静岡県立大学薬学部 医薬品創製化学分野

2025

NEW ! Thiobenzoic acid–catalyzed radical–radical cross–coupling between benzyl alcohols and benzophenones via hydrogen atom transfer
    R. Osanai, K. Watanabe, H. Egami*, Y. Hamashima*
  Tetrahedron Lett. 2025, 169, 155752     DOI:10.1016/j.tetlet.2025.155752

Direct Generation of Carboxyl Radicals from Carboxylic Acids Catalyzed by Photoactivated Ketones
    K. Yamashita*, H. Sano, Y. Goto, H. Hayashi*, Y. Hamashima*
  J. Am. Chem. Soc. 2025, ASAP     DOI:10.1021/jacs.5c04571

Formal Synthesis of Lobatamides A and C
   Y. Nakahara, T. Fukuda, R. Fujii, M. Kanakogi, H. Ouchi, F. Yoshimura, R. Takita, T. Kan, M. Inai*, Y. Hamashima*
  Org. Lett. 2025, 27, 12, 3066–3070.    DOI:10.1055/a-2117-8816

2024

Total Synthesis of (+)-Silybin A
   M. Inai*, H. Sagara, Y. Ueno, H. Ouchi, F. Yoshimura, T. Asakawa, Y. Hamashima*, T. Kan
  Chem. Pharm. Bull. 2024,  72, 6, 570–573.  DOI:10.1248/cpb.c24-00276

Thiobenzoic Acid-Catalyzed Cα–H Cross Coupling of Benzyl Alcohols with α-Ketoacid Derivatives
   K. Sato, H. Egami*, and Y. Hamashima*
  Org. Lett. 2024, 26, 25, 5285–5289.  DOI:10.1021/acs.orglett.4c01594

Asymmetric Fluorocyclization of Difluoroalkenes with Concomitant Formation of a Trifluoromethyl Group
   C. Igarashi, T. Mayumi, H. Egami*, and Y. Hamashima*
  Org. Lett. 2024, 26, 8, 1723–1727.  DOI:10.1021/acs.orglett.4c00312

Benzylic C(sp3)–H Alkoxylation through Visible-Light-Driven Oxidative Radical-Polar Crossover
   K. Yamashita*, F. Kawahara, and Y. Hamashima*
  Asian J. Org. Chem. 2024,  13, 4, e202300662  DOI:10.1002/ajoc.202300662

2023

Chiral Macrocyclic Catalysts for the Enantioselective Addition of Lithium Acetylides to Ketones
   K. Yamashita, Y. Tabata, K. Yamakawa, T. Mochizuki, K. Matsui, M. Hatano*, and K. Ishihara*
  J. Am. Chem. Soc. 2023,  145, 48, 26238–26248.    DOI:10.1021/jacs.3c08905

Charged chiral derivatization for enantioselective imaging of d-,l-2-hydroxyglutaric acid using ion mobility spectrometry/mass spectrometry
   E. Sugiyama, Y. Nishiya, K. Yamashita, R. Hirokawa, Y. Iinuma, T. Nirasawa, H. Mizuno, Y. Hamashima, and K. Todoroki*
  Chem. Commun. 2023,  59, 10916-10919.    DOI:org/10.1039/d3cc01963b

Switching Regioselectivity in the Asymmetric Bromocyclization of Difluoroalkenes Catalyzed by a Chiral Bisphosphine Oxide
   Y. Nakahara, R. Hirokawa, S. Uchida, K.Yamashita, and Y. Hamashima*
  Synlett  2023,  34, 20, 2476-2480.    DOI:10.1055/a-2117-8816

Experimental and Computational Investigation of Facial Selectivity Switching in Nickel–Diamine–Acetate-Catalyzed Michael Reactions
   Y. Sohtome, S. Komagawa, A. Nakamura, D. Hashizume, S. Lectard, M. Akakabe, Y. Hamashima, M. Uchiyama, and M. Sodeoka*
  J. Org. Chem. 2023, 88, 7764–7773.  DOI:org/10.1021/acs.joc.2c02732

Enantioselective Synthesis of Bromodifluoromethyl-containing Oxazolines by Concerted Lewis/Brønsted Base Catalysis with Chiral Bisphosphine Oxide
   R. Hirokawa, Y. Nakahara, S. Uchida, K. Yamashita, and Y. Hamashima
  Chem. Asian J. 2023,  18, e202300141.  DOI:org/10.1002/asia.202300141

