2024

2023

6-Shogaol, an Active Component of Ginger, Inhibits p300 Histione Acetyltransferase Activity and Attenuates the Development of Pressure-Overload-Induced Heart Failure.

Kawase Y, Sunagawa Y, Shimizu Kana, Funamoto M, Hamabe-Horiike T, Katanasaka Y, Shimizu S, Howke P, Mori K, Komiyama M, Hasegawa K, Morimoto T

Nutrients, 2023 May 8;15(9):2232. PMID: 37432400

Monodemethylated Metabolites of Orally Administered Nobiletin: Identification and Quantitation in Rat Plasma and Tissues.

Iwashita M, Shioi R, Sugiyama M, Hashizume K, Kan T, Naito S, Takai H, Kawase Y, Hamabe-Horiike T, Katanasaka Y, Sunagawa Y, Morimoto T.

J. Agric. Food Chem. 2023 Jul 5;71(26):10028-10036. PMID: 37347985

Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake.

Aoki T, Kinoshita J, Munesue S, Hamabe-Horiike T, Yamaguchi T, Nakamura Y, Okamoto K, Moriyama H, Nakamura K, Harada S, Yamamoto Y, Inaki N, Fushida S. 

Ann. Surg. Oncol. 2023 May;30(5):3125-3136. PMID: 36042102

Myogenetic Oligodeoxynucleotide Induces Myocardial Differentiation of Murine Pluripotent Stem Cells. 

Ishioka M, Nihashi Y, Sunagawa Y, Umezawa K, Shimosato T, Kagami H, Morimoto T, Takaya T.

Int. J. Mol. Sci. 2023 Sep 21;24(18):14380. PMID: 37762684

Randomised Double-blind Placebo-Controlled Multicentre Trial for the Effects of Yokukansan in Smokers with Depressive Tendencies.

Komiyama M, Ozaki Y, Wada H, Yamakage H, Satoh-Asahara N, Yasoda A, Sunagawa Y, Morimoto T, Takahashi Y, Hasegawa K.

Eur. Cardiol. 2023 Apr 25;18:e30. PMID: 37405335

MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes.

Kojima H, Sadahiro T, Muraoka N, Yamakawa H, Hashimoto H, Ishii R, Gosho M, Abe Y, Yamada Y, Nakano K, Honda S, Fujita R, Akiyama T, Sunagawa Y, Morimoto T, Tsukahara T, Hirai H, Fukuda K, Ieda M.

Stem Cell Reports. 2023 Jun 13;18(6):1274-1283. PMID: 37315521

2022

Ecklonia stolonifera Okamura Extract Suppresses Myocardial Infarction-Induced Left Ventricular Systolic Dysfunction by Inhibiting p300-HAT Activity.

Katagiri T, Sunagawa Y, Maekawa T, Funamoto M, Shimizu S, Shimizu K, Katanasaka Y, Komiyama M, Howke P, Hara H, Mori K, Hasegawa K, Morimoto T

Nutrients, 2022 Jan 28;14(3):580. PMID: 35276939

ANGPTL4 Expression Is Increased in Epicardial Adipose Tissue of Patients with Coronary Artery Disease

Katanasaka Y, Saito A, Sunagawa Y, Sari N, Funamoto M, Shimizu S, Shimizu K, Akimoto T, Ueki C, Kitano M, Hasegawa K, Sakaguchi G, Morimoto T

J. Clin. Med., 2022 Apr 27;11(9), 2449. PMID: 35566578

Ameliorating prediabetic subject status via fermented tea supplementation: A randomized, double-blind, parallel-group comparison study

Katanasaka Y, Sunagawa Y, Miyazaki Y, Funamoto M, Shimizu S, Shimizu K, Yamakage H, Satoh-Asahara N, Toyama K, Sabashi T, Suzuki M, Hamabe-Horiike T, Komiyama M, Wada H, Mori K, Hasegawa K, Morimoto T

J. Funct. Foods, 2022 18 Sep;97, 105257.

Gingival bleeding and pocket depth among smokers and the related changes after short-term smoking cessation

Mittal S, Komiyama M, Ozaki Y, Yamakage H, Satoh-Asahara N, Yasoda A, Wada H, Funamoto M, Shimizu K, Miyazaki Y, Katanasaka Y, Sunagawa Y, Morimoto T, Takahashi Y, Nakayama T, Hasegawa K

Acta Odontol. Scand. 2022 May;80(4):258-263. PMID: 34893003

Auraptene, a Citrus Peel-derived Natural Product, Prevents Myocardial Infarction-Induced Heart Failure by Activating PPARα in Rats 

Sunagawa Y, Kawaguchi S, Miyazaki Y, Katanasaka Y, Funamoto M, Shimizu K, Shimizu S, Hamabe-Horiike, Kawase Y, Komiyama M, Mori K, Murakami A, Hasegawa K, Morimoto T.

