- 2025
- Miyuki Yamaguchi, Kenichi Nakai, Kiho Morioka, Ayano Sato, Sakiko Fujiwara,
Hideyuki Konishi, Kei Manabe
"Ligand-Controlled C2- or C3-Selectivity Switching in the Palladium-Catalyzed
C–H Arylation of Nonsubstituted 1H-Pyrrole"Org. Lett. 2025, 27, 141-146.
- 2024
- Hideyuki Konishi, Yohei Aoki, Miyuki Yamaguchi, Kei Manabe "Selective
Syntheses of Unsymmetrical Diaryl Sulfides Enabled by a Sulfur Dioxide
Surrogate as a Divalent Sulfur Source and an Activating Agent" ACS Catal. 2024, 14, 15348-15355.
- 2023
- Miyuki Yamaguchi, Ryoya Hagiwara, Hana Muto, Kanami Gayama, Hideyuki Konishi,
Kei Manabe
"Pyrroloindoline/Pyridoindoline Synthesis via C3-Dearomative Arylation/Cyclization
of Tryptamine/Homotryptamine Derivatives Using Palladium−Dihydroxyterphenylphosphine
Catalyst" Org. Lett 2023, 25, 4913-4917.
- Keisuke Kinoshita, Miyuki Yamaguchi, Hirohisa Sasou, Hideyuki Konishi,
Kei Manabe
“Palladium-Catalyzed C‒H Arylation of [1,1'-Biphenyl]-2-ols with Chloroarenes”
Chem. Pharm. Bull. 2023, 71, 175-182.
- 2022
- Miyuki Yamaguchi, Sakiko Fujiwara, Yukiko Mori, Hideyuki Konishi, Kei Manabe
“Synthesis of Multisubstituted Pyrroles by Ligand-Controlled Site-Selective
Arylation and Their Transformation into Multiarylated Pyrrolines and Pyrrolidines”
Tetrahedron2022, 123, 132962.
- Hideyuki Konishi, Ririka Fujita, Miyuki Yamaguchi, Kei Manabe
"Synthesis of Symmetrical Sulfides Enabled by a Sulfur Dioxide Surrogate
Acting as a Divalent Sulfur Source" Org. Lett. 2022, 24, 3663-3667.
- Miyuki Yamaguchi, Kei Manabe
"Synthesis of Multisubstituted Benzofurans/Indoles Using Multichlorinated
Phenols/Anilines via Palladium-Catalyzed Site-Selective Sonogashira Coupling"
Heterocycles 2022, 104, 3-26.
- 2020
- Hideyuki Konishi, Minoru Kumon, Miyuki Yamaguchi, Kei Manabe "Palladium-Catalyzed
External-CO-Free Reductive Carbonylation of Aryl Sulfonates" Tetrahedron 2020, 76, 131639.
- Miyuki Yamaguchi, Ryoya Hagiwara, Kanami Gayama, Kohei Suzuki, Yusuke Sato,
Hideyuki Konishi, Kei Manabe "Direct C3-Selective Arylation of N-Unsubstituted
Indoles with Aryl Chlorides, Triflates, and Nonaflates Using Palladium-Dihydroxyterphenylphosphine
Catalyst" J. Org. Chem. 2020, 58, 10902-10912.
Hideyuki Konishi, Kei Manabe "Pd-Catalyzed External-CO-Free Carbonylation:
Preparation of 2,4,6-Trichlorophenyl 3,4-Dihydronaphthalene-2-Carboxylate"
Org. Synth. 2020, 97, 125-138.
Miyuki Yamaguchi, Kota Ogihara, Hideyuki Konishi, Kei Manabe
"Synthesis of 2,3-Disubstituted Indoles from Alkynylanilines and 2-Chlorophenols
Using Palladium‒Dihydroxyterphenylphosphine Catalyst" Tetrahedron Lett. 2020, 61, 151896.
-
- 2019
- Hideyuki Konishi, Kei Manabe
"Recent Progress on Catalytic Heck Carbonylations Using Carbon Monoxide
Surrogates"
Tetrahedron Lett. 2019, 60, 151147.
Miyuki Yamaguchi, Sakiko Fujiwara, Kei Manabe
"Synthesis of 2,2,5-Trisubstituted 2H-Pyrroles and 2,3,5-Trisubstituted
1H-Pyrroles by Ligand-Controlled Site-Selective Dearomative C2-Arylation
and Direct C3-Arylation"
Org. Lett. 2019, 21, 6972-6977.
