発表論文

2018
Miyuki Yamaguchi, Hayato Ozawa, Haruka Katsumata, Tomoyo Akiyama, Kei Manabe “One-Pot Synthesis of 2,3-Disubstituted Benzofurans from 2-Chlorophenols Using Palladium‒Dihydroxyterphenylphosphine Catalyst” Tetrahedron Lett. 2018, 59, 3175-3178.

Hideyuki Konishi, Suguru Futamata, Xi Wang, Kei Manabe “Rapid Formation of Fluoren-9-ones via Palladium-Catalyzed External Carbon Monoxide-Free Carbonylation” Adv. Synth. Catal. 2018, 360, 1805-1809.

Hideyuki Konishi, Tomoyuki Sekino, Kei Manabe “Palladium-Catalyzed External-CO-Free Carbonylation of Aryl Bromides Using 2,4,6-Trichlorophenyl Formate” Chem. Pharm. Bull. 2018, 66, 562-567.
Hideyuki Konishi "Creation of Novel Toxic Gas Surrogates and the Development of Safe and Facile Catalytic Reactions" Chem. Pharm. Bull. 2018, 66, 1-19.

Kota Sekiguchi, Erina Ogawa, Kohta Kurohane, Hideyuki Konishi, Narumi Mochizuki, Kei Manabe, Yasuyuki Imai “Adjuvant Effect of Short Chain Triacylglycerol Tributyrin on a Mouse Contact Hypersensitivity Model” Toxicol. Lett. 2018, 284, 56-62.
2017
Hyder Said, Yasutada Akiba, Kazuyuki Narimatsu, Koji Maruta, Ayaka Kuri, Ken-ichi Iwamoto, Atsukazu Kuwahara, Jonathan D. Kaunitz "FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats" Digestive Diseases and Sciences, 2017, 62, 1944-1952.
Yasutada Akiba, Koji Murata, Kazuyuki Narimatsu, Hyder Said, Izumi Kaji, Ayaka Kuri, Ken-ichi Iwamoto, Atsukazu Kuwahara, Jonathan D. Kaunitz "FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats" Am. J. Physiol. Gastrointest. Liver Physiol., 2017, 313, G117-G128.
Izumi Kaji, Yasutada Akiba, Takafumi Furuyama, Donald W. Adelson, Ken-ichi Iwamoto, Makoto Watanabe, Atsukazu Kuwahara, Jonathan D. Kaunitz "Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon."
Neurogastroent. Motil., 2017, 29.

Miyuki Yamaguchi, Kohei Suzuki, Yusuke Sato, Kei Manabe
"Palladium-Catalyzed Direct C3-Selective Arylation of N-Unsubstituted Indoles with Aryl Chlorides and Triflates" Org. Lett. 2017, 19, 5388-5391.
Hideyuki Konishi, Mika Matsubara, Keisuke Mori, Takaki Tokiwa, Sundaram Arulmozhiraja, Yuta Yamamoto, Yoshinobu Ishikawa, Hiroshi Hashimoto, Yasuteru Shigeta, Hiroaki Tokiwa, Kei Manabe
"Mechanistic Insight into Weak-Base-Catalyzed Generation of Carbon Monoxide from Phenyl Formate and Its Application to Catalytic Carbonylation at Room Temperature without Use of External Carbon Monoxide Gas" Adv. Synth. Catal. 2017, 359, 3592-3601.
Miyuki Yamaguchi, Kei Manabe
"Three-Step Synthesis of 2,5,7-Trisubstituted Indoles from N-Acetyl-2,4,6-trichloroaniline Using Pd-Catalyzed Site-Selective Cross-Coupling"Org. Biomol. Chem. 2017, 15, 6645-6655.
Hideyuki Konishi, Masataka Fukuda, Tsuyoshi Ueda, Kei Manabe
"Palladium-catalyzed External-CO-Free Reductive Carbonylation of Bromoarenes" Org. Synth. 2017, 94, 66-76.
Hideyuki Konishi, Hiromichi Tanaka, Kei Manabe
"Pd-Catalyzed Selective Synthesis of Cyclic Sulfonamides and Sulfinamides Using K2S2O5 as a Sulfur Dioxide Surrogate" Org. Lett. 2017, 19, 1578-1581.
2016
Hideyuki Konishi, Fumika Hoshino, Kei Manabe
“Practical Synthesis of Axially Chiral Dicarboxylates via Pd-Catalyzed External-CO-Free Carbonylation” Chem. Pharm. Bull. 2016, 64, 1438-1441.