Phytomedicine, 2022 Dec;107:154457. PMID: 36223697

Effects of high-absorption curcumin for the prevention of hypertensive heart disease: a double-blind, placebo-controlled, Randomised clinical study

Funamoto M, Sunagawa Y, Katanasaka Y, Kato T, Funada J, Ajiro Y, Komiyama M, Akao M, Yasoda A, Yamakage H, Satoh-Asahara N, Wada H, Ikeda Y, Morimoto T, Hasegawa K.

Eur. Heart J. Open, 2022 Sep 10;2(5):oeac057. PMID: 36172003

Study protocol to determine the effects of highly absorbable oral curcumin on the indicators of cognitive functioning: a double-blind randomised controlled trial

Komiyama M, Ozaki Y, Wada H, Yamakage H, Satoh-Asahara N, Kishimoto A, Katsuura Y, Imaizumi A, Hashimoto T, Sunagawa Y, Morimoto T, Hasegawa K.

BMJ Open. 2022 Sep 19;12(9):e057936. PMID: 36123102

Chrysanthemum morifolium extract ameliorates doxorubicin-induced cardiotoxicity by decreasing apoptosis

Ono M, Sunagawa Y, Mochizuki S, Funamoto M, Shimizu K, Shimizu S, Katanasaka Y, Komiyama M, Hawke P, Hara H, Arakawa Y, Mori K, Hasegawa K, Morimoto T.

Cancers. 2022 Jan 28;14(3):683. PMID: 35158951

Multimerization of the GATA4 transcription factor regulates transcriptional activity and cardiomyocyte hypertrophic response

Shimizu S, Sunagawa Y, Hajika N, Yorimitsu N, Katanasaka Y, Funamoto M, Miyazaki Y, Sari N, Shimizu K, Hasegawa K, Morimoto T.

Int. J. Biol. Sci. 2022 Jan 1;18(3):1079-1095. PMID: 35173540

Estrogen induces the expression of EBV lytic protein ZEBRA, a marker of poor prognosis in nasopharyngeal carcinoma

Dochi H, Kondo S, Murata T, Fukuyo M, Nanbo A, Wakae K, Jiang WP, Hamabe-Horiike T, Tanaka M, Nishiuchi T, Mizokami H, Moriyama-Kita M, Kobayashi E, Hirai N, Komori T, Ueno T, Nakanishi Y, Hatano M, Endo K, Sugimoto H, Wakisaka N, Juang SH, Muramatsu M, Kaneda A, Yoshizaki T.

Cancer Sci.  2022 Aug;113(8):2862-2877. PMID: 35633182

Crosstalk between cancer-associated fibroblasts and immune cells in peritoneal metastasis: inhibition in the migration of M2 macrophages and mast cells by Tranilast

Nakamura Y, Kinoshita J, Yamaguchi T, Aoki T, Saito H, Hamabe-Horiike T, Harada S, Nomura S, Inaki N, Fushida S.

Gastric Cancer. 2022 May;25(3):515-526. PMID: 34997450

Adipocytes contribute to tumor progression and invasion of peritoneal metastasis by interacting with gastric cancer cells as cancer associated fibroblasts

Hamabe-Horiike T, Harada A, Yoshida K, Kinoshita J, Yamaguchi T, Fushida S. 

Cancer Rep. 2023 Jan;6(1):e1647. PMID: 35691615

2021

Curcumin, an Inhibitor of p300-HAT Activity, Prevents the Development of Hypertension-Induced Left Ventricular Hypertrophy with Preserved Ejection Fraction in Dahl Rats.

Sunagawa Y, Funamoto M, Shimizu K, Shimizu S, Sari N, Katanasaka Y, Miyazaki Y, Kakeya H, Hasegawa K, Morimoto T. 

Nutrients. 2021 Jul 29;13(8):2608. PMID: 34444769

Metformin suppresses phenylephrine-induced hypertrophic responses by inhibiting p300-HAT activity in cardiomyocytes.

