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2025年

原著論文/Original papers

  1. Tomohiro Yamada, Aogu Furusho, Kenji Kojima, Eiji Sugiyama, Hajime Mizuno, Kaori Tsukakoshi, Hideki Hayashi, Takeshi Yamano, Takashi Hasebe, Toshimasa Toyo’oka, Kazunori Ikebukuro, Kenichiro Todoroki: Development of a mertansine-specific DNA aptamer and novel high-throughput sandwich enzyme-linked oligonucleotide assay for quantification and characterization of trastuzumab emtansine. Biosens. Bioelectron., 272, 117108 (2025). DOI: 10.1016/j.bios.2024.117108
  2. Aogu Furusho, Daiki Takeuchi, Jo Sakata, Takuma Yanagisawa, Hajime Mizuno, Yuta Terui, Masafumi Iharada, Hironori Takai, Eiji Sugiyama, Iwao Sakane, Kenichiro Todoroki: Mass spectrometric analysis of the amiodarone-induced alteration of phosphatidylcholines in living single cells. J. Pharm. Biomed. Anal., 265, 117045 (2025). DOI: 10.1016/j.jpba.2025.117045

2024年

原著論文/Original papers

  1. Kenichiro Todoroki, Nan Fukudo, Yuto Kudoh, Hajime Mizuno, Jun Zhe Min, Shimako Tanaka, Shinya Uchida, Noriyuki Namiki, Toshimasa Toyo’oka: Development of an on-site therapeutic drug monitoring method using a portable spectrometer. Anal. Sci., 40, 863–869 (2024). DOI: 10.1007/s44211-024-00513-x
  2. Chanudporn Sugiyama, Aogu Furusho, Kenichiro Todoroki, Eiji Sugiyama: Selective analysis of intracellular UDP-GlcNAc and UDP-GalNAc by hydrophilic interaction liquid chromatography-mass spectrometry.Anal. Methods, 16, 1821–1825 (2024). DOI:10.1039/d4ay00122b
  3. Miho Iduhara, Daiki Hosojima, Yutaro, Nakayama, Eiji Sugiyama, Kenichiro Todoroki, Hajime Mizuno: Influence of Corona Discharge Against Histamine. Jpn. J. Food Microbiol., 41, 37–41 (2024). DOI: 10.5803/jsfm.41.37
  4. Aogu Furusho, Chiharu Ishii, Takeyuki Akita, Mai Oyaide, Masashi Mita, Hiroshi Naraoka, Yoshinori Takano, Jason P. Dworkin, Yasuhiro Oba, Toshiki Koga, Kazuhiko Fukushima, Dan Aoki, Minako Hashiguchi, Hajime Mita, Yoshito Chikaraishi, Naohiko Ohkouchi, Nanako O. Ogawa, Saburo Sakai, Daniel P. Glavin, Jamie E. Elsila, Eric T. Parker, José C. Aponte, Hannah L. McLain, Francois-Regis Orthous-Daunay, Véronique Vuitton, Roland Thissen, Cédric Wolters, Philippe Schmitt-Kopplin, Alexander Ruf, Junko Isa, Norbert Hertkorn, John M. Eiler, Toshihiro Yoshimura, Haruna Sugahara, Heather V. Graham, Yoshihiro Furukawa, Daisuke Araoka, Satoru Tanaka, Takaaki Yoshikawa, Fumie Kabashima, Kazunori Sasaki, Hajime Sato, Tomoya Yamazaki, Morihiko Onose, Mayu Morita, Yuki Kimura, Kuniyuki Kano, Junken Aoki, Kosuke Fujishima, Shin-ichiro Nomura, Shogo Tachibana, Tomoki Nakamura, Takaaki Noguchi, Ryuji Okazaki, Hikaru Yabuta, Hisayoshi Yurimoto, Kanako Sakamoto, Toru Yada, Masahiro Nishimura, Aiko Nakato, Akiko Miyazaki, Kasumi Yogata, Masanao Abe, Tomohiro Usui, Makoto Yoshikawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Satoru Nakazawa, Tatsuaki Okada, Sei-ichiro Watanabe, Yuichi Tsuda, Kenji Hamase: Enantioselective three-dimensional high-performance liquid chromatographic determination of amino acids in the Hayabusa2 returned samples from the asteroid Ryugu. J. Chromatogr. Open, 5, 100134 (2024). DOI: 10.1016/j.jcoa.2024.100134
  5. Kevin Maafu Juma, Yuto Murakami, Kenta Morimoto, Teisuke Takita, Kenji Kojima, Koichiro Suzuki, Itaru Yanagihara, Soichiro Ikuta, Shinsuke Fujiwara, Kiyoshi Yasukawa: Achieving unprecedented stability in lyophilized recombinase polymerase amplification with thermostable pyruvate kinase from Thermotoga maritima. J. Biosci., Bioeng., 138, 29–35 (2024). DOI:10.1016/j.jbiosc.2024.04.003
  6. Tomohiro Yamada, Kaori Tsukakoshi, Aogu Furusho, Eiji Sugiyama, Hajime Mizuno, Hideki Hayashi, Takeshi Yamano, Hideki Kumobayashi, Takashi Hasebe, Kazunori Ikebukuro, Toshimasa Toyo’oka, Kenichiro Todoroki: Simple and fast one-step FRET assay of therapeutic mAb bevacizumab using anti-idiotype DNA aptamer for process analytical technology. Talana, 277, 126349 (2024). DOI: 10.1016/j.talanta.2024.126349
  7. Yuuki Ito, Noriko Mori, Ken Matsuo, Satoshi Tanaka, Kiyoshi Mori, Nao Kobayashi, Hajime Mizuno, Kenichiro Todoroki, Kojiro Nagai: Evidence of Tosufloxacin Deposition in the Kidneys of a Patient Presenting with Crystal Nephropathy. Intern. Med., 63, 2833–2837 (2024). DOI: 10.2169/internalmedicine.3082-23
  8. 青木 萌恵, 星野 智哉, 古庄 仰, 杉山 栄二, 水野 初, 伊藤 忍, 轟木 堅一郎: 内視鏡消毒剤中オルトフタルアルデヒドの高感度蛍光定量法の開発. 生涯健康科学ジャーナル, 1, 15–21 (2024). DOI: 10.60390/lifelongwellbeing.1.0_15
  9. 三浦 基靖, 河本 小百合, 柏倉 康治, 大澤 隆志, 内野 智信, 辻 大樹, 砂川 陽一, 鈴木 寛, 鈴木 崇代, 春日 広美, 橋本 博, 轟木 堅一郎, 森本 達也, 伊藤 邦彦, 賀川 義之, 内田 信也: 薬学教育における医療コミュニケーション及び医療スキル教育のための仮想現実（VR）コンテンツの開発. 生涯健康科学ジャーナル, 2, 11–23 (2024). DOI: 10.60390/lifelongwellbeing.2.0_11
  10. Yuko Terada, Takumi Hisada, Masaya Fujitani, Ryoka Nakayama, Serina Fukui, Kei Kanie, Ryuji Kato, Takashi Shigeta, Eiji Sugiyama, Hajime Mizuno, Kenichiro Todoroki, Keisuke Ito: (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl) pyrrolidine-2-carboxylate derivatization combined with UPLC/ESI-MS/MS as a powerful method for dipeptide determination in foods: An application example in fermented cocoa beans. J. Food Compost. Anal., 136, 106759 (2024). DOI: 10.1016/j.jfca.2024.106759 