 Asymmetric Fluorofunctionalizations with Carboxylate-Based Phase-Transfer Catalysts
   H. Egami, and Y. Hamashima*
  Chem. Rec. 2023,  23, e202200285.  DOI:org/10.1002/tcr.202200285

Amide-Ligand-Promoted Silver-Catalyzed C–H Fluorination via Radical/Polar Crossover
   K. Yamashita, Y. Fujiwara, and Y. Hamashima*
  J. Org. Chem. 2023,  88, 3, 1865–1874.  DOI:org/10.1021/acs.joc.2c02575

2022

Mechanistic Details of Asymmetric Bromocyclization with BINAP Monoxide: Identification of Chiral Proton-Bridged Bisphosphine Oxide Complex and Its Application to Parallel Kinetic Resolution
   K. Yamashita, R. Hirokawa, M. Ichikawa, T. Hisanaga, Y. Nagao, R. Takita, K. Watanabe, Y. Kawato and Y. Hamashima*
  J. Am. Chem. Soc. 2022,  144, 9, 3913-3924.   DOI:org/10.1021/jacs.1c11816

2021

Structure Dependence in Asymmetric Deprotonative Fluorination and Fluorocyclization Reactions of Allylamine Derivatives with Linked Binaphthyl Dicarboxylate Phase-Transfer Catalyst
   T. Niwa, K. Nishibashi, H. Sato, K. Ujiie, K. Yamashita, H. Egamiand Y. Hamashima*
  J. Am. Chem. Soc.  2021, 143, 40, 16599-16609. DOI:org/10.1021/jacs.1c06783

Design of synthetic polymer nanoparticles that inhibit glucoseabsorption from the intestine
   H. Koide, N. Hayashi, G. Yasuno, A. Okishima, Y. Hoshino, H. Egami, Y. Hamashima, N. Oku, T. Asai*
  Biochemical and Biophysical Research Communications  2021, 561, 1-6.   DOI:org/10.1016/j.bbrc.2021.05.005

Dearomative enantio- and diastereoselective difluorination of resorcinol derivatives
   M. Otsubo, K. Sakimoto, H. Egami and Y. Hamashima*
  Tetrahedron 2021,  96, 132355. DOI:org/10.1016/j.tet.2021.132355

Enhancement of target toxin neutralization effect in vivo by PEGylation of multifunctionalized lipid nanoparticles
   H. Koide, H. Suzuki, H. Ochiai, H. Egami, Y. Hamashima, N. Oku, T. Asai
   Biochemical and Biophysical Research Communications 2021,  561, 1-6. DOI:org/10.1016/j.bbrc.2021.03.073

Dual-Role Catalysis by Thiobenzoic Acid in Co-H Arylation under Photoirradiation
   F. Kobayashi, M. Fujita, T. Ide, Y. Ito, K. Yamashita, H. Egami, and Y. Hamashima*
   Acs Catal. 2021, 11, 82-87.   DOI:10.1021/acscatal.0c04722

2020

Oxidative and Redox-Neutral Approaches to Symmetrical Diamines and Diols by Single Electron Transfer/Hydrogen Atom Transfer Synergistic Catalysis
   M. Fujita, F. Kobayashi, T. Ide, H. Egami, Y. Hamashima*
   Eur. J. Org. Chem. 2020, 7151–7155. DOI:10.1002/ejoc.202001329

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst
   H. Egami, R. Hotta, M. Otsubo, T. Rouno, T. Niwa, K. Yamashita and Y. Hamashima*
   Org. Lett. 2020,  22, 5656-5660.  DOI:10.1021/acs.orglett.0c02026

Fluorofunctionalizations of C-C Multiple Bonds and C-H Bonds
   H. Egami*
  Chem. Pharm. Bull. 2020, 68, 491-511. DOI: 10.1248/cpb.c19-00856

Asymmetric Dearomative Fluorination of 2-Naphthols with Dicarboxylate Phse-Transfer Catalyst
   H. Egami, T. Rouno, T. Niwa, K .Masuda, K. Yamashita and Y. Hamashima
   Angew. Chem., Int. Ed. 2020,59, 14101-14105. DOI: 10.1002/anie.202005367
   Synfacts 2020, 16(08):,0966 DOI: 10.1055/s-0040-01707436