Sunagawa Y, Shimizu K, Katayama A, Funamoto M, Shimizu K, Nurmila S, Shimizu S, Miyazaki Y, Katanasaka Y, Hasegawa K, Morimoto T. 

J. Pharmacol. Sci. 2021 Oct;147(2):169-175. PMID: 34384564

A novel amorphous preparation improved curcumin bioavailability in healthy volunteers: a single-dose, double-blind, two-way crossover study. 

Sunagawa Y, Miyazaki Y, Funamoto M, Shimizu K, Shimizu S, Sari N, Katanasaka Y, Ito M, Ogawa T, Ozawa-Umeta H, Hasegawa K, Morimoto T. 

J Funct Foods. 2021 June, 81, 104443.

The Selective Serotonin 2A Receptor Antagonist Sarpogrelate Prevents Cardiac Hypertrophy and Systolic Dysfunction via Inhibition of the ERK1/2–GATA4 Signaling Pathway. 

Shimizu K, Sunagawa Y, Funamoto M, Honda H, Katanasaka Y, Murai N, Kawase Y, Hirako Y, Katagiri T, Yabe H, Shimizu S, Sari N, Wada H, Hasegawa K, Morimoto T. 

Pharmaceuticals. 2021 Dec 5;14(12):1268. PMID: 34959669

Zerumbone prevents pressure overload-induced left ventricular systolic dysfunction by inhibiting cardiac hypertrophy and fibrosis. 

Sari N, Katanasaka Y, Sugiyama Y, Sunagawa Y, Miyazaki Y, Funamoto M, Shimizu S, Shimizu K, Murakami A, Mori K, Wada H, Hasegawa K, Morimoto T. 

Phytomedicine. 2021 Nov;92:153744. PMID: 34563985

Clinically Administered Doses of Pitavastatin and Rosuvastatin. 

Katanasaka Y, Hirano S, Sunagawa Y, Miyazaki Y, Sato H, Funamoto M, Shimizu K, Shimizu S, Sari N, Hasegawa K, Morimoto T. 

Int Heart J.  2021;62(6):1379-1386. PMID: 34853228

Effect of Theaflavin on Oral Bacteria in Japanese Subjects: A Randomized, Placebo-Controlled, Double-Blind Study. 

Katanasaka Y, Yoshida N, Naitou H, Naruta R, Miyazaki Y, Sunagawa Y, Funamoto M, Shimizu K, Shimizu S, Sari N, Yamakage H, Satoh-Asahara N, Hasegawa K, Morimoto T. 

J Med Food. 2021 Nov;24(11):1186-1190. PMID: 34698557

Alpha Mangostin Derived from Garcinia magostana Linn Ameliorates Cardiomyocyte Hypertrophy and Fibroblast Phenotypes in Vitro. 

Sari N, Katanasaka Y, Sugiyama Y, Miyazaki Y, Sunagawa Y, Funamoto M, Shimizu K, Shimizu S, Hasegawa K, Morimoto T. 

Biol Pharm Bull. 2021;44(10):1465-1472. PMID: 34602555

Neutrophil/lymphocyte ratio is correlated with levels of inflammatory markers and is significantly reduced by smoking cessation. 

Komiyama M, Ozaki Y, Miyazaki Y, Katanasaka Y, Sunagawa Y, Funamoto M, Shimizu K, Yamakage H, Sato-Asahara N, Yasoda A, Wada H, Morimoto T, Hasegawa K. 

J Int Med Res. 2021 Jun;49(6):3000605211019223. PMID: 34187206

The curcumin analog GO-Y030 controls the generation and stability of regulatory T cells. 

Maruyama T, Kobayashi S, Nakatsukasa H, Moritoki Y, Taguchi D, Sunagawa Y, Morimoto T, Asao A, Jin Wenwen, Owada Y, Ishii N, Iwabuchi Y, Yoshimura A, Chen W, Shibata H. 

Front Immunol in Immunology. 2021 Jun 23;12:687669. PMID: 34248973

Histone Acetylation Domains Are Differentially Induced during Development of Heart Failure in Dahl Salt-Sensitive Rats. 

Funamoto M, Sunagawa Y, Katanasaka Y, Shimizu K, Miyazaki Y, Sari N, Shimizu S, Mori K, Wada H, Hasegawa K, Morimoto T. 

Int J Mol Sci. 2021 Feb 10;22(4):1771. PMID: 33578969

Effect of cacao polyphenol-rich chocolate on postprandial glycemia, insulin, and incretin secretion in healthy participants.

