{"id":481,"date":"2021-04-25T10:49:58","date_gmt":"2021-04-25T01:49:58","guid":{"rendered":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco_wp\/?page_id=481"},"modified":"2024-11-21T16:03:41","modified_gmt":"2024-11-21T07:03:41","slug":"1-%e3%82%a4%e3%83%b3%e3%82%b9%e3%83%aa%e3%83%b3%e5%88%86%e6%b3%8c%e5%88%b6%e5%be%a1%e6%a9%9f%e6%a7%8b%e3%81%ae%e8%a7%a3%e6%9e%90","status":"publish","type":"page","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/?page_id=481","title":{"rendered":"1. \u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"481\" class=\"elementor elementor-481\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a3e5d66 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a3e5d66\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0c4434e\" data-id=\"0c4434e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e52fa39 elementor-widget elementor-widget-heading\" data-id=\"e52fa39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1.\u3000\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u6790<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9cf8a9a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9cf8a9a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a2578aa\" data-id=\"a2578aa\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bb3d381 elementor-widget elementor-widget-text-editor\" data-id=\"bb3d381\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000; font-family: arial, helvetica, sans-serif;\">\u8fd1\u5e74\u306e\u300c\u79d1\u5b66\u6280\u8853\u91cd\u8981\u65bd\u7b56\u30a2\u30af\u30b7\u30e7\u30f3\u30d7\u30e9\u30f3\u300d\u306e\u91cd\u70b9\u7684\u53d6\u308a\u7d44\u307f\u306b\u63b2\u3052\u3089\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u5897\u3048\u7d9a\u3051\u308b\u7cd6\u5c3f\u75c5\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u306f\u3001\u7126\u7709\u306e\u8ab2\u984c\u3067\u3059\u3002\u6211\u304c\u56fd\u306e\u7cd6\u5c3f\u75c5\u306e\u5927\u534a\u3092\u5360\u3081\u308b\uff12\u578b\u7cd6\u5c3f\u75c5\u306e\u539f\u56e0\u3068\u3057\u3066\u306f\u3001\u81b5B\u7d30\u80de\u304b\u3089\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u969c\u5bb3\u306e\u5360\u3081\u308b\u5272\u5408\u304c\u5927\u304d\u3044\u3053\u3068\u304c\u81e8\u5e8a\u7814\u7a76\u3088\u308a\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3088\u3063\u3066\u3001\uff12\u578b\u7cd6\u5c3f\u75c5\u306e\u75c5\u56e0\u3092\u7a76\u660e\u3057\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u3092\u5275\u51fa\u3059\u308b\u306b\u306f\u3001\u81b5B\u7d30\u80de\u306b\u304a\u3051\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u5206\u5b50\u30b9\u30a4\u30c3\u30c1\u3067\u3042\u308bG\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7740\u76ee\u3057\u3001\u81b5B\u7d30\u80de\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u84c4\u3048\u3066\u3044\u308b\u5c0f\u80de(\u30a4\u30f3\u30b9\u30ea\u30f3\u9846\u7c92)\u306e\u52d5\u614b\u304c\u6642\u9593\u7684\u30fb\u7a7a\u9593\u7684\u306b\u3069\u306e\u3088\u3046\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u306e\u304b\u3092\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e667d52 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e667d52\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7b200c7\" data-id=\"7b200c7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2dc4254 elementor-widget elementor-widget-text-editor\" data-id=\"2dc4254\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u3000<span style=\"font-family: arial, helvetica, sans-serif; color: #000000;\">G\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001GTP\u578b\u304c\u6d3b\u6027\u578b(\u30b9\u30a4\u30c3\u30c1\u306e\u30aa\u30f3)\u3067GDP\u578b\u304c\u4e0d\u6d3b\u6027\u578b(\u30b9\u30a4\u30c3\u30c1\u306e\u30aa\u30d5)\u3068\u3053\u308c\u307e\u3067\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001GDP\u578b\u306eG\u30bf\u30f3\u30d1\u30af\u8cea(Rab27a)\u306b\u7d50\u5408\u3057\u3001\u4e0b\u6d41\u306b\u30b7\u30b0\u30ca\u30eb\u3092\u4f1d\u3048\u308b\u5206\u5b50(coronin3\u3001IQGAP1)\u3092\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u300cGDP\u578b\u4f9d\u5b58\u6027\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u300d\u306e\u6982\u5ff5\u3092\u63d0\u5531\u3057\u3001\u4f4e\u5206\u5b50\u91cfG\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u306f\u3069\u306e\u304f\u3089\u3044\u666e\u904d\u7684\u306a\u73fe\u8c61\u3067\u3042\u308b\u306e\u304b\u3092\u691c\u8a0e\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-42235e5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"42235e5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-545a8f9\" data-id=\"545a8f9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9a0bcd2 