18F-Labeled dihydromethidine: Positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain
    H. Egami, S. Nakagawa, Y. Katsura, M. Kanazawa, S. Nishiyama, T. Sakai, Y. Arano, H. Tsukada, O. Inoue, K. Todoroki * and Y. Hamashima*
   Org. Biomol. Chem. 2020, 18, 2387-2391. DOI: 10.1039/D0OB00126K

2019

High Efficiency Microwave Flow Chemistry toward Synthesis of Functional Materials and Pharmaceutical Cores
   J. P. Barham, E. Koyama, J. Sugiyama, Y. Norisane, H. Egami and Y. Hamashima*
   Ampere 2019, 409-417. DOI: 10.4995/Ampere2019.2019.9860

Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process
   M. Noshita, Y. Shimizu, H. Morimoto, S. Akai, Y. Hamashima, N. Ohneda, H. Odajima and T. Ohshima*
   Org. Process Res. Dev. 2019, 23, 588-594. DOI: 10.1021/acs.oprd.8b00424

Consice Synthesis of TAN1251C
   Y. Nagasawa, T. Asakawa, S. Shintaku, A. Masuda, K. Matsumura, M. Inai, Y. Ishikawa, M. Egi, Y. Hamashima and T. Kan*
   Heterocycles 2019, 99, 1095-1116.  DOI: 10.3987/COM-18-S(F)78

Enantioselective 5-exo-Fluorocyclization of Ene-Oximes
   T. Rouno, T. Niwa, K. Nishibashi, N. Yamamoto, H. Egami and Y. Hamashima*
   Molecules 2019, 24, 3464.  DOI: 10.3390/molecules24193464

Thiocyanation of Aromatic and Heteroaromatic Compounds with 1-Chloro-1,2-benziodoxol-3-(1H)-one and (Trimethylsilyl)isothiocyanate
   Y. Ito, A. Touyama, M. Uku, H. Egami*, and Y. Hamashima*
   Chem. Pharm. Bull. 2019, 67, 1015-1018. DOI:10.1248/cpb.c19-00352

Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule
   A. Okishima, H. Koide*, Y. Hoshino, H. Egami, Y. Hamashima, N. Oku, and T. Asai
  Biomacromolecules. 2019, 20, 1644–1654. DOI: 10.1021/acs.biomac.8b01820

Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle
   H. Koide, K. Yoshimatsu, Y. Hoshino, S. Ariizumi, A. Okishima, T. Ide, H. Egami, Y. Hamashima, Y. Nishimura, H. Kanazawa, Y. Miura, T. Asai, N. Oku*, and K. J. Shea*
   J. Control. Release.  2019, 295, 13-20. DOI: 10.1016/j.jconrel.2018.12.033

Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres for gene-silencing with siRNA
   A. Okamoto, H. Koide, N. Morita, Y. Hirai, Y. Kawato, H. Egami, Y. Hamashima, T. Asai, T. Dewa, and N. Oku*
   J. Control. Release.  2019, 295, 87-92. DOI:10.1016/j.jconrel.2018.12.044

Practical and Scalable Organic Reactions with Flow Microwave Apparatus
   H. Egami, and Y. Hamashima*
   Chem. Rec. 2019, 19, 157-171.  DOI: 10.1002/tcr.201800132

2018

C-alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor
   J. P. Barham, S, Tamaoki, H. Egami, N, Ohneda, T, Okamoto, H, Odajima, and Y. Hamashima*
   Org. Biomol. Chem.  2018, 16,7568-7573.  DOI: 10.1039/C8SC02965B

Regio- and chemoselective Csp3–H arylation of benzylamines by single electron transfer/hydrogen atom transfer synergistic catalysis
  T. Ide, J. P. Barham, M. Fujita, Y. Kawato, H. Egami, Y. Hamashima*
   Chem. Sci. 2018, 9, 8453-8460. DOI: 10.1039/C8SC02965B

Asymmetric Fluorination of Cyclic Tetrasubstituted Alkenes with a Pendant Amide Groups under Dianionic Phase-transfer Catalysis
  T. Niwa, K. Ujiie, H. Sato, H. Egami, Y. Hamashima*
   Chem. Pharm. Bull. 2018, 66, 920-922.  DOI:10.1248/cpb.c18-00551