Kawakami Y, Watanabe Y, Mazuka M, Yagi N, Sawazaki A, Koganei M, Natsume M, Kuriki K, Morimoto T, Asai T, Arai H. 

Nutrition. 2021 May;85:111128. PMID: 33545542

Short-term Changes in Self-rating Depression Scale Scores after Smoking Cessation in Neurotic Patients. 

Komiyama M, Ozaki Y, Miyazaki Y, Yasoda A, Wada H, Yamakage H, Satoh-Asahara N, Morimoto T, Shimatsu A, Takahashi Y, Hasegawa K. 

Intern Med. 2021 Apr 15;60(8):1175-1181. PMID: 33055476

The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice. 

Yura Y, Miura-Yura E, Katanasaka Y, Min KD, Chavkin N, Polizio AH, Ogawa H, Horitani K, Doviak H, Evans MA, Sano M, Wang Y, Boroviak K, Philippos G, Domingues AF, Vassiliou G, Sano S, Walsh K. 

Circ Res. 2021 Sep 3;129(6):684-698. PMID: 34315245

2020

Cacao Bean Polyphenols Inhibit Cardiac Hypertrophy and Systolic Dysfunction in Pressure Overload-induced Heart Failure Model Mice.

Sari N, Katanasaka Y, Honda H, Miyazaki Y, Sunagawa Y, Funamoto M, Shimizu K, Shimizu S, Wada H, Hasegawa K, Morimoto T.

Planta Med. 2020 Nov;86(17):1304-1312. PMID: 32645737

 The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice.

Shimizu K, Sunagawa Y, Funamoto M, Wakabayashi H, Genpei M, Miyazaki Y, Katanasaka Y, Sari N, Shimizu S, Katayama A, Shibata H,  Iwabuchi Y, Kakeya H, Wada H, Hasegawa K, Morimoto T.

Sci. Rep. 2020 Apr 28;10(1):7172. PMID: 32346115

Kosen-cha, a Polymerized Catechin-Rich Green Tea, as a Potential Functional Beverage for the Reduction of Body Weight and Cardiovascular Risk Factors: A Pilot Study in Obese Patients.

Katanasaka Y, Miyazaki Y, Sunagawa Y, Funamoto M, Shimizu K, Shimizu S, Sari N, Shimizu Y, Wada H, Hasegawa K, Morimoto T.

Biol Pharm Bull. 2020;43(4):675-681. PMID: 32238708

JAK2 Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4.

Yamamura S, Izumiya Y, Araki S, Nakamura T, Kimura Y, Hanatani S, Yamada T, Ishida T, Yamamoto M, Onoue Y, Arima Y, Yamamoto E, Sunagawa Y, Yoshizawa T, Nakagata N, Bober E, Braun T, Sakamoto K, Kaikita K, Morimoto T, Yamagata K, Tsujita K.

Hypertension. 2020 Jan;75(1):98-108.PMID: 31735083

 A Randomized Placebo-controlled, Double-blind Study of Kosen-cha, a Polymerized Catechin-rich Green Tea, for Obesity in Pre-obese Japanese Subjects.

Miyazaki Y, Katanasaka Y, Tsutsui Y, Sunagawa Y, Funamoto M, Shimizu K, Shimizu S, Sari N, Yamakage H, Satoh-Asahara N, Toyama K, Suzuki M, Shimizu A, Wada H, Hasegawa K, Morimoto T.

BPB Reports. 2020;3(6):202-207.

2019

Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus.

Funamoto M, Shimizu K, Sunagawa Y, Katanasaka Y, Miyazaki Y, Kakeya H, Yamakage H, Satoh-Asahara N, Wada H, Hasegawa K, Morimoto T.

J Diabetes Res. 2019 Nov 23; 8208237. PMID:31871950

Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.

Gorski PA, Jang SP, Jeong D, Lee A, Lee P, Oh JG, Chepurko V, Yang DK, Kwak TH, Eom SH, Park ZY, Yoo YJ, Kim DH, Kook H, Sunagawa Y, Morimoto T, Hasegawa K, Sadoshima J, Vangheluwe P, Hajjar RJ, Park WJ, Kho C.

Circ Res. 2019 Apr 26;124(9):e63-e80. PMID:30786847

Wnt5a-Mediated Neutrophil Recruitment Has an Obligatory Role in Pressure Overload-Induced Cardiac Dysfunction.

Wang Y, Sano S, Oshima K, Sano M, Watanabe Y, Katanasaka Y, Yura Y, Jung C, Anzai A, Swirski FK, Gokce N, Walsh K.

