ABSTRACT

Friday, September 7

I-9　(13：00-13：50) Chairman: Junichi YOSHIDA (Kyoto University)

「Toward Transformative Arene-Assembling Chemistry」

Kenichiro ITAMI (Nagoya University)

Organic molecules having aryl-aryl bonds (arene-assembled molecules) represent privileged structural motifs of unparalleled importance in virtually all areas of pure and applied chemistry. This talk will highlight elements of our efforts to address some of the challenges in arene-assembling chemistry. These endeavors have led to (i) new catalysts for C-H bond arylation of arenes and heteroarenes (ideal arene assembly), (ii) rapid synthesis of pharmaceuticals, bioactive compounds, and natural products (useful arene assembly), (iii) synthesis of aromatic carbon nanorings and tubes (circular arene assembly), and (iv) synthesis of extended polycyclic aromatic hydrocarbons (planar arene assembly).

I-10　(13：50-14：40)　Chairman: Takahiko Akiyama (Gakushuin University)

「Total Syntheses of Natural Products via Strategic Use of Claisen rearrangement and Ring-Closing Metathesis」

（Seoul National University, Korea） Sanghee Kim

Olefin metathesis, one of the most useful tools for the C-C bond formation, has changed the retrosynthetic analysis of molecular frameworks. Claisen Rearrangement is also a powerful tool for C-C bond formation. One of the major merits of Claisen Rearrangement is that the stereochemical outcome of the product can be easily predictable and can be controlled. A combination of Claisen Rearrangement and ring-closing olefin metathesis can provide an efficient synthetic route to many polycyclic natural products. We have achieved a number of total syntheses by the strategic use of these two reactions. Herein, our progress on this subject will be presented.