- Hiromichi Tanaka, Hideyuki Konishi, Kei Manabe "Palladium-Catalyzed
One-Step Synthesis of Symmetrical Diaryl Sulfones from Aryl Halides and
a Sulfur Dioxide Surrogate" Chem. Lett. 2019, 48, 760-763.
- 2018
- Miyuki Yamaguchi, Hayato Ozawa, Haruka Katsumata, Tomoyo Akiyama, Kei Manabe
“One-Pot Synthesis of 2,3-Disubstituted Benzofurans from 2-Chlorophenols
Using Palladium‒Dihydroxyterphenylphosphine Catalyst” Tetrahedron Lett. 2018, 59, 3175-3178.
Hideyuki Konishi, Suguru Futamata, Xi Wang, Kei Manabe “Rapid Formation
of Fluoren-9-ones via Palladium-Catalyzed External Carbon Monoxide-Free
Carbonylation” Adv. Synth. Catal. 2018, 360, 1805-1809.
Hideyuki Konishi, Tomoyuki Sekino, Kei Manabe “Palladium-Catalyzed External-CO-Free
Carbonylation of Aryl Bromides Using 2,4,6-Trichlorophenyl Formate” Chem. Pharm. Bull. 2018, 66, 562-567.
- Hideyuki Konishi "Creation of Novel Toxic Gas Surrogates and the Development
of Safe and Facile Catalytic Reactions" Chem. Pharm. Bull. 2018, 66, 1-19.
Kota Sekiguchi, Erina Ogawa, Kohta Kurohane, Hideyuki Konishi, Narumi Mochizuki,
Kei Manabe, Yasuyuki Imai “Adjuvant Effect of Short Chain Triacylglycerol
Tributyrin on a Mouse Contact Hypersensitivity Model” Toxicol. Lett. 2018, 284, 56-62.
- 2017
- Hyder Said, Yasutada Akiba, Kazuyuki Narimatsu, Koji Maruta, Ayaka Kuri,
Ken-ichi Iwamoto, Atsukazu Kuwahara, Jonathan D. Kaunitz "FFA3 Activation
Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy
via the GLP-2 Pathway in Rats" Digestive Diseases and Sciences , 2017, 62, 1944-1952.
- Yasutada Akiba, Koji Murata, Kazuyuki Narimatsu, Hyder Said, Izumi Kaji,
Ayaka Kuri, Ken-ichi Iwamoto, Atsukazu Kuwahara, Jonathan D. Kaunitz "FFA2
activation combined with ulcerogenic COX inhibition induces duodenal mucosal
injury via the 5-HT pathway in rats" Am. J. Physiol. Gastrointest. Liver Physiol., 2017, 313, G117-G128.
- Izumi Kaji, Yasutada Akiba, Takafumi Furuyama, Donald W. Adelson, Ken-ichi
Iwamoto, Makoto Watanabe, Atsukazu Kuwahara, Jonathan D. Kaunitz "Free
fatty acid receptor 3 activation suppresses neurogenic motility in rat
proximal colon."
Neurogastroent. Motil., 2017, 29.
- Miyuki Yamaguchi, Kohei Suzuki, Yusuke Sato, Kei Manabe
"Palladium-Catalyzed Direct C3-Selective Arylation of N-Unsubstituted
Indoles with Aryl Chlorides and Triflates" Org. Lett. 2017, 19, 5388-5391.
- Hideyuki Konishi, Mika Matsubara, Keisuke Mori, Takaki Tokiwa, Sundaram
Arulmozhiraja, Yuta Yamamoto, Yoshinobu Ishikawa, Hiroshi Hashimoto, Yasuteru
Shigeta, Hiroaki Tokiwa, Kei Manabe
"Mechanistic Insight into Weak-Base-Catalyzed Generation of Carbon
Monoxide from Phenyl Formate and Its Application to Catalytic Carbonylation
at Room Temperature without Use of External Carbon Monoxide Gas" Adv. Synth. Catal. 2017, 359, 3592-3601.
