研究業績

(2011年以降)

  1. Kotaro Hirano*, Chika Nakabayashi, Mao Sasaki, Miki Suzuki, Yuta Aoyagi, Kaori Tanaka, Akira Murakami, Masaki Tsuchiya, Eiji Umemoto, Shuji Takabayashi, Yasuo Kitajima, Yusuke Ono, Takehisa Matsukawa, Masayuki Matsushita, Yasuyuki Ohkawa, Yasuo Mori, Yuji Hara*. Mg2+ influx mediated by TRPM7 triggers the initiation of muscle stem cell activation. Sci. Adv., Vol 11, Issue 14 (2025). プレスリリース
  2. Masaki Tsuchiya, Nobuhiko Tachibana & Itaru Hamachi. Post-click labeling enables highly accurate single cell analyses of glucose uptake ex vivo and in vivo. Commun. Biol., 7, Article number: 459 (2024).
  3. Kotaro Hirano, Masaki Tsuchiya, Akifumi Shiomi, Seiji Takabayashi, Miki Suzuki, Yudai Ishikawa, Yuya Kawano, Yutaka Takabayashi, Kaori Nishikawa, Kohjiro Nagao, Eiji Umemoto, Yasuo Kitajima, Yusuke Ono, Keiko Nonomura, Hirofumi Shintaku, Yasuo Mori, Masato Umeda, Yuji Hara*. The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration. Life Sci. Alliance, 6, 2, e202201783 (2022).
  4. Akifumi Shiomi, Kohjiro Nagao, Nobuhiro Yokota, Masaki Tsuchiya, Utako Kato, Naoto Juni, Yuji Hara, Masayuki X Mori, Yasuo Mori, Kumiko Ui-Tei, Motohide Murate, Toshihide Kobayashi, Yuri Nishino, Atsuo Miyazawa, Akihisa Yamamoto, Ryo Suzuki, Stefan Kaufmann, Motomu Tanaka, Kazuya Tatsumi, Kazuyoshi Nakabe, Hirofumi Shintaku, Semen Yesylevsky, Mikhail Bogdanov, Masato Umeda. Extreme deformability of insect cell membranes is governed by phospholipid scrambling. Cell Rep., 35, 109219 (2021).
  5. Takuto Suito, Kohjiro Nagao, Kenichi Takeuchi, Naoto Juni, Yuji Hara, Masato Umeda . Functional expression of Δ12 fatty acid desaturase modulates thermoregulatory behaviour in Drosophila. Sci. Rep., 10, 11798 (2020).
  6. Akifumi Shiomi, Kohjiro Nagao, Hisae Kasai, Yuji Hara, Masato Umeda. Changes in the physicochemical properties of fish cell membranes during cellular senescence. Biosci. Biotechnol. Biochem. 84, 583-593 (2019).
  7. Naoto Matsuo, Kohjiro Nagao, Takuto Suito, Naoto Juni, Utako Kato, Yuji Hara, Masato Umeda. Different mechanisms for selective transport of fatty acids using a single class of lipoprotein in Drosophila. J. Lipid Res. 60, 1199-1211 (2019).
  8. Jessica C de Greef, Bram Slütter, Mary E Anderson, Rebecca Hamlyn, Raul O'Campo Landa, Ellison J McNutt, Yuji Hara, Lecia L Pewe, David Venzke, Kiichiro Matsumura, Fumiaki Saito, John T Harty, Kevin P Campbell. Protective role for the N-terminal domain of α-dystroglycan in Influenza A virus proliferation, Proc. Natl. Acad. Sci. USA., 116, 11396-11401 (2019).
  9. Tsuchiya Masaki, Yuji Hara (責任著者), Okuda Masaki, Itoh Karin, Nishioka Ryotaro, Shiomi Akifumi, Nagao Kohjiro, Mori Masayuki, Mori Yasuo, Ikenouchi Junichi, Suzuki Ryo, Tanaka Motomu, Ohwada Tomohiko, Aoki Junken, Kanagawa Motoi, Toda Tatsushi, Nagata Yosuke, Matsuda Ryoichi, Takayama Yasunori, Tominaga Makoto, Umeda Masato. Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Nature Commun., 9, 2049 (2018).
  10. Takuto Suito, Kohjiro Nagao, Masataka Hatano, Kenichi Kohashi, Aiko Tanabe, Hiromichi Ozaki, Jun Kawamoto, Tatsuo Kurihara, Tetsuo Mioka, Kazuma Tanaka, Yuji Hara, Masato Umeda. Synthesis of omega-3 long-chain polyunsaturated fatty acid-rich triacylglycerols in an endemic goby, Gymnogobius isaza, from Lake Biwa, Japan. J. Biochem. 164,127-140 (2018).
