2025
- Akira Ooka, Momoka Yamaguchi, Kensuke Suzuki, Shin-ya Saito, Yukiko K. Kaneko, Toshihide Kimura, Tomohisa Ishikawa: Differentiation-inducing factor-1 ameliorates liver fibrosis through the reversion of activated hepatic stellate cells
Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1871(5), 167802 (2025)
- Naoya Watanabe, Hisamitsu Ishihara, Ryota Shizu, Kouichi Yoshinari, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikawa: Diacylglycerol kinase ζ is a positive insulin secretion regulator in pancreatic β-cell line MIN6
Biochemical and Biophysical Research Communications 151109 (2024)
2024
- Naoki Dohi, Momoka Yamaguchi, Kyosuke Iwami, Yukiko K. Kaneko, Shin-ya Saito, Tomohisa Ishikawa: Mouse liver blood flow is regulated by hepatic stellate cells in response to the sympathetic neurotransmitter norepinephrine
Life Sciences 359, 123214 (2024)
- Takayuki Oguma, Takanori Kanazawa, Yukiko K Kaneko, Ren Sato, Miku Serizawa, Akira Ooka, Momoka Yamaguchi, Tomohisa Ishikawa, Hiromu Kondo: Effects of phospholipid type and particle size on lipid nanoparticle distribution in vivo and in pancreatic islets
Journal of controlled release 373 p.917–928 (2024)
- Megumi Kaji, Yukiko K Kaneko, Stella Amarachi Ihim, Ran Kanoh, Moe Yamamoto, Momoka Yamaguchi, Tomohisa Ishikawa: Oral ingestion of Shiikuwasha extract suppresses diabetes progression in db/db mice by preserving β-cell mass
Frontiers in Nutrition 10 1336133 (2024)
- 金子雪子：柑橘果皮由来成分の膵β細胞を標的とした抗糖尿病効果の構造活性相関研究
薬学研究奨励財団 薬学研究の進歩 研究成果報告集, 40, p.97-101
2023
- Soshiro Kodera, Toshihide Kimura, Tomoki Nishioka, Yukiko K. Kaneko, Momoka Yamaguchi, Kozo Kaibuchi, and Tomohisa Ishikawa: GDP-bound Rab27a regulates clathrin disassembly through HSPA8 after insulin secretion
Archives of Biochemistry and Biophysics, 749 (2023)
- 山下日菜子、山口桃生、刀坂泰史、大岡央、森本達也、石川智久：肝線維化へのアルギニンメチル基転移酵素PRMT5の関与
静岡実験動物研究会会報、48(1)、p.4-5 (2023)
- Mai Kato, Momoka Yamaguchi, Akira Ooka, Ryota Takahashi, Takuji Suzuki, Keita Onoda, Yuko Yoshikawa, Yuta Tsunematsu, Michio Sato, Yasukiyo Yoshioka, Miki Igarashi, Sumio Hayakawa, Kumiko Shoji, Yutaka Shoji, Tomohisa Ishikawa, Kenji Watanabe, Noriyuki Miyoshi: Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice
Scientific Reports 13, 8924 (2023)
- Yukiko K. Kaneko: Development of Therapeutic Agents with a Novel Mechanism of Action Targeting Pancreatic β-Cells for Diabetes
Biological and Pharmaceutical Bulletin 46(5) p640–646. (2023)
- Stella Amarachi Ihim, Yukiko K. Kaneko , Moe Yamamoto, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikawa: Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells
Biological and Pharmaceutical Bulletin 46(4) p630–635. (2023)
- 金子雪子：生活習慣病の新たな予防・治療法の創出を目指した次世代若手研究者による研究展開
日報薬事 第12719号 第6面 2023年3月17日
- Hirotake Ishida, Tomohisa Ishikawa, Shin-ya Saito: Enhanced Contraction of Arterial Smooth Muscle Cell in Skin Artery Is Sensitive to Hyperpolarization Mediated by BKCa Channel in Chronic Constriction Injury Model Rat
