2023年
[原著論文]
1. Shizuo Yamada, Masae Mochizuki, Junko Chimoto, Risa Futokoro, Satomi Kagota, Kazumasa Shinozuka. Development of a pharmacological evidence-based anticholinergic burden scale for medications used in older adults.
Geriatrics and Gerontology International, 23: 558–564 (2023)
2. Kazutaka Atobe, Yoshihisa Kato, Shizuo Yamada. Activation by Acanthopanax senticosus of vascular endothelium-specific receptor tyrosine kinase Tie2 in human umbilical vein endothelial cells (HUVECs)
Pharmacometrics,105: 43-48 (2023)
3. 山田靜雄、白井みち代、小野 憲、山野亜紀、照屋俊明、 禹 済泰： ノビレチン高純度粉末含有摂取による認知機能への影響
日本ポリフェノール学会雑誌 12：41-48（2023）
4. 白井みち代、望月美春、小野 憲、山田靜雄： 温泉・運動・食によるゴルフアスリートの打球飛距離及び主観的健康観に関する研究
応用薬理 104：33-39 （2023）
[総説]
1. Shizuo Yamada, Masae Mochizuki, Kazutaka Atobe, Yoshihisa Kato. Pharmacokinetic and pharmacodynamic considerations for the anticholinergic burden scale of drugs. (review)
Geriatrics and Gerontology International, 2023 Oct 23. doi: 10.1111/ggi.14706.
2. Yutaka Nakagawa, Shizuo Yamada: The relationships among metal homeostasis, mitochondria, and locus coeruleus in psychiatric and neurodegenerative disorders: Potential pathogenetic mechanism and therapeutic implications
Cellular and Molecular Neurobiology, 43: 963-989（2023)
3. Yutaka Nakagawa and Shizuo Yamada: Alterations in brain neural network and stress system in atopic dermatitis: novel therapeutic interventions (Review)
J Pharmacol Exp Ther, 385: 78-87（2023)
山田靜雄： 特集「機能性食品としてのキノコ」 巻頭言
機能性食品と薬理・栄養, 15: 347（2023）
2022年
[原著論文]
1.Shizuo Yamada, Ryo Niiya, Yoshihiko Ito, Yoshihisa Kato, Satomi Onoue. Comparative characterization on β-adrenoceptors in the bladder, heart and lung of rats: Alterations in spontaneously hypertensive rats.
J Pharmacol Sci, 148: 51–55 (2022)
2.Shizuo Yamada, Yoshihisa Kato. Effects of saw palmetto extract on the vanilloid receptor TRPV1.
Lower Urinary Tract Symptoms,14: 117-121 (2022)
3.Shizuo Yamada, Michiyo Shirai, Ken Ono, Shinji Kageyama. Beneficial effects of saw palmetto fruit extract on urinary symptoms in Japanese female subjects by a multicenter, randomized, double-blind, placebo-controlled study.
Nutrients, 14: 1190, doi:10.3390/nu14061190 (2022)
4.Shizuo Yamada, Michiyo Shirai, Yuko Inaba, Tsuyoshi Takara. Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: A randomized, placebo-controlled, double-blind parallel-group study.
Eur Rev Med Pharmacol Sci., 26: 4331-4345 (2022)
5.Shinji Kageyama, Seiji Ohmura, Shinsuke Hayami, Michiko Suzawa, Shizuo Yamada. A case report of active surveillance therapy: Citrus-peel extracts’ efficacy against prostate cancer
Case Report & Reviews. https://dx.doi.org/10.26717/BJSTR.2022.42.006827 (2022)
6.Masaharu Akita, Osamu Kimura, Kazutaka Atobe, Tetsuya Endo, Shizuo Yamada, Koichi Haraguchi, Yoshihisa Kato: Teratogenic effects of organohalogen contaminants extracted from whale bacon in a whole-rat-embryo culture system.