Circulation. 2019 Aug 6;140(6):487-499. PMID:31170826

JAK2 V617F-Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure.

Sano S, Wang Y, Yura Y, Sano M, Oshima K, Yang Y, Katanasaka Y, Min KD, Matsuura S, Ravid K, Mohi G, Walsh K.

JACC Basic Transl Sci. 2019 Sep 18;4(6):684-697. PMID:31709318

VTE and anti-coagulation therapy in cancer patients.

Miyazaki Y, Sase K, Hasegawa K, Morimoto T.

Eur Heart J Cardiovasc Pharmacother. 2019 Oct 1;5(4):189-191. PMID:31378809 Review

Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases.

Shimizu K, Funamoto M, Sunagawa Y, Shimizu S, Katanasaka Y, Miyazaki Y, Wada H, Hasegawa K, Morimoto T.

Eur Cardiol. 2019 Jul 11;14(2):117-122. PMID:31360234 Review

2018

The effects of dietary instruction on cardiovascular risk markers after smoking cessation: study protocol for a multicenter randomized controlled trial in Japan.

Komiyama M, Ozaki Y, Wada H, Yamakage H, Satoh-Asahara N, Morimoto T, Shimatsu A, Takahashi Y, Hasegawa K.

Trials. 2018 Oct 4;19(1):538. PMID:30286787

Noble Heart Failure Therapy Using Food Compositions

Morimoto T, Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Hasegawa K.

Yakugaku Zasshi. 2018;138(10):1263-1269. [Japanese Article] PMID:30270270

The smoking area was closed due to the measurement results of particulate matter at University of Shizuoka.

Miyazaki Y, Iwazaki Y, Amagai T, Sunagawa Y, Katanasaka Y, Takahashi Y, Komiyama M, Hasegawa K, Morimoto T.

Kinnen Kagaku. 2018;12(9):P1-P5. [Japanese Article]

Analysis of changes on adiponectin levels and abdominal obesity after smoking cessation.

Komiyama M, Wada H, Yamakage H, Satoh-Asahara N, Sunagawa Y, Morimoto T, Ozaki Y, Shimatsu A, Takahashi Y, Hasegawa K.

PLoS One. 2018;13(8):e0201244. PMID:30086171

Sex differences in nicotine dependency and depressive tendency among smokers.

Komiyama M, Yamakage H, Satoh-Asahara N, Ozaki Y, Morimoto T, Shimatsu A, Takahashi Y, Hasegawa K.

Psychiatry Res. 2018;267:154-159. PMID:29908483

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease.

Sano S, Oshima K, Wang Y, Katanasaka Y, Sano M, Walsh K.

Circ Res. 2018;123(3):335-341. PMID:29728415

A study on indices of apixaban anticoagulation: A single-center prospective study.

Komiyama M, Miyazaki Y, Wada H, Iguchi M, Abe M, Ogawa H, Akao M, Yamakage H, Satoh-Asahara N, Sunagawa Y, Morimoto T, Hasegawa K.

J Pharmacol Sci. 2018;137(2):105-109. PMID:29866521

Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes.

Sunagawa Y, Funamoto M, Sono S, Shimizu K, Shimizu S, Genpei M, Miyazaki Y, Katanasaka Y, Morimoto E, Ueno M, Komiyama M, Kakeya H, Wada H, Hasegawa K, Morimoto T.

J Pharmacol Sci. 2018;136(4):212-217. PMID:29602708

Effects of Products Containing Bacillus subtilis var. natto on Healthy Subjects with Neck and Shoulder Stiffness, a Double-Blind, Placebo-Controlled, Randomized Crossover Study.

Sunagawa Y, Okamura N, Miyazaki Y, Shimizu K, Genpei M, Funamoto M, Shimizu S, Katanasaka Y, Morimoto E, Yamakage H, Komiyama M, Satoh-Asahara N, Wada H, Suzuki M, Hasegawa K, Morimoto T.

Biol Pharm Bull. 2018;41(4):504-509. PMID:29415906

Association between monocyte chemoattractant protein-1 and blood pressure in smokers.

Komiyama M, Takanabe R, Ono K, Shimada S, Wada H, Yamakage H, Satoh-Asahara N, Morimoto T, Shimatsu A, Takahashi Y, Hasegawa K.

J Int Med Res. 2018;46(3):965-974. PMID:29098933

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome.