Scalable Microwave-assisted Johnson-Claisen Rearrangement with Continuous Flow Microwave System
  H. Egami, S. Tamaoki, M. Abe, N. Ohneda, T. Yoshimura, T. Okamoto, H. Odajima, N. Mase, K. Takeda, Y. Hamashima*
   Org. Process Res. Dev. 2018, 22, 1029-1033. DOI: 10.1021/acs.oprd.8b0018

Redox-neutral C−H cyanation of tetrahydroisoquinolines under photoredox catalysis
  T. Ide,  K. Shimizu, H. Egami, Y. Hamashima*
   Tetrahedron Lett. 2018, 59, 3258-3261. DOI: 10.1016/j.tetlet.2018.07.030

(E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acrylic Acid
H. Egami, T. Sawairi, S. Tamaoki, N. Ohneda, T. Okamoto, H. Odajima, Y. Hamashima*
   Molbank 2018, M996, DOI: 10.3390/M996

Simple Photo-induced Trifluoromethylation of Aromatic Rings
  H. Egami*, Y. Ito, T. Ide, S. Masuda, Y. Hamashima*
  Synthesis 2018, 50, 2948-2953. DOI: 10.1055/s-0037-1609759

Enantioselective Bromocyclization of Allylic Amides Mediated by Phosphorus Catalysis
  Y. Kawato, Y. Hamashima*
  Synlett 2018,  29, 1257-1271. DOI: 10.1055/s-0036-1591579

Enantioselective Synthesis of Nelfinavir via Asymmetric Bromocyclization of Bisallylic Amide
Y. Nagao, T. Hisanaga, T. Utsumi, H. Egami, Y. Kawato, Y. Hamashima*
  J. Org. Chem.  2018, 83, 7290-7295. DOI: 10.1021/acs.joc.8b00039
   Highlighted in Synfacts 2018, 14, 900 DOI: 10.1055/s-0037-1610560

Dianionic Phase-Transfer Catalyst for Asymmetric Fluorocyclization
H. Egami, T. Niwa, H. Sato, R. Hotta, T. Rouno, Y. Kawato, Y. Hamashima*
  J. Am. Chem. Soc.  2018, 140, 2785-2788. DOI: 10.1021/jacs.7b13690
   Highlighted in Synfacts 2018, 14, 534. DOI: 10.1055/s-0037-1609661

Photofluorination of Aliphatic C-H Bonds Promoted by the Phthalimide Group
H. Egami*, S. Masuda, Y. Kawato, Y. Hamashima*
  Org. Lett .  2018, 20, 1367-1370.  DOI: 10.1021/acs.orglett.8b00133

2017

Desymmetrization of Bisallylic Amides through Catalytic Enantioselective Bromocyclization with BINAP Monoxide
Y. Nagao, T. Hisanaga, H. Egami, Y. Kawato, Y. Hamashima*
    Chem. Eur. J.  2017, 23, 16758–16762 DOI: 10.1002/chem.201704847 《Most Accessed 11/2017》

Benzylic C-H Trifluoromethylation via Photoenol
T. Ide, S. Masuda, Y. Kawato, H. Egami, Y. Hamashima*
  Org. Lett.  2017, 19,4452-4455 DOI: 10.1021/acs.orglett.7b01971

Total Synthesis of TAN1251C via Diastereoselective Construction of the Azaspiro Skeleton
Y. Nagasaka, S. Shintaku, K. Matsumura, A. Masuda, T. Asakawa, M. Inai, M. Egi, Y. Hamashima, Y. Ishikawa, and T. Kan*
  Org. Lett.  2017, 19, 3839-3842 DOI: 10.1021/acs.orglett.7b01718

Synthetic Study on Pactamycin: Stereoselective Synthesis of the Cyclopentane Core Framework
A. Goto, S. Yoshimura, Y. Nakao, M. Inai, T. Asakawa, M. Egi, Y. Hamashima, M. Kondo, and T. Kan*
    Org. Lett.  2017, 19, 3358-3361 DOI: 10.1021/acs.orglett.7b01257

Enantioselective Allyl-, and Allenylboration of Aldehydes Catalyzed by Chiral Hydroxyl Carboxylic Acid
Y. Ota, Y. Kawato, H. Egami, Y. Hamashima*
     Synlett  2017, 28, 976-980 DOI: 10.1055/s-0036-1588690