Int. J. Environ. Res. Public Health. 19, 12065. https://doi.org/10.3390/ijerph191912065. (2022)
7.山田靜雄、伊藤由彦： ノコギリヤシ果実エキスの下部尿路症状改善作用
日本排尿機能学会誌 特集「下部尿路症状を改善する機能性食品」 32: 397–399（2022）
8.影山慎二、佐々木美晴、伊藤由彦、山田靜雄： 女性過活動膀胱患者に対するボタンボウフエキスの臨床効果
日本排尿機能学会誌 特集「下部尿路症状を改善する機能性食品」 32: 402–405（2022）
9.酒本貞昭、影山慎二、前島靖勲、山田靜雄： 間質性膀胱炎に対する発芽そば発酵エキスの臨床成績
日本排尿機能学会誌 特集「下部尿路症状を改善する機能性食品」 32: 411-414（2022）
10.白井みち代、影山慎二、鈴木理恵子、山田静雄： DHA/EPA強化はんぺんおよびノビレチン添加薬膳野菜スープによる健康QOLの改善効果
応用薬理 103：45-51（2022）
[総説]
1.Yutaka Nakagawa, Shizuo Yamada: The relationships among metal homeostasis, mitochondria, and locus coeruleus in psychiatric and neurodegenerative disorders: Potential pathogenetic mechanism and therapeutic implications
Cellular and Molecular Neurobiology, https://doi.org/10.1007/s10571-022-01234-3 892: 173737（2022)
2.山田靜雄、加藤善久、速水慎介： ミラベグロンによる膀胱β3受容体以外のOff-target効果-ムスカリン性受容体を中心に
日本排尿機能学会誌 32: 465–470（2022）
3.山田靜雄： 機能性食品と医食同源（総論）
日本排尿機能学会誌 特集「下部尿路症状を改善する機能性食品」 32: 393–394（2022）
4.山田靜雄： 医食同源と健康食品―排尿障害適用での科学的実証
応用薬理, 102: 47–54（2022）
[著書]
1.山田静雄： 補完代替医療と健康食品
応用細胞補完代替医療学 第２巻-健康を補完代替医療に求めて-. 猪岡尚志、光本泰秀 監修
（太陽書房出版）、pp. 145-158 (2022)
2021年
[原著論文]
1. Shizuo Yamada, Junko Chimoto, Mizuki Shiho, Takashi Okura, Kana Morikawa, Satomi Kagota, Hirokazu Wakuda, Kazumasa Shinozuka. Possible involvement of muscarinic receptor blockade in mirabegron therapy for patients with overactive bladder
J Pharmacol Exp Ther, 377: 201–206 (2021)
2. Satomi Kagota, Kana Morikawa, Hirotake Ishida, Junko Chimoto, Kana Maruyama-Fumoto, Shizuo Yamada, Kazumasa Shinozuka. Vasorelaxant effects of benzodiazepine, non-benzodiazepine sedative-hypnotics, and tandospirone on isolated rat arteries.
Eur J Pharmacol, 892: 173744 (2021)
3. Shizuo Yamada, Junko Chimoto, Mizuki Shiho, Takashi Okura, Kana Morikawa, Satomi Kagota, Kazumasa Shinozuka. Demonstration of muscarinic receptor binding activity of vibegron and its receptor occupancy in the bladder.
Int J Urol, 28: 1298–1303 (2021)
4. Shizuo Yamada, Michiyo Shirai, Ken Ono, Toshiaki Teruya, Aki Yamano, Je Tae Woo. Beneficial effects of a nobiletin-rich formulated supplement of Siikuwha (C. depressa) peel on cognitive function in elderly Japanese subjects; A multicenter, randomized, double-blind, placebo-controlled study.
Food Sci Nutr, 9: 6844–6853 (2021)
5. Hisae Oku, Fumika Kitagawa, Yoshihisa Kato, Toshitaka Minetoki, Masaomi Hara, Tomoya Miyashita, Shizuo Yamada. Anti-allergic effects of the subcritical water extract powder of Citrus unshiu in mouse and guinea-pig models.
J Med Food, 24: 533–540 (2021)
6. Yuki Ito, Rikako Ishibashi, Shiro Tajima, Taro Ueda, Shinji Kageyama, Shizuo Yamada, Jiro Saito. Suppressive effects of a supplement containing pomegranate fruit extract on urinary stress in women-A randomized, single-blind, placebo-controlled, parallel-group, three-arm study: a pilot study.