Biological and Pharmaceutical Bulletin 46(3) p399–403. (2023)
2022
Yukiko K. Kaneko, Ami Morioka, Misaki Sano, Maho Tashiro, Naoya Watanabe, Nahoko Kasahara, Masato Nojiri, Chihiro Ishiwatari, Kentaro Ichinose, Akira Minami, Takashi Suzuki, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikawa: Asymmetric dimethylarginine accumulation under hyperglycemia facilitates β-cell apoptosis via inhibiting nitric oxide production
Biochemical and Biophysical Research Communications Volume 637, p108–116. (2022)
Yukiko K. Kaneko, Yuki Tara, Stella Amarachi Ihim, MoeYamamoto, Megumi Kaji, Tomohisa Ishikawa: Nobiletin ameliorates glucose tolerance by protecting against β-cell loss in type-2 diabetic db/db mice
Phytomedicine Plus (2) 4, 100367 (2022)
Momoka Yamaguchi, Takanori Kanazawa, Sumire Morino, Shingo Iioka, Yuta Watanabe, Naoki Dohi, Kenjirou Higashi, Hiromu Kondo, Tomohisa Ishikawa: Increased Tropism of Extracellular Vesicles Derived from Palmitic Acid-Treated Hepatocytes to Activated Hepatic Stellate Cells
Membranes, 12(10), 1023, (2022)
Yukiko K. Kaneko, Toshiaki Sawatani, Tomohisa Ishikawa: Involvement of diacylglycerol kinase on the regulation of insulin secretion in pancreatic β-cells during type 2 diabetes.「膵β細胞脂質代謝分子によるインスリン分泌制御及び2型糖尿病病態形成への関与」
YAKUGAKU ZASSHI, 142(5) 457－463, (2022)
土肥直貴：多様な臓器から考える線維症治療への最先端アプローチ
日報薬事：p13、2022年3月18日
Momoka Yamaguchi, Saya Ohbayashi, Akira Ooka, Hinako Yamashita, Nanami Motohashi, Yukiko K. Kaneko, Toshihide Kimura, Shin-ya Saito, Tomohisa Ishikawa: Harmine suppresses collagen production in hepatic stellate cells by inhibiting DYRK1B
Biochemical and Biophysical Research Communications, Volume 600, p136-141 (2022)
金子雪子、石川智久：次世代糖尿病治療標的としての膵β細胞量の制御
石川智久：第145回日本薬理学会関東部会・研究室訪問
2021
Hirotake Ishida, Momoka Yamaguchi, Shin-ya Saito, Takuma Furukawa, John L. Shannonhouse, Yu Shin Kim, Tomohisa Ishikawa: Na+-dependent inactivation of vascular Na+/Ca2+ exchanger responsible for reduced peripheral blood flow in neuropathic pain model
European Journal of Pharmacology. Volume 910, 5 November, 174448 (2021)
Momoka Yamaguchi, Naoki Dohi, Akira Ooka, Shin-ya Saito, Tomohisa Ishikawa: Caffeine-induced inversion of prostaglandin E2 effects on hepatic stellate cell activation
Biomedicine & Pharmacotherapy.Volume 142, October, 111989 (2021)
Naoki Dohi, Momoka Yamaguchi, Reina Hase, Ryosuke Suzuki, Yumeto Wakabayashi, Ryota Nishiyama, Shin-ya Saito, Tomohisa Ishikawa: Quantitative real-time measurement of endothelin-1-induced contraction in single non-activated hepatic stellate cells
PLOS ONE. 16(8):e0255656. (2021)
Taiji Sato, Chihiro Ishiwatari, Yukiko K.Kaneko, Yoko Ishikawa, Yuki Kimura, Naoya Watanabe, Ikumi Aoshima, Yukari Matsuda, Takahiro Nakayama, Rina Chiba, Takahiro Fujimuki, Kai Iwata, Qiang Lu, Takako Usuki, Fumio Sakane, Tomohisa Ishikawa: Diacylglycerol kinaseδ functions as a proliferation suppressor in pancreatic β-cells