- Miyuki Yamaguchi, Kei Manabe
"Three-Step Synthesis of 2,5,7-Trisubstituted Indoles from N-Acetyl-2,4,6-trichloroaniline
Using Pd-Catalyzed Site-Selective Cross-Coupling"Org. Biomol. Chem. 2017, 15, 6645-6655.
- Hideyuki Konishi, Masataka Fukuda, Tsuyoshi Ueda, Kei Manabe
"Palladium-catalyzed External-CO-Free Reductive Carbonylation of
Bromoarenes" Org. Synth. 2017, 94, 66-76.
- Hideyuki Konishi, Hiromichi Tanaka, Kei Manabe
"Pd-Catalyzed Selective Synthesis of Cyclic Sulfonamides and Sulfinamides
Using K2S2O5 as a Sulfur Dioxide Surrogate" Org. Lett. 2017, 19, 1578-1581.
- 2016
- Hideyuki Konishi, Fumika Hoshino, Kei Manabe
“Practical Synthesis of Axially Chiral Dicarboxylates via Pd-Catalyzed
External-CO-Free Carbonylation” Chem. Pharm. Bull. 2016, 64, 1438-1441.

- Miyuki Yamaguchi, Tomoyo Akiyama, Hirohisa Sasou, Haruka Katsumata, Kei
Manabe
“One-Pot Synthesis of Substituted Benzo[b]furans and Indoles from Dichlorophenols/Dichloroanilines Using a Palladium-Dihydroxyterphenylphosphine
Catalyst” J. Org. Chem. 2016, 81, 5450–5463.
- Miyuki Yamaguchi, Mayu Higuchi, Kanae Tazawa, and Kei Manabe
"Three-Step Synthesis of Fluoranthenes through Pd-Catalyzed Inter
and Intramolecular C−H Arylation" J. Org. Chem. 2016, 81, 3967-3974.
- Miyuki Yamaguchi, Kei Manabe
“Ligand-Controlled Site-Selective Cross-Coupling” In Site-Selective Catalysis, Kawabata, T. Ed.: Springer International Publishing: Switzerland, 2016,
pp. 1-25.
- 2015
- Yasutada Akiba, Takuya Inoue, Izumi Kaji, Masaaki Higashiyama, Kazuyuki
Narimatsu, Ken-ichi Iwamoto, Masahiko Watanabe, Paul H. Guth, Eli Engel,
Atsukazu Kuwahara, J. D. Kaunitz, “Short-chain fatty acid sensing in rat
duodenum”Journal of Physiology2015, 593, 585-599.
Miyuki Yamaguchi, Kohei Suzuki, Kei Manabe, “Scalable Synthesis of Dihydroxyterphenylphosphine
Ligands” Tetrahedron 2015, 71, 2743-2747.
Hideyuki Konishi, Takashi Muto, Tsuyoshi Ueda, Yayoi Yamada, Miyuki Yamaguchi,
Kei Manabe, “Imidazole Derivatives as Accelerators for Ruthenium-Catalyzed
Hydroesterification and Hydrocarbamoylation of Alkenes: Extensive Ligand
Screening and Mechanistic Study” ChemCatChem 2015, 7, 836-845.
Hideyuki Konishi, Hiroki Nagase, Kei Manabe, "Concise Synthesis of
Cyclic Carbonyl Compounds from Haloarenes Using Phenyl Formate as the Carbonyl
Source" Chem. Commun. 2015, 51, 1854-1857.
- 2014
- Kei Manabe, Miyuki Yamaguchi, "Catalyst-Controlled Site-Selectivity
Switching in Pd-Catalyzed Cross-Coupling of Dihaloarenes" Catalysts 2014, 4, 307-320.
Hideyuki Konishi, Kei Manabe, “Formic Acid Derivatives as Practical Carbon
Monoxide Surrogates for Metal-Catalyzed Carbonylation Reactions” Synlett2014, 25, 1971-1986.
Miyuki Yamaguchi, Kei Manabe, “One-pot Synthesis of 2,4-Disubstituted Indoles
from N-Tosyl-2,3-dichloroaniline Using Palladium-Dihydroxyterphenylphosphine
Catalyst” Org. Lett. 2014, 16, 2386-2389.
Hideyuki Konishi, Tsuyoshi Ueda, Kei Manabe, “Pd-Catalyzed External-CO-Free
Carbonylation: Preparation of 2,4,6-Trichlorophenyl 3,4-Dihydronaphthalene-2-Carboxylate”
Org. Synth. 2014, 91, 39-51.