Jap Pharmacol Ther, 49: 143–153 (2021)
7. Yuki Ito, Yasumori Matsui, Masakazu Kobayashi, Taro Ueda, Yuji Matsushima, Shinji Kageyama, Shizuo Yamada, Jiro Saito. Suppressive effects of a supplement containing pomegranate fruit-derived punicalagin on urinary stress in healthy adult women-A randomized, double-blind, placebo-controlled, parallel-group study.
Jap Pharmacol Ther, 49: 155–166 (2021)
8. 宮島崇広、中田孝広、石橋理夏子、松井保公、影山慎二、山田静雄．マンゴスチン果皮由来α-マンゴスチン配合食品摂取による男性の夜間の排尿に関わる生理機能と生活の質の改善効果―プラセボ対照無作為化二重盲検並行群間比較試験―.
薬理と治療, 49: 2077–2089 (2021)
[総説]
1. Yutaka Nakagawa, Shizuo Yamada: A novel hypothesis on metal dyshomeostasis and mitochondrial dysfunction in amyotrophic lateral sclerosis: Potential pathogenetic mechanism and therapeutic implications.
Eur J Pharmacol, 892: 173737（2021)
2. 山田靜雄、白井みち代、吉木 拓、川田 晋: ケルセチン含有食品による抗アレルギー作用―プラセボ対照ランダム化二重盲検並行群間比較試験－.
アレルギーの臨床, 41: 338–342（2021）
3. 山田靜雄、白井みち代、吉木 拓、川田 晋: 7月号特集「アレルギーのチーム医療と医療行政」．機能性食品による抗アレルギー作用.
アレルギーの臨床, 41:589–593（2021）
4. 山田靜雄．特集「下部尿路症状を改善する機能性食品」 巻頭言.
機能性食品と薬理・栄養, 15: 347（2021）
5. 山田靜雄、伊藤由彦．特集「下部尿路症状を改善する機能性食品」．ノコギリヤシ果実エキスによる下部尿路症状の改善作用.
機能性食品と薬理・栄養, 15: 354–360（2021）
6. 前島靖勲 酒本貞昭、影山慎二、山田靜雄．特集「下部尿路症状を改善する機能性食品」．発芽そば発酵エキスの排尿障害に関する機能性.
能性食品と薬理・栄養, 15: 361–364（2021）
7. 山田靜雄．特集「下部尿路症状を改善する機能性食品」．キナ酸を含有するクランベリー飲料による健常成人女性の頻尿改善作用―プラセボ対照ランダム化二重盲検並行群間比較試験.
機能性食品と薬理・栄養, 15: 371–376（2021）
8. 伊藤由彦. 過活動膀胱治療薬はなぜ膀胱に作用するのか
ファルマシア（セミナー） 57: 927–930（2021）
2020年
[原著論文]
1. Shizuo Yamada, Shiori Kuraoka, Yoshihiko Ito, Satomi Kagota, Kazumasa Shinozuka, Satomi Onoue. Direct in vitro and in vivo demonstration of muscarinic receptor binding by the novel radioligand, [3H]5-hydroxymethyltolterodine, in the bladder and other tissues of rats
J Pharmacol Sci, 142: 127-130 (2020)
2. Shino Miyauchi-Wakuda, Satomi Kagota, Kana Maruyama-Fumoto, Yayoi Shiokawa, Shizuo Yamada, Kazumasa Shinozuka. Acanthopanax senticosus root extract exerts dual action on mouse ileal smooth muscle function, leading to modulation of gastrointestinal motility.
Biol Pharm Bull, 43: 817-822 (2020)
3. Kimio Sugaya, Hidetomi Yamagami, Saori Nishijima, Katsumi Kadekawa, Masanori Hizue, Yoshihiko Ito, Shizuo Yamada: Effects of combined treatment with fesoterodine and mirabegron in a pelvic congestion rat model: Results from in vitro and in vivo functional studies
Lower Urinary Tract Symptoms, 12: 173-179 (2020)
4. Shizuo Yamada, Yoshihiko Ito, Kana Morikawa, Satomi Kagota, Kazumasa Shinozuka. Effect of saw palmetto extract on urodynamic parameters, bladder contractility and pharmacological receptors in female rats
Academia Journal of Medicinal Plants, 8: 171-178 (2020)
5. Satomi Kagota, Kana Morikawa, Hirotake Ishida, Junko Chimoto, Kana Maruyama-Fumoto, Shizuo Yamada, Kazumasa Shinozuka. Vasorelaxant effects of benzodiazepine, non-benzodiazepine sedative-hypnotics, and tandospirone on isolated rat arteries.
