{"id":98,"date":"2019-04-18T17:20:30","date_gmt":"2019-04-18T08:20:30","guid":{"rendered":"http:\/\/w3pharm.u-shizuoka-ken.ac.jp\/yakuzai_wp\/?page_id=98"},"modified":"2019-04-24T11:54:41","modified_gmt":"2019-04-24T02:54:41","slug":"%e7%8f%be%e5%9c%a8%e3%81%ae%e7%a0%94%e7%a9%b6%e3%83%86%e3%83%bc%e3%83%9e","status":"publish","type":"page","link":"https:\/\/w3pharm.u-shizuoka-ken.ac.jp\/yakuzai\/?page_id=98","title":{"rendered":"\u73fe\u5728\u306e\u7814\u7a76\u30c6\u30fc\u30de"},"content":{"rendered":"\n
\n
\n
\n
\n
\n
\n

\u7814\u7a76\u5185\u5bb9<\/strong><\/h3>\n

\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u4f01\u696d\uff08\u88fd\u85ac\uff0c\u98df\u54c1\uff0c\u5316\u7ca7\u54c1\uff09\uff0c\u56fd\u5185\u5916\u306e\u5927\u5b66\u30fb\u7814\u7a76\u6a5f\u95a2\u3068\u306e\u5171\u540c\u7814\u7a76\u3068\u3057\u3066\u4e3b\u306b\u4ee5\u4e0b\u306e\u30c6\u30fc\u30de\u306b\u53d6\u308a\u7d44\u307f\uff0c\u7279\u8a31\u51fa\u9858\uff0c\u8ad6\u6587\u30fb\u5b66\u4f1a\u767a\u8868\u3092\u901a\u3058\u3066\u85ac\u5264\u79d1\u5b66\u306e\u767a\u5c55\u306b\u8ca2\u732e\u3057\u307e\u3059\uff0e

<\/p>\n

1.\u00a0<\/strong>\u85ac\u7269\u52d5\u614b\u5236\u5fa1\u306b\u3088\u308b\u526f\u4f5c\u7528\u306e\u56de\u907f<\/strong><\/h4>\n

\u526f\u4f5c\u7528\u3068\u85ac\u7269\u52d5\u614b\u306f\u975e\u5e38\u306b\u5bc6\u63a5\u306a\u95a2\u4fc2\u306b\u3042\u308a\u307e\u3059\uff0e\u305d\u3053\u3067\uff0c\u85ac\u7269\u52d5\u614b\u3092\u5de7\u307f\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u3067\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u6cbb\u7642\u6cd5\u304c\u63d0\u793a\u3067\u304d\u308b\u3088\u3046\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\uff0e\u7279\u306b\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u80ba\u3078\u306e\u76f4\u63a5\u7684\u306a\u85ac\u7269\u6295\u4e0e\u3092\u53ef\u80fd\u306b\u3059\u308b\u7c89\u672b\u5438\u5165\u88fd\u5264\u306e\u958b\u767a\u306b\u529b\u3092\u6ce8\u3044\u3067\u3044\u307e\u3059\uff0e\u4f8b\u3048\u3070\uff0c\u7279\u767a\u6027\u80ba\u7dda\u7dad\u75c7\u6cbb\u7642\u85ac\u3067\u3042\u308b Pirfenidone \u306f\u7d4c\u53e3\u6295\u4e0e\u5f8c\u306b\u5149\u6bd2\u6027\u3084\u6d88\u5316\u7ba1\u969c\u5bb3\u306a\u3069\u306e\u526f\u4f5c\u7528\u3092\u793a\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u65b0\u305f\u306b\u5438\u5165\u88fd\u5264\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066 (1) \u4f5c\u7528\u90e8\u4f4d\u3078\u306e\u76f4\u63a5\u7684\u85ac\u7269\u9001\u9054\u306b\u3088\u308b\u6295\u4e0e\u91cf\u306e\u6e1b\u5c11\uff0c(2) \u526f\u4f5c\u7528\u767a\u73fe\u7d44\u7e54\u3078\u306e\u85ac\u7269\u79fb\u884c\u91cf\u6e1b\u5c11\u3092\u5171\u306b\u9054\u6210\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3057\u305f\uff0e\u672c\u77e5\u898b\u306f\u65e2\u306b 13 \u30f6\u56fd\u306b\u56fd\u969b\u7279\u8a31\u51fa\u9858\u3092\u3057\u3066\u3044\u307e\u3059\uff0e