 

総説、プロシーディング、著書/Reviews, Proceedings, Books 

 

  1. Kenichiro Todoroki: Development of Novel Separation and Analytical Methods for Optically Active Substances and Therapeutic Monoclonal Antibodies Based on Liquid Chromatography. Chromatography, 45, 1-9 (2024).

 

2023年

原著論文/Original papers

  1. Kenichiro Todoroki, Jiaxing Tong, Moe Aoki, Nao Kobayashi, Ryota Isobe, Hiroyuki Tasaki, Tomohiro Yamada, Aogu Furusho, Eiji Sugiyama, Hajime Mizuno, Hideki Hayashi, Toshimasa Toyo’oka: Efficient screening of anti-idiotype DNA aptamers that bind specifically to trastuzumab for bioanalytical applications. J. Pharm. Biomed. Anal. Open, 1, 100006 (2023).
  2. Kenichiro Todoroki, Daichi Hamada, Tomohiro Yamada, Taro Saito, Yutaka Shimizu, Eiji Sugiyama, Hajime Mizuno, Hideki Hayashi, Kaori Tsukakoshi, Kazunori Ikebukuro: Development of a Liquid Chromatography-Based Versatile Bioanalysis for Bevacizumab Based on Pretreatment Combining Aptamer Affinity Purification and Centrifugal Ultrafiltration Concentration. Anal. Sci., 39, 1805-1811 (2023).
  3. Eiji Sugiyama, Yuki Nishiya, Kenji Yamashita, Ryo Hirokawa, Yoshiteru Iinuma, Takashi Nirasawa, Hajime Mizuno, Yoshitaka Hamashima, Kenichiro Todoroki: Charged Chiral Derivatization for Enantioselective Imaging of D-,L-2-Hydroxyglutaric Acid Using Ion Mobility Spectrometry/Mass Spectrometry. Chem. Comm., 59, 10916-10919 (2023). [Inside front cover]
  4. Hiroshi Naraoka, Yoshinori Takano, Jason P Dworkin, Yasuhiro Oba, Kenji Hamase, Aogu Furusho et al.: Soluble organic molecules in samples of the carbonaceous asteroid (162173) Ryugu. Science, 379, eabn9033 (2023).
  5. Sarah S. Zeichner, José C. Aponte, Surjyendu Bhattacharjee, Guannan Dong, Amy E. Hofmann, Jason P. Dworkin, Daniel P. Glavin, Jamie E. Elsila, Heather V. Graham, Hiroshi Naraoka, Yoshinori Takano, Shogo Tachibana, Allison T. Karp, Kliti Grice, Alex I. Holman, Katherine H. Freeman, Hisayoshi Yurimoto, Tomoki Nakamura, Takaaki Noguchi, Ryuji Okazaki, Hikaru Yabuta, Kanako Sakamoto, Toru Yada, Masahiro Nishimura, Aiko Nakato, Akiko Miyazaki, Kasumi Yogata, Masanao Abe, Tatsuaki Okada, Tomohiro Usui, Makoto Yoshikawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Satoru Nakazawa, Sei-Ichiro Watanabe, Yuichi Tsuda, Kenji Hamase, Kazuhiko Fukushima, Dan Aoki, Minako Hashiguchi, Hajime Mita, Yoshito Chikaraishi, Naohiko Ohkouchi, Nanako O. Ogawa, Saburo Sakai, Eric T. Parker, Hannah L. McLain, Francois-Regis Orthous-Daunay, Véronique Vuitton, Cédric Wolters, Philippe Schmitt-Kopplin, Norbert Hertkorn, Roland Thissen, Alexander Ruf, Junko Isa, Yasuhiro Oba, Toshiki Koga, Toshihiro Yoshimura, Daisuke Araoka, Haruna Sugahara, Aogu Furusho et al.: Polycyclic aromatic hydrocarbons in samples of Ryugu formed in the interstellar medium. Science, 382, 1411–1416 (2023).
  6. Eiji Sugiyama, Toru Higashi, Mao Nakamura, Hajime Mizuno, Toshimasa Toyo'oka, Kenichiro Todoroki: Precolumn Derivatization LC/MS Method for Observation of Efficient Hydrogen Sulfide Supply to the Kidney via D-Cysteine Degradation Pathway J. Pharm. Biomed. Anal., 222, 115088 (2023).
  7. Eiji Sugiyama, Mao Nakamura, Hajime Mizuno, Aogu Furusho, Kenichiro Todoroki: Simultaneous Determination of All Aminobutyric Acids by Chiral Derivatization and Liquid Chromatography-Tandem Mass Spectrometry. Anal. Sci., 39, 463–472 (2023).
  8. Yoshihiro Kato, Shinobu Kudoh, Eiji Sugiyama, Iwao Sakane, Naohiro Tsuyama, Toshimasa Toyo'oka, Kenichiro Todoroki, Hajime Mizuno: Influence of matrix effects by inorganic ions in single-cell direct mass spectrometry. Med. Mass Spectrom. 7, 43–52 (2023).
  9. Mizuki Yamazaki, Nao Komizo, Hirotoshi Iihara, Chiemi Hirose, Komei Yanase, Yuto Yamada, Junki Endo, Shuji Yamashita, Yasushi Ohno, Kenichiro Todoroki, Akio Suzuki, Hideki Hayashi: Relationship Between Osimertinib Concentration and Clinical Response in Japanese Patients With Non-small Cell Lung Cancer. Anticancer Res., 43, 725–732 (2023).
  10. Mizuki Yamazaki, Nao Komizo, Hirotoshi Iihara, Chiemi Hirose, Yuto Yamada, Yasushi Ohno, Shuji Yamashita, Kenichiro Todoroki, Akio Suzuki, Hideki Hayashi: Simultaneous and rapid determination of plasma concentrations of four tyrosine kinase inhibitors using liquid chromatography/tandem mass spectrometry in patients with non–small cell lung cancer. Chromatography, 44, 55-60 (2023).
  11. Tomonobu Uchino, Daichi Kamiya, Hiroaki Yagi, Hiyori Fujino-Shimaya, Ichiro Hatta, Shun Fujimori , Yasunori Miyazaki, Yukako Kirishita, Yuko Sano, Hajime Mizuno, Kenichiro Todoroki, Yoshiyuki Kagawa: Comparative analysis of intercellular lipid organization and composition between psoriatic and healthy stratum corneum. Chem. Phys. Lipids, 254, 105305 (2023).
  12. Jing Li, Xin Zhou, Morotomi Takashi, Kenichiro Todoroki, Toshimasa Toyo'oka, Qing Shi, Toufeng Jin, Jun Zhe Min: Development of a Novel Method for Analysing N-acetyl-dl-leucine Enantiomers in Human Fingernail by UPLC-ESI-MS/MS and the Evaluation in Diabetes Mellitus. Clin. Chim. Acta, 545, 117367 (2023).
  13. Xi-Ling Li, Yuxuan Li, Shuyun Xiao, Qingsong Li, Chengqiang Han, Danyang Liu, Tengfei Cui, Xiyang Rao, Kenichiro Todoroki, Guang Yang, Jun Zhe Min: Stable Isotope Labeling Differential Glycans Discovery in the Serum of Acute Myocardial Infarction by Ultrahigh-Performance Liquid Chromatography-Quadrupole-Orbitrap High Resolution Mass Spectrometry. Anal. Chim. Acta, 1264, 341269 (2023).
  14. Takahito Uchida, Yuki Sugiura, Eiji Sugiyama, Rae Maeda, Kenji F. Tanaka, Makoto Suematsu, Masaru Mimura, Hiroyuki Uchida: Metabolites for monitoring symptoms and predicting remission in patients with depression who received electroconvulsive therapy: a pilot study. Sci. Rep., 13, 13218 (2023).
  15. Kenichiro Todoroki, Chiemi Miyauchi, Tatsunosuke Tomita, Jun Zhe Min, Koichi Inoue, Toshimasa Toyo’oka: Liquid Chromatography Based Multiplex Gene Expression Analysis Using Fluorous Separation Technique with Fluorescence Detection. Chromatography, 44 , 125-131 (2023).