Eur J Pharmacol, 2020 Nov 19:173744. doi: 10.1016/j.ejphar.2020.173744. Online ahead of print.PMID: 33220270
5. Mizuki Watanabe, Takaaki Kobayashi, Yoshihiko Ito, Shizuo Yamada,Satoshi Shuto. Conformational restriction of histamine with a rigid bicyclo[3.1.0]hexane scaffold provided selective H3 receptor ligands
Molecules, 2020 Aug 5;25(16):3562. doi: 10.3390/molecules25163562.PMID: 32764432
6.望月正栄、地本純子、石田裕丈、石川智久、賀川義之、鈴木康之、鳥本一匡、鈴木真由美、海野由里子、速水慎介、山田 静雄: 多剤服用の高齢患者における抗コリン様有害事象と服用薬剤の調査および薬剤のムスカリン性受容体結合活性の評価
日本排尿機能学会雑誌, 30: 433-438（2020）
7. 山田 静雄、白井みち代、稲葉祐子、髙良 毅: ケルセチン含有食品の摂取がアレルゲンによる鼻目のアレルギー反応に及ぼす影響－プラセボ対照ランダム化二重盲検並行群間比較試験－
薬理と治療, 48: 1945-1959（2020）
[総説]
1. Yutaka Nakagawa, Shizuo Yamada: Metal homeostasis disturbances in neurodegenerative disorders, with special emphasis on Creutzfeldt-Jakob disease – Potential pathogenetic mechanism and therapeutic implications.
Pharmacol Ther, 207:107455（2020)
2. 山澤徳志子、山田静雄： 骨格筋の恒常性維持に対する機能性食品素材の役割
日本薬理学雑誌 （総説）、43, 10-11（2020）
[著書]
1. 山田静雄、伊藤由彦、鈴木朝日、黒川美保子、影山慎二： ノコギリヤシ.
機能性食品素材のためのヒト評価. 山本哲郎監修、（シーエムシー出版）、pp. 276-283 (2020)
2019年
[原著論文]
1. Shizuo Yamada, Shiori Kuraoka, Yoshihiko Ito, Yoshihisa Kato, and Satomi Onoue: Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration
J Pharmacol Sci 140: 73-78 (2019)
2. Shino Miyauchi-Wakuda, Satomi Kagota, Kana Maruyama-Fumoto, Hirokazu Wakuda, Shizuo Yamada, Kazumasa Shinozuka: Effect of royal jelly on mouse isolated ileum and gastrointestinal motility
J Med Food, 22: 789-796 (2019)
3. Hirokazu Wakuda, Takashi Okura, Kana Maruyama-Fumoto, Satomi Kagota, Yoshihiko Ito, Shino Miyauchi-Wakuda, Naoyuki Otani, Naoto Uemura, Shizuo Yamada, Kazumasa Shinozuka. Effects of anticholinergic drugs used for the therapy of overactive bladder on P-glycoprotein activity
Biol Pharm Bull. 42: 1996-2001 (2019)
4. Yayoi Shiokawa, Shino Miyauchi-Wakuda, Satomi Kagota, Kana Maruyama-Fumoto, Shizuo Yamada, Kazumasa Shinozuka. Acanthopanax senticosus induces vasorelaxation via endothelial nitric oxide-dependent and –independent pathways
Planta Medica 85: 1080-1087 (2019)
5. Yoshihisa Kato, Sekihiro Tamaki, Koichi Haraguchi, Shin-ichi Ikushiro, Yukiko Fujii, Chiho Ohta, Kazutaka Atobe, Osamu Kimura, Tetsuya Endo, Nobuyuki Koga, Shizuo Yamada, Masakuni Degawa. Kanechlor 500-mediated changes in serum and hepatic thyroxine levels primarily occur in a transthyretin-unrelated manner
J Appl Toxicol 39: 1701-1709 (2019)
6. Hirokazu Wakuda, Shino Miyauchi-Wakuda, Kana Morikawa, Kana Maruyama-Fumoto, Satomi Kagota, Yoshihiko Ito, Naoto Uemura, Shizuo Yamada, Kazumasa Shinozuka. Effect of fermented buckwheat sprouts extract and its ingredients on rat bladder.