<\/p>\n

\"\"\"\"\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0
[\u5438\u5165\u5264\u306e\u4f53\u5185\u52d5\u614b]<\/p>\n

2. <\/strong>\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3084\u7269\u6027\u5236\u5fa1\u3092\u5229\u7528\u3057\u305f\u85ac\u7269\u52d5\u614b\u30fb\u85ac\u52b9\u306e\u6539\u5584<\/strong><\/h4>\n

\u6211\u3005\u304c\u53d6\u308a\u7d44\u3080\u85ac\u5264\u79d1\u5b66\u306f\u751f\u7269\u85ac\u5264\u5b66\u3068\u7269\u7406\u85ac\u5264\u5b66\u306e 2 \u3064\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u5b66\u554f\u3067\u3059\uff0e\u85ac\u7269\u306e\u7269\u7406\u85ac\u5264\u5b66\u7684\u7279\u6027\u3092\u6226\u7565\u7684\u306b\u6539\u5909\u3059\u308b\u3053\u3068\u3067\uff0c\u751f\u7269\u85ac\u5264\u5b66\u7684\u7279\u6027\u3092\u6cbb\u7642\u306b\u9069\u3057\u305f\u5f62\u306b\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3059\uff0e\u4f8b\u3048\u3070\uff0c\u30ca\u30ce\u30af\u30ea\u30b9\u30bf\u30eb\u6280\u8853\u306e\u9069\u7528\u306b\u3088\u3063\u3066\u6c34\u306b\u6eb6\u3051\u306b\u304f\u3044\u85ac\u7269\u3067\u3042\u308b\u30c8\u30e9\u30cb\u30e9\u30b9\u30c8\u306e\u6eb6\u89e3\u6027\u306f\u8457\u3057\u304f\u5411\u4e0a\u3057\uff0c\u306a\u304a\u304b\u3064\u6d88\u5316\u7ba1\u7c98\u819c\u3078\u306e\u4ed8\u7740\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u98db\u8e8d\u7684\u306a\u7d4c\u53e3\u5438\u53ce\u6027\u306e\u5897\u5927\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3057\u305f\uff0e

\"\"\"\"
[\u30ca\u30ce\u30af\u30ea\u30b9\u30bf\u30eb\u88fd\u5264\u5316\u306b\u3088\u308b\u6eb6\u51fa\u6319\u52d5\u3068\u4f53\u5185\u52d5\u614b\u306e\u6539\u5584]<\/p>\n

3. <\/strong>\u75c5\u614b\u4e0b\u306e\u85ac\u7269\u52d5\u614b\u5909\u5316\u89e3\u6790\u3068\u305d\u306e\u6226\u7565\u7684\u306a\u56de\u907f\u65b9\u6cd5\u63a2\u7d22<\/strong><\/h4>\n