Sano S, Oshima K, Wang Y, MacLauchlan S, Katanasaka Y, Sano M, Zuriaga MA, Yoshiyama M, Goukassian D, Cooper MA, Fuster JJ, Walsh K.

J Med Coll Cardiol. 2018;71(8):875-886. PMID:29471939

2017

Smoking cessation reduces the lectin-like low-density lipoprotein receptor index, an independent cardiovascular risk marker of vascular inflammation.

Komiyama M, Wada H, Ono K, Yamakage H, Satoh-Asahara N, Shimada S, Akao M, Morimoto T, Shimatsu A, Takahashi Y, Sawamura T, Hasegawa K.

Heart Vessels. 2018;33(1):9-16. PMID:28761986

The Inhibitory Effects of Crucumin Glucuronide on p300-HAT Activity and Hypertrophic Phenylephrine-Induced Responses in Cardiomyocytes.

Genpei M, Sunagawa Y, Funamoto M, Shimizu K, Miyazaki Y, Katanasaka Y, Takahashi N, Kakeya H, Wada H, Hasegawa K, Morimoto T.

Eur Cardiol. 2017;12(2):107. PMID:30416577

Curcumin Analogue GO-Y030 Significantly Improves Pressure Overload-induced Heart Failure in Vivo.

Shimizu K, Funamoto M, Genpei M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Shibata H, Wada H, Hasegawa K, Morimoto T.

Eur Cardiol. 2017;12(2):106. PMID:30416576

A Novel Target Molecule of Nobiletin Derived from Citrus Peels has a Therapeutic Potency Against the Development of Heart Failure.

Sunagawa Y, Funamoto M, Suzuki A, Shimizu K, Sakurai R, Katanasaka Y, Miyazaki Y, Asakawa T, Kan T, Inagaki J, Wada H, Hasegawa K, Morimoto T.

Eur Cardiol. 2017;12(2):105. PMID:30416575

Development of Targeted Pharmacotherapy for Cardiovascular Disease

Katanasaka Y

Yakugaku Zasshi. 2017;137:1349-1353. [Japanese Article] PMID:29093370

2016

Regulation of Cardiac Transcription Factor GATA4 by Post-Translational Modification in Cardiomyocyte Hypertrophy and Heart Failure.

Katanasaka Y, Suzuki H, Sunagawa Y, Hasegawa K, Morimoto T.

Int Heart J. 2016;57(2):672-675. PMID:27818483

Time-dependent Changes of Atherosclerotic LDL Complexes after Smoking Cessation.

Komiyama M, Shimada S, Wada H, Yamakage H, Satoh-Asahara N, Shimatsu A, Akao M, Morimoto T, Takahashi Y, Hasegawa K.

J Atheroscler Thromb. 2016;23(11):1270-1275. PMID:27298048

Effect of statins on atherogenic serum amyloid A and α1-antitrypsin low-density lipoprotein complexes.

Miyazaki Y, Katanasaka Y, Sunagawa Y, Hirano-Sunagawa S, Funamoto M, Morimoto E, Komiyama M, Shimatsu A, Satoh-Asahara N, Yamakage H, Wada H, Hasegawa K, Morimoto T.

Int J Cardiol. 2016;225:332-336. PMID:27756037

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD.

Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto T.

Int J Chron Obstruct Pulmon Dis. 2016;11:2029-2034. PMID:27616885

Tyrosine phosphorylation of RACK1 triggers cardiomyocyte hypertrophy by regulating the interaction between p300 and GATA4.

Suzuki H, Katanasaka Y, Sunagawa Y, Miyazaki Y, Funamoto M, Wada H, Hasegawa K, Morimoto T.

Biochim Biophys Acta. 2016;1862(9):1544-1557. PMID:27208796

Functional Analysis of GATA4 Complex, a Cardiac Hypertrophy-response Transcriptional Factor, Using a Proteomics Approach

Sunagawa Y, Katanasaka Y, Wada H, Hasegawa K, Morimoto T.

Yakugaku Zasshi 2016;136(2):151-156. [Japanese Article] PMID:26831785

Secreted frizzled-related protein 5 diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury.

Nakamura K, Sano S, Fuster JJ, Kikuchi R, Shimizu I, Ohshima K, Katanasaka Y, Ouchi N, Walsh K.