日本排尿機能学会誌, 29: 451-455 (2019)
7. 影山慎二、春野明弘、伊藤由彦、藤島雅基、竹腰英夫、山田静雄： 急性膀胱炎を繰り返す成人女性に対するクロレラの再発予防効果に関する臨床研究
排尿障害プラクティス, 27：77-82（2019）
8.宮崎さやか、山田静雄、東野定律、渡邉順子、水上勝義： 在宅医療高齢者における処方薬剤と排尿障害の関連
日本老年医学会雑誌, 56: 301-311（2019）
2018年
[原著論文]
1. Takahisa Suzuki, Atsushi Otsuka, Yoshihiko Ito, Shizuo Yamada, Hideaki Miyake, Seiichiro Ozono. Isosamidin, an extract of Peucedanum japonicum, inhibits phenylephrine-mediated contractions of the human prostate in vitro.
Phytotherapy Res., 32: 949-952 (2018)
2. Yaoyue Liang, Satomi Kagota, Kana Maruyama, Yuri Oonishi, Shino Miyauchi-Wakuda, Yoshihiko Ito, Shizuo Yamada, Kazumasa Shinozuka, Royal jelly increases peripheral circulation by inducing vasorelaxation through nitric oxide production under healthy conditions
Biomed Pharmacother, 106, 1210-1219 (2018)
3. Tsuyoshi Yoshizawa, Yukio Hayashi, Akira Yoshida, Yoshihiko Ito, Kenya Yamaguchi, Shizuo Yamada, Satoru Takahashi: Concomitant alteration in number and affinity of P2X and muscarinic receptors are associated with bladder dysfunction in early stage of diabetic rats
Int Urol Nephrol, 50: 451-458 (2018)
4. Shuhei Kawamura, Yoshihiko Ito, Takatsugu Hirokawa, Eriko Hikiyama, Shizuo Yamada, Satoshi Shuto: Ligand-phospholipid conjugation: a versatile strategy for developing long-acting ligands that bind to membrane proteins by restricting the subcellular localization of the ligand
J Med Chem Lett., 61: 4020-4029 (2018)
5. Mizuki Watanabe, Takaaki Kobayashi, Yoshihiko Ito, Hayato Fukuda, Shizuo Yamada, Mitsuhiro Arisawa, Satoshi Shuto: Design and Synthesis of Histamine H3/H4 Receptor Ligands with a Cyclopropane Scaffold
Bioorg Med Chem Lett., 28: 3630-3633 (2018)
6. Junko Kimura, Kosuke Shimizu, Koji Kajima, Akihito Yokosuka, Yoshihiro Mimaki, Naoto Oku, Yasushi Ohizumi: Nobiletin reduces intracellular and extracellular β-amyloid in iPS cell-derived Alzheimer’s disease model neurons
Biol Pharm Bull., 41: 451-457 (2018)
7. Hiroto Sagara, Masaki Kanakogi, Yuki Tara, Hitoshi Ouchi, Junko Kimura, Yukiko Kaneko, Makoto Inai, Tomohiro Asakawa, Tomohisa Ishikawa, Toshiyuki Kan: Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations
Tetrahedron Lett., 59: 1816-1818 (2018)
8. 影山慎二、富永彩香、引山恵梨子、北村実穂、春野明弘、伊藤由彦、山田静雄：女性過活動膀胱患者に対するボタンボウフウエキスの臨床効果
泌尿器外科 31, 75-80（2018）
[総説]
1. Shizuo Yamada, Yoshihiko Ito, Saori Nishijima, Kimio Sugaya: Basic and clinical aspects of antimuscarinic agents used to treat overactive bladder.