 

総説、プロシーディング、著書/Reviews, Proceedings, Books 

 

  1. Chiho Hirayama, Ayana Kuno, Aogu Furusho, Eiji Sugiyama, Kenichiro Todoroki:  Current bioanalysis of molecularly targeted drugs using liquid chromatography–tandem mass spectrometry. Chromatography, 44, 45-54 (2023).
  2. Chiharu Ishii, Reiko Koga, Kenichiro Todoroki, Kenji Hamase: Amino acid and bioamine separations. Liquid Chromatography (Elsevier), 159-179 (2023).
  3. Eiji Sugiyama: Techniques for high spatial resolution in mass spectrometry. Anal. Sci., 39, 1199–1120 (2023).
  4. Eiji Sugiyama , Yuki Nishiya, Hajime Mizuno and Kenichiro Todoroki: Enantioselective Imaging of D-, L-2-hydroxyglutaric acid By Chiral Derivatization and Ion Mobility Spectrometry/Mass Spectrometry. Proceedings of the 6th International Symposium of the Kyoto Biomolecular Mass Spectrometry Society, Jan 30 (2023).

 

2022年

原著論文/Original papers

  1. Taro Saito, Yutaka Shimizu, Kaori Tsukakoshi, Koichi Abe, Jinhee Lee, Kinuko Ueno, Ryutaro Asano, Brian V.Jones, Tomohiro Yamada, Tatsuki Nakano, Jiaxing Tong, Asami Hishiki, Kodai Hara, Hiroshi Hashimoto, Koji Sode, Toshimasa Toyo’oka, Kenichiro Todoroki, Kazunori Ikebukuro: Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection. Biosens. Bioelectoron., 203, 114027 (2022).
  2. Kenichiro Todoroki, Ryota Isobe, Tomohiro Yamada, Taro Saito, Yutaka Shimizu, Kaori Tsukakoshi, Eiji Sugiyama, Hajime Mizuno, Hideki Hayashi, Kazunori Ikebukuro: Development of a Lateral Flow Assay for Bevacizumab Using an Anti-Idiotype DNA Aptamer as a Capture Molecule. Chromatography, 43, 73–77 (2022).
  3. Nao Kobayashi, Moe Aoki, Dai Tada, Urara Ota, Eiji Sugiyama, Hajime Mizuno, Masahiro Ishizuka, Kenichiro Todoroki: Hydrophilic Interaction Liquid Chromatography–Tandem Mass Spectrometry of 5-Aminolevulinic Acid for Low Concentration and Small Sample Volumes.Chromatography, 43, 143–147 (2022).
  4. Daiki Asakawa, Kenichiro Todoroki, Hajime Mizuno: Fragmentation of Protonated Histamine and Histidine by Electrospray Ionization In-Source Collision-Induced Dissociation. J. Am. Soc. Mass Spectrom., 33, 1716–1722 (2022).
  5. Xi-Ling Li, Chengqiang Han, Miao Luo, Shuyun Xiao, Jing Lia, Chenglong Yu, Shengyu Cheng, Yueying Jin, Yu Han, Kenichiro Todoroki, Qing Shi, Jun ZheMin: Relative quantitation of glycans in cetuximab using ultra-high-performance liquid chromatography-high-resolution mass spectrometry by Pronase E digestion. J. Chromatogr. A, 1677, 463302 (2022).
  6. Takanori Hiraide, Yoshifumi Morita, Makoto Horikawa, Eiji Sugiyama, Tomohito Sato, Tomoaki Kahyo, Satoru Furuhashi, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Takanori Sakaguchi, Hiroyuki Konno, Mitsutoshi Setou, Hiroya Takeuchi: Saturated Fatty Acids in Cell Membrane Lipids Induce Resistance to 5-Fluorouracil in Colorectal Cancer Cells. Anticancer Res., 42, 3313–3324 (2022).
  7. Yukako Shintani-Domoto, Yuki Sugiura, Makiko Ogawa, Eiji Sugiyama, Hiroyuki Abe, Takashi Sakatani, Ryuji Ohashi, Tetsuo Ushiku, Masashi Fukayama: N-terminal peptide fragment constitutes core of amyloid deposition of serum amyloid A: An imaging mass spectrometry study. PLoS ONE, 17, e0275993 (2022).
  8. Mai Oyaide, Aogu Furusho, Chiharu Ishii, Takeyuki Akita, Masashi Mita, Tomomi Ide, Kenji Hamase: Development of an off-line heart cutting two-dimensional HPLC system for enantioselective analysis of serine, threonine and allo-threonine in human physiological fluids. J. Pharm. Biomed. Anal., 217, 114807 (2022).
  9. Siew Hwei Yap, Cheng Siang Lee, Aogu Furusho, Chiharu Ishii, Syahirah Shaharudin, Nurul Syuhada Zulhaimi, Adeeba Kamarulzaman, Shahrul Bahyah Kumaruzzaman, Masashi Mita, Kok Hoong Leong, Kenji Hamase, Reena Rajasuriar: Plasma D-amino acids are associated with markers of immune activation and organ dysfunction in people with HIV. AIDS, 36, 911-921 (2022).