\u7279\u5b9a\u306e\u75c5\u6c17\u306b\u306a\u3063\u305f\u969b\u306b\uff0c\u4e00\u90e8\u306e\u6cbb\u7642\u85ac\u306e\u85ac\u7269\u52d5\u614b\u304c\u5927\u304d\u304f\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff0e\u4f8b\u3048\u3070\uff0c\u4f4e\u9178\u75c7\u3068\u547c\u3070\u308c\u308b\u80c3\u9178\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u305f\u72b6\u614b\u306b\u306a\u3063\u305f\u5834\u5408\u306b\u306f\u80c3\u5185 pH \u304c\u4e0a\u304c\u308b\u50be\u5411\u306b\u3042\u308a\uff0c\u305d\u306e\u969b\u306b\u5869\u57fa\u6027\u85ac\u7269\u306e\u5438\u53ce\u6027\u306f\u5927\u304d\u304f\u4e0b\u304c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff0e\u307e\u305f\uff0c\u6fc0\u3057\u3044\u75db\u307f\u3092\u611f\u3058\u305f\u969b\u306b\u306f\u75db\u307f\u6b62\u3081\u3092\u670d\u7528\u3057\u307e\u3059\u304c\uff0c\u5f37\u3044\u75db\u307f\u306e\u969b\u306b\u306f\u6d88\u5316\u7ba1\u306e\u52d5\u304d\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u85ac\u7269\u306e\u5438\u53ce\u9045\u5ef6\u304c\u8d77\u3053\u308a\uff0c\u75db\u307f\u6b62\u3081\u304c\u3059\u3050\u306b\u306f\u52b9\u304b\u306a\u3044\u3068\u3044\u3046\u6b8b\u5ff5\u306a\u73fe\u8c61\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\uff0e\u6211\u3005\u306f\u85ac\u7269\u52d5\u614b\u5236\u5fa1\u6280\u8853\u3092\u9069\u7528\u3057\u3066\uff0c\u3053\u306e\u3088\u3046\u306a\u75c5\u614b\u4e0b\u3067\u3082\u85ac\u7269\u52d5\u614b\u3068\u85ac\u52b9\u304c\u4f4e\u4e0b\u3057\u306a\u3044\u3088\u3046\u306a\u85ac\u5264\u958b\u767a\u306b\u8907\u6570\u6210\u529f\u3057\u3066\u3044\u307e\u3059\uff0e

\"\"\"\"
[\u30b8\u30d4\u30ea\u30c0\u30e2\u30fc\u30eb\u306e\u4e2d\u6027\u9818\u57df\u3067\u306e\u6eb6\u51fa\u6319\u52d5\u6539\u5584\u3068\u4f4e\u9178\u75c7\u30e2\u30c7\u30eb\u52d5\u7269\u306b\u304a\u3051\u308b\u4f53\u5185\u52d5\u614b\u306e\u6539\u5584]<\/p>\n

4. <\/strong>\u7d4c\u53e3\u5438\u53ce\u6027\u3068\u4f5c\u7528\u3092\u6539\u5584\u3057\u305f\u6a5f\u80fd\u6027\u98df\u54c1\u7d20\u6750\u306e\u65b0\u898f\u6295\u4e0e\u5f62\u614b\u958b\u767a<\/strong><\/h4>\n

\u30af\u30eb\u30af\u30df\u30f3\uff0c\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0 Q10<\/sub>\uff0c\u30ce\u30d3\u30ec\u30c1\u30f3\u306a\u3069\u306e\u6a5f\u80fd\u6027\u306f\u5e83\u304f\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u304c\uff0c\u3053\u308c\u3089\u306e\u7d4c\u53e3\u5438\u53ce\u6027\u304c\u6975\u3081\u3066\u4f4e\u3044\u3053\u3068\u306f\u610f\u5916\u3068\u77e5\u3089\u308c\u3066\u3044\u307e\u305b\u3093\uff0e\u6211\u3005\u306f\u3053\u308c\u3089\u306e\u6a5f\u80fd\u6027\u98df\u54c1\u7d20\u6750\u306e\u5438\u53ce\u6027\u3092\u5236\u5fa1\u3059\u308b\u751f\u7269\u85ac\u5264\u5b66\u4e0a\u306e\u56e0\u5b50\u3092\u660e\u3089\u304b\u306b\u3057\uff0c\u3053\u308c\u3089\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u52d5\u614b\u3068\u6a5f\u80fd\u6027\u3092\u5171\u306b\u6539\u5584\u3059\u308b\u8a66\u307f\u3092\u9032\u3081\u3066\u3044\u307e\u3059\uff0e\u4f8b\u3048\u3070\u6297\u8a8d\u77e5\u75c7\u6210\u5206\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u7d4c\u53e3\u5438\u53ce\u6027\u306f\u56fa\u4f53\u5206\u6563\u4f53\u88fd\u5264\u6280\u8853\u3092\u9069\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u7d04 14 \u500d\u3082\u5411\u4e0a\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\uff0e\u3053\u308c\u306b\u4f34\u3063\u3066\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u6a5f\u80fd\u6027\u3082\u98db\u8e8d\u7684\u306a\u6539\u5584\u3092\u8a8d\u3081\u307e\u3057\u305f\uff0e