The FASEB journal. e21420. volume 35(5) (2021)
山口桃生：類洞内皮細胞のGATA4欠損により肝臓は線維化へとスイッチされる
ファルマシア（トピックス）57巻6号、p.546 (2021)
2020
Akira Minami, Yuka Fujita, Sumika Shimba, Mako Shiratori, Yukiko K. Kaneko, Toshiaki Sawatani, Tadamune Otsubo, Kiyoshi Ikeda, Hiroaki Kanazawa, Yasuyo Mikami, Risa Sekita, Yuuki Kurebayashi, Tadanobu Takahashi, Taeko Miyagi, Tomohisa Ishikawa, Takashi Suzuki: The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion
Scientific Reports, 10, 5198 (2020)
Yusuke Wada, Mitsuhiro Kondo, Kumi Sakairi, Akira Nagashima, Kenichi Tokita, Hiroaki Tominaga, Hiroshi Tomiyama, Tomohisa Ishikawa: Renoprotective effects of a novel receptor-interacting protein kinase 2 Inhibitor, AS3334034, in uninephrectomized adriamycin-induced chronic kidney disease rats.
Journal of Pharmacology and Experimental Therapeutics, 374, 428–437 (2020)
金子雪子、菅敏幸、石川智久: 柑橘フラボノイドの膵β細胞機能に与える効果の検証と糖尿病進展抑止への可能性
日薬理誌(Folia Pharmacol Jpn.) 155(4), 209-213. (2020)
梶 萌、金子雪子、多良勇輝、山本萌絵、石川智久：Nobiletinは膵β細胞障害を抑制することで糖尿病改善効果を示す
静岡実験動物研究会会報、46(1)、p.8-9 (2020)
大岡央、古川翔平、山口桃生、齊藤真也、石川智久：細胞性粘菌由来低分子化合物DIF-1は肝線維化責任細胞の活性化を抑制する
静岡実験動物研究会会報、46(1)、p.10-11 (2020)
2019
Hirotake Ishida, Shin-ya Saito, Ayaka Horie, Tomohisa Ishikawa：Alleviation of mechanical stress-induced allodynia by improving blood flow in chronic constriction injury mice
European Journal of Pharmacology, 849, 67-74 (2019)
Hirotake Ishida, Shin-ya Saito, Naoki Dohi, Tomohisa Ishikawa：Mechanism of membrane depolarization involved in α1A-adrenoceptor-mediated contraction in rat tail and iliac arteries
Biological and Pharmaceutical Bulletin, 42, 1741-1745 (2019)
Shohei Furukawa, Momoka Yamaguchi, Akira Ooka, Haruhisa Kikuchi, Tomohisa Ishikawa, Shin-ya Saito：Differentiation-inducing factor-1 prevents hepatic stellate cell activation through inhibiting GSK3β inactivation
Biochemical and Biophysical Research Communications, 520, 140-144 (2019)
Toshiaki Sawatani, Yukiko K. Kaneko, Tomohisa Ishikawa：Dual effect of reduced type I diacylglycerol kinase activity on insulin secretion from MIN6 β-cells
Journal of Pharmacological Sciences. 140, 178-186 (2019)
Toshiaki Sawatani, Yukiko K. Kaneko, Isao Doutsu, Ai Ogawa, Tomohisa Ishikawa：TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells
American Journal of Physiology Cell Physiology, 316(3), C424-C443 (2019)
Toshihide Kimura, Mami Yamaoka, Takeshi Terabayashi, Kozo Kaibuchi, Tomohisa Ishikawa, Toshimasa Ishizaki：GDP-bound Rab27a dissociates from the endocytic machinery in a phosphorylation-dependent manner after insulin secretion
Biological and Pharmaceutical Bulletin, 42, 1532-1537 (2019)