  11. Banerjee Sravani, Aponte-Diaz Davis, Yeager Calvin, Sharma Suresh D, Ning Gang, Oh Hyung S, Han Qinxia, Umeda Masato, Yuji Hara, Wang Robert YL, Cameron Craig E. Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein. PLoS Pathog. 14, e1007086 (2018).
  12. Akira Murakami, Kohjiro Nagao, Naoto Juni, Yuji Hara, Masato Umeda. An N-terminal di-proline motif is essential for fatty acid-dependent degradation of Δ9-desaturase in Drosophila. J. Biol. Chem. 292, 19976-19986 (2017).
  13. Okuma Hidehiko, Saito Fumiaki, Mitsui Jun, Yuji Hara, Hatanaka Yuki, Ikeda Miki, Shimizu Teruo, Matsumura Kiichiro, Shimizu Jun, Tsuji Shoji, Sonoo Masahiro. Tubular aggregate myopathy caused by a novel mutation in the cytoplasmic domain of STIM1. Neurology Genet. e50 (2016).
  14. Ogawa Rina, Nagao Kohjiro, Taniuchi Kentaro, Tsuchiya Masaki, Kato Utako, Yuji Hara, Inaba Takehiko, Kobayashi Toshihide, Sasaki Yoshihiro, Akiyoshi Kazunari, Watanabe-Takahashi Miho, Nishikawa Kiyotaka, Umeda Masato. Development of a Novel Tetravalent Synthetic Peptide That Binds to Phosphatidic Acid. PLoS One. 10, e0131668 (2015).
  15. Endo Yukari, Noguchi Satoru, Yuji Hara, Hayashi K Yukiko, Motomura Kazushi, Miyatake Satoko, Murakami Nobuyuki, Tanaka Satsuki, Yamashita Sumimasa, Kizu Rika, Bamba Masahiro, Goto Yu-ichi, Matsumoto Naomichi, Nonaka Ikuya, Nishino Ichizo. Dominant mutations in ORAI1 cause tubular aggregate myopathy with hypocalcemia via constitutive activation of store-operated Ca2+ channels. Hum. Mol. Genet. 24, 637-648 (2015).
  16. Inamori Keiichiro, Willer Tobias, Yuji Hara, Venzke David, Anderson E Mary, Clarke F Nigel, Guicheney Pascale, Bönnemann G Carsten, Moore A Steven, Campbell P Kevin,. Endogenous Glucuronyltransferase Activity of LARGE or LARGE2 Required for Functional Modification of α-dystroglycan in Cells and Tissues. J. Biol. Chem. 289, 28138-28148 (2014).
  17. Willer Tobias, Inamori Kei-ichiro, Venzke David, Harvey Corinne, Morgensen Greg, Yuji Hara, Beltrán Valero de Bernabé D, Yu Liping, Wright Kevin M, Campbell Kevin P. The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation. eLife. doi: 10.7554/eLife.03941 (2014).
  18. Inamori Kei-ichiro, Yuji Hara, Willer Tobias, Anderson Mary E, Zhu Zihan, Yoshida-Moriguchi Takako, Campbell Kevin P. Xylosyl- and glucuronyltransferase functions of LARGE in alpha-dystroglycan modification are conserved in LARGE2. Glycobiology, 23, 295–302, (2013).
  19. Katano Masahiro, Numata Tomohiro, Aguan Kripamoy, Yuji Hara, Kiyonaka Shigeki, Yamamoto Shinichiro, Miki Takafumi, Sawamura Seishiro, Suzuki Toshimitsu, Yamakawa Kazuhiro, Mori Yasuo. The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death. Cell Calcium, 51, 179-185 (2012).
  20. Inamori Kei-ichiro, Yoshida-Moriguchi Takako, Yuji Hara, Anderson Mary E, Yu Liping, Campbell Kevin P. Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE. Science 335, 93-96 (2012).
  21. Yuji Hara#, Kanagawa Motoi#, Kunz Stefan, Yoshida-Moriguchi Takako, Satz Jakob S, Kobayashi Yvonne M, Zhu Zihan, Burden Steven J, Oldstone Michael B, Campbell Kevin P. Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection. Proc. Natl. Acad. Sci. U S A. 108, 17426-17431 (2011) (#: Co-first authors).
  22. Yuji Hara#, Balci-Hayta Burcu#, Yoshida-Moriguchi Takako, Kanagawa Motoi, Beltrán-Valero de Bernabé D, Gündeşli Hulya, Willer Tobias, Satz Jakob S, Crawford Robert W, Burden Steven J, Kunz Stefan, Oldstone Mochael B, Accardi Accardi, Talim Beril, Muntoni Francesco, Topaloğlu Haluk, Dinçer Pervin, Campbell Kevin P. A dystroglycan mutation associated with limb-girdle muscular dystrophy. N. Engl. J. Med. 364, 939-946 (2011) (#: Co-first authors).