 

総説、プロシーディング、著書/Reviews, Proceedings, Books 

 

  1. 轟木堅一郎: Chapter 4　HPLC 分析の実際、Appendix　応用分析例 分析化学実技シリーズ　機器分析編・８　液体クロマトグラフィー　日本分析化学会編 共立出版, (2022).
  2. 杉山栄二、水野初、轟木堅一郎: イオンモビリティースペクトロメトリーによる鏡像異性体の分離 J. Mass Spectrom. Soc. Jpn., 70, 74–¬76 (2022).

 

2021年

原著論文/Original papers

  1. Miho Shukuri, Miyu Uchino, Takafumi Sakamaki, Satoru Onoe, Rie Hosoi, Kenichiro Todoroki, Yasushi Arano, Toshihiro Sakaie, Hiromichi Akizawa, Osamu Inoue: Ex vivo imaging and analysis of ROS generation correlated with microglial activation in rat model with acute neuroinflammation induced by intrastriatal injection of LPS. Biochem. Biophys. Res. Commun., 584, 101–106 (2021).
  2. Rie Hosoi, Yuka Fujii, Hiroyuki Ohba, Miho Shukuri, Shingo Nishiyama, Masakatsu Kanazawa, Kenichiro Todoroki, Yasushi Arano, Toshihiro Sakai, Hideo Tsukada, Osamu Inoue: Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity.
    EJNMMI Res., 11, 99 (2021).
  3. Kenji Yahata, Hajime Mizuno, Eiji Sugiyama, Kenichiro Todoroki: Analysis of the intracellular localization of amiodarone using live single-cell mass spectrometry.
    J. Pharm. Biomed. Anal., 205, 114318 (2021).
  4. Daiki Asakawa, Eiji Sugiyama, Hajime Mizuno, Kenichiro Todoroki: Study of substituted phenethylamine fragmentation induced by electrospray ionization mass spectrometry and its application for highly sensitive analysis of neurotransmitters in biological samples.
    J. Am. Soc. Mass. Spectrom., 32, 2144–2152 (2021).
  5. Serina Fukui, Eiji Sugiyama, Hajime Mizuno, Iwao Sakane, Daiki Asakawa, Kazumi Saikusa, Yuki Nishiya, Yuri Amano, Kentaro Takahara, Daisuke Higo, Toshimasa Toyo'oka, Kenichiro Todoroki: Rapid chiral discrimination of oncometabolite DL-2-hydroxyglutaric acid using derivatization and field asymmetric waveform ion mobility spectrometry/mass spectrometry.
    J. Sep. Sci., 44, 3489–3496 (2021).
  6. Daiki Asakawa, Hajime Mizuno, Eiji Sugiyama, Kenichiro Todoroki: Fragmentation study of tryptophan-derived metabolites induced by electrospray ionization mass spectrometry for highly sensitive analysis. Analyst, 146, 2292–2300 (2021).
  7. Masayoshi Saito, Satoshi Horie, Hidenori Yasuhara, Akane Kashimura, Eiji Sugiyama, Takeaki Saijo, Hajime Mizuno, Hiroshi Kitajima, Kenichiro Todoroki: Metabolomic profiling of urine-derived extracellular vesicles from rat model of drug-induced acute kidney injury.
    Biochem. Biophys. Res. Commun., 546, 103–110 (2021).
  8. Kohei Miyamoto, Hajime Mizuno, Eiji Sugiyama, Toshimasa Toyo’oka, KenichiroTodoroki: Machine learning guided prediction of liquid chromatography–mass spectrometry ionization efficiency for genotoxic impurities in pharmaceutical products.
    J. Pharm. Biomed. Anal., 194, 113781 (2021).
  9. Yoichi Sekita, Yuki Sugiura, Akari Matsumoto, Yuki Kawasaki, Kazuya Akasaka, Ryo Konno, Momoka Shimizu, Toshiaki Ito, Eiji Sugiyama, Terushi Yamazaki, Eriko Kanai, Toshinobu Nakamura, Makoto Suematsu, Fumitoshi Ishino, Yoshio Kodera, Takashi Kohda, Tohru Kimura: AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation.
    Stem. Cell Res. Ther., 12, 510 (2021).
  10. Kenichiro Todoroki, Masaki Nakano, Hideyuki Yoshida, Hitoshi Nohta, Masatoshi Yamaguchi: Sensitive and selective LC determination of 5-hydroxyindoles through online electrochemical fluorescence derivatization using benzylamine.
    Chromatography, 42, 55 (2021).
  11. Kenichiro Todoroki, Kaori Yoshizato, Hideyuki Yoshida, Masatoshi Yamaguchi, Hitoshi Nohta: Sensing of acetylcholine-related compounds using cation-selective electrodes.
    BUNSEKI KAGAKU, 70, 261 (2021).
  12. 轟木堅一郎：ADCのバイオアナリシスの現状, BIO Clinica, 36(6), 58 (2021).
  13. 轟木堅一郎：IgGを認識するアプタマー, BIO Clinica, 36(14), 92 (2021).

