発表論文

2025
Miyuki Yamaguchi, Haruna Jimbo, Hideyuki Konishi, Mitsuru Kondo, Kei Manabe "Diastereoselective Synthesis of Pyrroloindolines by Palladium–Dihydroxyterphenylphosphine-Catalyzed C3-Dearomative Arylation/Cyclization of Substituted Tryptamines"Chem. Pharm. Bull. 2025, 73, 687–691.

Miyuki Yamaguchi, Kenichi Nakai, Kiho Morioka, Ayano Sato, Sakiko Fujiwara, Hideyuki Konishi, Kei Manabe
"Ligand-Controlled C2- or C3-Selectivity Switching in the Palladium-Catalyzed C–H Arylation of Nonsubstituted 1H-Pyrrole"Org. Lett. 2025, 27, 141-146.
2024
Hideyuki Konishi, Yohei Aoki, Miyuki Yamaguchi, Kei Manabe "Selective Syntheses of Unsymmetrical Diaryl Sulfides Enabled by a Sulfur Dioxide Surrogate as a Divalent Sulfur Source and an Activating Agent" ACS Catal. 2024, 14, 15348-15355.
2023
Miyuki Yamaguchi, Ryoya Hagiwara, Hana Muto, Kanami Gayama, Hideyuki Konishi, Kei Manabe
"Pyrroloindoline/Pyridoindoline Synthesis via C3-Dearomative Arylation/Cyclization of Tryptamine/Homotryptamine Derivatives Using Palladium−Dihydroxyterphenylphosphine Catalyst" Org. Lett 2023, 25, 4913-4917.
Keisuke Kinoshita, Miyuki Yamaguchi, Hirohisa Sasou, Hideyuki Konishi, Kei Manabe
“Palladium-Catalyzed C‒H Arylation of [1,1'-Biphenyl]-2-ols with Chloroarenes” Chem. Pharm. Bull. 2023, 71, 175-182.
2022
Miyuki Yamaguchi, Sakiko Fujiwara, Yukiko Mori, Hideyuki Konishi, Kei Manabe
“Synthesis of Multisubstituted Pyrroles by Ligand-Controlled Site-Selective Arylation and Their Transformation into Multiarylated Pyrrolines and Pyrrolidines” Tetrahedron2022, 123, 132962.
Hideyuki Konishi, Ririka Fujita, Miyuki Yamaguchi, Kei Manabe
"Synthesis of Symmetrical Sulfides Enabled by a Sulfur Dioxide Surrogate Acting as a Divalent Sulfur Source" Org. Lett. 2022, 24, 3663-3667.
Miyuki Yamaguchi, Kei Manabe
"Synthesis of Multisubstituted Benzofurans/Indoles Using Multichlorinated Phenols/Anilines via Palladium-Catalyzed Site-Selective Sonogashira Coupling" Heterocycles 2022, 104, 3-26.
2020
Hideyuki Konishi, Minoru Kumon, Miyuki Yamaguchi, Kei Manabe "Palladium-Catalyzed External-CO-Free Reductive Carbonylation of Aryl Sulfonates" Tetrahedron 2020, 76, 131639.
Miyuki Yamaguchi, Ryoya Hagiwara, Kanami Gayama, Kohei Suzuki, Yusuke Sato, Hideyuki Konishi, Kei Manabe "Direct C3-Selective Arylation of N-Unsubstituted Indoles with Aryl Chlorides, Triflates, and Nonaflates Using Palladium-Dihydroxyterphenylphosphine Catalyst" J. Org. Chem. 2020, 58, 10902-10912.


Hideyuki Konishi, Kei Manabe "Pd-Catalyzed External-CO-Free Carbonylation: Preparation of 2,4,6-Trichlorophenyl 3,4-Dihydronaphthalene-2-Carboxylate" Org. Synth. 2020, 97, 125-138.


Miyuki Yamaguchi, Kota Ogihara, Hideyuki Konishi, Kei Manabe
"Synthesis of 2,3-Disubstituted Indoles from Alkynylanilines and 2-Chlorophenols Using Palladium‒Dihydroxyterphenylphosphine Catalyst" Tetrahedron Lett. 2020, 61, 151896.
 