Pharmacol Ther, 189: 130-148（2018)
2. 山田静雄、伊藤由彦、宮崎さやか、影山慎二： 機能性食品の補完医療的効用.
日本腎泌尿器疾患予防医学研究会誌 26：17-21（2018）
3.宮崎さやか、望月正栄、松下範子、伊藤由彦、関 成人、渡邉順子、山田静雄：薬剤による排尿障害―添付文書の副作用発現頻度からのアプローチー
排尿障害プラクティス, 26 (No 1), 87-99（2018）
4.山田静雄：ソウパルメット（ノコギリヤシ）の成分と排尿トラブルへの利用
Medical Herb (日本メディカルハーブ協会)、43, 10-11（2018）
[著書]
1. 山田静雄： 泌尿生殖器疾患治療薬
治療薬の臨床薬理データブック．渡邉裕司 編集（日本医事新報社）、pp. 283-311 （2018）
2. 尾上誠良、山田静雄：固体分散製剤技術を用いた難水溶性クルクミンの溶解性ならびに経口吸収性の改善
難吸収性薬物の吸収性改善と新規投与製剤の開発．山本 昌 監修（シーエムシー出版）、pp. 34-40 （2018）
3. 山田静雄： 第７章 食品の薬効および医薬品との相互作用・併用効果の解析
抗ストレス食品の開発と展望Ⅱ．横越英彦 監修（シーエムシー出版）、pp. 79-90 （2018）
2017年
[原著論文]
1.Shinji Kageyama, Masanori Beppu, Hiromu Ohnogi, Sayaka Miyazaki, Akihiro Haruno, Yoshihiko Ito and Shizuo Yamada: Clinical Effects of Formulated Food of Peucedanum japonicum Extract and Saw Palmetto Extract in Male Patients with Lower Urinary Tract Symptoms
LUTS (Lower Urinary Tract Symptoms), DOI: 10.1111/luts.12155
2. Yoshihiko Ito, Shiori Kuraoka, Soma Endo, Ayaka Takahashi, Satomi Onoue, Shizuo Yamada: Urinary imidafenacin contributes to the long-lasting blockade of bladder muscarinic receptors: Effects of bilateral ligation of ureters
J Pharmacol Exp Ther., 360: 69-74(2017)
3.Akira Mizuno, Tomoshi Kameda, Tomoki Kuwahara, Hideyuki Endoh, Yoshihiko Ito, Shizuo Yamada, Kimiko Hasegawa, Akihito Yamano, Mizuki Watanabe, Mitsuhiro Arisawa, Satoshi Shuto: Cyclopropane-Based Peptidomimetics Mimicking Wide-Ranging Secondary Structures of Peptides: Conformational Analysis and Their Use in Rational Ligand Optimization
Chemistry, 23: 3159-3168(2017)
[総説]
1.山田静雄：メンズヘルスと機能性食品. 機能性食品と薬理栄養 10：267 (2017)
2.伊藤由彦、影山慎二、山田静雄：前立腺肥大による下部尿路症状に対する機能性食品. 機能性食品と薬理栄養 10：268-273 (2017)
3.山田静雄、伊藤由彦、影山慎二：ノコギリヤシ果実エキスとボタンボウフウエキスによる下部尿路症状の改善. NewDiet Therapy 33: 55-62 (2017)
2016年
[原著論文]
1.Masaki Ogoda, Yoshihito Ito, Yusuke Fuchihata, Satomi Onoue, Shizuo Yamada: Characterization of muscarinic and P2X receptors in the urothelium and detrusor muscle of the rat bladder
J Pharmacol Sci., 124: 1-6(2016)
2.Yoshihiko Ito, Michishi Kashiwabara, Akira Yoshida, Eriko Hikiyama, Satomi Onoue, Shizuo Yamada: Muscarinic receptor binding in rat bladder urothelium and detrusor muscle by intravesical solifenacin
Biol Pharm Bull, 39: 1167-1171(2016)
3.Shiori Kuraoka, Yoshihito Ito, Hirokazu Wakuda, Kazumasa Shinozuka, Satomi Onoue, Shizuo Yamada: Characterization of muscarinic receptor binding by the novel radioligand, [3H]imidafenacin, in the bladder and other tissues of rats
J Pharmacol Sci., 124: 1-6(2016)
2015年
[原著論文]
1.Hirokazu Wakuda, Shino Miyauchi, Kana Maruyama, Satomi Kagota, Kazuki Nakamura, Keizo Umegaki, Shizuo Yamada, Kazumasa Shinozuka: Differential effects of mitogen-activated protein kinase pathway inhibitors on P-glycoprotein activation.