総説、プロシーディング、著書/Reviews, Proceedings, Books 

  1. 轟木堅一郎、水野初: 13.1　質量分析法の装置構成、13.4　質量分析の実際（LC-MS、MALDI-MS）,
    分析化学データブック　日本分析化学会編 丸善出版, (2021).
  2. 轟木堅一郎、水野初: 第1章　分光分析法、第4章　臨床現場で用いる分析技術, パートナー分析化学Ⅱ 改訂第4版, 南江堂, (2021).
  3. 水野初: 第3章　容量分析総論, パートナー分析化学Ⅰ 改訂第4版, 南江堂, (2021).

 

2020年

原著論文/Original papers

  1. Kohei Miyamoto, Hajime Mizuno, Eiji Sugiyama, Toshimasa Toyo’oka, KenichiroTodoroki: Machine learning guided prediction of liquid chromatography–mass spectrometry ionization efficiency for genotoxic impurities in pharmaceutical products. J. Pharm. Biomed. Anal., 113781 (2020).
  2. Hiromichi Egami, Satoshi Nakagawa, Yuki Katsura, Masakatsu Kanazawa, Shingo Nishiyama, Toshihiro Sakai, Yasushi Arano, Hideo Tsukada, Osamu Inoue, Kenichiro Todoroki and Yoshitaka Hamashima: 18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain. [Front Cover]
    Org. Biomol. Chem., 18, 2387-2391 (2020).
  3. Kenichiro Todoroki, Tatsuki Nakano, Hideki Hayashi, Hajime Mizuno, Jun Zhe Min, Toshimasa Toyo'oka: Fluorescence Bioanalysis of Bevacizumab Using Pre-Column and Post-Column Derivatization - Liquid Chromatography After Immunoaffinity Magnetic Purification. Chromatography, 41, 115-122 (2020).
  4. Yosuke Shibata, Tomohiro Yamada, Eiji Sugiyama, Hajime Mizuno, Kenichiro Todoroki: Sensitive Method for LC Analysis of Therapeutic Monoclonal Antibodies Using a Centrifugal Filtration Device with Adsorption Suppression Treatment. Chromatography, 41, 123-128 (2020).
  5. Daiki Asakawa, Hajime Mizuno, Eiji Sugiyama, Kenichiro Todoroki: In-Source Fragmentation of Phenethylamines by Electrospray Ionization Mass Spectrometry: Toward Highly Sensitive Quantitative Analysis of Monoamine Neurotransmitters. Anal. Chem., 92, 12033-12039, 2020.
  6. Hajime Mizuno, Takuya Shindo, Keisuke Ito, Iwao Sakane, Yasuto Miyazaki, Toshimasa Toyo'oka, Kenichiro Todoroki: Development of a selective and sensitive analytical method to detect isomerized aspartic acid residues in crystallin using a combination of derivatization and liquid chromatography mass spectrometry.  J. Chromatogr. A., 1623, 461134, 2020.
  7. Tomonobu Uchino, Hiyori Fujino, Daichi Kamiya, Tomonori Suzuki, Yasunori Miyazaki, Kazuhiro Asada, Toshihiro Shirai, Hiroaki Yagi, Yuko Sano, Mutsumi Moriki, Hajime Mizuno, Kenichiro Todoroki, Midori Kimura, Yoshiyuki Kagawa: Association of dry skin with intercellular lipid composition of stratum corneum after erlotinib administration.  Cancer Chemother. Pharmacol., 86, 233-243, 2020.
  8. Hajime Mizuno, Yuta Kobayashi, Jun Zhe Min, Toshimasa Toyo'oka, Kenichiro Todoroki: Highly-sensitive analysis of vitamin D3 metabolites by liquid chromatography/electrochemistry/ electrospray ionization-mass spectrometry.  Medical Mass Spectrometry, 4, 58-64, 2020.
  9. Ryogo Furuhata, Yasuaki Kabe, Ayaka Kanai, Yuki Sugiura, Hitoshi Tsugawa, Eiji Sugiyama, Miwa Hirai, Takehiro Yamamoto, Ikko Koike, Noritada Yoshikawa, Hirotoshi Tanaka, Masahiro Koseki, Jun Nakae, Morio Matsumoto, Masaya Nakamura, Makoto Suematsu: Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes.  Commun. Biol., 3, 479 (2020).

総説、プロシーディング、著書/Reviews, Proceedings, Books 

  1. Kenichiro Todoroki, Hajime Mizuno, Eiji Sugiyama, Toshimasa Toyo’oka: Bioanalytical methods for therapeutic monoclonal antibodies andantibody–drug conjugates: A review of recent advances and futureperspectives.
    J. Pharm. Biomed. Anal., 179, 112991 (2020).
  2. Eiji Sugiyama, Ashwin N. Skelly, Makoto Suematsu, Yuki Sugiura: In situ imaging of monoamine localization and dynamics.
    Pharmacol. Ther., 208, 107478, (2020).
  3. 杉山栄二、水野 初、豊岡利正、轟木堅一郎：誘導体化法の進展が拓くキラル代謝物関連病態の解明. JSBMS Letters, 45, 4-9, (2020).
  4. 水野 初、加藤良浩、杉山栄二、豊岡利正、轟木堅一郎：1細胞質量分析による細胞内小器官局在分子解析. J. Mass Spectrom. Soc. Jpn., 68, 38-43, (2020).
  5. 水野 初、工藤 忍、杉山栄二、轟木堅一郎：Live Single-cell質量分析法による動物細胞内代謝物局在解析. 植物の生長調節, 55, (2020).
  6. 杉山栄二、杉浦悠毅：質量分析イメージングによる脳内モノアミン新規集積領域の同定. YAKUGAKU ZASSHI, 140, 979-983, (2020).
  7. Yuki Sugiura, Eiji Sugiyama, Makoto Suematsu: DESI-based imaging mass spectrometry in forensic science and clinical diagnosis.  Ambient Ionization Mass Spectrometry in Life Sciences, 107-118, (2020).
  8.  轟木堅一郎、明樂一己: （編集）　アップデート　薬学機器分析学.  廣川書店, (2020).