2016

Stereoselective Construction of 2-Vinyl 3-Hydroxybenzopyran Rings: Total Syntheses of Teadenols A and B
R. Yoshida, H. Ouchi, A. Yoshida, T. Asakawa, M. Inai, M. Egi, Y. Hamashima* and T. Kan*
     Org. Biomol. Chem. 2016, 14, 10783-10786 DOI/10.1039/C6OB02004F

α-Functionalization of Tetrahydroisoquinolines with Activated Alkyl Bromide under Photoredox Catalysis
T. Ide, K. Shimizu, Y. Kawato, H. Egami, and Y. Hamashima*
     Heterocycles 2017, 95, 738-747. DOI : 10.3987/COM-16-S(S)73  

Difunctionalization of Alkenes Using 1-Chloro-1,2-benziodoxol-3-(1H)-one
H. Egami*, T. Yoneda, M. Uku, T. Ide, Y. Kawato, and Y. Hamashima*
     J. Org. Chem. 2016 ,81, 4020-4030.  DOI/10.1021/acs.joc.6b00295

Practical Total Syntheses of Acromelic Acids A and B
M. Inai, H. Ouchi, A. Asahina, T. Asakawa, Y. Hamashima*, and T. Kan*
  Chem. Pharm. Bull.  2016, 64, 723-732.  DOI/org/10.1248/cpb.c16-00009

Synthesis of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol
T. Kan, T. Asakawa, Y. Kawabe, A. Yoshida, Y. Aihara, T. Manabe, Y. Hirose, A. Sakurada, M. Inai, Y. Hamashima, T. Furuta, and T. Wakimoto
J. Antibiot. 2016, 69, 299-312. DOI/10.1038/ja.2016.14

Highly Enantioselective Bromocyclization of Allylic Amides with a P/P=O Double-site Lewis Base Catalyst
Y. Kawato, H. Ono, A. Kubota, Y. Nagao, N. Morita, H. Egami, and Y. Hamashima*
Chem. Eur. J.   2016,  22, 2127-2133.  DOI/10.1002/chem.201503153

2015

Benzylic C–H Trifluoromethylation of Phenol Derivatives
H. Egami, T. Ide, Y. Kawato, and Y. Hamashima*
Chem. Commun. 2015,  51,  16675–16678. DOI: 10.1039/C5CC07011B

Asymmetric Fluorolactonization with a Bifunctional Hydroxyl Carboxylate Catalyst
H. Egami, J. Asada, K. Sato, D. Hashizume, Y. Kawato, and Y. Hamashima*
  J. Am. Chem. Soc. 2015, 137, 10132–10135. DOI: 10.1021/jacs.5b06546

Stereocontrolled Total Syntheses of Optically Active Furofuran Lignans
M. Inai, R. Ishikawa, N. Yoshida, N. Shirakawa, Y. Akao, Y. Kawabe, T. Asakawa, M. Egi, Y. Hamashima*, T. Kan*
  Synthesis 2015, 47, 3513-3521. DOI: 10.1055/s-0034-1378812

2-[(Neopentyl glycolato)boryl]phenyl Triflates and Halides for Fluoride-Ion-Mediated Generation of Functionalized Benzynes
T. Ikawa,* R. Yamamoto, A. Takagi, T. Ito, K. Shimizu, M. Goto, Y. Hamashima, S. Akai*
   Adv. Synth. Catal. 2015, 357, 2287-2300.  DOI: 10.1002/adsc.201500315

Concise Synthesis of Binaphthol-derived Chiral Dicarboxylic Acids
H. Egami, K. Sato, J. Asada, Y. Kawato, Y. Hamashima^*
  Tetrahedron 2015, 71, 6384–6388.  DOI:10.1016/j.tet.2015.05.041

Advanced Dress-up Chiral Columns: New Removable Chiral Stationary Phases for Enantioseparation of Chiral Carboxylic Acids
K. Todoroki, Y. Ishii, T. Ide, J.Z. Min, K. Inoue, X. Huang, W. Zhang, Y. Hamashima, T. Toyo'oka^*
Analytica Chimica Acta 2015, 882, 101-111.  DOI:org/10.1016/j.aca.2015.03.037