ADMET & DMPK, 3: 77-83 (2015)
[総説]
1.Pablo P. Werba, Shingen Misaka, Monica G. Giroli, Shizuo Yamada, Vi viana Cavalca, Keisuke Kawabe, Isabella Squellerio, Federica Laguzzi, Satomi Onoue, Fabrizio Veglia, Veronika Myasoedova, Kazuhiko Takeuchi, Eisuke Adachi, Naoki Inui, Elena Tremori, Hiroshi Watanabe: Overview of green tea interaction with cardiovascular drugs.
Current Phamraceutical Design, 21: 1213-1219 (2015)
2.山田靜雄： 生体内での薬物-受容体結合を基盤とした薬物動態と薬効の統合的解析
YAKUGAKU ZASSHI 135： 137-150 (2015)
3.山田静雄： 受容体タンパク結合実験
呼吸（講座 研究手法入門：薬理生理）, 34：286-292（2015）
4.山田静雄、伊藤由彦、尾上誠良：高齢者における薬物の体内動態・薬効の変化と飲食物・栄養素との相互作用
New Diet Therapy ニューダイエットセラピー日本臨床栄養協会誌（日本臨床栄養協会編集）31：35-46（2015）
[著書]
1.山田静雄： 機能性食品を中心とした薬学の発展
ファルマシア51：87（2015）
2.山田静雄： 機能性素材と薬物との相互作用
ソフトドリンク技術資料 177: 395-409（2015）
3.山田静雄： 「食と健康の科学」の正しい進展に向けてーこれからの食品機能研究のあり方についての考察
食と健康を科学する 創刊号 （クロレラ健康栄養研究会編集）提言 ｐ 69-84（2015）
2014年
[原著論文]
1.Sweety Nasrin, Eiji Masuda, Haruna Kugaya, Ayaka Osano, Yoshihito Ito and and Shizuo Yamada: Effect of saw palmetto extract on urodynamic parameters, bladder muscarinic and purinergic receptors and urinary cytokines in rats with cyclophosphamide-induced cystitis
LUTS (Lower Urinary Tract Symptoms), 6: 57-63(2014)
2.Akira Yoshida, Shiori Kuraoka, Yoshihito Ito, Takashi Okura, Yoshiharu Deguchi, Atsushi Otsuka, Seiichiro Ozona, Masayuki Takeda, Keisuke Masuyama, Isao Araki and Shizuo Yamada: Muscarinic receptor binding of the novel radioligand, [3H]imidafenacin in the human bladder and parotid gland
J Pharmacol Sci., 124: 40-46(2014)
3.Ayaka Osano, Yoshinari Yokoyama, Hideki Hayashi, Kunihiko Ito, Takashi Okura, Yoshiharu Deguchi, Yoshihiko Ito and Shizuo Yamada: Bladder endothelin-1 receptor binding of bosentan and ambrisentan
J Pharmacol Sci., 124: 86-91(2014)
4.Yoshinari Yokoyama, Ayaka Osano, Hideki Hayashi, Kunihiko Ito, Takashi Okura, Yoshiharu Deguchi, Yoshihiko Ito and Shizuo Yamada: Endothelin-1 receptors in rat tissues: Characterization by bosentan, ambrisentan and CI-1020
Biol Pharm Bull., 37: 461-465 (2014)
5.Shingen Misaka, Junichi Yatabe, Fabian Müller, Kozue Takano, Keisuke Kawabe, Hartmut Glaeser, Midori Yatabe, Satomi Onoue, Jose P Werba, Hiroshi Watanabe, Shizuo Yamada, Martin F Fromm and Junko Kimura. Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects.