 

2019年

原著論文/Original papers

  1. Serina Fukui, Takahiro Takayama, Toshimasa Toyo’oka, Hajime Mizuno, Kenichiro Todoroki: An accurate differential analysis of carboxylic acids in beer using ultra high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry based on chiral derivatization combining three isotopic reagents. Talanta, 205, 120146 (2019).
  2. Takahiro Takayama, Hajime Mizuno, Toshimasa Toyo’oka, Hiroyasu Akatsu, Koichi Inoue, Kenichiro Todoroki: Isotope Corrected Chiral and Achiral Nontargeted Metabolomics: An Approach for High Accuracy and Precision Metabolomics Based on Derivatization and Its Application to Cerebrospinal Fluid of Patients with Alzheimer’s Disease. Anal. Chem., 91, 4396-4404 (2019).
  3. Tomohiro Yamada, Taro Saito, Yoshia Hill, Yutaka Shimidzu, Kaori Tsukakoshi, Hajime Mizuno, Hideki Hayashi, Kazunori Ikebukuro, Toshimasa Toyo’oka, Kenichiro Todoroki: High-throughput bioanalysis of bevacizumab in human plasma based on enzyme-linked aptamer assay using anti-idiotype DNA aptamer. Anal. Chem., 91, 3125-3130 (2019).
  4. Tomohiro Yamada, Taro Saito, Yutaka Shimizu, Kaori Tsukakoshi, Hideki Hayashi, Hajime Mizuno, Daiki Tsuji, Keisuke Yamamoto, Kunihiko Itoh, Toshimasa Toyo’oka, Kazunori Ikebukuro, Kenichiro Todoroki: Anti-Idiotype DNA Aptamer Affinity Purification–High-Temperature Reversed-Phase Liquid Chromatography: A Simple, Accurate, and Selective Bioanalysis of Bevacizumab. Molecules, 24, 857 (2019).
  5. Takahiro Takayama, Hajime Mizuno, Toshimasa Toyo’oka, Kenichiro Todoroki: Introduction of design of experiments approach for efficient optimization of chiral derivatization conditions for D- and L-glyceric acids. Anal. Sci., 35, 1053-1056 (2019).
  6. Sae Sotomatsu, Tomohiro Yamada, Hajime Mizuno, Toshimasa Toyo’oka, Kenichiro Todoroki: High-Temperature Reversed-Phase LC Separation of Heavy and Light Chain Fragments of Therapeutic Monoclonal Antibodies and Antibody-Drug Conjugate Produced by Chemical Reduction. Chromatography, 40, 99-104 (2019).
  7. Eiji Sugiyama, Matteo M. Guerrini, Kurara Honda, Sidonia Fagarasan, Makoto Suematsu, Yuki Sugiura: Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging. iScience, 20, 359-372 (2019).
  8. Eiji Sugiyama, Takashige Kondo, Naoko Kuzumaki, Kurara Honda, Akihiro Yamanaka, Minoru Narita, Makoto Suematsu, Yuki Sugiura: Mechanical allodynia induced by optogenetic sensory nerve excitation activates dopamine signaling and metabolism in medial nucleus accumbens. Neurochem. Int., 129, 104494 (2019).
  9. Takuya Hayakawa, Shizuka Kawasaki, Yutaka Hirayama, Takuya Tsutsui, Eiji Sugiyama, Kiyo Adachi, Ryo Kon, Makoto Suematsu, Yuki Sugiura: A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis. Sci. Rep., 9, 3559 (2019).
  10. Emi Takeo, Yuki Sugiura, Tatsuki Uemura, Koshiro Nishimoto, Masanori Yasuda, Eiji Sugiyama, Sumio Ohtsuki, Tatsuya Higashi, Tetsuo Nishikawa, Makoto Suematsu, Eiichiro Fukusaki, Shuichi Shimma: Tandem Mass Spectrometry Imaging Reveals Distinct Accumulation Patterns of Steroid Structural Isomers in Human Adrenal Glands. Anal. Chem., 91, 8918-8925 (2019).
  11. Rie Hosoi, Sota Sato, Miho Shukuri, Yuka Fujii, Kenichiro Todoroki, Yasushi Arano Toshihiro Sakai, Osamu Inoue: A Simple Ex Vivo Semiquantitative Fluorescent Imaging Utilizing Planar Laser Scanner: Detection of Reactive Oxygen Species Generation in Mouse Brain and Kidney. Mol. Imaging, 18, 1536012118820421 (2019).
  12. Kotaro Yamamoto, Katsutoshi Takahashi, Lorenzo Caputi, Hajime Mizuno, Carlos E. Rodriguez‐Lopez, Tetsushi Iwasaki, Kimitsune Ishizaki, Hidehiro Fukaki, Miwa Ohnishi, Mami Yamazaki, Tsutomu Masujima, Sarah E. O'Connor, Tetsuro Mimura: The complexity of intercellular localisation of alkaloids revealed by single-cell metabolomics. New Phytol., 224, 848–859 (2019).

総説、プロシーディング、著書/Reviews, Proceedings, Books 

 