elementor-widget elementor-widget-image\" data-id=\"9a0bcd2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"549\" src=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/795316b92fc766b0181f6fef074f03fa-768x549.png\" class=\"attachment-medium_large size-medium_large wp-image-895\" alt=\"\" srcset=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/795316b92fc766b0181f6fef074f03fa-768x549.png 768w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/795316b92fc766b0181f6fef074f03fa-300x214.png 300w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/795316b92fc766b0181f6fef074f03fa-1024x732.png 1024w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/795316b92fc766b0181f6fef074f03fa-1536x1098.png 1536w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/795316b92fc766b0181f6fef074f03fa-2048x1464.png 2048w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-74bfd49 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"74bfd49\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-357b5cb\" data-id=\"357b5cb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4c6d567 elementor-widget elementor-widget-text-editor\" data-id=\"4c6d567\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: arial, helvetica, sans-serif; color: #000000;\">\u3000\u3055\u3089\u306b\u79c1\u305f\u3061\u306f\u3001\u958b\u53e3\u653e\u51fa\u306b\u3088\u308a\u7d30\u80de\u819c\u306b\u878d\u5408\u3057\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u9846\u7c92\u819c\u3092\u518d\u3073\u7d30\u80de\u5185\u306b\u53d6\u308a\u8fbc\u3080\u3053\u3068\u3067(\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9)\u3001\u7d30\u80de\u306e\u5bb9\u7a4d\u3092\u5206\u6ccc\u5f8c\u3082\u4e00\u5b9a\u306b\u4fdd\u3064\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u523a\u6fc0\u3067\u3042\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u306f\u3001\u540c\u6642\u306b\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306b\u95a2\u308f\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u7fa4(coronin3\u3068Rab27a)\u3092\u8db3\u5834\u30bf\u30f3\u30d1\u30af\u8cea(IQGAP1)\u3092\u4ecb\u3057\u3066\u7d30\u80de\u819c\u8fd1\u508d\u306b\u30ea\u30af\u30eb\u30fc\u30c8\u3057\u307e\u3059\u3002\u30ea\u30af\u30eb\u30fc\u30c8\u3055\u308c\u305fcoronin3\u306f\u3001GDP\u578bRab27a\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u9aa8\u683c(\u30a2\u30af\u30c1\u30f3)\u3092\u675f\u306d\u3001\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001GDP\u578b\u4f9d\u5b58\u6027\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u6700\u521d\u306e\u5831\u544a\u3067\u3059\u3002<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-35ac98d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"35ac98d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-727814e\" data-id=\"727814e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4d49e99 elementor-widget elementor-widget-image\" data-id=\"4d49e99\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"768\" height=\"520\" src=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/2b530e80c7d0de90885e285c5d798063-768x520.png\" class=\"attachment-medium_large size-medium_large wp-image-896\" alt=\"\" srcset=\"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/2b530e80c7d0de90885e285c5d798063-768x520.png 768w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/2b530e80c7d0de90885e285c5d798063-300x203.png 300w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/2b530e80c7d0de90885e285c5d798063-1024x694.png 1024w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/2b530e80c7d0de90885e285c5d798063-1536x1041.png 1536w, https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/pharmaco\/wp-content\/uploads\/2021\/04\/2b530e80c7d0de90885e285c5d798063-2048x1388.png 2048w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6d62d33 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6d62d33\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-348f861\" data-id=\"348f861\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6882dc4 elementor-widget elementor-widget-text-editor\" data-id=\"6882dc4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: arial, helvetica, sans-serif; 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