Miyuki Yamaguchi, Tomoyo Akiyama, Hirohisa Sasou, Haruka Katsumata, Kei Manabe
“One-Pot Synthesis of Substituted Benzo[b]furans and Indoles from Dichlorophenols/Dichloroanilines Using a Palladium-Dihydroxyterphenylphosphine Catalyst” J. Org. Chem. 2016, 81, 5450–5463.
Miyuki Yamaguchi, Mayu Higuchi, Kanae Tazawa, and Kei Manabe
"Three-Step Synthesis of Fluoranthenes through Pd-Catalyzed Inter and Intramolecular C−H Arylation" J. Org. Chem. 2016, 81, 3967-3974.

Miyuki Yamaguchi, Kei Manabe
“Ligand-Controlled Site-Selective Cross-Coupling” In Site-Selective Catalysis, Kawabata, T. Ed.: Springer International Publishing: Switzerland, 2016, pp. 1-25.

2015
Yasutada Akiba, Takuya Inoue, Izumi Kaji, Masaaki Higashiyama, Kazuyuki Narimatsu, Ken-ichi Iwamoto, Masahiko Watanabe, Paul H. Guth, Eli Engel, Atsukazu Kuwahara, J. D. Kaunitz, “Short-chain fatty acid sensing in rat duodenum”Journal of Physiology2015, 593, 585-599.


Miyuki Yamaguchi, Kohei Suzuki, Kei Manabe, “Scalable Synthesis of Dihydroxyterphenylphosphine Ligands” Tetrahedron 2015, 71, 2743-2747.


Hideyuki Konishi, Takashi Muto, Tsuyoshi Ueda, Yayoi Yamada, Miyuki Yamaguchi, Kei Manabe, “Imidazole Derivatives as Accelerators for Ruthenium-Catalyzed Hydroesterification and Hydrocarbamoylation of Alkenes: Extensive Ligand Screening and Mechanistic Study” ChemCatChem 2015, 7, 836-845.


Hideyuki Konishi, Hiroki Nagase, Kei Manabe, "Concise Synthesis of Cyclic Carbonyl Compounds from Haloarenes Using Phenyl Formate as the Carbonyl Source" Chem. Commun. 2015, 51, 1854-1857.


2014
Kei Manabe, Miyuki Yamaguchi, "Catalyst-Controlled Site-Selectivity Switching in Pd-Catalyzed Cross-Coupling of Dihaloarenes" Catalysts 2014, 4, 307-320.


Hideyuki Konishi, Kei Manabe, “Formic Acid Derivatives as Practical Carbon Monoxide Surrogates for Metal-Catalyzed Carbonylation Reactions” Synlett2014, 25, 1971-1986.


Miyuki Yamaguchi, Kei Manabe, “One-pot Synthesis of 2,4-Disubstituted Indoles from N-Tosyl-2,3-dichloroaniline Using Palladium-Dihydroxyterphenylphosphine Catalyst” Org. Lett. 2014, 16, 2386-2389.


Hideyuki Konishi, Tsuyoshi Ueda, Kei Manabe, “Pd-Catalyzed External-CO-Free Carbonylation: Preparation of 2,4,6-Trichlorophenyl 3,4-Dihydronaphthalene-2-Carboxylate” Org. Synth. 2014, 91, 39-51.