2018年

原著論文/Original papers

  1. Takashi Oka, Hajime Mizuno, Masumi Sakata, Hirofumi Fujita, Tadashi Yoshino, Yoshihisa Yamano, Kozo Utsumi, Tsutomu Masujima, Atae Utsunomiya: Metabolic abnormalities in adult T-cell leukemia/lymphoma and induction of specific leukemic cell death using photodynamic therapy. Sci. Rep., 8, 14979 (2018)
  2. Qing Shia, Ryugo Hashimoto, Tadamune Otsubo, Kiyoshi Ikeda, Kenichiro Todoroki, Hajime Mizuno, Dongri Jin, Toshimasa Toyo’oka, Zhe Jiang, Jun Zhe Min: A novel, simplified strategy of relative quantification N-glycan: Quantitative glycomics using electrospray ionization mass spectrometry through the stable isotopic labeling by transglycosylation reaction of mutant enzyme Endo-M-N175Q. J. Pharm. Biomed. Anal., 149, 365–373 (2018)
  3. Kenichiro Todoroki, Yuto Kudoh, Misuzu Nakamura, Yuki Shimizu, Takamitsu Sasaki, Hideyuki Otsuki, Keisuke Wada, Jun Zhe Min, Hajime Mizuno, Kouichi Yoshinari, Toshimasa Toyo’oka: Sensitive and Comprehensive LC-MS/MS Analyses of Chiral Pharmaceuticals and Their Hepatic Metabolites Using Ovomucoid Column. Anal. Sci., 34, 1011–1015 (2018)
  4. Qingkun Ma, Aoi Uchibe, Qing Shi, Toshimasa Toyo’oka, Chun-Yan Xu, Jun Zhe Min: Development of Highly Sensitive Analysis Method for Histamine and Metabolites in Pregnant Women’s Fingernail by UPLC-ESI-MS. Anal. Sci., 34, 1023–1029 (2018)
  5. Ryoko Tomita, Kenichiro Todoroki, Tadashi Hayama, Hideyuki Yoshida, Toshihiro Fujioka, Manabu Nakashima, Masatoshi Yamaguchi, Hitoshi Nohta: Assessment of Anticancer Drug Effects on Pancreatic Cancer Cells under Glucose-Depleted Conditions Using Intracellular and Extracellular Amino Acid Metabolomics. Biol. Pharm. Bull., 41, 220–228 (2018)
  6. Yuan Huang, Wenyu Zhang, Qing Shi, Toshimasa Toyo'oka, Jun Zhe Min: Determination of ,L-Amino Acids in Collagen from Pig and Cod Skins by UPLC Using Pre-column Fluorescent Derivatization. Food Analytical Methods, 11, 3130–3137 (2018)
  7. Masahiro Numako, Toshimasa Toyo'oka, Ichiro Noge, Yutaka Kitagawa, Hajime Mizuno, Kenichiro Todoroki: Risk assessment of diabetes mellitus using dried saliva spot followed by ultra-performance liquid chromatography with fluorescence and mass spectrometry. Microchem. J., 142, 202–207 (2018)

総説、プロシーディング、著書/Reviews, Proceedings, Books

  1. Kenichiro Todoroki, Tomohiro Yamada, Hajime Mizuno, Toshimasa Toyo’oka: Current Mass Spectrometric Tools for the Bioanalyses of Therapeutic Monoclonal Antibodies and Antibody-Drug Conjugates. Anal. Sci., 34, 397–406 (2018)

 

2017年

原著論文/Original papers

  1. Tsukasa Sasaki, Kenichiro Todoroki, Toshimasa Toyo'oka: Simultaneous optimization of pH and binary organic composition by grid form modeling of the retention behavior in reversed-phase ultra high-performance liquid chromatography. J. Pharm. Biomed. Anal., 146, 251-260 (2017)
  2. Momoka Yamaguchi, Shin-ya Saito, Ryota Nishiyama, Misuzu Nakamura, Kenichiro Todoroki, Toshimasa Toyo'oka, Tomohisa Ishikawa: Caffeine Suppresses the Activation of Hepatic Stellate Cells cAMP-Independently by Antagonizing Adenosine Receptors. Biol. Pharm. Bull., 4, 658-664 (2017)
  3. Daiki Asakawa, Hajime Mizuno, Toshimasa Toyo’oka: Gas-Phase Stability of Negatively Charged Organophosphate Metabolites Produced by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization. J. Am. Soc. Mass Spectrom., 28, 2561-2568 (2017)
  4. Sora Enya, Chikana Yamamoto, Hajime Mizuno, Tsuyoshi Esaki, Hsin-Kuang Lin, Masatoshi Iga, Kana Morohashi, Yota Hirano, Hiroshi Kataoka, Tsutomu Masujima, Yuko Shimada-Niwa, Ryusuke Niwa: Dual Roles of Glutathione in Ecdysone Biosynthesis and Antioxidant Function During Larval Development in Drosophila. Genetics, 207, 1519-1532 (2017)
  5. Yoshihito Fujita, Koichi Inoue, Tasuku Sakamoto, Saya Yoshizawa, Maiko Tomita, Toshimasa Toyo'oka, Kazuya Sobue: A novel, simplified strategy of relative quantification N-glycan: Relationship between dexmedetomidine dose and plasma dexmedetomidine concentration in critically ill infants: a prospective observational cohort study. Korean J. Anesthesiol., 70, 426-433 (2017)
  6. Kenichiro Furuki, Toshimasa Toyo'oka, Hideto Yamaguchi: A novel rapid analysis using mass spectrometry to evaluate downstream refolding of recombinant human insulin-like growth factor-1 (mecasermin). Rapid. Commun. Mass Spectrom., 31, 1267–1278 (2017)
  7. Kenichiro Furuki, Toshimasa Toyo'oka: Retention of glycopeptides analyzed using hydrophilic interaction chromatography is influenced by charge and carbon chain length of ion-pairing reagent for mobile phase. Biomed. Chromatogr., 31, e3988 (pp1-13) (2017)
  8. Kenichiro Furuki, Toshimasa Toyo'oka, Kazutoshi Ban: Highly sensitive glycosylamine labelling of O-glycans using non-reductive β-elimination. Anal. Bioanal. Chem., 409, 2269-2283 (2017)
  9. Xi-Ling Li, Qing Shi, Wenlong Jin, Gao Li, Kenichiro Todoroki, Hajime Mizuno, Toshimasa Toyo'oka, Jun Zhe Min: Uric acid quantification in fingernail of gout patients and healthy volunteers using HPLC-UV. Biomed. Chromatogr., 31, e3864 (pp1-7) (2017)
  10. Kenichiro Furuki, Toshimasa Toyo'oka: Determination of thiol-to-protein ratio and drug-to-antibody ratio by in-line size exclusion chromatography with post-column reaction.　Anal. Biochem., 527, 33-44 (2017)

総説、プロシーディング、著書/Reviews, Proceedings, Books

  1. Toshimasa Toyo'oka: Derivatization-based high-throughput bioanalysis by LC-MS. Anal. Sci., 33, 555-564 (2017)
  2. Hajime Mizuno, Kazuki Ueda, Yuta Kobayashi, Naohiro Tsuyama, Kenichiro Todoroki, Jun Zhe Min, Toshimasa Toyo'oka: The great importance of normalization of LC-MS data for highly-accurate non-targeted metabolomics. Biomed. Chromatogr., 31, e3864 (pp1-7) (2017)
  3. 水野　初、津山尚宏: 升島先生を偲んで－1細胞質量分析までの研究の足跡－ J. Mass Spectrom. Soc. Jpn., 65, 141-145 (2017)