Mami Yamaoka, Takeshi Terabayashi, Tomoki Nishioka, Kozo Kaibuchi, Tomohisa Ishikawa, Toshimasa Ishizaki, Toshihide Kimura：IRR is involved in glucose-induced endocytosis after insulin secretion
Journal of Pharmacological Sciences, 140, 300-304 (2019)
土肥直貴，岩見恭介，山口桃生，齊藤真也，石川智久：自律神経による肝星細胞の肝類洞血流調節機構の解析
静岡実験動物研究会会報、45(1)、p.22 (2019)
山口桃生：用語解説 肝星細胞
静岡実験動物研究会会報、45(1)、p.34 (2019)
2018
Hirotake Ishida, Shin-ya Saito, Tomohisa Ishikawa.：α1A-Adrenoceptors, but not α1B- or α1D-adrenoceptors, contribute to enhanced contractile response to phenylephrine in cooling conditions in the rat tail artery
European Journal of Pharmacology. 838, 120-128 (2018)
Hirotake Ishida, Shin-ya Saito, Eita Hishinuma, Tomoaki Kitayama. Tomohisa Ishikawa.：Differential contribution of calcium channels to α1-adrenoceptor-mediated contraction is responsible for diverse responses to cooling between rat tail and iliac arteries
European Journal of Pharmacology. 826, 9-16 (2018)
Hiroto Sagara, Masaki Kanakogi, Yuki Tara; Hitoshi Ouchi, Junko Kimura, Yukiko Kaneko, Makoto Inai, Tomohiro Asakawa, Tomohisa Ishikawa, Toshiyuki Kan: Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations
Tetrahedron Letters, 59(19), 1816-1818 (2018)
木村有希、増田真也、内田光咲、齊藤真也、石川智久：平滑筋を用いたアシル化ブテノリド誘導体の生物活性機序の解明
静岡実験動物研究会会報、44(1)、pp.28-29 (2018)
石川智久：活動紹介 伝統ある静岡実験動物研究会
LABIO21、73、pp.42 (2018)
2017
Hirotake Ishida, Shin-ya Saito, Eita Hishinuma, Tomohisa Ishikawa: Differential contribution of nerve-derived noradrenaline to high K+-induced contraction depending on type of artery
Biological and Pharmaceutical Bulletin, 40, 56-60 (2017)
Izumi Serizawa, Nozomi Iwasaki, Hirotake Ishida, Shin-ya Saito, Tomohisa Ishikawa: G-protein coupled estrogen receptor-mediated non-genomic facilitatory effect of estrogen on cooling-induced reduction of skin blood flow in mice
European Journal of Pharmacology, 797, 26-31 (2017)
Momoka Yamaguchi, Ryota Nishiyama, Shin-ya Saito, Misuzu Nakamura, Kenichiro Todoroki, Toshimasa Toyo’oka, Tomohisa Ishikawa: Caffeine suppresses the activation of hepatic stellate cells cAMP-independently by antagonizing adenosine receptors
Biological and Pharmaceutical Bulletin, 40, 658-64 (2017)
Miki Takii, Yukiko K. Kaneko, Kiriko Akiyama, Yuki Aoyagi, Yuki Tara, Tomohiro Asakawa, Makoto Inai, Toshiyuki Kan, Kiyomitsu Nemoto, Tomohisa Ishikawa: Insulinotropic and anti-apoptotic effects of nobiletin in INS-1D β-cells
Journal of Functional Foods, 30, 8-15 (2017)
石川智久：AGORA 遠い昔の海外留学回想録
日本薬理学雑誌、150、pp.121-122 (2017)
石田裕丈、古川琢麻、齊藤真也、石川智久：神経障害性疼痛時に発生する皮膚血流障害のメカニズムの解明
静岡実験動物研究会会報、43(1)、pp.11-12 (2017)
2015
Taiji Sato, Yukiko K. Kaneko, Toshiaki Sawatani, Akiko Noguchi, Tomohisa Ishikawa: Obligatory role of early Ca2+ responses in H2O2-induced β-cell apoptosis
Biol. Pharm. Bull. 38(10), 1599-1605 (2015)
Yukiko K. Kaneko, Tomohisa Ishikawa: Diacylglycerol signaling pathway in pancreatic β-cells: the essential role of diacylglycerol kinase in the regulation of insulin secretion
