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Clinical Pharmacology & Genetics

It is known that the efficiency of drugs is often varied from person to person. We consider one of the possible reasons to be the genetic defects of drug-metabolizing enzymes, receptors, and transporters. Analysis of the presence of genetic defects, that is to say the genetic polymorphisms, affecting the drug response in patients in advance will help the physicians select the suitable drugs with optimal dose and route of administration for patients to be going on medication. This may serve the avoidance of administration of drugs to non-responsive patients followed by the saving of drug expenses.
We aim at the clinical application of personal genetic information for optimization of medication, for prevention and therapy of the diseases, and for development of antibody-based medicines.


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Prof. Kunihiko Itoh

Department of
Clinical Pharmacology & Genetics,
School of Pharmaceutical Sciences, University of Shizuoka


52-1 Yada, Suruga-ku, Shizuoka
422-8526 Japan

TEL +81-54-264-5673
FAX +81-54-264-5673

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