2019
Hideyuki Konishi, Kei Manabe
"Recent Progress on Catalytic Heck Carbonylations Using Carbon Monoxide Surrogates"
Tetrahedron Lett. 2019, 60, 151147.

Miyuki Yamaguchi, Sakiko Fujiwara, Kei Manabe
"Synthesis of 2,2,5-Trisubstituted 2H-Pyrroles and 2,3,5-Trisubstituted 1H-Pyrroles by Ligand-Controlled Site-Selective Dearomative C2-Arylation and Direct C3-Arylation"
Org. Lett. 2019, 21, 6972-6977.
Hiromichi Tanaka, Hideyuki Konishi, Kei Manabe "Palladium-Catalyzed One-Step Synthesis of Symmetrical Diaryl Sulfones from Aryl Halides and a Sulfur Dioxide Surrogate" Chem. Lett. 2019, 48, 760-763.
2018
Miyuki Yamaguchi, Hayato Ozawa, Haruka Katsumata, Tomoyo Akiyama, Kei Manabe “One-Pot Synthesis of 2,3-Disubstituted Benzofurans from 2-Chlorophenols Using Palladium‒Dihydroxyterphenylphosphine Catalyst” Tetrahedron Lett. 2018, 59, 3175-3178.

Hideyuki Konishi, Suguru Futamata, Xi Wang, Kei Manabe “Rapid Formation of Fluoren-9-ones via Palladium-Catalyzed External Carbon Monoxide-Free Carbonylation” Adv. Synth. Catal. 2018, 360, 1805-1809.

Hideyuki Konishi, Tomoyuki Sekino, Kei Manabe “Palladium-Catalyzed External-CO-Free Carbonylation of Aryl Bromides Using 2,4,6-Trichlorophenyl Formate” Chem. Pharm. Bull. 2018, 66, 562-567.
Hideyuki Konishi "Creation of Novel Toxic Gas Surrogates and the Development of Safe and Facile Catalytic Reactions" Chem. Pharm. Bull. 2018, 66, 1-19.

Kota Sekiguchi, Erina Ogawa, Kohta Kurohane, Hideyuki Konishi, Narumi Mochizuki, Kei Manabe, Yasuyuki Imai “Adjuvant Effect of Short Chain Triacylglycerol Tributyrin on a Mouse Contact Hypersensitivity Model” Toxicol. Lett. 2018, 284, 56-62.
2017
Hyder Said, Yasutada Akiba, Kazuyuki Narimatsu, Koji Maruta, Ayaka Kuri, Ken-ichi Iwamoto, Atsukazu Kuwahara, Jonathan D. Kaunitz "FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats" Digestive Diseases and Sciences , 2017, 62, 1944-1952.
Yasutada Akiba, Koji Murata, Kazuyuki Narimatsu, Hyder Said, Izumi Kaji, Ayaka Kuri, Ken-ichi Iwamoto, Atsukazu Kuwahara, Jonathan D. Kaunitz "FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats" Am. J. Physiol. Gastrointest. Liver Physiol., 2017, 313, G117-G128.
Izumi Kaji, Yasutada Akiba, Takafumi Furuyama, Donald W. Adelson, Ken-ichi Iwamoto, Makoto Watanabe, Atsukazu Kuwahara, Jonathan D. Kaunitz "Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon."
Neurogastroent. Motil., 2017, 29.