Biol. Pharm. Bull. 38(5), 669-673 (2015)
Yukiko K. Kaneko, Miki Takii, Yumiko Kojima, Hiroko Yokosawa, Tomohisa Ishikawa: Structure-dependent inhibitory effects of green tea catechins on insulin secretion from pancreatic β-cells
Biol. Pharm. Bull. 38(3), 476-481 (2015)
Tomohisa Ishikawa: Recent progress in the research of insulin secretion
Biol. Pharm. Bull. 38, 655 (2015)
石川智久： 図解 薬理学 ―6章 代謝系の薬理―
南山堂（分担執筆） (2015)
2014
Kazunori Goto, Shin-ya Saito, Tomohisa Ishikawa: Enhanced vasoconstriction to α1-adrenoceptor stimulation during cooling in mouse cutaneous plantar arteries
Eur. J. Pharmacol., 742, 1-7 (2014)
Yukisato Ishida, Kazuo Obara, Richard J Paul: Myosin Phosphorylation Dissociated from Force under Hypoxic and Glucose-Free Conditions in the Guinea Pig Taenia Caeci.
Muscle Res. Cell Motil., 35, 243 (2014)
石川智久： 詳解 薬理学 ―第1章 総論； 第2章 生理活性物質； 第9章 循環器系に作用する薬物―
廣川書店（分担執筆） (2014)
2013
Yukiko Kurohane Kaneko, Yosuke Kobayashi, Keisuke Motoki, Kunihito Nakata, Shoko Miyagawa, Mao Yamamoto, Daiki Hayashi, Yasuhito Shirai, Fumio Sakane, Tomohisa Ishikawa.: Depression of type I diacylglycerol kinases in pancreatic β-Cells grom male mice results in impaired insulin secretion
Endocrinology, 154, 4089-4098 (2013) [Abstract]
Masaki Honda, Ryuichi Komatsu, Takehito Isobe, Mitsuyasu Tabo, Tomohisa Ishikawa: Involvement of the Autonomic Nervous System in Diurnal Variation of Corrected QT Intervals in Common Marmosets
J Pharmacol Sci., 121, 131-137 (2013) [Abstract]
Yoshiki Sahara, Shin-ya Saito, Tomohisa Ishikawa: Involvement of nitric oxide production in the impairment of skin blood flow response to local cooling in diabetic db/db mice
Eur. J. Pharmacol., 720, 147-179 (2013)
Yukiko Kurohane Kaneko, Tomohisa Ishikawa: Dual role of nitric oxide in pancreatic β-cells
J Pharmacol Sci., 123, 295-300 (2013)
石田裕丈、菱沼瑛太、北川智章、齊藤真也、石川智久: ラット尾動脈および総腸骨動脈における興奮機構の相違
日本薬理学雑誌, 142(4), p4 (2013)
2012
Takeshi Yoshimura, Akitoshi Ito, Shin-ya Saito, Mineko Takeda, Hiroshi Kuriyama, Tomohisa Ishikawa: Calcitonin ameliorates enhanced arterial contractility after chronic constriction injury of the sciatic nerve in rats
Fundam. Clin. Pharmacol., 26, 315-321 (2012) [Abstract]
Kimiaki Suzuki, Shin-ya Saito, Tomohisa Ishikawa: Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2 receptor-mediated extracellular Ca2+ influx in rat aorta
Eur. J. Pharmacol., 677, 123-130 (2012) [Abstract]
Koichi Nakayama, Yoshiyuki Tanabe, Kazuo Obara, Tomohisa Ishikawa: Mechanosensitivity of Pancreatic β-cells, Adipocytes, and Skeletal Muscle Cells: The Therapeutic Targets of Metabolic Syndrome
Mechanically Gated Channels and their Regulation, Springer pp.379-404 (2012)
山口桃生、西山良太、齊藤真也、石川智久：肝星細胞活性化に対するカフェインの作用解析
日本薬理学雑誌, 140(4), 17P (2012)
金子雪子、野尻雅人、笠原七帆子、石川智久：膵β細胞における構成型 NO 合成酵素 (cNOS) 活性調節に対する高血糖の影響
日本薬理学雑誌, 140(4), 20P (2012)
金子雪子：エストロゲンはどのように２型糖尿病を防ぐのか.
