ABSTRACT

Friday, September 7

I-11　(14：55-15：45)　Chairman: Takehide NISHI (Daiichi Sankyo Co., Ltd.)

「Development and Application of FI Catalysts for the Oligomerization and Polymerization of Olefinic Monomers」

Terunori FUJITA (Mitsui Chemicals Singapore R&D Centre Pte Ltd.)

In the late 1990s, we developed phenoxy-imine ligated early transition metal catalysts (FI catalysts) for the oligomerization and polymerization of olefinic monomers. FI catalysts possess unique structural (static and dynamic) and electronic features that make FI catalysts different from group 4 metallocene catalysts. FI catalysts have a uniqueness that results in distinctive olefin oligomerization and polymerization and in the creation of value-added olefin-based materials. In this lecture, I would like to introduce the key features, applications, and emerging industrial potential of FI catalysts.

I-12　(15:45-16:35)　Chairman: Kin-ichi TADANO (Keio University)

「From One Idea to the Other: A Chain of Events」

Tohru FUKUYAMA (The University of Tokyo )

A variety of ideas are either conceived or executed during the course of total synthesis. Regardless of their success or failure, one idea would form a basis for the next one. For example, development of a novel indole synthesis gave us an opportunity to develop a facile coupling reaction between alcohol and amine derivatives. In addition, the initial failure in synthesizing catharanthine using our first-generation indole synthesis led us to develop a much more versatile second-generation indole synthesis. The synthetic route we developed for catharanthine also gave a great hint for the efficient synthesis of oseltamivir. Some examples of such a chain of events will be discussed.