c55\u8a98\u767a\u6027\u7cd6\u53d6\u308a\u8fbc\u307f\u6a5f\u69cb<\/span><\/p><p style=\"text-align: right;\"><span style=\"color: #000000;\">\u7b4b\u751f\u7406\u306e\u96c6\u3044 \uff08\u6771\u4eac\uff09\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u30012015\u5e7412\u670819\u65e5<\/span><\/p><\/div><\/div><\/div><\/div><\/div><\/section><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>2026 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2026 \u68ee\u5cf6 \u5343\u6674\u3001\u91d1\u5b50 \u96ea\u5b50\u3001\u5c71\u53e3 \u6843\u751f\u3001\u6cb3\u5408 \u4f51\u7f8e\u3001\u91d1\u6ca2 \u8cb4\u61b2\u3001\u77f3\u5ddd \u667a\u4e45 : \u81b5\u03b2\u7d30\u80de\u30a2\u30dd\u30c8&hellip; <\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1811","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/index.php?rest_route=\/wp\/v2\/pages\/1811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1811"}],"version-history":[{"count":223,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/index.php?rest_route=\/wp\/v2\/pages\/1811\/revisions"}],"predecessor-version":[{"id":3182,"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/index.php?rest_route=\/wp\/v2\/pages\/1811\/revisions\/3182"}],"wp:attachment":[{"href":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}