RESEARCH » Research Subjects

Research Subjects

Graduate Program in Pharmacy

Molecular Medicine (Prof. MORIMOTO, Tatsuya)

  1. Study on cardiac nuclear signaling pathway in heart failure
  2. Epigenetic analysis of transcriptional responses to cardiac hypertrophy
  3. Translational research for heart failure therapy with curcumin
  4. Application of functional foods to treatment of cardiovascular diseases

Bio-informational Pharmacology (Prof. KUROKAWA, Junko)

  1. Research on ion channels and transporters as therapeutic targets in the gender specific medicine (GSM)
  2. Cardiac pharmacology and toxicology using iPS cells and in silico modeling
  3. Molecular mechanisms on sex differences in inflammatory muscle diseases
  4. Molecular mechanisms to maintain adipogenic stem cells in undifferentiated state

Pharmacy Practice & Science (Prof. UCHIDA, Shinya)

  1. Development and clinical evaluation of confectionary shaped dosage forms, orally disintegrating tablets, and hospital formulations
  2. PK/PD analyses of drugs for optimal and personalized pharmaceutical therapies
  3. Clinical impacts of drug interactions and genetic polymorphisms of drug-metabolizing enzymes, transporters and receptors
  4. Evaluations of clinical impact of pharmacists on pharmacotherapy, and development of new pharmacist work

Clinical Pharmaceutics (Prof. TSUJI, Daiki)

  1. Study on factors affecting distribution or clinical efficacy of drugs
  2. Analysis and application of necessary data of drug reactions for pharmaceutical care
  3. Pharmaceutical evaluation of drugs and development of new formulations based on pharmaceutical characteristics
  4. Study on factors affecting development or clinical state of diabetes or rheumatism

Clinical Pharmacology & Genetics (Prof. ITOH, Kunihiko)

  1. Analysis of genetic polymorphisms affecting the drug response for optimization of medication
  2. Analysis of the diseases-related biomarker for prevention and therapy of the diseases
  3. Development of human recombinant antibodies useful for diagnosis and therapy of cancer, and so on
  4. Development of molecular targeting drugs based on the antibody epitope analysis

 

Graduate Program in Pharmaceutical Sciences

Organic Chemistry (Prof. MANABE, Kei)

  1. Development of high-performance catalysts for efficient molecular transformation
  2. Development of environmentally friendly molecular transformation
  3. Creation of new functional materials and biologically active compounds
  4. Studies on mechanisms of chemical reactions

Analytical and Bioanalytical Chemistry (Prof. TODOROKI, Kenichiro)

  1. Development of new analytical methods for next-generation biopharmaceuticals
  2. Development of new analytical tools for omics analysis
  3. Single-cell metabolomics
  4. Development of the analytical methods for high-selective molecular imaging

Molecular Toxicology (Prof. YOSHINARI, Kouichi)

  1. Understanding of molecular mechanisms for the expression of drug-metabolizing enzymes
  2. Investigation on the physiological/toxicological roles of xenobiotic-responsive nuclear receptors
  3. Studies on the mechanisms, prevention and treatment of cancers
  4. Development of chemical safety evaluation systems and alternatives to animal experiments

Physical Biochemistry (Prof. HASHIMOTO, Hiroshi)

  1. X-ray structural analysis and functional study of disease-related proteins
  2. Structural biology to unravel molecular mechanism underlying DNA damage response
  3. Studies on structure and function of proteins involved in control of chromosome structure
  4. Structural and functional studies of proteins involved in regulation of cancer cell proliferation

Integrative Physiology (Prof. HARA, Yuji)

  1. The role of membrane proteins activated by physical force in muscle stem cells
  2. The development of“ mechanomedicine” for neuromuscular diseases
  3. The role of phospholipid translocases in physiological systems
  4. Zinc signaling in brain functions and diseases

Synthetic Organic & Medicinal Chemistry (Prof. TAKITA, Ryo)

  1. Total synthesis of biological active natural products
  2. Synthesis of probe for elucidation of biological function
  3. Development of novel synthetic method
  4. Synthesis of active constituent of Shizuoka speciality foods

Pharmaceutical Engineering (Prof. KONDO, Hiromu)

  1. Design of particles and examination of manufacturing process
  2. Development of novel physical evaluation methods
  3. Structural analyses of pharmaceutics
  4. Development of novel DDS (Drug Delivery System) technologies

Synthetic Organic Chemistry (Prof. HAMASHIMA, Yoshitaka)

  1. Development of novel catalytic reactions and asymmetric synthesis
  2. Chemical studies on organofluorine compounds
  3. Development of light-driven novel molecular transformations
  4. Synthesis of bio-functional molecules and their applications

Pharmacology (Prof. ISHIKAWA, Tomohisa)

  1. Signal transduction involved in functional regulation of insulin secretion, cell proliferation, and apoptosis in pancreatic β cells
  2. Signal transduction involved in functional regulation of hepatic stellate cell activation and constriction.
  3. Signaling mechanisms underlying the development of diabetes and liver fibrosis and application to disease prevention
  4. Development of therapeutic approach for diabetes and liver fibrosis by applying bioactive natural products

Scientific English (Assoc. Prof. HAWKE, Philip)

  1. Curriculum development to improve students’ basic scientific English and advanced discussion skills
  2. Preparing students to present their research at international scientific conferences
  3. Training students to effectively write and edit their own academic papers
  4. Carrying out linguistic analysis of the specialized language used by the scientific community

Center for Drug Discovery (Prof. ASAI, Akira)

  1. Development of new drug screening system focused on signal transduction and immuno-oncology
  2. Lead discovery and optimization for developing new anticancer agents
  3. Research on mode of action and biomarker for drug candidates
  4. Analysis and regulation of intracellular molecular network with bioactive small molecules

Center for Pharma-Food Research (Prof. YAMADA, Shizuo)

  1. Basic and clinical research for the development and better use of novel pharmaceuticals and functional foods
  2. Basic and clinical research of combination effects of pharmaceuticals and functional foods

 

Graduate Program in Pharmaceutical and Nutritional Sciences

Biochemistry (Prof. TAKEUCHI, Hideyuki)

  1. Exploring how glycans regulate Notch signaling and pharmaceutical application
  2. Function of glycoconjugates in virus replication and development of antiviral agents
  3. Role of sugar chains in synaptic development and function of the brain
  4. Elucidation of the regulatory mechanism of stem cells by glycosylation

Medical Biochemistry (Prof. ASAI, Tomohiro)

  1. The development of nucleic acid delivery systems
  2. DDS research applied to cancer diagnosis and treatment
  3. DDS research on renal disease treatment
  4. The development of plastic antibodies that adsorb target molecules in vivo

Pharmacognosy (Prof. WATANABE, Kenji)

  1. Plant biotechnology
  2. Chemical biology through biosyntheses
  3. Screening of physiologically active natural products
  4. Methodology for genome mining and biosynthesis

Biopharmacy (Prof. ONOUE, Satomi)

  1. Pharmacokinetic and pharmacodynamic studies to de-risk drug candidates
  2. DDS development and pharmacokinetic studies on therapeutic peptides/proteins
  3. Safety evaluation of drug candidates based on pharmacokinetic and physicochemical properties
  4. Biopharmaceutical studies on nutraceuticals for improved pharmacokinetics and efficacy

Microbiology & Immunology (Prof. UMEMOTO, Eiji)

  1. Physiological roles of innate immune cell populations in the mucosal tissues
  2. Analysis of bioactive metabolites and their receptors in the immune system
  3. Molecular mechanism of host defense against pathogenic bacteria
  4. Roles of TRP channels in chemical allergy induction on the skin