- 2013
- Miyuki Yamaguchi, Takeshi Kimura, Naomi Shinohara, Kei Manabe, “Repetitive
Two-Step Method for o,o,p- and o,p-Oligophenylene Synthesis through Pd-Catalyzed
Cross-Coupling of Hydroxyterphenylboronic Acid” Molecules 2013, 18, 15207-15219.
Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, "Palladium-Catalyzed
Fluorocarbonylation Using N-Formylsaccharin as CO Source: General Access
to Carboxylic Acid Derivatives" Org. Lett. 2013, 15, 5370-5373.
Miyuki Yamaguchi, Haruka Katsumata, Kei Manabe, "One-Pot Synthesis
of Substituted Benzo[b]furans from Mono- and Dichlorophenols Using Palladium
Catalysts Bearing Dihydroxyterphenylphosphine" J. Org. Chem. 2013, 78, 9270-9281.
Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, “Palladium-Catalyzed Reductive
Carbonylation of Aryl Halides with N-Formylsaccharin as a CO Source”Angew. Chem. Int. Ed. 2013, 52, 8611-8615.
Kei Manabe, Takeshi Kimura, “Repetitive Synthetic Method for o,o,p-Oligophenylenes
Using C−H Arylation” Org. Lett. 2013,15, 374-377.
Yumiko Suzuki, Mai Murofushi, Kei Manabe, “One-Pot Synthesis of Unsymmetrical
Benzils and N-Heteroarenes through Nucleophilic Aroylation Catalyzed by
N-Heterocyclic Carbene” Tetrahedron 2013, 69, 470.
- 2012
- Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, “Trichlorophenyl Formate:
Highly Reactive and Easily Accessible Crystalline CO Surrogate for Palladium-Catalyzed
Carbonylation of Aryl/Alkenyl Halides and Triflates” Org. Lett. 2012,14, 5370.
Hideyuki Konishi, Tsuyoshi Ueda, Takashi Muto, Kei Manabe, "Remarkable
Improvement Achieved by Imidazole Derivatives in Ruthenium-Catalyzed Hydroesterification
of Alkenes Using Formates" Org. Lett. 2012, 14, 4722.
Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, "Preparation of α,β-Unsaturated
Esters and Amides via External-CO-Free Palladium-Catalyzed Carbonylation
of Alkenyl Tosylates" Tetrahedron Lett.2012, 53, 5171-5175..
Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, "Palladium-Catalyzed
Carbonylation of Aryl, Alkenyl, and Allyl Halides with Phenyl Formate"
Org. Lett. 2012, 14, 3100-3103.
-
- 2011
- Ishikawa, S.; Manabe, K. "Hydroxylated Terphenylphosphine Ligands
for Palladium-Catalyzed Ortho-Selective Cross-Coupling of Dibromophenols,
Dibromoanilines, and Their Congeners with Grignard Reagents" Tetrahedron 2011, 67, 10156-10163.
Manabe, K.; Ohba, M.; Matsushima, Y. "A Repetitive One-Step Method
for Oligoarene Synthesis Using Catalyst-Controlled Chemoselective Cross-Coupling"
Org. Lett. 2011, 13, 2436-2439.
- 2010
- Wang, J.-R.; Manabe, K. “Hydroxyterphenylphoshine-Palladium Catalyst for
Benzo[b]furan Synthesis from 2-Chlorophenols. Bifunctional Ligand Strategy
for Cross-Coupling of Chloroarenes” J. Org. Chem. 2010, 75, 5340-5342.
Konishi, H.; Itoh, T.; Manabe, K. “Site-Selective Cross-Coupling of Dichlorinated
Benzo-Fused Nitrogen-Heterocycles with Grignard Reagents” Chem. Pharm. Bull.2010, 58, 1255-1258.
Ishikawa, S.; Manabe, K. “DHTP Ligands for the Highly Ortho-Selective,
Palladium-Catalyzed Cross-Coupling with Grignard Reagents: A Conformational
Approach for Catalyst Improvement” Angew. Chem. Int. Ed.2010, 49, 772-775.
Ishikawa, S.; Manabe, K. “Synthesis of Hydroxylated Oligoarene-Type Phosphines
by a Repetitive Two-Step Method” Tetrahedron 2010, 66, 297-303.