Enantioselective Bromocyclization of Allylic Amides Catalyzed byBINAP Derivatives
Y. Kawato, A. Kubota, H. Ono, H. Egami, Y, Hamashima^*
Org. Lett. 2015, 17, 1244-1247.   DOI:10.1021/acs.orglett.5b00220

Development of a Highly Efficient Single-mode Microwave Applicator with a Resonant Cavity and Its Application to Continuous Flow Syntheses
S. Yokosawa, N. Ohneda, K. Muramatsu, T. Okamoto, H, Odashima, T. Ikawa, J. Sugiyama, M. Fujita, T. Sawairi, H. Egami, Y, Hamashima, M. Egi, S. Akai^*
RSC Adv. 2015, 5, 10204-10210.   DOI:10.1039/C4RA12428F

2014

Dual Catalysis with Copper and Rhenium for Trifluoromethylation of Propargylic Alcohols: Efficient Synthesis of α-Trifluoromethylated Enones
H. Egami, T. Ide, M. Fujita, T. Tojo, Y, Hamashima^*, M. Sodeoka^*
Chem. Eur. J. 2014, 20, 12061–12065.  DOI:10.1002/chem.201403447

Total Syntheses of (+)-Sesamin and (+)-Sesaminol
R. Ishikawa, N. Yoshida, Y.Akao, Y. Kawabe, M. Inai, T. Asakawa, Y. Hamashima^*, T. Kan^*
Chem. Lett. 2014, 43, 1572-1574. DOI:10.1246/cl.140613

Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes
K. Ikeuchi, R. Fujii, S. Sugiyama, T. Asakawa, M. Inai, Y. Hamashima, J. H. Choi, T. Suzuki, H. Kawagishi^*, T. Kan^*
Org. Biomol. Chem., 2014, 12, 3813-3815.  DOI:10.1039/C4OB00705K

Stereocontrolled Total Synthesis of Hedyotol A
Y. Kawabe, R. Ishikawa, Y. Akao, A. Yoshida, M. Inai, T. Asakawa, Y. Hamashima^*, T. Kan^*
Org. Lett., 2014, 16, 1976-1979.  DOI:10.1021/ol500524y

Practical Total Syntheses of Acromelic Acids A and B
H. Ouchi, A. Asahina, T. Asakawa, M. Inai, Y. Hamashima^*, T. Kan^*
Org. Lett., 2014, 16, 1980-1983.  DOI:10.1021/ol500529w

Practical Synthesis of Kainoids: A New Chemical Probe Precursor and a Fluorescent Probe
S. Sasaki, H. Suzuki, H. Ouchi, T. Asakawa, M. Inai, R. Sakai, K. Shimamoto, Y. Hamashima^*, T. Kan^*
Org. Lett. 2014, 16, 564-567. DOI:10.1021/ol403434e

Synthetic Studies of Fisetin, Myricetin and Nobiletin Analogs and Related Probe Molecules
A. Hiza, Y. Tsukaguchi, T. Ogawa, M. Inai, T. Asakawa, Y. Hamashima^*, T. Kan^*
HETEROCYCLES 2014, 88, 1371-1396. DOI:10.3987/COM-13-S(S)107

2013

Stereocontrolled total synthesis of sphingofungin E
K. Ikeuchi, M. Hayashi, T. Yamamoto, M. Inai, T. Asakawa, Y. Hamashima, T. Kan
Eur. J. Org. Chem. 2013, 30, 6789-6792. DOI:10.1002/ejoc.201301065

Chemoselective Hydrogenation Reaction of Unsaturated Bonds in the Presence of o-Nitrobenzenesulfonyl Group
A. Kawanishi, C. Miyamoto, Y. Yabe, M. Inai, T. Asakawa, Y. Hamashima, H. Sajiki, T. Kan^*
Org. Lett. 2013, 15, 1306-1309.  DOI:10.1021/ol4002448

Synthesis of Theaflavin via Biomimetic Oxidative Coupling Reaction
Y. Kawabe, Y. Aihara, Y. Hirose, A. Sakurada, A. Yoshida, M. Inai, T. Asakawa, Y. Hamashima^*, T. Kan^*
Synlett 2013, 479-482. DOI:10.1055/s-0032-1318131

Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification
S. Fujishiro, K. Dodo, E. Iwasa, Y. Sohtome, Y. Hamashima, A. Ito, M. Yoshida, M. Sodeoka^*
Bioorg. Med. Chem. Lett. 2013, 23, 733-736. DOI:10.1016/j.bmcl.2012.11.087

2012

Catalytic Desymmetrization of Cyclohexadienes via Asymmetric Bromolactonization
K. Ikeuchi, K. Ido, S. Yoshimura, T. Asakawa, M. Inai, Y. Hamashima^*, T. Kan^*
Org. Lett. 2012, 14, 6016-6019.