Miyuki Yamaguchi, Kohei Suzuki, Yusuke Sato, Kei Manabe
"Palladium-Catalyzed Direct C3-Selective Arylation of N-Unsubstituted Indoles with Aryl Chlorides and Triflates" Org. Lett. 2017, 19, 5388-5391.
Hideyuki Konishi, Mika Matsubara, Keisuke Mori, Takaki Tokiwa, Sundaram Arulmozhiraja, Yuta Yamamoto, Yoshinobu Ishikawa, Hiroshi Hashimoto, Yasuteru Shigeta, Hiroaki Tokiwa, Kei Manabe
"Mechanistic Insight into Weak-Base-Catalyzed Generation of Carbon Monoxide from Phenyl Formate and Its Application to Catalytic Carbonylation at Room Temperature without Use of External Carbon Monoxide Gas" Adv. Synth. Catal. 2017, 359, 3592-3601.
Miyuki Yamaguchi, Kei Manabe
"Three-Step Synthesis of 2,5,7-Trisubstituted Indoles from N-Acetyl-2,4,6-trichloroaniline Using Pd-Catalyzed Site-Selective Cross-Coupling"Org. Biomol. Chem. 2017, 15, 6645-6655.
Hideyuki Konishi, Masataka Fukuda, Tsuyoshi Ueda, Kei Manabe
"Palladium-catalyzed External-CO-Free Reductive Carbonylation of Bromoarenes" Org. Synth. 2017, 94, 66-76.
Hideyuki Konishi, Hiromichi Tanaka, Kei Manabe
"Pd-Catalyzed Selective Synthesis of Cyclic Sulfonamides and Sulfinamides Using K2S2O5 as a Sulfur Dioxide Surrogate" Org. Lett. 2017, 19, 1578-1581.
2016
Hideyuki Konishi, Fumika Hoshino, Kei Manabe
“Practical Synthesis of Axially Chiral Dicarboxylates via Pd-Catalyzed External-CO-Free Carbonylation” Chem. Pharm. Bull. 2016, 64, 1438-1441.

Miyuki Yamaguchi, Tomoyo Akiyama, Hirohisa Sasou, Haruka Katsumata, Kei Manabe
“One-Pot Synthesis of Substituted Benzo[b]furans and Indoles from Dichlorophenols/Dichloroanilines Using a Palladium-Dihydroxyterphenylphosphine Catalyst” J. Org. Chem. 2016, 81, 5450–5463.
Miyuki Yamaguchi, Mayu Higuchi, Kanae Tazawa, and Kei Manabe
"Three-Step Synthesis of Fluoranthenes through Pd-Catalyzed Inter and Intramolecular C−H Arylation" J. Org. Chem. 2016, 81, 3967-3974.

Miyuki Yamaguchi, Kei Manabe
“Ligand-Controlled Site-Selective Cross-Coupling” In Site-Selective Catalysis, Kawabata, T. Ed.: Springer International Publishing: Switzerland, 2016, pp. 1-25.

2015
Yasutada Akiba, Takuya Inoue, Izumi Kaji, Masaaki Higashiyama, Kazuyuki Narimatsu, Ken-ichi Iwamoto, Masahiko Watanabe, Paul H. Guth, Eli Engel, Atsukazu Kuwahara, J. D. Kaunitz, “Short-chain fatty acid sensing in rat duodenum”Journal of Physiology2015, 593, 585-599.


Miyuki Yamaguchi, Kohei Suzuki, Kei Manabe, “Scalable Synthesis of Dihydroxyterphenylphosphine Ligands” Tetrahedron 2015, 71, 2743-2747.


Hideyuki Konishi, Takashi Muto, Tsuyoshi Ueda, Yayoi Yamada, Miyuki Yamaguchi, Kei Manabe, “Imidazole Derivatives as Accelerators for Ruthenium-Catalyzed Hydroesterification and Hydrocarbamoylation of Alkenes: Extensive Ligand Screening and Mechanistic Study” ChemCatChem 2015, 7, 836-845.


Hideyuki Konishi, Hiroki Nagase, Kei Manabe, "Concise Synthesis of Cyclic Carbonyl Compounds from Haloarenes Using Phenyl Formate as the Carbonyl Source" Chem. Commun. 2015, 51, 1854-1857.


2014
Kei Manabe, Miyuki Yamaguchi, "Catalyst-Controlled Site-Selectivity Switching in Pd-Catalyzed Cross-Coupling of Dihaloarenes" Catalysts 2014, 4, 307-320.

Hideyuki Konishi, Kei Manabe, “Formic Acid Derivatives as Practical Carbon Monoxide Surrogates for Metal-Catalyzed Carbonylation Reactions” Synlett2014, 25, 1971-1986.


Miyuki Yamaguchi, Kei Manabe, “One-pot Synthesis of 2,4-Disubstituted Indoles from N-Tosyl-2,3-dichloroaniline Using Palladium-Dihydroxyterphenylphosphine Catalyst” Org. Lett. 2014, 16, 2386-2389.


Hideyuki Konishi, Tsuyoshi Ueda, Kei Manabe, “Pd-Catalyzed External-CO-Free Carbonylation: Preparation of 2,4,6-Trichlorophenyl 3,4-Dihydronaphthalene-2-Carboxylate” Org. Synth. 2014, 91, 39-51.