J Biol Chem. 2016;291(6):2566-2575. PMID:26631720

2015

Effects of Statins on Left Ventricular Diastolic Function in Patients with Dyslipidemia and Diastolic Dysfuncion(Stat-LVDF Study)

Morimoto T, Katanasaka Y, Sunagawa Y, Hirano S, Myazaki Y, Funamoto M, Hojo Y, Suzuki H, Morimoto E, Ueno M, Shimatsu A, Satoh-Asahara N, Yamakage H, Wada H, Hasegawa K.

Biol Pharm Bull. 2015;38(9):1404-1409. PMID:26328497

2014

Optimal dose-setting study of curcumin for improvement of left ventricular systolic function after myocardial infarction in rats.

Sunagawa Y, Sono S, Katanasaka Y, Funamoto M, Hirano S, Miyazaki Y, Hojo Y, Suzuki H, Morimoto E, Marui A, Sakata R, Ueno M, Kakeya H, Wada H, Hasegawa K, Morimoto T.

J Pharmacol Sci. 2014;126(4):329-36. PMID:25409899

An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease.

Kikuchi R, Nakamura K, MacLauchlan S, Ngo DT, Shimizu I, Fuster JJ, Katanasaka Y, Yoshida S, Qiu Y, Yamaguchi TP, Matsushita T, Murohara T, Gokce N, Bates DO, Hamburg NM, Walsh K.

Nat Med. 2014;20(12):1464-71. PMID:25362254

Synergistic anti-tumor effects of a novel phosphatidyl inositol-3 kinase/mammalian target of rapamycin dual inhibitor BGT226 and gefitinib in non-small cell lung cancer cell lines.

Katanasaka Y, Kodera Y, Yunokawa M, Kitamura Y, Tamura T, Koizumi F.

Cancer Lett. 2014;347(2):196-203. PMID:24614285

2013

Drinkable preparation of Theracurmin exhibits high absorption efficiency--a single-dose, double-blind, 4-way crossover study.

Morimoto T, Sunagawa Y, Katanasaka Y, Hirano S, Namiki M, Watanabe Y, Suzuki H, Doi O, Suzuki K, Yamauchi M, Yokoji T, Miyoshi-Morimoto E, Otsuka Y, Hamada T, Imaizumi A, Nonaka Y, Fuwa T, Teramoto T, Kakeya H, Wada H, Hasegawa K.

Biol Pharm Bull. 2013;36(11):1708-14. PMID:24189415

Enhanced active targeting via cooperative binding of ligands on liposomes to target receptors.

Sugiyama T, Asai T, Nedachi YM, Katanasaka Y, Shimizu K, Maeda N, Oku N.

PLoS One. 2013 Jun 28;8(6):e67550. doi: 10.1371/journal.pone.0067550. Print 2013. PMID:23840738

Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma.

Katanasaka Y, Kodera Y, Kitamura Y, Morimoto T, Tamura T, Koizumi F.

Mol Cancer. 2013 Apr 25;12(1):31. PMID:23617883

Application of curcumin to heart failure therapy by targeting transcriptional pathway in cardiomyocytes.

Katanasaka Y, Sunagawa Y, Hasegawa K, Morimoto T.

Biol Pharm Bull. 2013;36(1):13-7. PMID:23302632

Protective Effects of Shichimotsu-koka-To on Irreversible Thy-1 Nephritis.

Takahiko Ono, Kohei Kamikado, Tatsuya Morimoto.

Biol Pharm Bull. 2013; 36(1), 41-47. PMID:23131611

2012

Efficacy of everolimus, a novel mTOR inhibitor, against basal-like triple-negative breast cancer cells.

Mayu Yunokawa, Fumiaki Koizumi, Yuka Kitamura, Yasufumi Katanasaka, Naoko Okamoto, Makoto, Kodaira, Kan Yonemori, Chikako Shimizu, Masashi Ando, Kenkichi Masutomi, Teruhiko Yoshida, Yasuhiro Fujiwara, Kenji Tamura.

Cancer Sci.2012; 103, 1665-71. PMID:22703543

Low density lipoprotein apheresis ameliorates IFN-gamma production in patients with nephrotic syndrome.

Hitomi Miyata-Watanabe, Kazuko Uno, Takahiko Ono, Masatomo Yashiro, Atsushi Fukatsu, Toru Kita,Takeshi Kimura and Eri Muso.

Ther Apher Dial, 2012; 16, 189-94. PMID: 22458400

A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.

Sunagawa Y, Wada H, Suzuki H, Sasaki H, Imaizumi A, Fukuda H, Hashimoto T, Katanasaka Y, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K, Morimoto T.