Stereocontrolled Total Synthesis of (+)- UCS1025A
K. Uchida, T. Ogawa, Y. Yasuda, H. Mimura, T. Fujimoto, T. Fukuyama, T. Wakimoto, T. Asakawa, Y. Hamashima^*, T. Kan^*
Angew. Chem., Int. Ed. 2012, 51, 12850-12853.

Total Synthesis of (-)-Lemonomycin
A. Yoshida, M. Akaiwa, T. Asakawa, Y. Hamashima, S. Yokoshima, T. Fukuyama, T. Kan^*
Chem. Eur. J. 2012, 18, 11192-11195.

A Short-step Asymmetric Synthesis of Dehydrodiconifery Alcohol (DCA) via C-H Insertion Reaction
S. Matsumoto, T. Asakawa, Y. Hamashima^*, T. Kan^*
Synlett 2012, 1082-1084.

Copper-Catalyzed Trifluoromethylation of Allylsilanes
R. Shimizu, H. Egami, Y. Hamashima^*, M. Sodeoka^*
Angew. Chem., Int. Ed. 2012, 51, 4577-4580.

Catalytic Asymmetric Mono-fluorination of a-Keto Ester: Synthesis of Optically Active a-Hydroxy-b-fluoro Esters and a-Amino-b-fluoro Esters
S. Suzuki, Y. Kitamura, S. Lectard, Y. Hamashima^*, M. Sodeoka^*
Angew. Chem., Int. Ed. 2012, 51, 4581-4585.

Synthesis and Biological Activities of Chaetocin and its Derivatives
M. Sodeoka, K. Dodo, Y. Teng, K. Iuchi, Y. Hamashima, E. Iwasa, S. Fujishiro
Pure Appl. Chem. 2012, 84, 1369-1378.

2011年以前は　PDF で。

英文総説

Chemical synthesis of tea polyphenols and related compounds
T. Asakawa, Y. Hamashima, T. Kan
Current Pharmaceutical Design 2013, 19, 6207-6217.

Epipolythiodiketopiperazine Alkaloids: Total Syntheses and Biological Activities
E. Iwasa, Y. Hamashima, M. Sodeoka
Israel J. Chem. 2011, 51, 420-433.

Recent Advances in Catalytic Enantioselective Fluorination Reactions
S. Lectard, Y. Hamashima, M. Sodeoka
Adv. Synth. & Catal. 2010, 352, 2708-2732.

Development of Novel Catalytic Asymmetric Reactions Using Cationic Group-10 Metal Complexes: With a Special Focus on Reactions in which Palladium Enolates Plays a Key Role
Y. Hamashima, M. Sodeoka
TCI MAIL 2010, 140, 2-16.

Chiral Pd aqua complex-catalyzed asymmetric C-C bond-forming reactions: a Brønsted acid-base cooperative system
M. Sodeoka, Y. Hamashima
Chem. Commun. 2009, 5787-5798.

Catalytic Enantioselective a-Fluorination of Carbonyl Compounds Using Chiral Transition Metal Complexes
Y. Hamashima, M. Sodeoka
J. Synth. Org. Chem., Jpn. 2007, 65, 1099-1107.

Acid-Base Catalysis of Chiral Palladium Complexs: Development of Novel Asymmetric Reactions and Their Application to Synthesis of Drug Candidates
Y. Hamashima
Chem. Pharm. Bull. 2006, 54, 1351-1364.

Enantioselective Fluorination Reactions Catalyzed by Chiral Palladium Complexes
Y. Hamashima, M. Sodeoka
Synlett 2006, 1467-1478.

Development of Catalytic Asymmetric Reactions via Chiral Palladium Enolates
Y. Hamashima, M. Sodeoka
Chem. Rec. 2004, 4, 231-242.

和文総説

「アニオン性相間移動触媒の創製と不斉フッ素化反応の開発」
江上寛通, 濱島義隆
有機合成化学協会誌　2022, 80, 632-644.