Clin Pharmacol Ther., 95: 432-438 (2014)
6.Hirokazu Wakuda, Shinya Uchida, Masahiko Ikeda, Masaki Tabuchi, Yasumitsu Akahoshi, Kazumasa Shinozuka, Shizuo Yamada: Is hyperuricemia a risk factor for arteriosclerosis? Uric acid and arteriosclerosis in apolipoprotein E-deficient mice.
Biol Pharm Bull, 37: 1866-1871 (2014)
7.Yoshihisa Kato, Koichi Haraguchi, Mao Onishi, Shinichi Ikushiro, Tetsuya Endo, Chiho Ohta, Nobuyuki Koga, Shizuo Yamada, and Masakuni Degawa. 3,3′,4,4′-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in mice occurs mainly through enhanced accumulation of thyroxine in the liver.
Biol Pharm Bull., 37: 504-509 (2014)
8.Tomoko Hatano, Yuka Sameshima, Mami Kawabata, Shizuo Yamada, Kazumasa Shinozuka, Toshikatsu Nakabayashi, Hideya Mizuno. St. John’s wort promotes adipocyte differentiation and modulates NF-B activation in 3T3-L1 cells.
Biol Pharm Bull., 37: 1132-1138 (2014)
9.Kosuke Shimizu, Tomohiro Asakawa, Norihiro Harada, Dai Fukumoto, Hideo Tsukada, Tomohiro Asai, Shizuo Yamada, Toshiyuki Kan and Naoto Oku: Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin
PLOS ONE, 9: e85520. doi:10.1371 (2014)
10.Nodoka Yasuda, Takayuki Ishii, Dai Oyama, Yurika Agato, Tatsuya Furuka, Akihiko Sato, Kosuke Shimizu, Tomohiro Asai, Tomohiro Asakawa, Toshiyuki Kan, Shizuo Yamada, Yasushi Ohizumi, Naoto Oku: Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebaralartery-occluded rats.
Brain Res., 1559: 46-54 (2014)
11.Jinno, Norimasa; Tagashira, Mizuka; Tsurui, Kazuyuki; Yamada, Shizuo: Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: Risk assessment of acylglucuronides using human hepatocytes”.
Xenobiotica., 44: 644-686 (2014)
[総説]
1.山田静雄、伊藤由彦： エビデンスに基づく機能性食品の現況と展望Ⅰ. 機能性食品の安全性・薬物との相互作用
Pharma Medica 8月号特集 18: 24-32 (2014)
2.菅 敏幸、浅川倫宏、奥 直人、清水広介、山田静雄、原田典弘、塚田秀夫: カテキンプローブの合成と分子イメージングー緑茶の有効成分カテキンを光らせる
化学 69:38-42 (2014)
[著書]
1.Shizuo Yamada, Yuko Taki, Shingen Misaka, Takashi Okura, Yoshiharu Deguchi, Keizo Umegaki, Hiroshi Watanabe, Yasuo Watanabe and Margot Skinner: Pharmacokinetic and pharmacodynamic interaction of functional foods with medicines
Bioactives in Fruit: Health Benefits and Functional Foods, First Edition, (authored/edited By Margot Skinner and Denise Hunter, Wiley-Blackwell, West Sussex, UK) pp. 59-79 (2014)
2.Shizuo Yamada, Shingen Misaka, Yoshihiko Ito, Hiroshi Watanabe and Keizo Umegaki: Effects of natural products on pharmacokinetics and pharmacodynamics of drugs
Pharma-Nutrition, AAPS Advances in the Pharmaceutical Sciences Series 12 (edited ｂy Gert Folkerts and Johan Garssen, American Association of Pharmaceutical Scientists 2014) pp. 189-211 (2014)
3.山田静雄、伊藤由彦： 生物薬剤学 ４．薬物分布実験法 4.1 タンパク結合 4.1.2 受容体タンパク結合
薬剤学実験法 必携マニュアルーPharmaceutical Scientistのために、日本薬剤学会出版委員会 編集（南江堂）、pp. 112-123 （2014）
4.山田静雄： 臨床オリエンテドー下部尿路の受容体と薬理
神経因性膀胱ベッドサイドマニュアル、榊原隆次 編集、㈱中外医学社出版、pp. 21-34 (2014)