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Protein Crystallography, Structural Biology & Drug design

Last modified on 05-Apr-2019

Protein adopts a particular three-dimensional structure and protein function is directly correlated with its structure. Structural biology reveals protein function based on its three-dimensional structure, and provides structural basis to regulate the function. We analyze protein structures by X-ray crystallography that is a powerful method to determined protein structure at atomic resolution. We mainly focus proteins involved DNA replication, repair (especially DNA damage tolerance), chromosome structure, cell-cycle, transcription and signal transduction. Those proteins are mostly involved in human diseases such as cancer and infection. We reveal three-dimensional structures and function of those proteins, and perform molecular design and chemical synthesis, namely structure-based drug design (SBDD).
In combination with X-ray crystallography, we will employ multiple methods including small angle X-ray scattering (SAXS), NMR, computational science, mass spectroscopy (MS), and cryo EM to clarify mechanisms underlying more complex biological events.

 

<Contact>
Hiroshi Hashimoto, PhD.
(TEL & FAX) +81 54 264 5644
(E-mail) hash # u-shizuoka-ken.ac.jp (Replace # with @)
(Street Address) 52-1 Yada, Suruga-ku, Shizuoka 422-8002, Japan.