2013
Miyuki Yamaguchi, Takeshi Kimura, Naomi Shinohara, Kei Manabe, “Repetitive Two-Step Method for o,o,p- and o,p-Oligophenylene Synthesis through Pd-Catalyzed Cross-Coupling of Hydroxyterphenylboronic Acid” Molecules 2013, 18, 15207-15219.

Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, "Palladium-Catalyzed Fluorocarbonylation Using N-Formylsaccharin as CO Source: General Access to Carboxylic Acid Derivatives" Org. Lett. 2013, 15, 5370-5373.


Miyuki Yamaguchi, Haruka Katsumata, Kei Manabe, "One-Pot Synthesis of Substituted Benzo[b]furans from Mono- and Dichlorophenols Using Palladium Catalysts Bearing Dihydroxyterphenylphosphine" J. Org. Chem. 2013, 78, 9270-9281.


Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, “Palladium-Catalyzed Reductive Carbonylation of Aryl Halides with N-Formylsaccharin as a CO Source”Angew. Chem. Int. Ed. 2013, 52, 8611-8615.


Kei Manabe, Takeshi Kimura, “Repetitive Synthetic Method for o,o,p-Oligophenylenes Using C−H Arylation” Org. Lett. 2013,15, 374-377.


Yumiko Suzuki, Mai Murofushi, Kei Manabe, “One-Pot Synthesis of Unsymmetrical Benzils and N-Heteroarenes through Nucleophilic Aroylation Catalyzed by N-Heterocyclic Carbene” Tetrahedron 2013, 69, 470.

2012
Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, “Trichlorophenyl Formate: Highly Reactive and Easily Accessible Crystalline CO Surrogate for Palladium-Catalyzed Carbonylation of Aryl/Alkenyl Halides and Triflates” Org. Lett. 2012,14, 5370.

Hideyuki Konishi, Tsuyoshi Ueda, Takashi Muto, Kei Manabe, "Remarkable Improvement Achieved by Imidazole Derivatives in Ruthenium-Catalyzed Hydroesterification of Alkenes Using Formates" Org. Lett. 2012, 14, 4722.

Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, "Preparation of α,β-Unsaturated Esters and Amides via External-CO-Free Palladium-Catalyzed Carbonylation of Alkenyl Tosylates" Tetrahedron Lett.2012, 53, 5171-5175..


Tsuyoshi Ueda, Hideyuki Konishi, Kei Manabe, "Palladium-Catalyzed Carbonylation of Aryl, Alkenyl, and Allyl Halides with Phenyl Formate" Org. Lett. 2012, 14, 3100-3103.
 
2011
Ishikawa, S.; Manabe, K. "Hydroxylated Terphenylphosphine Ligands for Palladium-Catalyzed Ortho-Selective Cross-Coupling of Dibromophenols, Dibromoanilines, and Their Congeners with Grignard Reagents" Tetrahedron 2011, 67, 10156-10163.


Manabe, K.; Ohba, M.; Matsushima, Y. "A Repetitive One-Step Method for Oligoarene Synthesis Using Catalyst-Controlled Chemoselective Cross-Coupling" Org. Lett. 2011, 13, 2436-2439.

2010
Wang, J.-R.; Manabe, K. “Hydroxyterphenylphoshine-Palladium Catalyst for Benzo[b]furan Synthesis from 2-Chlorophenols. Bifunctional Ligand Strategy for Cross-Coupling of Chloroarenes” J. Org. Chem. 2010, 75, 5340-5342.

Konishi, H.; Itoh, T.; Manabe, K. “Site-Selective Cross-Coupling of Dichlorinated Benzo-Fused Nitrogen-Heterocycles with Grignard Reagents” Chem. Pharm. Bull.2010, 58, 1255-1258.


Ishikawa, S.; Manabe, K. “DHTP Ligands for the Highly Ortho-Selective, Palladium-Catalyzed Cross-Coupling with Grignard Reagents: A Conformational Approach for Catalyst Improvement” Angew. Chem. Int. Ed.2010, 49, 772-775.


Ishikawa, S.; Manabe, K. “Synthesis of Hydroxylated Oligoarene-Type Phosphines by a Repetitive Two-Step Method” Tetrahedron 2010, 66, 297-303.