ファルマシア, 48(3), 243 (2012)
2011
Kazuo Obara, Kiyotaka Ukai, Tomohisa Ishikawa: Mechanism of potentiation by tea epigallocatechin of contraction in porcine coronary artery: The role of protein kinase Cδ-mediated CPI-17 phosphorylation
Eur. J. Pharmacol., 668, 414-418 (2011) [Abstract]
Masahiro Takada, Akiko Noguchi, Yurie Sayama, Yukiko Kaneko, Tomohisa Ishikawa: Inositol 1,4,5-trisphosphate receptor-mediated initial Ca2+ mobilization constitutes a triggering signal for hydrogen peroxide-induced apoptosis in INS-1 β-cells
Biol. Pharm. Bull., 34, 954-958 (2011) [Abstract]
元木啓介、金子雪子、石川智久：膵β細胞インスリン分泌調節におけるI型ジアシルグリセロールキナーゼの役割
日本薬理学雑誌、138(4), p6 (2011)
齊藤真也、西山良太、山口桃生、石川智久：カフェインはマウス肝星細胞の活性化を抑制する
日本薬理学雑誌、138(4), p8 (2011)
滝口茂幸、宇田宗晃、小原一男、藤井孝治、石川智久：マウスヒラメ筋における伸展刺激誘発性糖取り込みへのインテグリン/FAK経路の関与
日本薬理学雑誌、138(4), p8 (2011)
2010
Kazuo Obara, Ayako Mitate, Kayo Nozawa, Makiko Watanabe, Yoshihiko Ito and Koichi Nakayama: Interactive role of protein phosphatase 2A and protein kinase Ca in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery
Vasc. Res. 47, 115-127 (2010)
金子雪子、小林洋輔、元木啓介、藤貫貴大、石川智久：脂質シグナル調節分子ジアシルグリセロールキナーゼの膵β細胞における発現・機能解析
日本薬理学雑誌、136(4), 5P (2010)
2009
Toshihide Kashihara, Koichi Nakayama, Toshio Matsuda, Akemichi Baba, Tomohisa Ishikawa: Role of Na+/Ca2+ exchanger-mediated Ca2+ entry in pressure-induced myogenic constriction in rat posterior cerebral arteries
J. Pharmacol. Sci., 110, 218-222 (2009) [Abstract]
Toshihide Kashihara, Kazunori Goto, Yoshiki Sahara, Koichi Nakayama, Tomohisa Ishikawa: Differential involvement of α1-adrenoceptors in vasoconstrictor responses to cooling in mouse plantar arteries in vitro and in vivo.
J. Smooth Muscle Res., 45, 87-95 (2009) [Abstract]
Yukiko Kaneko, Toshihide Kimura, Shigeki Taniguchi, Midori Souma, Yumiko Kojima, Yuka Kimura, Hideo Kimura, Ichiro Niki: Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose.
FEBS Lett., 583, 377-382 (2009) [Abstract]
Koichi Nakayama, Kazuo Obara, Tomohisa Ishikawa, Shigeru Nishizawa: Specific Mechanotransduction signaling involved in myogenic responses of the cerebral arteries.
Mechanosensitivity in Cells and Tissues. Mechanosensitivity of the Heart, 453-481, Springer, Dordrecht (2009).