2013
Miyuki Yamaguchi, Takeshi Kimura, Naomi Shinohara, Kei Manabe, “Repetitive Two-Step Method for o,o,p- and o,p-Oligophenylene Synthesis through Pd-Catalyzed Cross-Coupling of Hydroxyterphenylboronic Acid” Molecules 2013, 18, 15207-15219.


Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, "Palladium-Catalyzed Fluorocarbonylation Using N-Formylsaccharin as CO Source: General Access to Carboxylic Acid Derivatives" Org. Lett. 2013, 15, 5370-5373.


Miyuki Yamaguchi, Haruka Katsumata, Kei Manabe, "One-Pot Synthesis of Substituted Benzo[b]furans from Mono- and Dichlorophenols Using Palladium Catalysts Bearing Dihydroxyterphenylphosphine" J. Org. Chem. 2013, 78, 9270-9281.


Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, “Palladium-Catalyzed Reductive Carbonylation of Aryl Halides with N-Formylsaccharin as a CO Source”Angew. Chem. Int. Ed. 2013, 52, 8611-8615.


Kei Manabe, Takeshi Kimura, “Repetitive Synthetic Method for o,o,p-Oligophenylenes Using C−H Arylation” Org. Lett. 2013,15, 374-377.


Yumiko Suzuki, Mai Murofushi, Kei Manabe, “One-Pot Synthesis of Unsymmetrical Benzils and N-Heteroarenes through Nucleophilic Aroylation Catalyzed by N-Heterocyclic Carbene” Tetrahedron 2013, 69, 470.

2012
Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, “Trichlorophenyl Formate: Highly Reactive and Easily Accessible Crystalline CO Surrogate for Palladium-Catalyzed Carbonylation of Aryl/Alkenyl Halides and Triflates” Org. Lett. 2012,14, 5370.


Hideyuki Konishi, Tsuyoshi Ueda, Takashi Muto, Kei Manabe, "Remarkable Improvement Achieved by Imidazole Derivatives in Ruthenium-Catalyzed Hydroesterification of Alkenes Using Formates" Org. Lett. 2012, 14, 4722.


Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, "Preparation of α,β-Unsaturated Esters and Amides via External-CO-Free Palladium-Catalyzed Carbonylation of Alkenyl Tosylates" Tetrahedron Lett.2012, 53, 5171-5175..


Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, "Palladium-Catalyzed Carbonylation of Aryl, Alkenyl, and Allyl Halides with Phenyl Formate" Org. Lett. 2012, 14, 3100-3103.

2011
Ishikawa, S.; Manabe, K. "Hydroxylated Terphenylphosphine Ligands for Palladium-Catalyzed Ortho-Selective Cross-Coupling of Dibromophenols, Dibromoanilines, and Their Congeners with Grignard Reagents" Tetrahedron 2011, 67, 10156-10163.


Manabe, K.; Ohba, M.; Matsushima, Y. "A Repetitive One-Step Method for Oligoarene Synthesis Using Catalyst-Controlled Chemoselective Cross-Coupling" Org. Lett. 2011, 13, 2436-2439.

2010
Wang, J.-R.; Manabe, K. “Hydroxyterphenylphoshine-Palladium Catalyst for Benzo[b]furan Synthesis from 2-Chlorophenols. Bifunctional Ligand Strategy for Cross-Coupling of Chloroarenes” J. Org. Chem. 2010, 75, 5340-5342.


Konishi, H.; Itoh, T.; Manabe, K. “Site-Selective Cross-Coupling of Dichlorinated Benzo-Fused Nitrogen-Heterocycles with Grignard Reagents” Chem. Pharm. Bull.2010, 58, 1255-1258.


Ishikawa, S.; Manabe, K. “DHTP Ligands for the Highly Ortho-Selective, Palladium-Catalyzed Cross-Coupling with Grignard Reagents: A Conformational Approach for Catalyst Improvement” Angew. Chem. Int. Ed.2010, 49, 772-775.


Ishikawa, S.; Manabe, K. “Synthesis of Hydroxylated Oligoarene-Type Phosphines by a Repetitive Two-Step Method” Tetrahedron 2010, 66, 297-303.