2016年

原著論文/Original papers

  1. Takahiro Takayama, Haruhito Tsutsui, Ippei Shimizu, Tatsuya Toyama, Nobuyasu Yoshimoto,Yumi Endo, Koichi Inoue, Kenichiro Todoroki, Jun Zhe Min, Hajime Mizuno, Toshimasa Toyo'oka: Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry. Clin. Chim. Acta, 452, 18-26 (2016).
  2. Masahiro Numako, Takahiro Takayama, Ichiro Noge, Yutaka Kitagawa, Kenichiro Todoroki, Hajime Mizuno, Jun Zhe Min, Toshimasa Toyo'oka: Dried Saliva Spot (DSS) as a Convenient and Reliable Sampling for Bioanalysis: An Application for the Diagnosis of Diabetes Mellitus. Anal. Chem., 88, 635-639 (2016).
  3. Mayu Suzuki, Mitsuyoshi Furuhashi, Shogo Sesoko, Kazuhiro Kosuge, Toshio Maeda, Kenichiro Todoroki, Koichi Inoue , Jun Zhe Min, Toshimasa Toyo'oka: Determination of creatinine-related molecules in saliva by reversed-phase liquid chromatography with tandem mass spectrometry and the evaluation of hemodialysis in chronic kidney disease patients, Anal. Chim. Acta, 911, 92-99 (2016).
  4. Kenichiro Todoroki, Misuzu Nakamura, Yuhi Sato, Kanoko Goto, Tatsuki Nakano, Yasuhiro Ishii, Jun Zhe Min, Koichi Inoue, Toshimasa Toyo'oka: 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride as an Enantioseparation Enhancer for Chiral Derivatization-LC Analysis of D- and L-Amino acids. Chromatography, 37, 23-28 (2016).
  5. Hideki Hayashi,Yutaro Kita, Hirotoshi Iihara, Koumei Yanase, Yasushi Ohno, Chiemi Hirose, Maya Yamada, Kenichiro Todoroki, Kiyoyuki Kitaichi, Shinya Minatoguchi, Yoshinori Itoh, Tadashi Sugiyama: Simultaneous and rapid determination of gefitinib, erlotinib and afatinib plasma levels using liquid chromatography/tandem mass spectrometry in patients with non-small-cell lung cancer. Biomed. Chromatogr., DOI 10.1002/bmc.3642.
  6. Xi-Ling Li, Qing Shi2, Wenlong Jin, Gao Li, Kenichiro Todoroki, Hajime Mizuno, Toshimasa Toyo'oka, Jun Zhe Min: Uric acid quantification in fingernail of gout patients and healthy volunteers using HPLC-UV. Biomed. Chromatogr., DOI 10.1002/bmc.3687.
  7. Koichi Inoue, Yasuto Miyazaki, Keiko Unno, Jun Zhe Min, Kenichiro Todoroki, Toshimasa Toyo'oka: Stable isotope dilution HILIC-MS/MS method for accurate quantification of glutamic acid, glutamine, pyroglutamic acid, GABA and theanine in mouse brain tissues. Biomed. Chromatogr., 30, 55-61 (2016).
  8. Kenichiro Todoroki, Tatsuki Nakano, Yasuhiro Eda, Kaname Ohyama, Hideki Hayashi, Daiki Tsuji, Jun Zhe Min, Koichi Inoue, Naoki Iwamoto, Atsushi Kawakami, Yukitaka Ueki, Kunihiko Itoh, Toshimasa Toyo'oka: Bioanalysis of bevacizumab and infliximab by high-temperature reversed-phase liquid chromatography with fluorescence detection after immunoaffinity magnetic purification. Anal. Chim. Acta, 916, 112-119 (2016).
  9. Koichi Inoue, Chihiro Tanada, Takahiro Hosoya, Shuhei Yoshida, Takashi Akiba, Jun Zhe Min, Kenichiro Todoroki, Yutaka Yamano, Shigenori Kumazawa, Toshimasa Toyo'oka: Principal component analysis of molecularly based signals from infant formula contaminations using LC-MS and NMR in foodomics. J. Sci. Fodd Agric., 96, 3876-03881 (2016).
  10. Ryoko Tomita, Kenichiro Todoroki, Hiroshi Maruoka, Hideyuki Yoshida, Toshihiro Fujioka, Manabu Nakashima, Masatoshi Yamaguchi, Hitoshi Nohta: Amino Acid Metabolomics Using LC-MS/MS: Assessment of Cancer-Cell Resistance in a Simulated Tumor Microenvironment. Anal. Sci., 32, 893-900 (2016).
  11. Hajime Mizuno, Yasuto Miyazaki, Keisuke Ito, Kenichiro Todoroki, Jun Zhe Min, Toshimasa Toyo'oka: A rapid and sensitive detection of D-Aspartic acid in Crystallin by chiral derivatized liquid chromatography mass spectrometry. J. Chromatogr. A, 1467, 318-325 (2016).
  12. Jun Zhe Min, Keisuke Nagai, Qing Shi, Wenjun Zhou, Kenichiro Todoroki, Koichi Inoue, Yong-Ill Lee, Toshimasa Toyo’oka: Highly sensitive derivatization reagents possessing positively charged structures for the determination of oligosaccharides in glycoproteins by high-performance liquid chromatography electrospray ionization tandem mass spectrometry. J. Chromatogr. A, 1465, 79-89 (2016).
  13. Kenichiro Furuki, Toshimasa Toyo'oka: Effect of stationary phase and ion-pairing reagents on the retention of glycopeptides using hydrophilic interaction chromatography-mode HPLC. Biomed. Chromatogr., in press.

総説、プロシーディング、著書/Reviews, Proceedings, Books

  1. 轟木堅一郎、中野達基、豊岡利正：「解説」LCを用いる抗体医薬品の血中濃度分析の現状　ぶんせき, 6, p.203-210 (2016) .
  2. Diagnostic Approach to Disease Using Non-invasive Samples Based on Derivatization and LC-ESI-MS/MS (Review Article). Biol. Pharm. Bull., 39, 1397-1411 (2016).