Biol Pharm Bull. 2012;35(2):139-44. PMID:22293342

α1-Antitrypsin low-density-lipoprotein serves as a marker of smoking-specific oxidative stress.

Wada H, Ura S, Satoh-Asahara N, Kitaoka S, Mashiba S, Akao M, Abe M, Ono K, Morimoto T, Fujita M, Shimatsu A, Takahashi Y, Hasegawa K.

J Atheroscler Thromb. 2012;19(1):47-58. PMID:22027559

2011

Distinct characteristics of circulating vascular endothelial growth factor-a and C levels in human subjects.

Wada H, Ura S, Kitaoka S, Satoh-Asahara N, Horie T, Ono K, Takaya T, Takanabe-Mori R, Akao M, Abe M, Morimoto T, Murayama T, Yokode M, Fujita M, Shimatsu A, Hasegawa K.

PLoS One. 2011;6(12):e29351. PMID:22206010

A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats.

Sunagawa Y, Morimoto T, Wada H, Takaya T, Katanasaka Y, Kawamura T, Yanagi S, Marui A, Sakata R, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K.

Circ J. 2011;75(9):2151-9. PMID:21737953

Innovative preparation of curcumin for improved oral bioavailability.

Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T.

Biol Pharm Bull. 2011;34(5):660-5.PMID:21532153

2010

Excessive apoptosis as a downstream molecular event during the development of congenital heart diseases.

Kaichi S, Hasegawa K, Morimoto T.

Circ J. 2010 Nov;74(11):2297-8. PMID:20962417

Treatment effects of renin-angiotensin system inhibitor and calcium channel blocker in patients with coronary artery narrowing (from the Japanese Coronary Artery Disease Study).

Fujita M, Sasayama S, Terasaki F, Mitani S, Morimoto T, Yamazaki T, Hayashi D, Kohro T, Okada Y, Nagai R; JCAD Study Investigators.

Heart Vessels. 2010 Nov;25(6):453-9. PMID:20922538

Sairei-to ameliorates rat peritoneal fibrosis partly through suppression of oxidative stress.

Kitamoto M, Kato K, Sugimoto A, Kitamura H, Uemura K, Takeda T, Wu C, Nogaki F, Morimoto T, Ono T.

Nephron Exp Nephrol. 2011;117(3):e71-81. PMID:20881432

Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes.

Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K.

J Cell Physiol. 2011 Jan;226(1):248-54.PMID:20665673

Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.

Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T.

Cardiovasc Res. 2010 Nov 1;88(2):314-23. PMID:20547733

Novel heart failure therapy targeting transcriptional pathway in cardiomyocytes by a natural compound, curcumin.

Morimoto T, Sunagawa Y, Fujita M, Hasegawa K.

Circ J. 2010 Jun;74(6):1059-66. .PMID:20467147

Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts.

Takaya T, Wada H, Morimoto T, Sunagawa Y, Kawamura T, Takanabe-Mori R, Shimatsu A, Fujita Y, Sato Y, Fujita M, Kimura T, Sawamura T, Hasegawa K.

Circ J. 2010 Apr;74(4):723-9. PMID:20190428

Transmitral E/A ratio decreases in association with abdominal fat accumulation in patients with impaired glucose tolerance or mild diabetes without left ventricular hypertrophy.

Wada H, Shinjo D, Kameda S, Ono K, Satoh N, Morimoto T, Osakada G, Nakano T, Fujita M, Shimatsu A, Hasegawa K.

Heart Vessels. 2010 Jan;25(1):45-50. PMID:20091398

Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.

Sunagawa Y, Morimoto T, Takaya T, Kaichi S, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K.

J Biol Chem. 2010 Mar 26;285(13):9556-68. PMID:20081228

Two crystal modifications of (Pro-Pro-Gly)4-Hyp-Hyp-Gly-(Pro-Pro-Gly)4 reveal the puckering preference of Hyp(X) in the Hyp(X):Hyp(Y) and Hyp(X):Pro(Y) stacking pairs in collagen helices.

Okuyama K, Morimoto T, Narita H, Kawaguchi T, Mizuno K, Bachinger HP, Wu G, Noguchi K.

Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):88-96. PMID:20057053

Aldosterone signaling associates with p300/GATA4 transcriptional pathway during the hypertrophic response of cardiomyocytes.

Yoshida Y, Morimoto T, Takaya T, Kawamura T, Sunagawa Y, Wada H, Fujita M, Shimatsu A, Kita T, Hasegawa K.

Circ J. 2010 Jan;74(1):156-62. PMID:19966502