「遷移金属錯体の酸・塩基作用を利用する触媒的不斉反応の開発」
濱島義隆, 袖岡幹子
有機合成化学協会誌　2011, 69, 972-984.

「カチオン性10族金属触媒を用いた不斉触媒反応の新展開：パラジウムエノラートを鍵とする反応を中心として」
濱島義隆, 袖岡幹子
TCIメール 2008, 140, 2-21.

「パラジウム触媒による不斉フッ素化反応」
濱島義隆, 袖岡幹子
触媒 2007, 49, 20-24.

「Pd錯体による酸／塩基反応を鍵とする触媒的不斉反応の開発」
濱島義隆
Yakugaku Zasshi 2005, 125, 785-793.

「エナンチオ選択的フッ素化反応の新展開」
濱島義隆, 袖岡幹子
ファルマシア 2004, 40, 507-511.

「触媒的不斉マイケル反応」
濱島義隆, 袖岡幹子
ファルマシア 2003, 39, 664-665.

「ルイス酸−ルイス塩基複合多点認識不斉触媒の創製と展開」
金井求, 濱島義隆, 高村昌弘, 柴崎正勝
有機合成化学協会誌 2001, 59, 766-778.

「ルイス酸−ルイス塩基型多点認識不斉触媒の開発」
金井求, 濱島義隆, 柴崎正勝
ファルマシア 1999, 35, 690-694.

「相間移動触媒の設計に基づくオレフィン類の不斉フッ素官能基化反応の開発」
   江上寛通，濱島義隆
　月刊ファインケミカル 2019年10月号（シーエムシー出版）pp.22–30

「アニオン性相関移動触媒の創成と不斉フッ素化」
   江上寛通，濱島義隆
　月刊化学工業 2019年9月号（化学工業社）pp.6–13

「学際的創薬科学論」
   石川智久，橋本博，濱島義隆，吉成浩一  共著
　 京都廣川書店

「フロー型マイクロ波照射装置を用いる有機合成」
   江上寛通，濱島義隆
　化学プロセスのスケールアップ、連続化（技術情報協会）pp.494–506

「不斉ハロ環化反応による高機能性キラル合成素子の開発」
   川戸勇士，濱島義隆
　有機分子触媒の開発と工業利用（監修： 秋山隆彦, シーエムシー出版）第26章

「有機分子触媒による不斉ブロモ環化反応の開発」
   川戸勇士，濱島義隆
　月刊ファインケミカル 2017年3月号（シーエムシー出版）pp.12–20

Carbon-Carbon Bond-Forming Reactions via Transmetallation Using Silyl Enol Ethers
Y. Hamashima, M. Sodeoka
In Comprehensive Chirality (E. M. Carreira, H. Yamamoto et al. Eds.: Elsevier), Vol. 4, 210-213 (2012).

「いろいろなキラル分子」
濱島義隆
化学と教育, 2009, 57, 148-151.

「マクマリー有機化学　生命反応へのアプローチ」
柴崎正勝　他　監訳　翻訳担当 (2009)

Michael Addition Reactions
Y. Hamashima, M. Sodeoka
In Handbook of C-H Transformations (G. Dyker, Ed.; Wiley-VHC), Vol. 2, 347-359 (2005)

「Mannich 反応」
濱島義隆, 袖岡幹子
有機合成のための触媒反応103 (檜山為次郎, 野崎京子 編, 東京化学同人) pp.92-93 (2004).

Asymmetric Reactions Catalyzed by Chiral Palladium Aqua and Hydroxo Complexes
袖岡幹子, 濱島義隆
有機合成創造の軌跡 (有機合成化学協会　編) pp.192-193 (2002).

・ 日本薬学会　会員
・ 日本化学会　会員
・ 有機合成化学協会　会員
・ アメリカ化学会　会員
・ 有機合成化学協会東北・北海道支部常任幹事（2002~2005年度）
・ 理化学研究所客員研究員（2010~2012）
・ 日本薬学会ファルマシアトピックス小委員　（2008-2010年度）
・ 有機合成化学協会東海支部庶務幹事（2012年度）
・ 第29回有機合成化学セミナー実行委員会事務局（2012年）
・ 第12回次世代を担う有機合成化学シンポジウム実行委員長（2014年, 内定）