\"\"\"\"
[\u30ce\u30d3\u30ec\u30c1\u30f3\u306e\u7269\u6027\u30fb\u52d5\u614b\u6539\u5584\u3068\u305d\u308c\u306b\u4f34\u3046\u809d\u4fdd\u8b77\u52b9\u679c\u306e\u5897\u5927]<\/p>\n

5. <\/strong>\u5316\u5408\u7269\u306e\u7269\u6027\u30fb\u52d5\u614b\u60c5\u5831\u304b\u3089\u306e\u526f\u4f5c\u7528\u30ea\u30b9\u30af\u4e88\u6e2c<\/strong><\/h4>\n

\u526f\u4f5c\u7528\u3092\u65e9\u671f\u306b\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u533b\u85ac\u54c1\u306e\u958b\u767a\u6210\u529f\u7387\u3092\u9ad8\u3081\uff0c\u3088\u308a\u5b89\u5168\u306a\u6cbb\u7642\u6cd5\u3092\u63d0\u793a\u3059\u308b\u3053\u3068\u306b\u7d50\u5b9f\u3059\u308b\u3053\u3068\u306f\u60f3\u50cf\u3059\u308b\u306b\u5bb9\u6613\u3067\u3059\uff0e\u6211\u3005\u306f\u533b\u85ac\u54c1\u3042\u308b\u3044\u306f\u5316\u7ca7\u54c1\u306e\u7269\u6027\u3068\u52d5\u614b\u60c5\u5831\u304b\u3089\u52b9\u7387\u3088\u304f\u526f\u4f5c\u7528\u3092\u4e88\u6e2c\u3059\u308b\u624b\u6cd5\u958b\u767a\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\uff0e\u3053\u306e\u4e00\u74b0\u3068\u3057\u3066\uff0c\u5149\u7dda\u904e\u654f\u75c7\u3068\u3088\u3070\u308c\u308b\u526f\u4f5c\u7528\u306e\u4e88\u6e2c\u3092\u7c21\u4fbf\u306b\u5b9f\u65bd\u53ef\u80fd\u306a\u65b0\u898f\u6280\u8853\u958b\u767a\u306b\u6210\u529f\u3057\uff0c2013 \u5e74\u306b\u306f\u6211\u3005\u306e\u958b\u767a\u3057\u305f\u624b\u6cd5\u304c\u56fd\u969b\u533b\u85ac\u54c1\u8a66\u9a13\u6cd5\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3 (ICH S10 guideline) \u306b\u63a1\u7528\u3055\u308c\u307e\u3057\u305f\uff0e\u3055\u3089\u306b\u5316\u7ca7\u54c1\u3084\u98df\u54c1\u306e\u5b89\u5168\u6027\u8a55\u4fa1\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u3082\u672c\u624b\u6cd5\u306e\u63a1\u7528\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\uff0e\u57fa\u790e\u7814\u7a76\u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u30ec\u30ae\u30e5\u30e9\u30c8\u30ea\u30fc\u30b5\u30a4\u30a8\u30f3\u30b9\u4e0a\u306e\u8ca2\u732e\u3082\u76ee\u6307\u3057\u3066\u4eca\u5f8c\u3082\u7814\u7a76\u6d3b\u52d5\u3092\u63a8\u9032\u3057\u307e\u3059\uff0e

\"\"\"\"
[\u85ac\u5264\u6027\u5149\u7dda\u904e\u654f\u75c7\u306e\u30ea\u30b9\u30af\u56e0\u5b50]<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\u00a0<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
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\u00a0<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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