Shin-ya Saito: Toxins affecting actin filaments and microtubules
In Marin Toxins as Research Tools, Nobuhiro Fusetani, William Kem eds. Springer, pp. 187-219 (2009)
小林洋輔、金子雪子、石川智久： 膵β細胞におけるジアシルグリセロールキナーゼの発現と機能解析
日本薬理学雑誌、133, 17P (2009)
鈴木公章、西島愛美、齊藤真也、石川智久： U46619で誘発される血管収縮反応におけるPLA2およびカチオンチャネルの役割
日本薬理学雑誌、134, 19P (2009)
2008
Takaaki Sunouchi, Kimiaki Suzuki, Koichi Nakayama, Tomohisa Ishikawa: Dual effect of nitric oxide on ATP-sensitive K+ channels in rat pancreatic beta-cells
Pflugers Arch.-Eur. J. Physiol., 456, 573-579 (2008) [Abstract]
Toshihide Kashihara, Koichi Nakayama, Tomohisa Ishikawa: Distinct roles of protein kinase C isoforms in myogenic constriction of rat posterior cerebral arteries
J. Pharmacol. Sci., 108, 446-454 (2008) [Abstract]
Akiko Noguchi, Masahiro Takada, Koichi Nakayama, Tomohisa Ishikawa: cGMP-independent anti-apoptotic effect of nitric oxide on thapsigargin-induced apoptosis in the pancreatic beta-cell line INS-1
Life Sci., 83, 865-870 (2008) [Abstract]
Kazuo Obara, Yoshihiko Ito, Hiroki Shimada, Koichi Nakayama: The relaxant effect of okadaic acid on canine basilar artery involves activation of PKCalpha and phosphorylation of the myosin light chain at Thr-9
Eur. J. Pharmacol., 598, 87-93 (2008) [Abstract]
Toshihide Kimura, Yukiko Kaneko, Shogo Yamada, Hisamitsu Ishihara, Takao Senda, Akihiro Iwamatsu, Ichiro Niki: The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines
J. Cell Sci., 121, 3092-3098 (2008) [Abstract]
Yukio Yuzawa, Ichiro Niki, Tomoki Kosugi, Shoichi Maruyama, Futoshi Yoshida, Motohiro Takeda, Yoshiaki Tagawa, Yukiko Kaneko, Toshihide Kimura, Noritoshi Kato, Jyunichiro Yamamoto, Waichi Sato, Takahiro Nakagawa, Seiichi Matsuo: Diabetic nephropathy in transgenic mice overexpressing beta cell calmodulin
J. Am. Soc. Nephrol., 19, 1701-1711(2008) [Abstract]
石川智久： ラット、マウスを用いたIn Vivo皮膚微小循環解析法
日本薬理学雑誌、132, 79-82 (2008)
小原一男：プロテインキナーゼCによるミオシン軽鎖リン酸化の制御.
血管医学 9, 239-245 (2008)
2007
Masaki Honda, Mika Suzuki, Koichi Nakayama, Tomohisa Ishikawa: Role of alpha2C-adrenoceptors in local cooling-induced reduction of skin blood flow in mice
Br. J. Pharmacol., 152, 91-100 (2007) [Abstract]
Shin Tsunekawa, Naoki Yamamoto, Katsura Tsukamoto, Yuji Itoh, Yukiko Kaneko, Toshihide Kimura, Yoh Ariyoshi, Yoshitaka Miura, Yutaka Oiso, Ichiro Niki: Protection of pancreatic beta cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies
J. Endocrinol., 193, 65-74 (2007) [Abstract]
Atsushi Ikeda, Taisuke Miyazaki, Sho Kakizawa, Yasushi Okuno, Soken Tsuchiya, Akira Myomoto, Shin-ya Saito, Tetsuji Yamamoto, Tetsuo Yamazaki, Masamitsu Iino, Gozoh Tsujimoto, Masahiko Watanabe, Hiroshi Takeshima: Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins
Biochem. Biophys. Res. Commun., 363, 835-839 (2007) [Abstract]
金子雪子、木村俊英、仁木一郎: 硫化水素とインスリン分泌
内分泌・糖尿病科, 25, 245-249 (2007)
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